Abstract:
:Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in several organs of the ERE-Luc reporter mouse. By molecular imaging, we show that ER activation is present in nonreproductive organs to an extent similar to that observed with the administration of 17beta-estradiol, and it is not influenced by orchiectomy or treatment with an aromatase inhibitor. This, together with the use of a completely synthetic diet, proves that the activation of ERs observed is due to estrogenic compounds present in commercial diets and that it is not a secondary event determined by food consumption and metabolism. The pervasiveness of estrogenic compounds in nature poses the question of how relevant and necessary is the daily ingestion of natural compounds active through the ERs for the maintenance of a correct metabolism in both male and female mammals.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Ciana P,Brena A,Sparaciari P,Bonetti E,Di Lorenzo D,Maggi Adoi
10.1210/en.2005-0660subject
Has Abstractpub_date
2005-12-01 00:00:00pages
5144-50issue
12eissn
0013-7227issn
1945-7170pii
en.2005-0660journal_volume
146pub_type
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