Abstract:
:Active immunization of male rabbits results in a marked increase in plasma testosterone (T) and in the fraction of T bound to circulating proteins. In order to identify the cause of the increased T levels, the half-life of T after castration, and the metabolic clearance rate (MCR) and production rate (PR) after a single injection of tritiated T were determined in normal and immunized rabbits. In the immunized animals the half-life of T was significantly longer, the MCR showed a 10-fold decrease (10.2 +/- 3.2 1/day compared to 108 +/- 43 1/day) and the PR was increased from 0.44 +/- 0.34 mg/day to 1.20 +/- 0.36 mg/day compared with the control group. The binding of T to circulating antibodies is considered to be the direct cause of the decreased MCR and, via the diminished negative feedback at the hypothalamic-pituitary levels, the indirect cause of the increased PR in the immunized animals.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Wickings EJ,Becher A,Nieschlag Edoi
10.1210/endo-98-5-1142subject
Has Abstractpub_date
1976-05-01 00:00:00pages
1142-6issue
5eissn
0013-7227issn
1945-7170journal_volume
98pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::After incubation with 0.5 mM isobutylmethylxanthine, 1 microM dexamethasone, and 1 microM insulin for 72 h, 3T3-L1 cells acquire the phenotypic characteristics of mature adipocytes, including a hormone-sensitive particulate cAMP phosphodiesterase activity. In addition, adipocytes contain soluble cAMP and calmodulin-se...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-4-1350
更新日期:1984-10-01 00:00:00
abstract::We have previously demonstrated that the gonadotropin-mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death-related genes, including members of the bcl-2 gene family (bcl-2, bax, and bcl-x). Recently, the product of the p53 tumor suppressor gene, a pro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.4.7895650
更新日期:1995-04-01 00:00:00
abstract::Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa209
更新日期:2021-01-01 00:00:00
abstract::We analyzed the nature of the thyroid hormone-binding proteins in bullfrog plasma using N-bromoacetyl-[125I]T3 as an affinity labeling probe. Polyacrylamide gel electrophoresis under nondenaturing conditions of the bullfrog N-bromoacetyl-[125I]T3-labeled plasma proteins revealed two proteins with specific binding to T...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.5.8477670
更新日期:1993-05-01 00:00:00
abstract::Cultures of Sertoli cells were treated with freshly isolated, intact germ cells to determine if germ cells were capable of influencing Sertoli cell function. By using two-dimensional polyacrylamide gel electrophoresis and autoradiography, germ cells were found to increase several-fold the incorporation of [32P]orthoph...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-4-1317
更新日期:1987-04-01 00:00:00
abstract::We have studied the suitability of the insulin-receptor complex as a substrate for hepatic lysosomal and cytoplasmic insulin-degrading enzymes. Broken lysosome preparations degraded receptor-bound insulin more slowly than free insulin; most of the degradation of bound insulin could be accounted for by prior dissociati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-1-381
更新日期:1983-01-01 00:00:00
abstract::To begin to assess the function of the cell cycle regulator cyclin D3 during gametogenesis, the present study examined its expression, interacting partners, and associated kinase activity in the murine testis and ovary. In the early stages of postnatal testicular development, cyclin D3 protein was detected in spermato...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.6.6756
更新日期:1999-06-01 00:00:00
abstract::The pattern of glucagon gene expression and the posttranslational processing of proglucagon was studied in the fetal and neonatal rat. Pancreatic immunoreactive glucagon (IRG) and glucagon-like immunoreactivity (GLI) were low in both fetal pancreas and intestine, respectively. Immediately after birth, pancreatic IRG r...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2217
更新日期:1990-11-01 00:00:00
abstract::In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0220
更新日期:2005-11-01 00:00:00
abstract::Carbonyl cyanide trifluoromethoxyphenylhydrazone (FCCP), a protonophore, and methylamine, a weak base, agents that dissipate hydrogen gradients across cellular membranes, were used to probe the coupling of hydrogen gradients to the processing and secretion of the glycoprotein hormone hCG by human choriocarcinoma cells...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-1-416
更新日期:1986-07-01 00:00:00
abstract::Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-1-141
更新日期:1984-01-01 00:00:00
abstract::Native PRL and des-amido forms 1, 2, and 3 were tested for their individual immunochemical and receptor-binding abilities. The results show that deamidation of either secreted mouse PRL or stored ovine PRL alters their binding in a radioreceptor assay. For each accumulated deamidation there was a statistically signifi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-1-353
更新日期:1985-01-01 00:00:00
abstract::A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities and failed to increase...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa097
更新日期:2020-08-01 00:00:00
