Vasopressin messenger ribonucleic acid in supraoptic and suprachiasmatic nuclei: appearance and circadian regulation during development.

abstract：:We have studied the two estrogen receptor (ER) subtypes, ER alpha and ER beta, and chimeric constructs with ER alpha and ER beta to examine the bioactivities of these receptors and their responses to estrogen and antiestrogen ligands. Transcriptional activity of ER beta is highly dependent on cell/promoter context and...

journal_title：Endocrinology

authors： McInerney EM,Weis KE,Sun J,Mosselman S,Katzenellenbogen BS

更新日期：1998-11-01 00:00:00

abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactivity in the adrenal gland of the frog, Rana ridibunda, was examined by the indirect immunofluorescence technique. Using an antiserum directed against rat alpha-CGRP, the presence of a network of positive fibers was observed in the adrenal pare...

journal_title：Endocrinology

authors： Esneu M,Delarue C,Remy-Jouet I,Manzardo E,Fasolo A,Fournier A,Saint-Pierre S,Conlon JM,Vaudry H

更新日期：1994-07-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...

journal_title：Endocrinology

authors： Antonipillai I,Vogelsang J,Horton R

更新日期：1986-07-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:Extracts of spinach contain somatostatin (SRIF)-related material (6-80 pg/g wet wt). The SRIF-related material, when purified on HPLC, was recovered as two major mol wt forms; one that eluted with a retention time similar to that of synthetic SRIF-28 and reacted in both N- and C-terminal-specific immunoassays, and a s...

journal_title：Endocrinology

authors： LeRoith D,Pickens W,Wilson GL,Miller B,Berelowitz M,Vinik AI,Collier E,Cleland CF

更新日期：1985-11-01 00:00:00

abstract：:TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...

journal_title：Endocrinology

authors： Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4 measurements, but qWestern is technically complex and labor intensiv...

journal_title：Endocrinology

authors： Yang Q,Eskurza I,Kiernan UA,Phillips DA,Blüher M,Graham TE,Kahn BB

更新日期：2012-03-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:Cysteamine [2-aminoethanethiol (CySH)] reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily assayable, releasable PRL. This would represent a previously unrecognized mechanism for secretory re...

journal_title：Endocrinology

authors： Lorenson MY,Jacobs LS

更新日期：1984-10-01 00:00:00

abstract：:Although estrogens are neuroprotective in young adult animal models of stroke, clinical trials demonstrate that estrogens increase the incidence and severity of stroke in aged women. We have previously shown that experimental stroke pathophysiology differs between young adult and aged rats. The aim of this study was t...

journal_title：Endocrinology

authors： Leon RL,Li X,Huber JD,Rosen CL

更新日期：2012-07-01 00:00:00

abstract：:The purpose of this experiment was to determine whether surgical stress on the morning of proestrus would elicit an early release of gonadotropin from the pituitary. Animals exhibiting 5-day estrous cycles underwent bilateral sham-ovariectomy under ether anesthesia at 0800 h of proestrus. These animals had high levels...

journal_title：Endocrinology

authors： Nequin LG,Alvarez JA,Campbell CS

更新日期：1975-09-01 00:00:00

abstract：:Sodium butyrate (NaB), a dietary micronutrient, is a potent growth inhibitor that initiates cell differentiation in many cell types, including prostate cancer cells. The molecular mechanisms by which these effects occur remain largely unknown. In this study, we investigated the effects of NaB on the expression of IGF ...

journal_title：Endocrinology

authors： Tsubaki J,Hwa V,Twigg SM,Rosenfeld RG

更新日期：2002-05-01 00:00:00

abstract：:Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of mal...

journal_title：Endocrinology

authors： Yu AM,Fukamachi K,Krausz KW,Cheung C,Gonzalez FJ

更新日期：2005-07-01 00:00:00

abstract：:Testicular cytosol from Sprague-Dawley rats was shown to possess an estradiol binding component which exhibited the properties of a receptor. Specific binding of estradiol by the receptor was shown, at 4C in vitro, to reach equilibrium by 6 h. That level of binding was maintained at a plateau for 18 h. Estradiol bindi...

journal_title：Endocrinology

authors： Abney TO

更新日期：1976-08-01 00:00:00

abstract：:LPXRFamide (LPXRFa) peptides have been characterized for their ability to inhibit gonadotropin (GTH) release in birds and stimulate growth hormone (GH) release in frogs. However, their involvement in regulating the reproductive hypothalamo-pituitary-gonadal axis in mammals and fish is inconclusive. To study the role o...

journal_title：Endocrinology

authors： Biran J,Golan M,Mizrahi N,Ogawa S,Parhar IS,Levavi-Sivan B

更新日期：2014-11-01 00:00:00

abstract：:Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...

