Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy- and 4-acetoxy-androstene-3,17-dione.

abstract：:GH3 cells are a PRL-secreting adenoma cell line derived from pituitary lactotropes. These cells have been stably transfected with rat GnRH receptor complementary DNA to produce four cell lines: GGH(3)1', GGH(3)2', GGH(3)6', and GGH(3)12'. In response to either GnRH or Buserelin (a metabolically stable GnRH agonist), t...

journal_title：Endocrinology

authors： Stanislaus D,Arora V,Awara WM,Conn PM

更新日期：1996-03-01 00:00:00

abstract：:The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...

journal_title：Endocrinology

authors： Anan M,Uchihashi K,Aoki S,Matsunobu A,Ootani A,Node K,Toda S

更新日期：2011-04-01 00:00:00

abstract：:The regulation of GRF secretion was studied using a fetal rat hypothalamic cell culture system. The cells were subjected to short term release experiments on days 10-18 after plating, and GRF secretion was assessed by RIA. The identity of GRF immunoreactivity in the incubation medium was confirmed by reverse phase liq...

journal_title：Endocrinology

authors： Baes M,Vale WW

更新日期：1989-01-01 00:00:00

abstract：:The current study was designed to investigate the ability of prostaglandin F2 alpha (PGF2 alpha) to activate a second messenger system (phosphatidylinositol pathway) in corpora lutea (CL) of rhesus monkeys. Activation of this pathway was assessed by monitoring the hydrolysis of phosphatidylinositol to inositol phospha...

journal_title：Endocrinology

authors： Houmard BS,Guan Z,Stokes BT,Ottobre JS

更新日期：1992-08-01 00:00:00

abstract：:Early life exposure to immunological challenge has programming effects on the adult hypothalamo-pituitary-adrenocortical axis stress responsivity, and stress is known to suppress GnRH pulse generator activity, especially LH pulses. We investigated the effects of neonatal exposure to endotoxin on stress-induced suppres...

journal_title：Endocrinology

authors： Li XF,Kinsey-Jones JS,Knox AM,Wu XQ,Tahsinsoy D,Brain SD,Lightman SL,O'Byrne KT

更新日期：2007-12-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Osteocalcin, a synthetic osteoblast-specific protein, has recently emerged as an important regulator of energy metabolism, but the underlying mechanisms are not fully understood. In the present study, mice fed a high-fat diet and receiving osteocalcin showed reduced body weight gain, less fat pad gain, and improved in...

journal_title：Endocrinology

authors： Zhou B,Li H,Xu L,Zang W,Wu S,Sun H

更新日期：2013-03-01 00:00:00

abstract：:In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...

journal_title：Endocrinology

authors： Kjos T,Gotoh E,Tkacs N,Shackelford R,Ganong WF

更新日期：1991-08-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabol...

journal_title：Endocrinology

authors： Herrera-Moro Chao D,León-Mercado L,Foppen E,Guzmán-Ruiz M,Basualdo MC,Escobar C,Buijs RM

更新日期：2016-09-01 00:00:00

abstract：:Steroid hormones can differentially modify gonadotropin release stimulated by GnRH. Decreased GnRH-mediated gonadotropin release has been observed in vitro after pretreatment with androgens or glucocorticoids. In this study, we tested this phenomenon further with the use of a new cytochemical stain for a potent biotin...

journal_title：Endocrinology

authors： Tibolt RE,Childs GV

更新日期：1985-07-01 00:00:00

abstract：:Antiestrogens such as tamoxifen are the mainstay of treatment for estrogen receptor-positive breast cancer. However, their effectiveness is limited by the development of endocrine resistance, allowing tumor regrowth and progression. Importantly, in vitro MCF7 cell models of acquired tamoxifen resistance (TamR cells) d...

journal_title：Endocrinology

authors： Taylor KM,Vichova P,Jordan N,Hiscox S,Hendley R,Nicholson RI

更新日期：2008-10-01 00:00:00

abstract：:We have established immortalized human granulosa cells by triple transfection of primary cells obtained from in vitro fertilization patients with SV40 DNA, Ha-ras oncogene, and a temperature sensitive (ts) mutant of the tumor suppressor gene p53 (p53val135). Forty-one clones were isolated, and their steroidogenic resp...

journal_title：Endocrinology

authors： Hosokawa K,Dantes A,Schere-Levy C,Barash A,Yoshida Y,Kotsuji F,Vlodavsky I,Amsterdam A

更新日期：1998-11-01 00:00:00

abstract：:Vascular smooth muscle cells (SMC) are major constituents of the medial layer of blood vessels and are involved in the development of atherosclerotic plaque. SMC secrete copious IL-6 under basal conditions that can be increased by cytokines such as tumor necrosis factor-alpha and interleukin-1beta (IL-1beta). The goal...

