GnRH and GnRH receptor genes in the human genome.

abstract：:Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...

journal_title：Endocrinology

authors： Roa J,Vigo E,Castellano JM,Navarro VM,Fernández-Fernández R,Casanueva FF,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-06-01 00:00:00

abstract：:The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for transgender individuals dramatically alters estrogen and testosterone levels and consequently could have widespread consequences for cardiovascular health. Yet, no prec...

journal_title：Endocrinology

authors： Goetz TG,Mamillapalli R,Sahin C,Majidi-Zolbin M,Ge G,Mani A,Taylor HS

更新日期：2018-02-01 00:00:00

abstract：:Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role of endogenous relaxin in the pathogenesis of primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old relaxin (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/...

journal_title：Endocrinology

authors： Hewitson TD,Mookerjee I,Masterson R,Zhao C,Tregear GW,Becker GJ,Samuel CS

更新日期：2007-02-01 00:00:00

abstract：:The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding, gastric emptying, and energetic responses involve vagal transmission and central nervous system processing. Despite a lack of studies aimed at determining which central nervous system regions are critical for the GLP-1R respons...

journal_title：Endocrinology

authors： Hayes MR,Skibicka KP,Grill HJ

更新日期：2008-08-01 00:00:00

abstract：:In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...

journal_title：Endocrinology

authors： Brock O,Bakker J

更新日期：2013-08-01 00:00:00

abstract：:Polypeptide YY(3-36) (PYY(3-36)) is a gastrointestinal secreted molecule, agonist of neuropeptide Y (NPY) receptor subtypes Y2 and Y5, recently involved in the control of food intake. Notably, several factors with key roles in energy homeostasis conduct pleiotropic effects upon the reproductive axis. However, whether ...

journal_title：Endocrinology

authors： Fernandez-Fernandez R,Aguilar E,Tena-Sempere M,Pinilla L

更新日期：2005-03-01 00:00:00

abstract：:Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and hormones. The role...

journal_title：Endocrinology

authors： Pauliina Markkula S,Lyons D,Yueh CY,Riches C,Hurst P,Fielding B,Heisler LK,Evans ML

更新日期：2016-12-01 00:00:00

abstract：:Dopaminergic (DA) neurons located in the preoptico-hypothalamic region of the brain exert a major neuroendocrine control on reproduction, growth, and homeostasis by regulating the secretion of anterior pituitary (or adenohypophysis) hormones. Here, using a retrograde tract tracing experiment, we identified the neurons...

journal_title：Endocrinology

authors： Fontaine R,Affaticati P,Bureau C,Colin I,Demarque M,Dufour S,Vernier P,Yamamoto K,Pasqualini C

更新日期：2015-08-01 00:00:00

abstract：:We have investigated the effect of GH on microtubular physiology in Chinese hamster ovary (CHO) cells stably transfected with the complementary DNA for the rat GH receptor (CHO-GHR(1-638)). We show here that after 30 min of human GH (hGH) treatment of CHO-GHR(1-638) cells, there was a significant increase in the level...

journal_title：Endocrinology

authors： Goh EL,Pircher TJ,Lobie PE

更新日期：1998-10-01 00:00:00

abstract：:Fetal adrenal steroid hydroxylase activity and messenger RNA (mRNA) expression increases concurrent with the preterm rise in fetal plasma cortisol during late gestation in sheep. By placing bilateral lesions of the fetal paraventricular nuclei (PVN) we have previously demonstrated that the fetal PVN is necessary for t...

journal_title：Endocrinology

authors： Myers DA,McDonald TJ,Nathanielsz PW

更新日期：1992-07-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...

journal_title：Endocrinology

authors： Shih CH,Chen SL,Yen CC,Huang YH,Chen CD,Lee YS,Lin KH

更新日期：2004-06-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:The present study was conducted to elucidate the possible molecular mechanisms involved in the antispermatogenic activity of l-CDB-4022, an indenopyridine. In this study 45-d-old male Sprague-Dawley rats were treated with a single oral dose of l-CDB-4022 (2.5 mg/kg) or vehicle, and blood and testes were collected at v...

journal_title：Endocrinology

authors： Koduri S,Hild SA,Pessaint L,Reel JR,Attardi BJ

更新日期：2008-04-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:We have investigated the effects of hCG and estradiol on the time course of the inhibition of C17-20-lyase and the depletion of the estradiol cytosol receptor in testicular tissue of male rats. In hCG-treated animals the first significant decrease in C17-20-lyase activity was observed 16 h after injection of the hormo...

