Abstract:
:This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressures, heart rate, and plasma hormone concentrations during 30-min infusions of three doses of nitroprusside (1, 2, and 4 micrograms/kg.min). Between-group differences were determined by comparing the relationships between arterial or atrial pressure and plasma hormone concentrations. Hypotension-induced increases in heart rate and plasma levels of vasopressin, ACTH, and cortisol were blunted when the dogs were pregnant. In contrast, reflex increases in PRA and angiotensin-II were increased. These results indicate that the activity of the baroreceptor reflex is altered during pregnancy in dogs.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Brooks VL,Keil LCdoi
10.1210/endo.135.5.7956910subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1894-901issue
5eissn
0013-7227issn
1945-7170journal_volume
135pub_type
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