journal_title：Endocrinology

authors： Maret A,Clamens S,Delrieu I,Elhage R,Arnal JF,Bayard F

更新日期：1999-06-01 00:00:00

abstract：:We have studied whether activation of cell adhesion kinase beta (CAKbeta) is involved in stretch-induced signaling pathway in cultured rat vascular smooth muscle cells. Cyclic stretch (1 Hz) induced a rapid (within 1 min) phosphorylation of CAKbeta, whose effect was time and strength dependent. Both Ca(2+) and Na(+) i...

journal_title：Endocrinology

authors： Iwasaki H,Yoshimoto T,Sugiyama T,Hirata Y

更新日期：2003-06-01 00:00:00

abstract：:The anterior pituitary (AP) is made of five different cell types. The relative abundance and phenotype of AP cells may change in different physiological situations as an expression of pituitary plasticity. Here, we analyze in detail the phenotype of mouse corticotropes and the effects of acute cold stress on AP cell p...

journal_title：Endocrinology

authors： Senovilla L,Núñez L,Villalobos C,García-Sancho J

更新日期：2008-05-01 00:00:00

abstract：:Using a rat model of chronic central leptin infusion in which neuropeptide Y neurons develop leptin resistance, we examined whether leptin signal transduction mechanism in the hypothalamus is altered during central leptin infusion. Adult male rats were infused chronically into the lateral cerebroventricle with leptin ...

journal_title：Endocrinology

authors： Pal R,Sahu A

更新日期：2003-09-01 00:00:00

abstract：:An assay was developed to detect tritium-labeled ovine FSH beta-subunit [( 3H]oFSH beta) secreted from primary ovine pituitary cultures. This procedure used affinity-enriched antibodies raised against reduced and carbamylmethylated oFSH beta (RCM-oFSH beta) in a two-cycle immunoextraction procedure. A discrete species...

journal_title：Endocrinology

authors： Whitfield GK,Miller WL

更新日期：1984-07-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00

abstract：:The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...

journal_title：Endocrinology

authors： Pfeiffer A,Herz A,Loriaux DL,Pfeiffer DG

更新日期：1985-06-01 00:00:00

abstract：:Kisspeptin is the product of the Kiss1 gene that regulates GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the preoptic area (POA) and arcuate nucleus (ARC), and expression is up-regulated in the caudal ARC during the periovulatory period. We hypothesized that kisspeptin neurons in the ARC are activ...

journal_title：Endocrinology

authors： Smith JT,Li Q,Pereira A,Clarke IJ

更新日期：2009-12-01 00:00:00

abstract：:It has been postulated that the rate of hepatic very low density lipoprotein (VLDL) apolipoprotein (apo) B secretion is dependent upon the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. To test this hypothesis in vivo, apoB kinetic studies were carried out in miniature pigs before and after 21 ...

journal_title：Endocrinology

authors： Burnett JR,Wilcox LJ,Telford DE,Kleinstiver SJ,Barrett PH,Newton RS,Huff MW

更新日期：1999-11-01 00:00:00

abstract：:Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to ...

journal_title：Endocrinology

authors： Thaler JP,Schwartz MW

更新日期：2010-09-01 00:00:00

abstract：:G protein-coupled receptor kinases (GRK 1-6) stimulate short-term desensitization (< 5 min) by phosphorylating G-protein coupled receptors, and also participate in receptor sequestration, which may relate to intermediate-term desensitization (30-60 min). The existence of such kinases and hence a potential role for the...

journal_title：Endocrinology

authors： Neill JD,Musgrove LC,Sellers JC,Duck LW

更新日期：1996-09-01 00:00:00

abstract：:The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...

journal_title：Endocrinology

authors： Wehrenberg WB,Gaillard RC

更新日期：1989-01-01 00:00:00

abstract：:Tuberoinfundibular peptide is a recently discovered agonist for the PTH receptor-2; the latter has a wide distribution including the external zone of the median eminence of the hypothalamus, suggesting a role in neuroendocrine function. We have investigated the effects of tuberoinfundibular peptide on the hypothalamo-...

journal_title：Endocrinology

authors： Ward HL,Small CJ,Murphy KG,Kennedy AR,Ghatei MA,Bloom SR

更新日期：2001-08-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:Myocardial fibrosis is a key pathological change in a variety of heart diseases contributing to the development of heart failure, arrhythmias, and sudden death. Recent studies have shown that relaxin prevents and reverses cardiac fibrosis. Endogenous expression of relaxin was elevated in the setting of heart disease; ...

journal_title：Endocrinology

authors： Gu HP,Lin S,Xu M,Yu HY,Du XJ,Zhang YY,Yuan G,Gao W

更新日期：2012-08-01 00:00:00

abstract：:Stress-responsive neurons of the hypothalamic paraventricular nucleus (PVN) show functional plasticity and adapt to repeated restraint (RR) stress. To investigate whether neuronal adaptation to the homotypic stress also affects their response to a heterotypic stressor, we used in situ hybridization with intronic and e...

journal_title：Endocrinology

authors： Ma XM,Lightman SL,Aguilera G

更新日期：1999-08-01 00:00:00

abstract：:Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indic...

journal_title：Endocrinology

authors： Okamura K,Taurog A,Krulich L

更新日期：1981-08-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00