Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination.

abstract：:We developed a coculture system comprising primary rat adipocytes and L6 rat skeletal muscle cells to allow investigation of the effects of physiologically relevant mixtures of adipokines. We observed that coculture, or adipocyte-conditioned media, increased glucose uptake in muscle cells. An adipokine that could pote...

journal_title：Endocrinology

authors： Vu V,Kim W,Fang X,Liu YT,Xu A,Sweeney G

更新日期：2007-09-01 00:00:00

abstract：:Both peroxisome proliferator-activated receptor-alpha (PPARalpha) and pancreatic/duodenal homeobox-1 (PDX-1) have been reported to be associated with glucose-stimulated insulin secretion (GSIS), but the relationship between PPARalpha and PDX-1 is not yet fully understood. In the present study, we tested the hypothesis...

journal_title：Endocrinology

authors： Sun Y,Zhang L,Gu HF,Han W,Ren M,Wang F,Gong B,Wang L,Guo H,Xin W,Zhao J,Gao L

更新日期：2008-02-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknow...

journal_title：Endocrinology

authors： Wang X,Cahill CM,Piñeyro MA,Zhou J,Doyle ME,Egan JM

更新日期：1999-10-01 00:00:00

abstract：:The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood...

journal_title：Endocrinology

authors： Franck-Lissbrant I,Häggström S,Damber JE,Bergh A

更新日期：1998-02-01 00:00:00

abstract：:The possible role of the pentose phosphate shunt in thyroid hormone secretion was investigated in vivo and in vitro with mouse thyroid glands. Thyroidal endocytosis in response to TSH, a step of thyroid hormone secretion, was evaluated for its dependency upon the pentose phosphate shunt by using 6-aminonicotinamide (6...

journal_title：Endocrinology

authors： Hashizume K,Onaya T,Sato A

更新日期：1975-10-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:The effects of somatostatin (SRIF) on the production and release of TSH and its subunits have been investigated in bovine anterior pituitary monolayer cultures. SRIF caused a dose-dependent inhibition of TSH and subunit release by TRH, with a half-maximal effective dose of 3 X 10(-8) M. This effect was time dependent ...

journal_title：Endocrinology

authors： Ridgway EC,Klibanski A,Martorana MA,Milbury P,Kieffer JD,Chin WW

更新日期：1983-06-01 00:00:00

abstract：:Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horse...

journal_title：Endocrinology

authors： Bubenik GA,Brown GM,Grota LJ

更新日期：1975-01-01 00:00:00

abstract：:The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...

journal_title：Endocrinology

authors： Wong EH,Tan CH,Khoo HE,Ng FH,Lim KL,Ciaraldi TP

更新日期：1995-04-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase activity and reductase mRNA level were determined in adrenals from hamsters treated with ACTH, with or without cycloheximide or aminoglutethimide. Both reductase activity and reductase mRNA level were similarly enhanced by ACTH administration compared to levels...

journal_title：Endocrinology

authors： Lehoux JG,Lefebvre A,De Médicis E,Bélisle S,Bellabarba D

更新日期：1989-07-01 00:00:00

abstract：:Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure and a greater susce...

journal_title：Endocrinology

authors： Hall JA,Ribich S,Christoffolete MA,Simovic G,Correa-Medina M,Patti ME,Bianco AC

更新日期：2010-09-01 00:00:00

abstract：:Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...

journal_title：Endocrinology

authors： Roth JD,Coffey T,Jodka CM,Maier H,Athanacio JR,Mack CM,Weyer C,Parkes DG

更新日期：2007-12-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:Chloroquine is widely used as a lysosomal enzyme inhibitor, and while effects on DNA repair and membrane recycling have also been reported, there has been no investigation of effects on the processing of secretory products. To determine whether chloroquine had any effect on secretion and secretory organelles, we monit...

journal_title：Endocrinology

authors： Conconi MV,Walker AM

更新日期：1984-03-01 00:00:00

abstract：:Isoforms of the recently cloned vesicular glutamate transporters (VGLUT1-3) selectively accumulate glutamic acid into synaptic vesicles in excitatory axon terminals and are viewed as reliable markers for glutamatergic neurons. Our present studies provided dual-label in situ hybridization evidence that virtually all (9...

journal_title：Endocrinology

authors： Hrabovszky E,Turi GF,Kalló I,Liposits Z

更新日期：2004-09-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00

abstract：:PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH ...

