Testicular peritubular cells secrete a protein under androgen control that inhibits induction of aromatase activity in Sertoli cells.

abstract：:Fluorescence resonance energy transfer using genetically encoded biosensors has proven to be a powerful technique to monitor the spatiotemporal dynamics of cAMP signals stimulated by G(s)-coupled receptors in living cells. In contrast, real-time imaging of G(i)-mediated cAMP signals under native conditions remains cha...

journal_title：Endocrinology

authors： Jacobs S,Calebiro D,Nikolaev VO,Lohse MJ,Schulz S

更新日期：2010-09-01 00:00:00

abstract：:Protein iodination in the thyroid is largely confined to the surface of the epithelium. Intracellular iodine binding is insignificant. We have tested our hypothesis that the key mechanism in the control of intracellular iodination is the control of the intracellular availability of H2O2. The sites of iodination were i...

journal_title：Endocrinology

authors： Ekholm R,Björkman U

更新日期：1997-07-01 00:00:00

abstract：:We investigated the effects of the peripheral administration of 17 beta-estradiol (E2), estrone (E1), and the catecholestrogens, 2-hydroxyestradiol (2-OHE2) and 2-hydroxyestrone, (2-OHE1), on anterior pituitary gland PRL release in the prepuberal rat. Steroids in oil were injected sc into 25-day-old female and 35- to ...

journal_title：Endocrinology

authors： Rodriguez-Sierra JF,Blake CA

更新日期：1982-02-01 00:00:00

abstract：:Macrophages are known to release a lipophilic factor that stimulates testosterone production by Leydig cells. This macrophage-derived factor (MDF) is thought to be physiologically relevant, because removal of macrophages from the testis results in altered testosterone secretion and reduced fertility. The purpose of th...

journal_title：Endocrinology

authors： Nes WD,Lukyanenko YO,Jia ZH,Quideau S,Howald WN,Pratum TK,West RR,Hutson JC

更新日期：2000-03-01 00:00:00

abstract：:The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the secretory pathway and is the site where protein folding and quality control are initiated. The storage and release of Ca2+ are critical physiological functions of the ER. Disrupted ER homeostasis activates the unfolded protein respo...

journal_title：Endocrinology

authors： Zhang IX,Raghavan M,Satin LS

更新日期：2020-02-01 00:00:00

abstract：:We demonstrated previously that glucocorticoids differentially affect the levels of the two pituitary gonadotropins, LH and FSH, both in vivo and in vitro. In vivo, the effect of glucocorticoids is GnRH independent, indicating a direct action on the gonadotrope, and it leads to selective up-regulation of the pituitary...

journal_title：Endocrinology

authors： Kilen SM,Szabo M,Strasser GA,McAndrews JM,Ringstrom SJ,Schwartz NB

更新日期：1996-09-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. Chronic repercussions of ApN treatment or overexpression on adiposity and body weight are still controversial. Here, we generated a transgenic (Tg) mouse model allowing persistent and mod...

journal_title：Endocrinology

authors： Bauche IB,El Mkadem SA,Pottier AM,Senou M,Many MC,Rezsohazy R,Penicaud L,Maeda N,Funahashi T,Brichard SM

更新日期：2007-04-01 00:00:00

abstract：:The effects of L-leucine, D-leucine, and L-isoleucine upon the secretion of glucagon and insulin were investigated using the isolated, perfused rat pancreas. All experiments were conducted in the presence of 5.6 mM D-glucose. Ten-minute perfusions of 2, 5, and 10 mM L-leucine induced the release of glucagon and insuli...

journal_title：Endocrinology

authors： Pek S,Santiago JC,Tai TY

更新日期：1978-10-01 00:00:00

abstract：:Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This response, which can be reversed by elevation of intraoocyte cAMP levels, is associated with interruption of gap junctional communication (GJC) within the ovarian follicle. In the present study, we examined the hypothesis that disruptio...

journal_title：Endocrinology

authors： Sela-Abramovich S,Edry I,Galiani D,Nevo N,Dekel N

更新日期：2006-05-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:Dog thyroid slices released in their incubation medium prostaglandins E2 (PGE2), F2 alpha (PGF2 alpha), 15-keto-13,14-dihydro-F2 alpha, and thromboxane B2 (TxB2), as measured by direct RIA. This release could be inhibited by indomethacin and naproxen, indicating that it corresponded to a neosynthesis. Carbamylcholine ...

journal_title：Endocrinology

authors： Boeynaems JM,Waelbroeck M,Dumont JE

更新日期：1979-10-01 00:00:00

abstract：:The aim of this study was to identify and characterize binding sites for inhibin in primary cultures of ovine anterior pituitary cells. Recombinant human 31-kDa inhibin A was iodinated by an optimized lactoperoxidase procedure. Fractionation of the labeled protein by gel filtration chromatography on Sephadex G-100 in ...

journal_title：Endocrinology

authors： Hertan R,Farnworth PG,Fitzsimmons KL,Robertson DM

更新日期：1999-01-01 00:00:00

abstract：:Nonesterified fatty acids (NEFAs) have been recently shown in the rat to be involved in steroid hormone expression, having effects on plasma transport and intracellular activity. This study examines the influence of saturated and unsaturated NEFAs on estradiol (E2) binding to cytosol from human uterus, breast, and mel...

