Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression.

abstract：:A heterologous RIA for rat GH-releasing factor (rGRF) was established using synthetic rGRF-(1-43)OH for both standard reference and radioiodination with the antiserum produced against human GRF-(1-44) NH2. The regional distribution of rGRF-like immunoreactivity (LI) in rat hypothalamus was examined according to the Pa...

journal_title：Endocrinology

authors： Kita T,Chihara K,Abe H,Minamitani N,Kaji H,Kodama H,Kashio Y,Okimura Y,Fujita T,Ling N

更新日期：1985-01-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1) has an important role as an early intermediary between the insulin and IGF receptors and downstream molecules that participate in insulin and IGF-I signal transduction. Here we employed an antisense oligonucleotide (IRS-1AS) to inhibit whole-body expression of IRS-1 in vivo and eva...

journal_title：Endocrinology

authors： Araújo EP,De Souza CT,Gasparetti AL,Ueno M,Boschero AC,Saad MJ,Velloso LA

更新日期：2005-03-01 00:00:00

abstract：:Nuclear binding of cytoplasmic estrogen receptors was measured in an in vitro cell-free system, using various mixtures of cytosols and nuclei from uteri of mature (6-9 month old) and senescent (24-25 month old) Wistar rats. Both nuclei and cytoplasmic receptors from senescent uteri were 25-35% less efficient in suppor...

journal_title：Endocrinology

authors： Chuknyiska RS,Haji M,Foote RH,Roth GS

更新日期：1985-02-01 00:00:00

abstract：:Tobacco smoking favorably influences the course of Hashimoto thyroiditis, possibly through the antiinflammatory proprieties of nicotine. In this study we tested anatabine, another tobacco alkaloid, in a model of experimental autoimmune thyroiditis. Experimental autoimmune thyroiditis was induced by different doses of ...

journal_title：Endocrinology

authors： Caturegli P,De Remigis A,Ferlito M,Landek-Salgado MA,Iwama S,Tzou SC,Ladenson PW

更新日期：2012-09-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...

journal_title：Endocrinology

authors： Brodie AM,Longcope C

更新日期：1980-01-01 00:00:00

abstract：:In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using acyl-ghrelin knockout mice have suggested that the rise in GH during food restriction is essential to s...

journal_title：Endocrinology

authors： Gahete MD,Córdoba-Chacón J,Luque RM,Kineman RD

更新日期：2013-01-01 00:00:00

abstract：:PTH-related protein (PTHrP) is expressed in a stretch-responsive manner in several types of smooth muscle. We previously demonstrated the production of PTHrP in adult rat heart muscle. In this study, we demonstrate the production of PTHrP in the cardiovascular systems of several mammalian species, including human. We ...

journal_title：Endocrinology

authors： Burton DW,Brandt DW,Deftos LJ

更新日期：1994-07-01 00:00:00

abstract：:Previous studies have shown that aldosterone plus salt loading cause cardiac hypertrophy in rats in vivo, and that in vitro, both aldosterone and glucose stimulate fibroblast growth. The present studies examined the effects of adrenal steroids via mineralocorticoid and glucocorticoid receptors (MR and GR) on [3H]leuci...

journal_title：Endocrinology

authors： Sato A,Funder JW

更新日期：1996-10-01 00:00:00

abstract：:Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have decreased GSH synthesis. Nicotinamide nucleotide transhydrogenase, an inner mitochondr...

journal_title：Endocrinology

authors： Nakamura BN,Fielder TJ,Hoang YD,Lim J,McConnachie LA,Kavanagh TJ,Luderer U

更新日期：2011-07-01 00:00:00

abstract：:Thyroid hormones (TH) are actively taken up into target cells via TH-transmembrane transporters (THTT). Their activity and expression patterns define a layer of endocrine regulation that is poorly understood. Therefore, THTT are potential targets for interfering agents (endocrine disruptors) as well as for pharmacolog...

journal_title：Endocrinology

authors： Jayarama-Naidu R,Johannes J,Meyer F,Wirth EK,Schomburg L,Köhrle J,Renko K

更新日期：2015-07-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...

journal_title：Endocrinology

authors： Hampel U,Klonisch T,Sel S,Schulze U,Garreis F,Seitmann H,Zouboulis CC,Paulsen FP

更新日期：2013-06-01 00:00:00

abstract：:Removal of the 18-hydroxy group of the hemiacetal form of aldosterone transforms its activity from that of pure agonist to predominant antagonist. The 18-deoxy derivative possesses one third of the binding affinity of aldosterone for the cytoplasmic mineralocorticoid receptor of rat kidney and exhibits an approximate ...

journal_title：Endocrinology

authors： Ulick S,Marver D,Adam WR,Funder JW

更新日期：1979-05-01 00:00:00

abstract：:We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily. They form heterodimer with a retinoid X receptor, recruit transcriptional cofactor...

journal_title：Endocrinology

authors： Lim HJ,Moon I,Han K

更新日期：2004-06-01 00:00:00

abstract：:We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-subunit by muscle electroporation in female BALB/c mice. The onset of orbital pathology is characterized by muscle inflammation, adipogenesis, and...

