Abstract:
:Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently associated with genetic alterations leading to activation of the MAPK signaling pathway. The two most frequently affected genes, BRAF and RET, are activated by either point mutation or as a result of chromosomal rearrangement. These mutations are tumorigenic in thyroid follicular cells and correlate with specific phonotypical features and biological properties of papillary carcinomas, including tumor aggressiveness and response to radioiodine therapy. Molecular inhibitors that block RET/PTC or BRAF kinase activity have shown substantial therapeutic effects in the experimental systems and are currently being tested in clinical trials.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Ciampi R,Nikiforov YEdoi
10.1210/en.2006-0921subject
Has Abstractpub_date
2007-03-01 00:00:00pages
936-41issue
3eissn
0013-7227issn
1945-7170pii
en.2006-0921journal_volume
148pub_type
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