Acute intravenous corticotropin-releasing factor administration: effects on insulin secretion in lean and genetically obese fa/fa rats.

abstract：:Epidermal growth factor (EGF) and TGFalpha are well known for their activities in the ovary. Both factors initiate signal transduction by binding to the common EGF receptor that has been demonstrated in the ovary across vertebrates from fish to humans. Using zebrafish as the model, we demonstrated in the present study...

journal_title：Endocrinology

authors： Pang Y,Ge W

更新日期：2002-01-01 00:00:00

abstract：:Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homolo...

journal_title：Endocrinology

authors： Ellsworth BS,White BR,Burns AT,Cherrington BD,Otis AM,Clay CM

更新日期：2003-03-01 00:00:00

abstract：:Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...

journal_title：Endocrinology

authors： Varayoud J,Ramos JG,Bosquiazzo VL,Muñoz-de-Toro M,Luque EH

更新日期：2008-11-01 00:00:00

abstract：:An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, decrease triglyceride accumulation in the adipocyte and...

journal_title：Endocrinology

authors： Ruderman NB,Saha AK,Kraegen EW

更新日期：2003-12-01 00:00:00

abstract：:Growth hormone-releasing factor-like immunoreactivity (GRF-LI) was detected in partially purified extracts of rat hypothalamus and duodenum with a highly specific RIA for rat GRF (rGRF). The concentration of rGRF-LI in the rat hypothalamus was 32.5 fmol/mg dry weight (455 fmol or 3.18 ng/region), while the rat duodenu...

journal_title：Endocrinology

authors： Bruhn TO,Mason RT,Vale WW

更新日期：1985-10-01 00:00:00

abstract：:Maternal obesity at conception increases the risk of offspring obesity, thus propagating an intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to high fat-diets, gaining greater body weight, fat mass, and additional metabolic sequelae compared to lean controls. In this report, we id...

journal_title：Endocrinology

authors： Shankar K,Zhong Y,Kang P,Lau F,Blackburn ML,Chen JR,Borengasser SJ,Ronis MJ,Badger TM

更新日期：2011-11-01 00:00:00

abstract：:The role of the carboxy-terminal domain of the Glut 1 glucose transporter was investigated using an antipeptide antibody to the C-terminal part of the molecule. The study was performed in fibroblasts transfected with the cDNA coding for the human insulin receptor. These cells acutely respond to insulin for glucose tra...

journal_title：Endocrinology

authors： Tanti JF,Gautier N,Cormont M,Baron V,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1992-11-01 00:00:00

abstract：:In this study, site-directed mutagenesis and biochemical strategies have been used to establish whether disulfide bonding between extracellular Cys residues contributes to the structural integrity of the GnRH receptor (GnRH-R) and, if so, to delineate the nature of the bonding patterns involved. The majority of G prot...

journal_title：Endocrinology

authors： Cook JV,Eidne KA

更新日期：1997-07-01 00:00:00

abstract：:Plasma immunoreactive PRL responses to indoleamines and their metabolites were studied in urethane-anesthetized rats. All drugs were injected into the lateral ventricle and blood samples were serially collected from a jugular vein. Serotonin and melatonin caused a significant increase in plasma PRL with peak values at...

journal_title：Endocrinology

authors： Iwasaki Y,Kato Y,Ohgo S,Abe H,Imura H,Hirata F,Senoh S,Tokuyama T,Hayaishi O

更新日期：1978-07-01 00:00:00

abstract：:Obesity is associated with systemic inflammation and elevated levels of TNFα, leading to impaired glucose tolerance. In humans, obesity is also associated with reduced nutrient-stimulated secretion of the intestinal incretin hormone, glucagon-like peptide-1 (GLP-1). We hypothesized that TNFα plays a direct role in the...

journal_title：Endocrinology

authors： Gagnon J,Sauvé M,Zhao W,Stacey HM,Wiber SC,Bolz SS,Brubaker PL

更新日期：2015-11-01 00:00:00

abstract：:Activating ras point mutations are frequently found in skeletal muscle tumors such as rhabdomyosarcomas. In this study we investigated the impact of two different H-ras mutants in skeletal muscle differentiation: RasV12, a constitutively active form, and RasV12C40, a mutant deficient in Raf1 activation. Stably transfe...

journal_title：Endocrinology

authors： De Alvaro C,Nieto-Vazquez I,Rojas JM,Lorenzo M

更新日期：2008-02-01 00:00:00

abstract：:Galanin (GAL) has recently emerged as an important neuroendocrine regulator which participates in the control of several pituitary and hypothalamic hormones. Our earlier observation that GAL stimulates LHRH release from nerve terminals of the median eminence as well as basal LH and LHRH-induced LH secretion from pitui...

journal_title：Endocrinology

authors： López FJ,Meade EH Jr,Negro-Vilar A

更新日期：1993-02-01 00:00:00

abstract：:As the regulator of pituitary reproductive hormone synthesis, the hypothalamic neuropeptide GnRH is the central regulator of reproduction. A hallmark of GnRH action is the differential control of gene expression in pituitary gonadotropes through varied pulsatile stimulation. Among other signaling events, GnRH activati...

