Abstract:
:Plasma immunoreactive PRL responses to indoleamines and their metabolites were studied in urethane-anesthetized rats. All drugs were injected into the lateral ventricle and blood samples were serially collected from a jugular vein. Serotonin and melatonin caused a significant increase in plasma PRL with peak values at 10-20 min after the injection. Significant increase in plasma PRL were also observed after the administration of 5-hydroxykynurenamine (5-HK), a newly identified serotonin metabolite. The potency of 5-HK was less than that of serotonin but much greater than that of melatonin. In contrast, plasma PRL did not change significantly in response to N-acetyl-5-methoxykynurenamine, another newly identified metabolite of melatonin, or a vehicle solution. Simultaneous administration of melatonin significantly blunted the plasma PRL response to serotonin, whereas the rise in plasma PRL induced by 5-HK was not blunted by melatonin. These results suggest that indoleamines as well as their metabolites play a role in regulating PRL secretion in rats.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Iwasaki Y,Kato Y,Ohgo S,Abe H,Imura H,Hirata F,Senoh S,Tokuyama T,Hayaishi Odoi
10.1210/endo-103-1-254subject
Has Abstractpub_date
1978-07-01 00:00:00pages
254-8issue
1eissn
0013-7227issn
1945-7170journal_volume
103pub_type
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