journal_title：Endocrinology

authors： Berchner-Pfannschmidt U,Moshkelgosha S,Diaz-Cano S,Edelmann B,Görtz GE,Horstmann M,Noble A,Hansen W,Eckstein A,Banga JP

更新日期：2016-04-01 00:00:00

abstract：:In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...

journal_title：Endocrinology

authors： Ikegami K,Atsumi Y,Yorinaga E,Ono H,Murayama I,Nakane Y,Ota W,Arai N,Tega A,Iigo M,Darras VM,Tsutsui K,Hayashi Y,Yoshida S,Yoshimura T

更新日期：2015-02-01 00:00:00

abstract：:We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) ca...

journal_title：Endocrinology

authors： Bhonagiri P,Pattar GR,Horvath EM,Habegger KM,McCarthy AM,Elmendorf JS

更新日期：2009-04-01 00:00:00

abstract：:Estradiol (E) treatment of spayed macaques induces progestin receptors (PR) in pituitary gonadotropes, but not lactotropes. In contrast, levels of pituitary estrogen receptors (ER) remain constant in spayed or E-treated monkeys. In monkey pituitary cultures, the number of PR-positive cells varies depending on the dono...

journal_title：Endocrinology

authors： Sprangers SA,Fahrenbach WH,Bethea CL

更新日期：1991-04-01 00:00:00

abstract：:Mammary gland explants from mature virgin mice, rats, and rabbits exhibit an increased rate of both DNA and casein syntheses when cultured in the presence of specific combinations of insulin, hydrocortisone, and PRL. If cytosine arabinoside, a potent inhibitor of DNA synthesis, is added to the culture medium, casein s...

journal_title：Endocrinology

authors： Nicholas KR,Bolander FF Jr,Sankaran L,Topper YJ

更新日期：1983-03-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:T3 stimulates in vitro GH secretion, whereas somatomedins have been shown to suppress GH. We, therefore, tested the effects of a recombinant human insulin-like growth factor analog (IGF-I; Thr 59) on T3-induced GH secretion. Pituitary monolayer cultures were derived from 4- to 7-week surgically thyroidectomized male r...

journal_title：Endocrinology

authors： Melmed S,Yamashita S

更新日期：1986-04-01 00:00:00

abstract：:A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...

journal_title：Endocrinology

authors： Wannemacher RW Jr,Pekarek RS,Thompson WL,Curnow RT,Beall FA,Zenser TV,DeRubertis FR,Beisel WR

更新日期：1975-03-01 00:00:00

abstract：:3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...

journal_title：Endocrinology

authors： Piehl S,Heberer T,Balizs G,Scanlan TS,Smits R,Koksch B,Köhrle J

更新日期：2008-06-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00

abstract：:Although prolactinomas can be effectively treated with dopamine agonists, about 20% of patients develop dopamine resistance or tumor recurrence after surgery, indicating a need for better understanding of underlying disease mechanisms. Although estrogen-induced rat prolactinomas have been widely used to investigate th...

journal_title：Endocrinology

authors： Tong Y,Zheng Y,Zhou J,Oyesiku NM,Koeffler HP,Melmed S

更新日期：2012-08-01 00:00:00

abstract：:Certain metabolic properties of hormonally responsive osteogenic sarcoma cells derived from a transplantable rat tumor have been compared with those of related normal rat bone cells. All studies were carried out on cells grown in monolayer culture. Normal rat bone cells derived by repeated collagenase/trypsin digestio...

journal_title：Endocrinology

authors： Partridge NC,Alcorn D,Michelangeli VP,Kemp BE,Ryan GB,Martin TJ

更新日期：1981-01-01 00:00:00

abstract：:The actions of IGFs are regulated at various levels. One mechanism involves binding to IGF-binding protein-3 (IGFBP-3) for transport, thus governing bioavailability. IGFBP3 transcription is modulated by many hormones and agents that stimulate or inhibit growth. We have previously shown in pediatric and adult cohorts a...

journal_title：Endocrinology

authors： Paquette J,Bessette B,Ledru E,Deal C

更新日期：2007-12-01 00:00:00

abstract：:The effect of gonadotropins on phosphodiesterase activity of rat granulosa cells was studied in an in vitro model. Granulosa cells were prepared from hypophysectomized or intact, estrogen-primed immature female rats and treated with FSH, hCG, or (Bu)2cAMP in vitro. Phosphodiesterase activity was determined in cell hom...

journal_title：Endocrinology

authors： Conti M,Kasson BG,Hsueh AJ

更新日期：1984-06-01 00:00:00

abstract：:A monoclonal antibody which recognizes the [125I]human GH ([125I]hGH)-binding proteins of rabbit liver has been produced using hybridoma technology. A CB6F1/J mouse was immunized over a period of 82 days with a partially purified GH receptor (GHr) preparation. On the 83rd day, spleen cells from the mouse were fused wi...

journal_title：Endocrinology

authors： Simpson JS,Hughes JP,Friesen HG

更新日期：1983-06-01 00:00:00