Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia.

abstract：:The PRL-stimulating effect of metoclopramide (2-methoxy-5-chloroprocainamide) was examined in normal and adrenalectomized male rats pretreated with DL-p-chlorophenylalanine methyl ester (PCPA), an inhibitor of serotonin biosynthesis. PCPA significantly reduced the hypothalamic content of serotonin, increased basal PRL...

journal_title：Endocrinology

authors： Fang VS,Shian LR

更新日期：1981-05-01 00:00:00

abstract：:Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...

journal_title：Endocrinology

authors： Ashkenazi H,Cao X,Motola S,Popliker M,Conti M,Tsafriri A

更新日期：2005-01-01 00:00:00

abstract：:Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be determined. Using two...

journal_title：Endocrinology

authors： Date Y,Kojima M,Hosoda H,Sawaguchi A,Mondal MS,Suganuma T,Matsukura S,Kangawa K,Nakazato M

更新日期：2000-11-01 00:00:00

abstract：:A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest that a midregion PTHrP fragment may be biologically active, we hypothes...

journal_title：Endocrinology

authors： Orloff JJ,Ganz MB,Nathanson MH,Moyer MS,Kats Y,Mitnick M,Behal A,Gasalla-Herraiz J,Isales CM

更新日期：1996-12-01 00:00:00

abstract：:IGF binding proteins-3 and -4, whether given in the perfused rat heart or given iv in the intact animal, cross the microvascular endothelium of the heart and distribute in subendothelial tissues. IGF binding protein-3, like IGF-I/II, localizes in cardiac muscle, with lesser concentrations in CT elements. In contrast, ...

journal_title：Endocrinology

authors： Knudtson KL,Boes M,Sandra A,Dake BL,Booth BA,Bar RS

更新日期：2001-09-01 00:00:00

abstract：:Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity. We now report the cloning and sequencing of a full-length murine endoglin complementary DNA of 2902 base pairs which hybridizes ...

journal_title：Endocrinology

authors： St-Jacques S,Cymerman U,Pece N,Letarte M

更新日期：1994-06-01 00:00:00

abstract：:Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...

journal_title：Endocrinology

authors： Tse A,Lee AK

更新日期：1998-05-01 00:00:00

abstract：:The pancreatic polypeptide cell, the only mature endocrine cell in the fetal pig pancreas, produces equimolar amounts of two peptides, pancreatic polypeptide and pancreatic icosapeptide, from the same precursor. The amino acid sequence of pancreatic polypeptide is more homogeneous among species, whereas pancreatic ico...

journal_title：Endocrinology

authors： Amaratunga A,Tuch BE,Han XG,Georges P,Dean SK,Scott H

更新日期：2001-10-01 00:00:00

abstract：:The distribution of peptide YY (PYY)-like immunoreactivity (IR) in rat tissues was determined by specific RIA after extraction with boiled 1 N acetic acid. The high concentration of PYY-IR was observed in the gastrointestinal tract, with concentrations gradually increasing from the duodenum to the end of colon. The co...

journal_title：Endocrinology

authors： Miyachi Y,Jitsuishi W,Miyoshi A,Fujita S,Mizuchi A,Tatemoto K

更新日期：1986-06-01 00:00:00

abstract：:A cell-free system was used to characterize the binding reaction between the progesterone receptor and nuclear acceptor sites prepared from rat placenta. Two forms of receptor-acceptor complex were examined. One was extracted from nuclei by exposure to 0.6 M KCl; the other type was resistant to salt extraction. Kineti...

journal_title：Endocrinology

authors： Ogle TF

更新日期：1987-07-01 00:00:00

abstract：:It is well established that endotoxemia disrupts reproductive capability, and several proinflammatory cytokines, especially IL-1 beta, IL-6, and TNF-alpha in the brain, have been implicated in this endocrine aberration. However, no previous study has directly compared the effects of the three major proinflammatory cyt...

journal_title：Endocrinology

authors： Watanobe H,Hayakawa Y

更新日期：2003-11-01 00:00:00

abstract：:Previous studies have shown that atrial natriuretic peptides (ANPs) inhibit the secretion of aldosterone by isolated rat adrenal glomerulosa cells stimulated by angiotensin II, ACTH, and potassium. Structure-function studies have concentrated on the significance of the C- and N-terminal chains for the biological activ...

journal_title：Endocrinology

authors： Craven TG,Kem DC,Schiebinger RJ

更新日期：1988-03-01 00:00:00

abstract：:Indwelling, exteriorized, jugular vein catheters were placed in five thyroidectomized ewes at a time when myxedema was manifested clinically and chemically and three euthyroid sheep were used as controls. Post-operatively, tracer doses of [125I]-iodovasopressin were injected and serial blood specimens were obtained fo...

journal_title：Endocrinology

authors： Skowsky WR,Fisher DA

更新日期：1977-04-01 00:00:00

abstract：:Mammary glands from second generation vitamin D-deficient mice and rats were examined for their ability to make the major milk proteins, casein and alpha-lactalbumin, both in vivo and in vitro. The glands from the rachitic animals were morphologically indistinguishable from those of age-matched controls. When placed i...

journal_title：Endocrinology

authors： Bhattacharjee M,Wientroub S,Vonderhaar BK

更新日期：1987-09-01 00:00:00

abstract：:Daily treatment with 1 mg of the GnRH antagonist [Ac-delta 3-Pro1,pC1-D-Phe2,D-Trp3,6,N alpha MeLeu7]-GnRH abolished mating behavior and disrupted spermatogenesis in male rats within 2 weeks. This was accompanied by a sharp decrease in plasma testosterone (T) levels as well as sexual organ weights while body weight re...

