Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor.

abstract：:In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with ...

journal_title：Endocrinology

authors： Varghese S,Rydziel S,Jeffrey JJ,Canalis E

更新日期：1994-06-01 00:00:00

abstract：:The present study assesses the relationship between G-proteins and protein kinase-C (PKC) in the gonadotrope. Cells were depleted of PKC with 1 microM phorbol 12-myristate 13-acetate for 12 h, followed by medium 199-BSA for 6 h before treatment with vehicle, pertussis toxin (PTX), cholera toxin (CTX), or (Bu)2cAMP (dB...

journal_title：Endocrinology

authors： Barnes SJ,Conn PM

更新日期：1993-12-01 00:00:00

abstract：:The long-acting synthetic enkephalin FK 33-824 (FK) potently inhibits LH secretion in gonadectomized prepubertal male and female rats. The effect is reversible by coinjection of naloxone. We have observed an age-related decrease in the ability of FK to reduce LH secretion in the 48 h post-gonadectomized rat. Thus, the...

journal_title：Endocrinology

authors： Wilkinson M,Bhanot R

更新日期：1982-03-01 00:00:00

abstract：:Binding of lactogenic hormones to particulate and solubilized microsomal membranes isolated from mammary glands of lactating mice is inhibited by direct addition of 10(-10) M or greater concentrations of triphenylethylene antiestrogens [i.e. tamoxifen (TAM), 4-hydroxy-tamoxifen, and Nafoxidine] to the binding assays. ...

journal_title：Endocrinology

authors： Biswas R,Vonderhaar BK

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells. Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with G...

journal_title：Endocrinology

authors： Baratta M,Saleri R,Mainardi GL,Valle D,Giustina A,Tamanini C

更新日期：2002-02-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatl...

journal_title：Endocrinology

authors： Townsend SE,Gannon M

更新日期：2019-08-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:Testicular tissue of normal and hCG-stimulated European eels was incubated in vitro with tritiated progesterone or androstenedione as substrates. The following compounds were isolated and identified: 5 beta-androstane-3,17-dione; 17 beta-hydroxy-5 beta-androstan-3-one; androst-4-ene-3,11,17-trione (adrenosterone); 11 ...

journal_title：Endocrinology

authors： Eckstein B,Cohen S,Hilge V

更新日期：1982-03-01 00:00:00

abstract：:The xenoestrogen bisphenol A (BPA) has been shown to mimic estrogen both in vivo and in vitro. BPA stimulates PRL secretion and the expression of a PRL regulating factor from the posterior pituitary in the estrogen-sensitive Fischer 344 rat (F344), but not in Sprague-Dawley (SD) rats. The goal of the present studies w...

journal_title：Endocrinology

authors： Steinmetz R,Mitchner NA,Grant A,Allen DL,Bigsby RM,Ben-Jonathan N

更新日期：1998-06-01 00:00:00

abstract：:Molecular mechanisms underlying unloading-induced reduction of bone formation have not yet been fully understood. In vitro, Runx2 has been suggested to be involved in mechanical signaling in osteoblasts. However, the roles of Runx2 in vivo during the bone response to mechanical stimuli have not yet been known. The pur...

journal_title：Endocrinology

authors： Salingcarnboriboon R,Tsuji K,Komori T,Nakashima K,Ezura Y,Noda M

更新日期：2006-05-01 00:00:00

abstract：:Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...

journal_title：Endocrinology

authors： Martinez-Arguelles DB,Papadopoulos V

更新日期：2015-01-01 00:00:00

abstract：:Ghrelin is an acylated peptide recently isolated from rat stomach that potently stimulates GH release in vitro and in vivo in rat and man. Ghrelin specifically activates the receptor for the growth hormone secretagogues (GHS-Rla), and it has been proposed as the endogenous ligand mimicked by these synthetic compounds....

journal_title：Endocrinology

authors： Torsello A,Ghe' C,Bresciani E,Catapano F,Ghigo E,Deghenghi R,Locatelli V,Muccioli G

更新日期：2002-05-01 00:00:00

abstract：:Local release of TGF-beta during times of high bone turnover leads to elevated levels within the bone microenvironment, and we have shown that TGF-beta suppresses osteoclast apoptosis. Therefore, understanding the influences of TGF-beta on bone resorbing osteoclasts is critical to the design of therapies to reduce exc...

journal_title：Endocrinology

authors： Ruan M,Pederson L,Bradley EW,Bamberger AM,Oursler MJ

更新日期：2010-04-01 00:00:00

abstract：:We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

journal_title：Endocrinology

authors： Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

更新日期：1993-10-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at a high level in the fetal pituitary and decreases profoundly between embryonic day 19 and postnatal day 1 (PN1), with a further decrease from PN1 to PN4. In this series of experiments, we investigated the hypothesis that dopamine 2 receptor (Dr...

journal_title：Endocrinology

authors： Winters SJ,Ghooray DT,Yang RQ,Holmes JB,O'Brien AR,Morgan J,Moore JP Jr

更新日期：2014-07-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in chemoprevention of colon cancer and others by inhibiting prostaglandin synthesis. In this report, we used LNCaP cells, an androgen-responsive human prostate carcinoma cell line, to study the effects of two NSAIDs, flufenamic acid (FA) and piroxicam ...