journal_title：Endocrinology

authors： Nguyen KA,Intriago RE,Upadhyay HC,Santos SJ,Webster NJ,Lawson MA

更新日期：2010-10-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00

abstract：:The time sequence of the metabolism of [4-14C] pregnenolone to testosterone in homogenates of human and rat testis was studied with special emphasis on the chain of events in the early 15 min of incubation. The incubations were performed at 32 C in the presence of NAD and a NADPH-generating system. The various interme...

journal_title：Endocrinology

authors： Weusten JJ,Smals AG,Hofman JA,Kloppenborg PW,Benraad TJ

更新日期：1987-05-01 00:00:00

abstract：:The effects of rat CRF, arginine vasopressin (VP), oxytocin (OXY), and isoproterenol (ISO) on the biosynthesis and release of pro-ACTH/endorphin-derived peptides by monolayer cultures of rat anterior pituitary cells in complete serum-free medium (CSFM) were studied. When cells were exposed to hormone for 3 h, CRF, VP,...

journal_title：Endocrinology

authors： Wand GS,Eipper BA

更新日期：1987-03-01 00:00:00

abstract：:Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently associated with genetic alterations leading to activation of the MAPK signaling pathway. The two most frequently affected genes, BRAF and RET, are activated by either point mutation or as a result of chromosomal rearrangement. Th...

journal_title：Endocrinology

authors： Ciampi R,Nikiforov YE

更新日期：2007-03-01 00:00:00

abstract：:To determine the presence of a PRL-binding protein (PRL-BP) in rat serum, female rats were ovariectomized and administered sc estradiol benzoate capsules. Serum was incubated with [125I]rat PRL (rPRL) for 1 h at 37 C with or without different doses of rPRL, ovine PRL (oPRL), or rGH. Separation of the [125I]rPRL-PRL-BP...

journal_title：Endocrinology

authors： Cohen H,Guillaumot P,Sabbagh I

更新日期：1993-06-01 00:00:00

abstract：:Tumoral insulin-producing cells of the RINm5F line display a poor secretory response to D-glucose. Relative to basal insulin output, which corresponds to a fractional release of stored hormone close to 25%/90 min, the glucose-induced increment in insulin release does not exceed 28 +/- 7%. The low efficiency of D-gluco...

journal_title：Endocrinology

authors： Valverde I,Barreto M,Malaisse WJ

更新日期：1988-04-01 00:00:00

abstract：:Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism. Mice were injected with syngeneic tumor cells transduced with the human IL-1beta gene. Serum IL-1beta levels increased exponentially with time. Secretion of IL-1beta from the developed tumors was associated w...

journal_title：Endocrinology

authors： Metzger S,Nusair S,Planer D,Barash V,Pappo O,Shilyansky J,Chajek-Shaul T

更新日期：2004-11-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:Increased toxicant exposure and resultant environmentally induced diseases are a tradeoff of industrial productivity. Dioxin [2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)], a ubiquitous byproduct, is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytoch...

journal_title：Endocrinology

authors： Khan Z,Zheng Y,Jones TL,Delaney AA,Correa LF,Shenoy CC,Khazaie K,Daftary GS

更新日期：2018-01-01 00:00:00

abstract：:Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...

journal_title：Endocrinology

authors： Ogle TF,Kitay JI

更新日期：1976-01-01 00:00:00

abstract：:Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...

journal_title：Endocrinology

authors： Zimmermann RC,Xiao E,Bohlen P,Ferin M

更新日期：2002-07-01 00:00:00

abstract：:Marked development of the mammary parenchyma (ducts, lobules, and alveoli) occurs during the last third of the 115-day gestation period in the gilt. These changes in the mammary gland are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin play...

journal_title：Endocrinology

authors： Winn RJ,Baker MD,Merle CA,Sherwood OD

更新日期：1994-09-01 00:00:00

abstract：:A method to prepare suspension cultures of highly viable pinealocytes is described. Pineal glands of neonatal or adult rats can be used; the best yield is obtained from neonatal glands. Morphological examination of the cells indicates that they have a normal, healthy appearance and retain some structures typical of ne...

journal_title：Endocrinology

authors： Buda M,Klein DC

更新日期：1978-10-01 00:00:00

abstract：:We have previously shown that dopamine-evoked inhibition of corticosteroid production from adrenocortical cells is mediated through a decrease in prostaglandin biosynthesis. Since the catecholamine did not alter the stimulatory effect of arachidonic acid, it was proposed that dopamine may inhibit the formation of arac...

journal_title：Endocrinology

authors： Morra M,Leboulenger F,Desrues L,Tonon MC,Vaudry H

更新日期：1991-05-01 00:00:00

abstract：:Hydrogen peroxide acts as electron acceptor in the oxidative reactions (iodination and coupling) by which the thyroid hormones are formed. Regulation of the generation of H2O2 was studied in monolayer cultures of the FRTL-5 rat thyroid cell line and in primary monolayer cultures of porcine thyroid cells. Both cell typ...

journal_title：Endocrinology

authors： Björkman U,Ekholm R

更新日期：1992-01-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:Dysregulation of the hypothalamic-pituitary-adrenocortical axis has been theoretically linked to the processes of aging for decades. To investigate the effects of age on high frequency rhythms of plasma ACTH at the time of circadian activation, integrated 2-min blood samples were collected over 4 h in 10 young and 14 ...

journal_title：Endocrinology

authors： Carnes M,Goodman BM,Lent SJ,Vo H

更新日期：1993-08-01 00:00:00