Growth hormone-releasing factor secretion from fetal hypothalamic cell cultures is modulated by forskolin, phorbol esters, and muscimol.

abstract：:Serum levels of progesterone in hysterectomized gilts were determined to evaluate the effects of exogenous 17 beta-estradiol (17 beta-E2) on the secretory activity of aging corpora lutea. Gilts were hysterectomized on day 6 of the estrous cycle and given im injections of 17 beta-E2 to mimic blood levels of endogenous ...

journal_title：Endocrinology

authors： Musah AI,Ford JJ,Anderson LL

更新日期：1984-11-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Apoptosis is the process of cellular self-destruction, and genes such as bcl-2 and bax are known to inhibit and promote apoptosis, respectively. In this study, we show that apoptosis can be induced in pancreatic beta-cell lines, and we investigate the apoptotic pathways through the bcl-2 and bax genes and intracellula...

journal_title：Endocrinology

authors： Mizuno N,Yoshitomi H,Ishida H,Kuromi H,Kawaki J,Seino Y,Seino S

更新日期：1998-03-01 00:00:00

abstract：:Hypoxia plays a vital role in the progression of endometriosis. Additionally, integrin-mediated aberrant adhesion is also essential for establishment of endometriotic lesions. In this study, we sought to determine the function of hypoxia in integrin-mediated adhesion of endometrial stromal cells (ESCs) in endometriosi...

journal_title：Endocrinology

authors： Lin X,Dai Y,Xu W,Shi L,Jin X,Li C,Zhou F,Pan Y,Zhang Y,Lin X,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:In GH4C1 cells, membrane depolarization induces a rapid and sustained increase in the cytosolic free calcium concentration ([Ca2+]i). In the present study we have investigated the role of [Ca2+]i in the regulation of basal intracellular pH (pHi). Depolarizing GH4C1 cells in buffer containing 0.4 mM extracellular Ca2+ ...

journal_title：Endocrinology

authors： Törnquist K,Tashjian AH Jr

更新日期：1992-02-01 00:00:00

abstract：:Cathepsin-D has been previously reported to cleave intact PTH into PTH-(1-34) and -(35-84) in membranous fractions of rat and bovine kidney. Whether PTH degradation occurs by intact kidney cells, however, has not been examined in detail. We have, therefore, examined this possibility using an opossum kidney (OK) cell l...

journal_title：Endocrinology

authors： Yamaguchi T,Fukase M,Nishikawa M,Fujimi T,Fujita T

更新日期：1988-12-01 00:00:00

abstract：:17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and it has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on ...

journal_title：Endocrinology

authors： Dai R,Edwards MR,Heid B,Ahmed SA

更新日期：2019-01-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a ...

journal_title：Endocrinology

authors： Stengel A,Goebel M,Million M,Stenzel-Poore MP,Kobelt P,Mönnikes H,Taché Y,Wang L

更新日期：2009-01-01 00:00:00

abstract：:We have recently identified gonadotropes as target cells for ATP action via ATP receptors of the P2U subtype. The present studies have used gonadotrope-derived alpha T3-1 cells to examine the possible signaling mechanisms subserving ATP action in gonadotropes. Addition of ATP produced a biphasic intracellular Ca2+ (Ca...

journal_title：Endocrinology

authors： Chen ZP,Kratzmeier M,Poch A,Xu S,McArdle CA,Levy A,Mukhopadhyay AK,Lightman SL

更新日期：1996-01-01 00:00:00

abstract：:A myometrial explant culture system was developed to investigate the effect of progesterone and the antiprogestagen RU486 on prostacyclin (PGI2) and thromboxane A2 (TXA2) synthesis by the rat myometrium. After culture, eicosanoid synthesis was stimulated with arachidonic acid (AA) and the calcium ionophore A23187 (A23...

journal_title：Endocrinology

authors： Jeremy JY,Dandona P

更新日期：1986-08-01 00:00:00

abstract：:PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates...

journal_title：Endocrinology

authors： Lanske B,Divieti P,Kovacs CS,Pirro A,Landis WJ,Krane SM,Bringhurst FR,Kronenberg HM

更新日期：1998-12-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:The hypothesis that hydrogen peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). Luteal regression was induced during midpseudopregnancy by injection of 500 micrograms prostaglandin F2 alpha (P...

journal_title：Endocrinology

authors： Riley JC,Behrman HR

更新日期：1991-04-01 00:00:00

abstract：:The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells. Previous work showed dynamic changes in the GnRH-glial-capillary network in the median eminence under different ...

journal_title：Endocrinology

authors： Yin W,Wu D,Noel ML,Gore AC

更新日期：2009-12-01 00:00:00

abstract：:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...

journal_title：Endocrinology

authors： Larson KR,Russo KA,Fang Y,Mohajerani N,Goodson ML,Ryan KK

更新日期：2017-10-01 00:00:00

abstract：:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...

journal_title：Endocrinology

authors： Blackard WG,Guzelian PS,Small ME

更新日期：1978-08-01 00:00:00

abstract：:Insulin and insulin-like growth factors (IGFs) stimulate responses in skeletal muscle that include effects on carbohydrate and fat metabolism, protein turnover, growth, and differentiation. To gain insight into the relative importance of insulin and IGFs at different stages of development, the expression of their spec...

