Abstract:
:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) by mass spectrometry, which allows metabolites to be identified based on the presence of this unique isotope signature. Endogenous T(1)AM levels depend upon thyroid status and decrease upon induction of hypothyroidism. However, in hypothyroid mice replaced with H-T(4), the isotope-labeled H-T(3) metabolite is detected, but no isotope-labeled T(1)AM is detected. These data suggest that T(1)AM is not an extrathyroidal metabolite of T(4), yet is produced by a process that requires the same biosynthetic factors necessary for T(4) synthesis.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TSdoi
10.1210/en.2012-1254subject
Has Abstractpub_date
2012-11-01 00:00:00pages
5659-67issue
11eissn
0013-7227issn
1945-7170pii
en.2012-1254journal_volume
153pub_type
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