Adenovirus-directed expression of functional luteinizing hormone (LH) receptors in undifferentiated rat granulosa cells: evidence for differential signaling through follicle-stimulating hormone and LH receptors.

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1beta to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, release T lymphocyte chemotactic activity. The effect of IL-1beta ...

journal_title：Endocrinology

authors： Gianoukakis AG,Martino LJ,Horst N,Cruikshank WW,Smith TJ

更新日期：2003-07-01 00:00:00

abstract：:The effects of retinoic acids (RAs) on development of seminal vesicles (SVs) of neonatal mice were investigated in vitro. SVs from 0-day-old male mice were cultured for 2-6 days in serum-free, chemically defined medium containing transferrin and BSA supplemented with 5alpha-dihydrotestosterone (DHT; 10(-8) M) and insu...

journal_title：Endocrinology

authors： Tanji N,Yokoyama M,Takeuchi M,Terada N,Dahiya R,Cunha GR

更新日期：1996-07-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) improves glucose metabolism and growth in patients with leprechaunism. We investigated signal transduction through IGF-I receptor in comparison with epidermal growth factor (EGF) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprec...

journal_title：Endocrinology

authors： Takahashi Y,Tobe K,Kadowaki H,Katsumata D,Fukushima Y,Yazaki Y,Akanuma Y,Kadowaki T

更新日期：1997-02-01 00:00:00

abstract：:Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might i...

journal_title：Endocrinology

authors： Trombly DJ,Woodruff TK,Mayo KE

更新日期：2009-02-01 00:00:00

abstract：:To assess the possible source of progesterone in the fetal fluids of pregnant sheep, we measured the changes in progesterone concentrations in amniotic fluid (AF) and allantoic fluid (ALF) during pregnancy and compared these values with those in the maternal and fetal circulations. In acute experiments, the concentrat...

journal_title：Endocrinology

authors： Power SG,Patrick JE,Carson GD,Challis JR

更新日期：1982-02-01 00:00:00

abstract：:In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...

journal_title：Endocrinology

authors： Kjos T,Gotoh E,Tkacs N,Shackelford R,Ganong WF

更新日期：1991-08-01 00:00:00

abstract：:Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in mammalian serum, but the source of the circulating enzyme is unknown. Pancreatic islets have been reported to contain and secrete GPI-PLD. In this report we examined the regulation of GPI-PLD secretion from beta TC3 cells, a mouse insulinom...

journal_title：Endocrinology

authors： Deeg MA,Verchere CB

更新日期：1997-02-01 00:00:00

abstract：:In teleosts, the pituitary contains a single glycoprotein gonadotropic hormone (GTH) composed of two dissimilar alpha- and beta-subunits. The European eel, Anguilla anguilla L, is sexually immature at the silver stage due to a deficiency in GTH synthesis and secretion. In previous studies we (S.D., YA.F.) have demonst...

journal_title：Endocrinology

authors： Counis R,Dufour S,Ribot G,Quérat B,Fontaine YA,Jutisz M

更新日期：1987-09-01 00:00:00

abstract：:Glucose stimulation of pancreatic beta-cells triggers electrical activity (slow waves of membrane potential with superimposed spikes) that is best monitored with intracellular microelectrodes. Closure of ATP-sensitive K+ channels underlies the depolarization to the threshold potential and participates in the increase ...

journal_title：Endocrinology

authors： Henquin JC

更新日期：1998-03-01 00:00:00

abstract：:Previously, three receptors, xTRHR1, xTRHR2, and xTRHR3, were cloned from brain tissue of Xenopus laevis with primers designed using sequences from the mammalian TRH receptor (TRHR) subtype 1. We expressed the Xenopus receptors in HEK 293EM cells and studied their binding and signaling properties using a series of TRH...

journal_title：Endocrinology

authors： Lu X,Bidaud I,Ladram A,Gershengorn MC

更新日期：2003-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...

journal_title：Endocrinology

authors： Montuenga LM,Mariano JM,Prentice MA,Cuttitta F,Jakowlew SB

更新日期：1998-09-01 00:00:00

abstract：:A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...

journal_title：Endocrinology

authors： Xiao J,Sun B,Cai GP

更新日期：2010-07-01 00:00:00

abstract：:To further our understanding of the role of pituitary gonadotropin secretion in the control of corpus luteum function during the primate menstrual cycle, we have used an experimental model which enables us to directly control pituitary gonadotropin secretion throughout the luteal phase. Specifically, we have asked whe...

journal_title：Endocrinology

authors： Hutchison JS,Zeleznik AJ

更新日期：1985-09-01 00:00:00

abstract：:Historically, much of the research on health effects of environmental pollutants focused on ascertaining whether compounds were carcinogenic. More recent findings show that environmental contaminants also exert insidious effects by disrupting hormone action. Of particular concern are findings that developmental exposu...