journal_title：Endocrinology

authors： Ben-awadh AN,Delgado-Calle J,Tu X,Kuhlenschmidt K,Allen MR,Plotkin LI,Bellido T

更新日期：2014-08-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:A novel NADPH-dependent cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) was purified by sequential fractionation of rat liver cytosol on Q-Sepharose, phenyl-Sepharose, red-Sepharose, and polyacrylamide gel electrophoresis under nondenaturing conditions. The CTBP had a sedimentation coefficient of 5.1S...

journal_title：Endocrinology

authors： Kobayashi M,Hashizume K,Suzuki S,Ichikawa K,Takeda T

更新日期：1991-10-01 00:00:00

abstract：:A heterologous RIA for ovine inhibin was developed which was sufficiently sensitive and specific to describe the peripheral concentrations of immunoreactive inhibin (iINH) during the estrous cycle of the ewe and to examine the effects of cautery of ovarian follicles on concentrations of iINH in ovarian and jugular ven...

journal_title：Endocrinology

authors： Findlay JK,Clarke IJ,Robertson DM

更新日期：1990-01-01 00:00:00

abstract：:Type I iodothyronine 5' deiodinase (5'DI) contains selenocysteine, encoded by a UGA codon, and this amino acid is essential for maximum catalytic efficiency in this enzyme. We recently showed that translation of UGA as selenocysteine in this protein requires a specific sequence of about 250 nucleotides in the 3' untra...

journal_title：Endocrinology

authors： Berry MJ,Maia AL,Kieffer JD,Harney JW,Larsen PR

更新日期：1992-10-01 00:00:00

abstract：:Neonatal exposure to high doses of estrogen results in permanent suppression of prostate growth and reduced sensitivity to androgens in adulthood. It is unclear whether alterations in prostate growth are due to a direct effect of estrogens on the gland or are the result of hypothalamic-pituitary-gonadal axis suppressi...

journal_title：Endocrinology

authors： Jarred RA,Cancilla B,Prins GS,Thayer KA,Cunha GR,Risbridger GP

更新日期：2000-09-01 00:00:00

abstract：:Somatostatin was infused via the portal vein at a rate of 50 ng/min in a group of eight conscious dogs beginning 30 min before and continuing for 6 h after the ingestion of an 800-g fat-protein meal. The fasting and postprandial levels of plasma somatostatin-like immunoreactivity (SLI), insulin, glucagon, and triglyce...

journal_title：Endocrinology

authors： Schusdziarra V,Harris V,Arimura A,Unger RH

更新日期：1979-06-01 00:00:00

abstract：:We sequenced the complementary DNA (cDNA) encoding guinea pig LHRH from an expression library derived from the preoptic area-anterior hypothalamus. Data from in situ hybridization and RNase protection assays verified that the cloned cDNA was complementary to guinea pig LHRH messenger RNA. The architecture of the deduc...

journal_title：Endocrinology

authors： Jimenez-Liñan M,Rubin BS,King JC

更新日期：1997-10-01 00:00:00

abstract：:Pdx-1 plays a key role in the development of the pancreas and the control of islet gene transcription and has also been proposed as a dominant regulator of the alpha- vs. beta-cell phenotype via extinction of proglucagon expression. To ascertain the relationship between Pdx-1 and proglucagon gene expression, we examin...

journal_title：Endocrinology

authors： Flock G,Cao X,Drucker DJ

更新日期：2005-01-01 00:00:00

abstract：:In this study, site-directed mutagenesis and biochemical strategies have been used to establish whether disulfide bonding between extracellular Cys residues contributes to the structural integrity of the GnRH receptor (GnRH-R) and, if so, to delineate the nature of the bonding patterns involved. The majority of G prot...

journal_title：Endocrinology

authors： Cook JV,Eidne KA

更新日期：1997-07-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00

abstract：:Hypoxia and biological responses to hypoxia are commonly encountered in both normal and pathologic cellular processes. Here we report that extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as a...

journal_title：Endocrinology

authors： Zelko IN,Folz RJ

更新日期：2005-01-01 00:00:00

abstract：:Estradiol imprinting plays an important role in the regulation of galanin (GAL) gene expression in the rat. In the anterior pituitary gland, GAL gene expression is greatly induced by estrogen. The relative involvement that the two estrogen receptor subtypes, alpha and beta, have in regulating this induction is not kno...

journal_title：Endocrinology

authors： Shen ES,Hardenburg JL,Meade EH,Arey BJ,Merchenthaler I,López FJ

更新日期：1999-06-01 00:00:00