journal_title：Endocrinology

authors： Alexandrides T,Moses AC,Smith RJ

更新日期：1989-02-01 00:00:00

abstract：:Hypothalamic enzymatic activities capable of degrading LHRH may play a physiological role in the neuroendocrine control of LHRH. There is increasing evidence, however, that these enzymes are not peptide specific. The present study in the ewe analyzed the possibility that the specificity of LHRH-degrading activity (LHR...

journal_title：Endocrinology

authors： Advis JP,Kuljis RO,Dey G

更新日期：1985-06-01 00:00:00

abstract：:Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...

journal_title：Endocrinology

authors： Abboud M,Puglisi DA,Davies BN,Rybchyn M,Whitehead NP,Brock KE,Cole L,Gordon-Thomson C,Fraser DR,Mason RS

更新日期：2013-09-01 00:00:00

abstract：:We have previously demonstrated that, in prostate cancer cells, androgens up-regulate IGF-I receptor (IGF-IR) by inducing cAMP-response element-binding protein (CREB) activation and CREB-dependent IGF-IR gene transcription through androgen receptor (AR)-dependent membrane-initiated effects. This IGF-IR up-regulation i...

journal_title：Endocrinology

authors： Malaguarnera R,Sacco A,Morcavallo A,Squatrito S,Migliaccio A,Morrione A,Maggiolini M,Belfiore A

更新日期：2014-04-01 00:00:00

abstract：:Ovarian steroids act on unidentified neurons to trigger preovulatory secretion of GnRH. In the rat, important steroid target cells reside in the anterior medial preoptic nucleus (AMPN), a sexually dimorphic structure essential for stimulatory effects of ovarian steroids on LH secretion. The AMPN contains neurotensin (...

journal_title：Endocrinology

authors： Alexander MJ,Dobner PR,Miller MA,Bullock BP,Dorsa DM,Leeman SE

更新日期：1989-10-01 00:00:00

abstract：:This study was conducted to determine the feasibility of using replication-defective adenovirus vectors to express receptors for LH. Two vectors were constructed, one that directs the expression of wild-type human LH receptor (LHr; AdRSVLHrwt) and another that directs the expression of the constitutively activated D57...

journal_title：Endocrinology

authors： Bebia Z,Somers JP,Liu G,Ihrig L,Shenker A,Zeleznik AJ

更新日期：2001-06-01 00:00:00

abstract：:The mechanism by which aluminum chloride stimulates de novo bone formation is unknown. To evaluate the role of bone remodeling and mature osteoblastic function in aluminum-induced neoosteogenesis, we compared the osteogenic effects of aluminum in normal beagles to those in animals with low turnover osteomalacia induce...

journal_title：Endocrinology

authors： Quarles LD,Drezner MK

更新日期：1992-07-01 00:00:00

abstract：:The distribution pattern of messenger RNAs (mRNAs) for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor and the detection of IGF-binding sites in sections of ovine ovary were demonstrated using in situ hybridization and autoradiography. Ovaries were collected from 30 ewes at time points throug...

journal_title：Endocrinology

authors： Perks CM,Denning-Kendall PA,Gilmour RS,Wathes DC

更新日期：1995-12-01 00:00:00

abstract：:The effect of [D-Trp6]LHRH, a potent agonist of LHRH, on pituitary-testicular responses was investigated in male rhesus monkeys. Acute administration of 5, 25, or 500 micrograms [D-Trp6]LHRH produced dose-related increases in serum testosterone and bioassayable LH levels. The administration of 500 micrograms [D-Trp6]L...

journal_title：Endocrinology

authors： Sundaram K,Connell KG,Bardin CW,Samojlik E,Schally AV

更新日期：1982-04-01 00:00:00

abstract：:The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...

journal_title：Endocrinology

authors： Furman A,Rotmensch S,Kohen F,Mashiach S,Amsterdam A

更新日期：1986-05-01 00:00:00

abstract：:Many aspects of reproductive function are corrected in hypogonadal mice with preoptic area grafts (HPG/POA). Gonadotropin release and gonadal development are dependent on the presence of GnRH cells within the grafts and GnRH innervation of the median eminence. This study examined the effect of a known modulator of GnR...

journal_title：Endocrinology

authors： Saitoh Y,Silverman AJ,Gibson MJ

更新日期：1991-05-01 00:00:00

abstract：:DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA da...

journal_title：Endocrinology

authors： Chesnokova V,Zonis S,Barrett RJ,Gleeson JP,Melmed S

更新日期：2019-06-01 00:00:00

abstract：:Recent evidence suggests that growth hormone-releasing peptides (GHRPs) mimic an unidentified native GH-releasing hormone (GHRH)-amplifying hormone. GHRH has been shown to stimulate food intake acting on the central nervous system. The present studies were conducted to test the hypothesis that GHRPs may also potentiat...

journal_title：Endocrinology

authors： Okada K,Ishii S,Minami S,Sugihara H,Shibasaki T,Wakabayashi I

更新日期：1996-11-01 00:00:00

abstract：:To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the ...

journal_title：Endocrinology

authors： Sourla A,Martel C,Labrie C,Labrie F

更新日期：1998-02-01 00:00:00