journal_title：Endocrinology

authors： Petersen SL,Krishnan S,Hudgens ED

更新日期：2006-06-01 00:00:00

abstract：:Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents. The reduction in adiposity is related to decreased food intake and increased energy expenditure. However, the molecular mechanisms through which TPM induces weight loss are contradictory and remain to be clarified. Whether TPM treatme...

journal_title：Endocrinology

authors： Caricilli AM,Penteado E,de Abreu LL,Quaresma PG,Santos AC,Guadagnini D,Razolli D,Mittestainer FC,Carvalheira JB,Velloso LA,Saad MJ,Prada PO

更新日期：2012-09-01 00:00:00

abstract：:The initial steps involved in mediating the transduction of PTH signal via its G protein-coupled receptors are well understood and occur through the activation of cAMP and phospholipase C pathways. However, the cellular and molecular mechanisms for subsequent receptor desensitization are less well understood. Recently...

journal_title：Endocrinology

authors： Miles RR,Sluka JP,Santerre RF,Hale LV,Bloem L,Boguslawski G,Thirunavukkarasu K,Hock JM,Onyia JE

更新日期：2000-01-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-1, IGF binding protein (IGFBP)-2, and IGFBP-3 are expressed in the rat brain in regions of neuronal loss by 3 days after hypoxic- ischemic (HI) brain injury and IGF-2 somewhat later. Central administration of rh-IGF-1 after HI injury reduces neuronal loss in vivo. To clarify the mode o...

journal_title：Endocrinology

authors： Guan J,Williams CE,Skinner SJ,Mallard EC,Gluckman PD

更新日期：1996-03-01 00:00:00

abstract：:Specific polyclonal antisera to the rat estrogen receptor (rER) were developed using a synthetic peptide as the antigen. The peptide corresponds to amino acids 270-284 deduced from the cloned rER cDNA and has no homology to other steroid hormone receptors. Antipeptide antisera raised in rabbits specifically recognize ...

journal_title：Endocrinology

authors： Furlow JD,Ahrens H,Mueller GC,Gorski J

更新日期：1990-09-01 00:00:00

abstract：:AtT20/D16v is a clonal strain of mouse pituitary tumor cells which synthesizes and secretes ACTH. Somatostatin, a hypothalamic tetradecapeptide, has been shown to inhibit the release of PRL, GH, and TSH from the pituitary gland. We have characterized specific binding sites for somatostatin on AtT20/D16v cells and demo...

journal_title：Endocrinology

authors： Richardson UI,Schonbrunn A

更新日期：1981-01-01 00:00:00

abstract：:Thyroid hormones increase bone turnover in vivo and stimulate bone resorption in vitro. Clinical states associated with excess circulating thyroid hormone levels are known to produce osteoporosis. To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence ...

journal_title：Endocrinology

authors： Britto JM,Fenton AJ,Holloway WR,Nicholson GC

更新日期：1994-01-01 00:00:00

abstract：:We have investigated the effects of veratridine, a Na+ channel activator, and ouabain, an inhibitor of Na+-K+-ATPase, on short term (1-h) PRL release from primary cultures of rat anterior pituitary cells and from the rat anterior pituitary cell line GH4C1 in culture. Both compounds should increase intracellular Na+. V...

journal_title：Endocrinology

authors： Scammell JG,Dannies PS

更新日期：1983-10-01 00:00:00

abstract：:Congenital hypothyroidism with thyroid dysgenesis (TD) is a frequent human condition characterized by elevated levels of TSH in response to reduced thyroid hormone levels. Congenital hypothyroidism is a genetically heterogeneous disease. In the majority of cases studied, no causative mutations have been identified and...

journal_title：Endocrinology

authors： Amendola E,De Luca P,Macchia PE,Terracciano D,Rosica A,Chiappetta G,Kimura S,Mansouri A,Affuso A,Arra C,Macchia V,Di Lauro R,De Felice M

更新日期：2005-12-01 00:00:00

abstract：:The effect of osmotic changes on aldosterone production, [Ca2+]i and voltage-gated Ca2+ currents, was studied in cultured rat glomerulosa cells. Alteration of osmolarity by sucrose addition in the 250-330 mosM range did not influence aldosterone production per se, but it substantially affected K+-stimulated aldosteron...

journal_title：Endocrinology

authors： Makara JK,Petheö GL,Tóth A,Spät A

更新日期：2000-05-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:The present study employed the dehydroepiandrosterone (DHA) loading test to determine if the placenta in baboons remains functional following fetectomy. A bolus iv injection of 100 mg DHA was given to 4 baboons prior to and at various intervals following fetectomy at midgestation. Blood samples were withdrawn over a 4...

journal_title：Endocrinology

authors： Albrecht ED,Pepe GJ

更新日期：1985-02-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00