abstract::We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0456
更新日期:2005-11-01 00:00:00
abstract::Sorbin is a 153-amino acid peptide that was initially discovered in the porcine duodenum. We have reported previously that this peptide regulates intestinal electrolyte transport and have described accumulation sites in the rat digestive tract. In the present study, we investigated the anatomical distribution and the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.11.5502
更新日期:1997-11-01 00:00:00
abstract::The present study was conducted to elucidate the possible molecular mechanisms involved in the antispermatogenic activity of l-CDB-4022, an indenopyridine. In this study 45-d-old male Sprague-Dawley rats were treated with a single oral dose of l-CDB-4022 (2.5 mg/kg) or vehicle, and blood and testes were collected at v...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1332
更新日期:2008-04-01 00:00:00
abstract::In the rat ovary, follicle cells produce and respond to activin, but as yet, the functional significance of the autocrine/paracrine effects of ovarian activin remains equivocal. To assess the effects of activin on folliculogenesis, normal cycling female rats were injected once every 8 h over a 40-h period with recombi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.11.7588210
更新日期:1995-11-01 00:00:00
abstract::Early obesity and late onset of insulin resistance associated with hormonal imbalances occur in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and explores some molecular links of horm...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0647
更新日期:2007-12-01 00:00:00
abstract::Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.6.8854
更新日期:2002-06-01 00:00:00
abstract::In the Syrian hamster, a sharp peak in pineal melatonin occurs toward the end of the dark period. In the present communication, we describe characteristics of this rhythm. First, the time of the initial increase in pineal melatonin is not altered by daily melatonin injections that induce gonadal regression. Second, th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-5-1525
更新日期:1980-11-01 00:00:00
abstract::This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.5.7956910
更新日期:1994-11-01 00:00:00
abstract::Once reserved solely for the treatment of short stature, the now readily available recombinant GH has expanded the use of the hormone to include the treatment of cardiovascular, renal, muscular, skeletal, immunological, psychosocial, and metabolic abnormalities associated with GH deficiency. There are also proposals f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1333
更新日期:2007-06-01 00:00:00
abstract::The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0432
更新日期:2004-12-01 00:00:00
abstract::The short loop feedback effect of PRL was studied in young (4-5 months of age) and old (24-26 months of age) ovariectomized rats after a single iv injection of bovine PRL (bPRL, 500 micrograms/100 g BW) or BSA (500 micrograms/100 g BW). Blood samples were collected via intraatrial cannula every 20 min for assay of PRL...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-4-1452
更新日期:1983-10-01 00:00:00
abstract::Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-1-205
更新日期:1984-07-01 00:00:00
abstract::In situ hybridization detected a transient, sex-specific transcription of somatostatin gene in the central part of the rat medial preoptic nucleus, which coincides with the sexually dimorphic nucleus of the preoptic area (SDN-POA), during, but not after, the establishment of sex difference. On postnatal d 1 (day of bi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1214
更新日期:2007-03-01 00:00:00
abstract::Synthetic selective thyroid hormone (TH) receptor (TR) modulators (STRM) exhibit beneficial effects on dyslipidemias in animals and humans and reduce obesity, fatty liver, and insulin resistance in preclinical animal models. STRM differ from native TH in preferential binding to the TRβ subtype vs. TRα, increased uptak...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1325
更新日期:2012-01-01 00:00:00
abstract::The product of the ob/ob gene, leptin, is known to be able to exert a modulator, role on HPA axis function. The aim of the present study was to determine whether endogenous ACTH and glucocorticoids exert any regulatory effect on leptin secretion. For this purpose bilaterally adrenalectomized (ADX) or sham operated (Sh...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.9.6291
更新日期:1998-09-01 00:00:00
abstract::The effects of insulin and glucose, alone and combined, on diacylglycerol (DAG), protein kinase-C (PKC), and glucose transport were compared in rat adipocytes and solei incubated in medium containing 0-20 mM glucose. In both tissues insulin rapidly stimulated [3H]DAG production from [3H]glycerol; extracellular glucose...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-6-2937
更新日期:1991-06-01 00:00:00
abstract::We developed a coculture system comprising primary rat adipocytes and L6 rat skeletal muscle cells to allow investigation of the effects of physiologically relevant mixtures of adipokines. We observed that coculture, or adipocyte-conditioned media, increased glucose uptake in muscle cells. An adipokine that could pote...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0020
更新日期:2007-09-01 00:00:00