LPXRFa, the piscine ortholog of GnIH, and LPXRF receptor positively regulate gonadotropin secretion in Tilapia (Oreochromis niloticus).

abstract：:Studies were carried out to determine whether the actions of prolactin on the metabolism of the mammary gland may involve polyamines. In mouse mammary gland explants that were preincubated for 2 days with insulin plus hydrocortisone, the rate of [3H]leucine incorporation into casein was enhanced in a prolactin-like ma...

journal_title：Endocrinology

authors： Rillema JA,Linebaugh BE,Mulder JA

更新日期：1977-02-01 00:00:00

abstract：:To identify genes that are differentially expressed in the developing testis we used representational difference analysis of complementary DNA from gonads of mouse embryos at 13.5 days postcoitum (dpc). Three genes were identified. One of them was a novel gene termed tescalcin that encoded a putative EF-hand Ca(2+)-bi...

journal_title：Endocrinology

authors： Perera EM,Martin H,Seeherunvong T,Kos L,Hughes IA,Hawkins JR,Berkovitz GD

更新日期：2001-01-01 00:00:00

abstract：:Interferon-tau (IFNtau) is the embryonic signal responsible for pregnancy recognition in ruminants. The primary action of IFNtau is believed to be mediated through inhibition of prostaglandin F(2alpha) (PGF(2alpha)) released from the endometrial epithelial cells in response to oxytocin (OT). Our working hypothesis was...

journal_title：Endocrinology

authors： Krishnaswamy N,Danyod G,Chapdelaine P,Fortier MA

更新日期：2009-02-01 00:00:00

abstract：:Tumoral insulin-producing cells of the RINm5F line display a poor secretory response to D-glucose. Relative to basal insulin output, which corresponds to a fractional release of stored hormone close to 25%/90 min, the glucose-induced increment in insulin release does not exceed 28 +/- 7%. The low efficiency of D-gluco...

journal_title：Endocrinology

authors： Valverde I,Barreto M,Malaisse WJ

更新日期：1988-04-01 00:00:00

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:A perifusion system has been developed in which a dose-dependent response of isolated Leydig tumor cells to steroidogenic stimuli, as assessed by the rates of steroid production, can be measured as a function of time. In response to a continuous perifusion for 340 min with a saturating concentration of hCG, ovine LH (...

journal_title：Endocrinology

authors： Segaloff DL,Puett D,Ascoli M

更新日期：1981-02-01 00:00:00

abstract：:Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabo...

journal_title：Endocrinology

authors： Neier K,Cheatham D,Bedrosian LD,Gregg BE,Song PXK,Dolinoy DC

更新日期：2019-07-01 00:00:00

abstract：:The steady state levels of the prodynorphin-derived opioid peptides, dynorphin A, dynorphin B, and alpha-neo-endorphin, have been extensively studied in the magnocellular/posterior pituitary system of the rat. To determine whether the rat system serves as a general model for prodynorphin processing in the mammalian po...

journal_title：Endocrinology

authors： Dores RM,Akil H

更新日期：1987-01-01 00:00:00

abstract：:The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventr...

journal_title：Endocrinology

authors： van Houten M,Khan MN,Khan RJ,Posner BI

更新日期：1981-06-01 00:00:00

abstract：:Vitamin D receptor (VDR) null mice develop hypocalcemia, hyperparathyroidism, rickets, osteomalacia and alopecia. Normalization of mineral ion homeostasis prevents all of these abnormalities except alopecia. Hair reconstitution assays, performed in athymic nude mice, demonstrate that the lack of VDR in keratinocytes l...

journal_title：Endocrinology

authors： Chen CH,Sakai Y,Demay MB

更新日期：2001-12-01 00:00:00

abstract：:The antiapoptotic molecule Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein (FLIP) inhibits Fas-mediated apoptosis by blocking activation of caspase-8. We previously showed that expression of transgenic FLIP on thyroid epithelial cells (TECs) of DBA/1 and CBA/J mice promoted earlier resol...

journal_title：Endocrinology

authors： Fang Y,Braley-Mullen H

更新日期：2008-07-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is specifically and reversibly bound by particulate fractions from adrenals from fetal calves and lambs. These binding sites appear to be located primarily in the adrenal medulla and have properties very similar to those which we have detected in adult human, bovine, and ovine adrenal medulla. ...

journal_title：Endocrinology

authors： Karaplis AC,Powell WS

更新日期：1981-12-01 00:00:00

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh ...

journal_title：Endocrinology

authors： Kassis JA,Walent JH,Gorski J

更新日期：1984-08-01 00:00:00

abstract：:Leptin signaling in the hypothalamic arcuate nucleus (ARC) is hypothesized to play an important role in energy homeostasis. To investigate whether leptin signaling limited to this brain area is sufficient to reduce food intake and body weight, we used adenoviral gene therapy to express the signaling isoform of the lep...

journal_title：Endocrinology

authors： Morton GJ,Niswender KD,Rhodes CJ,Myers MG Jr,Blevins JE,Baskin DG,Schwartz MW

更新日期：2003-05-01 00:00:00

abstract：:The ALP1 [aci-reductone dioxygenase (ARD)-like protein 1] gene was identified in a comprehensive cDNA subtraction aimed at identifying genes regulated by androgens in the rat ventral prostate. ALP1 is homologous to the ARD/ARD' that were discovered in Klebsiella pneumoniae as enzymes that have the same polypeptide seq...

