Abstract:
:This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatly influences β-cell survival and proliferation. Within the islet, β-cells contact the ECM, which is deposited primarily by intraislet endothelial cells, and this interaction has been shown to modulate proliferation and survival. ECM-localized growth factors, such as vascular endothelial growth factor and cellular communication network 2, signal through specific receptors and integrins on the β-cell surface. Further understanding of how the ECM functions to influence β-cell proliferation and survival will provide targets for enhancing functional β-cell mass for the treatment of diabetes.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Townsend SE,Gannon Mdoi
10.1210/en.2019-00206subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1885-1894issue
8eissn
0013-7227issn
1945-7170pii
5527764journal_volume
160pub_type
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