journal_title：Endocrinology

authors： Benassayag C,Vallette G,Hassid J,Raymond JP,Nunez EA

更新日期：1986-01-01 00:00:00

abstract：:Stimulation of mitogenesis in rat Nb2 node lymphoma cells by human (h) PRL was inhibited by inhibitors of Na+/H+ exchange (viz. amiloride and its analogs) and inhibitors of protein kinases (isoquinolinesulfonamide derivatives). The most potent were ethylisopropylamiloride (EP-Am) (IC50, 13 microM) and H-7, selective f...

journal_title：Endocrinology

authors： Too CK,Walker A,Murphy PR,Cragoe EJ Jr,Jacobs HK,Friesen HG

更新日期：1987-10-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis adapts to periods of chronic or repeated stress. We have now investigated whether there is any differential effect of repeated immobilization stress on CRH and arginine vasopressin (AVP) gene transcription in the hypothalamic paraventricular nucleus (PVN), using probes for both ...

journal_title：Endocrinology

authors： Ma XM,Levy A,Lightman SL

更新日期：1997-10-01 00:00:00

abstract：:Benzodiazepines (BZs) have been shown to modulate voltage-sensitive Ca2+ channels in a number of neuronal and nonneuronal cell types and to competitively antagonize TRH binding to receptors on cells of the nervous system and anterior pituitary gland. Because interaction of TRH with its receptor is known to cause enhan...

journal_title：Endocrinology

authors： Gershengorn MC,Thaw CN,Geras-Raaka E

更新日期：1988-07-01 00:00:00

abstract：:Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...

journal_title：Endocrinology

authors： Max SR,Toop J

更新日期：1983-07-01 00:00:00

abstract：:In the spiny dogfish (Squalus acanthias), germ cells and adjacent steroidogenic elements are topographically segregated within the testis according to stage of development. In the experiments reported here, we have taken advantage of this favorable anatomical arrangement to demonstrate stage-specific variations in ste...

journal_title：Endocrinology

authors： Callard GV,Pudney JA,Mak P,Canick JA

更新日期：1985-10-01 00:00:00

abstract：:ACTH and cAMP stimulate steroidogenesis and the mitochondrial electron transport system for steroid hydroxylation in cultured mouse adrenal cortex tumor cells. During this stimulation, the biosynthesis of adrenodoxin, a non-heme iron protein which is one of the electron transport enzymes, was examined. 14C-labeled adr...

journal_title：Endocrinology

authors： Asano K,Harding BW

更新日期：1976-10-01 00:00:00

abstract：:Male Sprague-Dawley rats were infused continuously for 13 days with vehicle or 75 pmol (31.2 ng)/day 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by means of Alzet osmotic minipumps implanted s.c. Animals infused with 1,25-(OH)2D3 exhibited mild hypercalcemia (11.2 vs. 10.2 mg/dl in controls), a 136% increase in the serum ...

journal_title：Endocrinology

authors： Wronski TJ,Halloran BP,Bikle DD,Globus RK,Morey-Holton ER

更新日期：1986-12-01 00:00:00

abstract：:Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of these peptides and their regulated expression by ...

journal_title：Endocrinology

authors： Overgaard A,Ruiz-Pino F,Castellano JM,Tena-Sempere M,Mikkelsen JD

更新日期：2014-10-01 00:00:00

abstract：:Based on the finding that retinoic acid (RA) increases 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptor number in ROS 17/2 cells, we investigated the effects of RA on the ability of 1,25-(OH)2D3 to regulate alkaline phosphatase activity and PTH-responsive adenylate cyclase in these cells. A maximally effective dose of...

journal_title：Endocrinology

authors： Grigoriadis AE,Petkovich PM,Rosenthal EE,Heersche JN

更新日期：1986-08-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that epidermal growth factor (EGF), induces intracellular alkalinization in chicken granulosa cells by activating a sodium-dependent and amiloride-sensitive Na+/H+ antiporter. In the present investigation we have examined the possible involvement of protein kinase...

journal_title：Endocrinology

authors： Li M,Morley P,Tsang BK

更新日期：1991-12-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We ...

journal_title：Endocrinology

authors： Sun X,Cappelletti M,Li Y,Karp CL,Divanovic S,Dey SK

更新日期：2014-10-01 00:00:00

abstract：:Several observations suggest that GH stimulates sebaceous gland growth and development. Therefore, we studied the effects of GH and insulin-like growth factors (IGFs), alone and with androgen, on sebaceous epithelial cell (sebocyte) growth and differentiation in vitro. The rat preputial cell culture model system was u...

journal_title：Endocrinology

authors： Deplewski D,Rosenfield RL

更新日期：1999-09-01 00:00:00

abstract：:There are many precedents for the production from a single precursor of multiple peptides, with independent receptors and different bioactivities. Gastrin-releasing peptide (GRP) is initially synthesized as amino acids 1-27 of a 125-residue precursor, proGRP, and is subsequently cleaved and amidated to form GRP18-27. ...

journal_title：Endocrinology

authors： Patel O,Dumesny C,Shulkes A,Baldwin GS

更新日期：2007-03-01 00:00:00

abstract：:The effects of leptin on the levels of CRF messenger RNA (mRNA) in the paraventricular hypothalamic nucleus (PVN), on the activation of the PVN CRF cells, and on the plasma levels of corticosterone were investigated in lean (+/?) and obese (ob/ob) C57BL/6J male mice. Murine leptin was s.c. infused using osmotic minipu...

journal_title：Endocrinology

authors： Huang Q,Rivest R,Richard D

更新日期：1998-04-01 00:00:00

abstract：:The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal ca...

journal_title：Endocrinology

authors： Prosser CG,Sankaran L,Hennighausen L,Topper YJ

更新日期：1987-04-01 00:00:00