journal_title：Endocrinology

authors： Zhu W,Smith A,Young CY

更新日期：1999-11-01 00:00:00

abstract：:The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in ch...

journal_title：Endocrinology

authors： Cheng S,Xing W,Pourteymoor S,Schulte J,Mohan S

更新日期：2016-01-01 00:00:00

abstract：:The large-Maf transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) has been found to be crucial for insulin transcription and synthesis and for pancreatic β-cell function and maturation. However, insights about the effects of small Maf factors on β-cells are limited. Our goal was to elu...

journal_title：Endocrinology

authors： Nomoto H,Kondo T,Miyoshi H,Nakamura A,Hida Y,Yamashita K,Sharma AJ,Atsumi T

更新日期：2015-10-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:Many human breast tumors are driven by high intratumor concentrations of 17beta-estradiol that appear to be locally synthesized. The role of aromatase is well established, but the possible contribution of the steroid sulfatase (STS), which liberates estrogens from their biologically inactive sulfates, has been inadequ...

journal_title：Endocrinology

authors： James MR,Skaar TC,Lee RY,MacPherson A,Zwiebel JA,Ahluwalia BS,Ampy F,Clarke R

更新日期：2001-04-01 00:00:00

abstract：:Synthesis of GH, PRL, and proopiomelanocortin (POMC) by the adult ovine pituitary was examined by culturing intact tissue explants in vitro and analyzing newly synthesized proteins by two-dimensional gel electrophoresis. Spots on autoradiographs of two-dimensional gels were identified by comigration with known standar...

journal_title：Endocrinology

authors： Miller WL,Leisti S,Johnson LK

更新日期：1982-10-01 00:00:00

abstract：:To investigate the possibility that a common phenomenon might exist by which glucocorticoids influence responses to thyroid hormones, the cytosol levels of four proteins were measured after 2 days of treatment with L-T3 (T3; 50 micrograms/100 g. day 2) and/or cortisone (2 mg/100 g./day) in adult male hypothyroid rats....

journal_title：Endocrinology

authors： Shapiro LE,Sachchidananda J

更新日期：1982-08-01 00:00:00

abstract：:Pancreatic membrane receptors for cholecystokinin (CCK) in obese and nonobese Zucker rats were compared with the use of a biologically active [125I]iodo-CCK-8 radioprobe. Membrane homogenates from obese rats bound half the amount of radioligand in 2 h as did membranes from lean rats (specifically bound, 7.0% vs. 14.0%...

journal_title：Endocrinology

authors： Praissman M,Izzo RS

更新日期：1986-08-01 00:00:00

abstract：:GnRH, the main regulator of reproduction, is produced in a variety of tissues outside of the hypothalamus, its main site of synthesis and release. We aimed to determine whether GnRH produced in the female rat pituitary and ovaries is involved in the processes leading to ovulation. We studied the expression patterns of...

journal_title：Endocrinology

authors： Schirman-Hildesheim TD,Bar T,Ben-Aroya N,Koch Y

更新日期：2005-08-01 00:00:00

abstract：:Ovarian surface epithelium (OSE) is the most conceivable cell origin of epithelial ovarian carcinomas. Unlike many other epithelial tumors, the precancerous lesion acquires expression of epithelial markers, e.g. E-cadherin and claudins, suggesting that OSE cells undergo mesenchymal to epithelial transition (MET) durin...

journal_title：Endocrinology

authors： Zhu Y,Nilsson M,Sundfeldt K

更新日期：2010-11-01 00:00:00

abstract：:A variety of chronic stress paradigms have been shown to increase basal activity in the hypothalamic-pituitary-adrenocortical axis, resulting in hypercorticoidism. Despite this, chronically stressed rats typically exhibit facilitated ACTH responses to acute novel stress, suggesting that the activity of some central ne...

journal_title：Endocrinology

authors： Scribner KA,Akana SF,Walker CD,Dallman MF

更新日期：1993-12-01 00:00:00

abstract：:The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragments in the regulatio...

journal_title：Endocrinology

authors： Mazerbourg S,Zapf J,Bar RS,Brigstock DR,Lalou C,Binoux M,Monget P

更新日期：1999-09-01 00:00:00

abstract：:FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this...

journal_title：Endocrinology

authors： Shibata EF,Matsuda JJ,Volk KA,Collison KA,Segaloff DL

更新日期：1992-08-01 00:00:00

abstract：:The purpose of these experiments was to determine if the powerful effect of sodium chloride concentration on angiotensin II- and potassium-stimulated aldosterone secretion by isolated perfused adrenal glands is mediated by the sodium or chloride ion or by the obligatory change in osmolality. We used isolated Ringer's ...

journal_title：Endocrinology

authors： Schneider EG,Radke KJ,Ulderich DA,Taylor RE Jr

更新日期：1985-04-01 00:00:00