journal_title：Endocrinology

authors： Ramaswamy S,Dwarki K,Ali B,Gibbs RB,Plant TM

更新日期：2013-05-01 00:00:00

abstract：:Estrogen regulates the function, growth, and proliferation of lactotropes in the pituitary. We report here that low-density lipoprotein (LDL) receptor (LDLR) gene expression and LDL uptake are strongly up-regulated by estrogen in pituitary somatolactotropic GH(3) cells. The uptake of LDL was significantly inhibited by...

journal_title：Endocrinology

authors： Smith PM,Cowan A,White BA

更新日期：2004-07-01 00:00:00

abstract：:Administration of ovine or rat PRL to animals, including man, has resulted in decreased urine volume and increased urine osmolality. Contamination of PRL preparations with vasopressin is the most likely explanation for the apparent antidiuretic effect. In this study, diabetes insipidus rats lacking vasopressin(homozyg...

journal_title：Endocrinology

authors： Adler RA,Dolphin S,Szefler M,Sokol HW

更新日期：1979-10-01 00:00:00

abstract：:The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all f...

journal_title：Endocrinology

authors： Dunn JF,Wilson JD

更新日期：1975-06-01 00:00:00

abstract：:Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...

journal_title：Endocrinology

authors： Tsuchida K,Vaughan JM,Wiater E,Gaddy-Kurten D,Vale WW

更新日期：1995-12-01 00:00:00

abstract：:Human myometrium contains hCG/LH receptors. There are fewer of these receptors during labor compared to no labor at preterm or term deliveries. Exogenous hCG can directly inhibit oxytocin-stimulated human myometrial contractions. These findings suggest that hCG may directly maintain myometrial quiescence during pregna...

journal_title：Endocrinology

authors： Ambrus G,Rao CV

更新日期：1994-12-01 00:00:00

abstract：:Although polychlorinated biphenyls (PCBs) have been shown to accumulate in the adrenal, little is known about the effects of these endocrine disruptors on adrenal steroidogenesis. Our previous studies showed that high concentrations of PCB126 stimulated CYP11B1 and CYP11B2 mRNA expression and consequently raised corti...

journal_title：Endocrinology

authors： Lin TC,Chien SC,Hsu PC,Li LA

更新日期：2006-03-01 00:00:00

abstract：:Two corticotropin-releasing factor 2 receptor (CRF2R)-selective peptides have been recently described, urocortin II (also known as stresscopin-related peptide) and urocortin III (stresscopin). We have used urocortin II to evaluate the effects of activation of the CRF2R on skeletal muscle-related physiological processe...

journal_title：Endocrinology

authors： Hinkle RT,Donnelly E,Cody DB,Bauer MB,Isfort RJ

更新日期：2003-11-01 00:00:00

abstract：:To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV...

journal_title：Endocrinology

authors： Punjabi M,Arnold M,Rüttimann E,Graber M,Geary N,Pacheco-López G,Langhans W

更新日期：2014-05-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma cells (804G-ECM) has positive effects on rat primary beta-cell function and survival in vitro. The aim of this study was to define beta-cell genes induced by this ECM with a specific focus on cytokines. Analysis of differential ...

journal_title：Endocrinology

authors： Ribaux P,Ehses JA,Lin-Marq N,Carrozzino F,Böni-Schnetzler M,Hammar E,Irminger JC,Donath MY,Halban PA

更新日期：2007-11-01 00:00:00

abstract：:We have demonstrated previously that both rat and human liver microsomes contain a highly specific binding protein for the anabolic steroids stanozolol (ST) and danazol (DA). In this study we solubilized the male rat liver ST-binding protein (STBP) and investigated the following parameters: 1) pharmacological properti...

journal_title：Endocrinology

authors： Luzardo OP,Machín RP,Díaz-Chico BN,Fernández L

更新日期：2000-09-01 00:00:00

abstract：:The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in R...

journal_title：Endocrinology

authors： Jouishomme H,Whitfield JF,Chakravarthy B,Durkin JP,Gagnon L,Isaacs RJ,MacLean S,Neugebauer W,Willick G,Rixon RH

更新日期：1992-01-01 00:00:00

abstract：:To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

journal_title：Endocrinology

authors： Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

更新日期：2009-05-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms whereby ovarian hormones, and particularly estrogens, modulate fat cell metabolism, we investigated the effects of estradiol administration on c-fos and c-jun expressions in fat cells from ovariectomized (OVX) rats. Estradiol treatment resulted in a rapid increase in c-fo...

journal_title：Endocrinology

authors： Garcia E,Lacasa D,Giudicelli Y

更新日期：2000-08-01 00:00:00