journal_title：Endocrinology

authors： Oram S,Jiang F,Cai X,Haleem R,Dincer Z,Wang Z

更新日期：2004-04-01 00:00:00

abstract：:Sex chromosome imbalance in males is linked to a supernumerary X chromosome, a condition resulting in Klinefelter syndrome (KS; 47, XXY). KS patients suffer from infertility, hypergonadotropic hypogonadism, and cognitive impairments. Mechanisms of KS pathophysiology are poorly understood and require further exploratio...

journal_title：Endocrinology

authors： Wistuba J,Luetjens CM,Stukenborg JB,Poplinski A,Werler S,Dittmann M,Damm OS,Hämäläinen T,Simoni M,Gromoll J

更新日期：2010-06-01 00:00:00

abstract：:The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...

journal_title：Endocrinology

authors： Jamaluddin MFB,Ko YA,Kumar M,Brown Y,Bajwa P,Nagendra PB,Skerrett-Byrne DA,Hondermarck H,Baker MA,Dun MD,Scott RJ,Nahar P,Tanwar PS

更新日期：2018-02-01 00:00:00

abstract：:Using a primary culture of neonatal rat heart, we investigated the properties of iodothyronine 5'-deiodinating activity in the heart. 125I- release from [125I] reverse T3 incubated with cell homogenates depended on the concentrations of protein and dithiothreitol, pH, incubation time, and temperature of the incubation...

journal_title：Endocrinology

authors： Mori Y,Nishikawa M,Toyoda N,Yonemoto T,Matsubara H,Inada M

更新日期：1991-06-01 00:00:00

abstract：:We investigated the effect of TSH on calcium transport in mouse thyroid, as well as the influence of iodide thereupon. Thyroid lobes were incubated in Krebs-Ringer bicarbonate buffer containing [45Ca2+] and the time-dependent uptake of [45Ca2+] by the lobes was observed. In the presence of 0.5 mU/ml TSH, the uptake of...

journal_title：Endocrinology

authors： Hashizume K,Ichikawa K,Komiya I,Onaya T

更新日期：1984-05-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:After hormonal ablation, 90% of the secretory epithelial cells of the prostate undergo apoptosis, and the remaining cells are reorganized as the tissue is remodeled. Using differential display RT-PCR of total RNA extracted from the rat ventral prostate before and 4 days after castration, we have cloned and sequenced a...

journal_title：Endocrinology

authors： Morrissey C,Bennett S,Nitsche E,Guenette RS,Wong P,Tenniswood M

更新日期：1999-07-01 00:00:00

abstract：:The conversion of T4 to T3 in the brain and anterior pituitary gland contributes significantly to the T3 content of these tissues and appears to be an important modulator of thyroid hormone action. In the present study, the antimanic agent lithium was demonstrated in cultured neural and pituitary tissue to have a sign...

journal_title：Endocrinology

authors： St Germain DL

更新日期：1987-04-01 00:00:00

abstract：:Localized expression of cytochromes P450 17 alpha-hydroxylase (P450c17) and aromatase (P450arom) was investigated in embryonic cell layers of elongating porcine blastocysts by immunocytochemistry. Blastocysts were flushed from the uterus on day 12 of pregnancy, fixed in paraformaldehyde, embedded in paraffin, sectione...

journal_title：Endocrinology

authors： Conley AJ,Christenson LK,Ford SP,Christenson RK

更新日期：1994-12-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5-year survival rate <35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified maternal embryonic leucine zipper kinase (MELK) as 4.1-fold overexpressed in ACC compared with normal adrenal samples. High MELK...

journal_title：Endocrinology

authors： Kiseljak-Vassiliades K,Zhang Y,Kar A,Razzaghi R,Xu M,Gowan K,Raeburn CD,Albuja-Cruz M,Jones KL,Somerset H,Fishbein L,Leong S,Wierman ME

更新日期：2018-07-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes mellitus are associated with impaired postprandial secretion of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct effects of insulin and insulin resistance on the L cell are unknown. We therefore hypothesized that the L cell is responsive to insulin and...

journal_title：Endocrinology

authors： Lim GE,Huang GJ,Flora N,LeRoith D,Rhodes CJ,Brubaker PL

更新日期：2009-02-01 00:00:00

abstract：:Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...

journal_title：Endocrinology

authors： Goodman RL,Maltby MJ,Millar RP,Hileman SM,Nestor CC,Whited B,Tseng AS,Coolen LM,Lehman MN

更新日期：2012-12-01 00:00:00

abstract：:Previous studies indicate that magnesium, like calcium, stimulates the release of calcitonin (CT) from the thyroid gland. On the other hand, C-cell hyperplasia has been noted in magnesium-deficient dogs and rats. To explore further possible interrelationships between magnesium and CT, 21-day-old Sprague-Dawley male ra...

journal_title：Endocrinology

authors： Anast CS,Gardner DW

更新日期：1985-06-01 00:00:00

abstract：:Uterine ornithine decarboxylase (ODC) activity is reported to increase after estrogen administration to fetal, neonatal, immature, and adult rats, suggesting that it may be a useful marker in studies of the development of estrogen responsiveness. Standard conditions were validated for enzyme assay of uterine cytosols ...

journal_title：Endocrinology

authors： Olson ME,Sheehan DM,Branham WS

更新日期：1983-11-01 00:00:00

abstract：:GH3 rat pituitary cells have L-type voltage-gated calcium channels, and both the rate of uptake of 45Ca2+ and the concentration of intracellular free calcium ion ([Ca2+]i) are increased by depolarization with high potassium. Cells incubated for several days with 10 nM epidermal growth factor (EGF) responded to depolar...

journal_title：Endocrinology

authors： Hinkle PM,Nelson EJ,Haymes AA

更新日期：1993-07-01 00:00:00