journal_title：Endocrinology

authors： Rivier C,Rivier J,Vale W

更新日期：1981-05-01 00:00:00

abstract：:Active immunization of male rabbits results in a marked increase in plasma testosterone (T) and in the fraction of T bound to circulating proteins. In order to identify the cause of the increased T levels, the half-life of T after castration, and the metabolic clearance rate (MCR) and production rate (PR) after a sing...

journal_title：Endocrinology

authors： Wickings EJ,Becher A,Nieschlag E

更新日期：1976-05-01 00:00:00

abstract：:In the developing follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are the primary stimulators of steroidogenesis in granulosa and theca cells. The steroidogenic actions of both these gonadotropins are largely if not exclusively mediated through cAMP. Previous studies have shown that EGF and T...

journal_title：Endocrinology

authors： Gangrade BK,Davis JS,May JV

更新日期：1991-11-01 00:00:00

abstract：:The distribution of androgen receptor expression within the developing rat gubernaculum was examined at different times during fetal and neonatal development using polyclonal antibodies directed at the amino-terminus (amino acids 1-21) and the carboxy-terminus (amino acids 898-917) of the androgen receptor. These stud...

journal_title：Endocrinology

authors： Husmann DA,McPhaul MJ

更新日期：1991-01-01 00:00:00

abstract：:To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

journal_title：Endocrinology

authors： Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

更新日期：2009-05-01 00:00:00

abstract：:Specific binding sites for PRL were identified on isolated intestinal epithelial cells from both male and female rabbits. These receptors exhibited a very high affinity for PRL (Kd = 5 x 10(-11) M) and were immunologically very similar to the well characterized mammary PRL receptor. About 3500 PRL receptors/cell were ...

journal_title：Endocrinology

authors： Dusanter-Fourt I,Belair L,Gespach C,Djiane J

更新日期：1992-05-01 00:00:00

abstract：:We previously showed that receptor-like protein tyrosine phosphatase (RPTP)-alpha inhibited insulin-increased prolactin gene transcription. Others suggested that RPTPalpha was a key intermediary between integrins and activation of Src. We present evidence that inhibition of insulin-increased prolactin gene transcripti...

journal_title：Endocrinology

authors： Vulin AI,Jacob KK,Stanley FM

更新日期：2005-08-01 00:00:00

abstract：:Experiments were conducted to obtain information on the possible transfer of TSH and thyroid hormones from mother rats to their infants via milk. The mothers were thyroidectomized by surgical or chemical (tapazole) means to eliminate maternal thyroid hormones from milk while increasing its content of TSH. Their pups w...

journal_title：Endocrinology

authors： Glasscock GF,Nicoll CS

更新日期：1983-03-01 00:00:00

abstract：:The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...

journal_title：Endocrinology

authors： Blackmore JK,Karmakar S,Gu G,Chaubal V,Wang L,Li W,Smith CL

更新日期：2014-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose etiology is presently unknown. Probably the most consistent and widespread deficit seen in this syndrome is that of the basal forebrain cholinergic system. We have previously demonstrated that estradiol (E2) modulates the function of these neur...

journal_title：Endocrinology

authors： Singh M,Meyer EM,Simpkins JW

更新日期：1995-05-01 00:00:00

abstract：:The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate...

journal_title：Endocrinology

authors： Liu Y,Yan C,Wang Y,Nakagawa Y,Nerio N,Anghel A,Lutfy K,Friedman TC

更新日期：2006-11-01 00:00:00

abstract：:We studied the direct effects of glucocorticoids on plasminogen activator (PA) production by rat granulosa cells. PA production was assayed by culturing rat granulosa cells on [125I]fibrin plates and determining the extent of fibrinolysis after addition of the specific substrate plasminogen. In granulosa cells from pr...

journal_title：Endocrinology

authors： Wang C,Leung A

更新日期：1989-04-01 00:00:00

abstract：:Ractopamine [1-(4-hydroxyphenyl-2-(1-methyl-3-(4-hydroxyphenyl)propylamino)ethanol] enhances protein accretion in skeletal muscle (sm) of pigs. Experiments were conducted to elucidate fractional protein synthesis (FSR) and mRNA abundance for alpha-actin in sm of pigs fed a 16% protein diet containing 20 parts/million ...

journal_title：Endocrinology

authors： Helferich WG,Jump DB,Anderson DB,Skjaerlund DM,Merkel RA,Bergen WG

更新日期：1990-06-01 00:00:00

abstract：:We studied the structural and functional characteristics of insulin receptors from rat brain and liver from late gestation through adulthood as well as from cultured neuronal and glial cells from neonatal rats. Specific insulin binding was present on membrane preparations from brain and liver at all stages of developm...

journal_title：Endocrinology

authors： Lowe WL Jr,Boyd FT,Clarke DW,Raizada MK,Hart C,LeRoith D

更新日期：1986-07-01 00:00:00

abstract：:To assess the effect of breast feeding on circulating thyroid hormone levels in the suckling neonate, we examined serum concentrations of T4, T3, and rT3 by RIA in 12- and 15-day-old rat pups fasted for 3 or 6 h before, at, and hourly for 3 or 4 h after suckling. In both age groups, serum T4 levels decreased significa...

journal_title：Endocrinology

authors： Oberkotter LV

更新日期：1988-07-01 00:00:00

abstract：:The concentration of biologically active LH in rhesus monkey (Macaca mulatta) serum was measured by a highly sensitive bioassay based upon testosterone production by dispersed rat interstitial cells. The sensitivity of the in vitro bioassay was equal to or higher than that of radioimmunoassay, with detection limits of...

journal_title：Endocrinology

authors： Dufau ML,Hodgen GD,Goodman AL,Catt KJ

更新日期：1977-06-01 00:00:00