journal_title：Endocrinology

authors： Brinkmann A,Leemborg I,Rommerts F,van der Molen H

更新日期：1982-05-01 00:00:00

abstract：:The follicular phase rise in circulating estradiol causes a suppression of GnRH pulse amplitude and an increase in pulse frequency before stimulation of the preovulatory GnRH surge in the ewe. Studies in which samples were collected at 10-min intervals were found unsuitable to determine whether GnRH secretion is exclu...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Mauger D,Karsch FJ

更新日期：1995-04-01 00:00:00

abstract：:Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...

journal_title：Endocrinology

authors： Campbell WB,Pettinger WA

更新日期：1975-12-01 00:00:00

abstract：:GH controls its own secretion through a mechanism involving short-loop feedback regulation of the synthesis and release of GH-releasing hormone (GHRH). GHRH neurons coexpress the peptide galanin, but the functional significance of this coexpression is unknown. In this study, we tested the hypotheses that 1) galanin ge...

journal_title：Endocrinology

authors： Chan YY,Grafstein-Dunn E,Delemarre-van de Waal HA,Burton KA,Clifton DK,Steiner RA

更新日期：1996-12-01 00:00:00

abstract：:We employed a short term system of dispersed adult mouse hypothalamic cells, as previously described in the rat, to examine the roles of calcium and calmodulin in SRIF release. Incubation studies were performed 24 h after hypothalamic cell dispersion. SRIF release, as determined by RIA was stimulated in a dose-depende...

journal_title：Endocrinology

authors： Richardson S,Twente S

更新日期：1985-07-01 00:00:00

abstract：:A model for the study of testicular function in experimental uremia induced by subtotal nephrectomy in mature male rats is described. Glomerular filtration rate was reduced by 87%, resulting in stable uremia for up to 13 weeks with characteristic biochemical changes and reduction in weight of testes, prostate, seminal...

journal_title：Endocrinology

authors： Handelsman DJ,Spaliviero JA,Turtle JR

更新日期：1985-11-01 00:00:00

abstract：:Specific serum binding of 25-hydroxy-cholecalciferol (25-OHD3) was measured by saturation analysis in rats of various ages, and during vitamin D deprivation. The serum binding capacity for 25-OHD3 was observed to increase until age 6-8 weeks, then decline and remain stable thereafter at 3.7 x 10(-6) M. The 25-hydroxyv...

journal_title：Endocrinology

authors： Rojanasathit S,Haddad JG

更新日期：1977-03-01 00:00:00

abstract：:Oxytocin (OT) has a dual action in the uterus: a uterotonic action on myometrial cells and a prostaglandin (PG)-releasing action on endometrial/decidual cells. It had not been determined whether the OT-binding sites or receptors on the myometrial and the endometrial/decidual membranes are of the same type or may repre...

journal_title：Endocrinology

authors： Chan WY,Chen DL,Manning M

更新日期：1993-03-01 00:00:00

abstract：:We studied the effects of 17 beta-estradiol (E2) and PTH on alkaline phosphatase activity in SaOS-2 cells that had been passaged and grown continually in the presence (SaOS + Dex) or absence (SaOS - Dex) of 10(-8) M dexamethasone (Dex). We showed that the more differentiated SaOS + Dex cells had higher alkaline phosph...

journal_title：Endocrinology

authors： Rao LG,Wylie JN,Sutherland MS,Murray TM

更新日期：1994-02-01 00:00:00

abstract：:Our previous studies have identified a role for annexin 1 (also called lipocortin 1) in the regulatory actions of glucocorticoids (GCs) on the release of PRL from the rat anterior pituitary gland. In the present study we used antisense and immunoneutralization strategies to extend this work. Exposure of rat anterior p...

journal_title：Endocrinology

authors： Taylor AD,Philip JG,John CD,Cover PO,Morris JF,Flower RJ,Buckingham JC

更新日期：2000-06-01 00:00:00

abstract：:The effect of an i.v. administration of different doses (250, 500, and 1000 pmol) of ovine CRF (oCRF) on plasma glucose and insulin levels in lean and genetically obese fa/fa rats was investigated. In both phenotypes, i.v. CRF promoted a rapid (peak at 1 min) transient doubling of basal insulin levels without a concom...

journal_title：Endocrinology

authors： Rohner-Jeanrenaud F,Jeanrenaud B

更新日期：1992-04-01 00:00:00

abstract：:Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat that a 22% reduction in bone mineral density generated by ovariectomy was associated with a 2-fold reduction of transforming growth factor-beta 3 (TGF beta 3) messenger RNA expression in th...

journal_title：Endocrinology

authors： Yang NN,Bryant HU,Hardikar S,Sato M,Galvin RJ,Glasebrook AL,Termine JD

更新日期：1996-05-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00