Localization of G protein alpha-subunits in the human fetal adrenal gland.

abstract：:For 3 yr, 1-yr synchronized circannual rhythms were found for the chick oviduct weights, amounts of soluble protein, concentrations of the progesterone receptor in this organ, and capacity of this steroid-receptor complex in cytosol in bind in vitro to deoxyribonucleoprotein acceptor sites. By fitting the data with 1-...

journal_title：Endocrinology

authors： Spelsberg TC,Halberg F

更新日期：1980-10-01 00:00:00

abstract：:To determine if oxytocin (OT) is present in cynomolgus monkey corpus luteum, OT was measured by a specific and sensitive RIA in 13 corpora lutea, ovarian venous plasma on the ipsilateral side and peripheral venous plasma at different stages of the luteal phase. Serial dilution of acetic acid extract of the corpus lute...

journal_title：Endocrinology

authors： Khan-Dawood FS,Marut EL,Dawood MY

更新日期：1984-08-01 00:00:00

abstract：:Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals (NLSs) within the proteins and specific NLS-binding proteins. NLSs have been identified in the hinge region of both receptors. We have identified the cellular ...

journal_title：Endocrinology

authors： LaCasse EC,Lochnan HA,Walker P,Lefebvre YA

更新日期：1993-03-01 00:00:00

abstract：:GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs...

journal_title：Endocrinology

authors： Kraicer J,Lussier B,Moor BC,Cowan JS

更新日期：1988-04-01 00:00:00

abstract：:Thyroid hormones play a major role in body homeostasis, regulating energy expenditure and cardiovascular function. Given that obese people or athletes might consider rapid weight loss as beneficial, voluntary intoxication with T4 preparations is a growing cause for thyrotoxicosis. However, the long-lasting effects of ...

journal_title：Endocrinology

authors： Hoefig CS,Harder L,Oelkrug R,Meusel M,Vennström B,Brabant G,Mittag J

更新日期：2016-07-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:In cultured rat pituitary cells, increases in the cytosolic calcium concentration ([Ca2+]i) and LH release are induced by activation of GnRH receptors as well as by nonreceptor-mediated stimuli. Treatment of pituitary cells with the myosin light chain kinase (MLCK) inhibitor, wortmannin, attenuated GnRH-induced LH rel...

journal_title：Endocrinology

authors： Rao K,Paik WY,Zheng L,Jobin RM,Tomić M,Jiang H,Nakanishi S,Stojilkovic SS

更新日期：1997-04-01 00:00:00

abstract：:We have analyzed the factors responsible for the circadian variation in rat hepatic mRNA-S14. Regulation of this sequence, which is found in lipogenic tissues and encodes a protein (S14) believed to be associated with fatty acid synthesis, is an excellent model of the interaction of thyroid hormone and dietary factors...

journal_title：Endocrinology

authors： Kinlaw WB,Fish LH,Schwartz HL,Oppenheimer JH

更新日期：1987-04-01 00:00:00

abstract：:Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...

journal_title：Endocrinology

authors： Qin J,Zhao N,Wang S,Liu S,Liu Y,Cui X,Wang S,Xiang Y,Fan C,Li Y,Shan Z,Teng W

更新日期：2020-04-01 00:00:00

abstract：:Aged (16-month-old) female rats (n = 8/treatment) were injected for 12 days with GH (100 micrograms/100 g x day), PTH (8 micrograms/100 g x day), GH plus PTH, or vehicle (V) in an experiment designed to determine the effects of these hormones on intestinal mineral absorption in senescent rats. PTH and GH increased fra...

journal_title：Endocrinology

authors： Fleet JC,Bruns ME,Hock JM,Wood RJ

更新日期：1994-04-01 00:00:00

abstract：:The lipolysis, ketosis and hypertriglyceridemia of fasted rats in late pregnancy may be related to decreased insulin secretion geared to decreased glucose availability. In odd-carbon fatty acid enriched (OCE) rats, the odd-carbon fatty acids (OCFA) mobilized during fasting provide terminal three-carbon residues which ...

journal_title：Endocrinology

authors： Kim S,Pi-Sunyer FX

更新日期：1977-02-01 00:00:00

abstract：:We have cloned a type of cDNA for a functional glandular kallikrein, designated as mouse Klk21 (mKlk21), from the adult mouse testis cDNA library. mKlk21 was expressed in the kidney, submaxillary glands, and testis of the mouse. In the testis, mKlk21 mRNA was detectable at 4 wk of postnatal development and became more...

journal_title：Endocrinology

authors： Matsui H,Takahashi T

更新日期：2001-11-01 00:00:00

abstract：:Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). We have now found that both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of ghrelin in freely feeding rats stimu...

journal_title：Endocrinology

authors： Wren AM,Small CJ,Ward HL,Murphy KG,Dakin CL,Taheri S,Kennedy AR,Roberts GH,Morgan DG,Ghatei MA,Bloom SR

更新日期：2000-11-01 00:00:00

abstract：:Obesity is associated with chronic inflammation and liver steatoses. Numerous proinflammatory cytokines have been reported to regulate liver glucose and lipid metabolism, thus contributing to the pathogenesis of liver steatosis and/or metabolic dysfunction. Nuclear factor-κB-inducing kinase (NIK) is stimulated by many...

journal_title：Endocrinology

authors： Liu Y,Sheng L,Xiong Y,Shen H,Liu Y,Rui L

更新日期：2017-05-01 00:00:00

abstract：:It is known that renin is present in fetal membranes, with the highest concentration in the chorion laeve (reflected chorion). The purpose of this study was to identify and localize renin in human chorion laeve. Indirect immunofluorescent analysis, using antiserum against pure human kidney renin, revealed a single lay...

journal_title：Endocrinology

authors： Poisner AM,Wood GW,Poisner R,Inagami T

更新日期：1981-10-01 00:00:00

abstract：:The estrogen-induced and -dependent Syrian hamster renal tumor is the most intensively studied model in estrogen carcinogenesis. Yet, it remains confounding that the kidney of this species behaves as an estrogen target tissue. As both reproductive and urinary systems arise from the same germinal ridge, we propose that...

journal_title：Endocrinology

authors： Li JJ,Weroha SJ,Davis MF,Tawfik O,Hou X,Li SA

更新日期：2001-09-01 00:00:00

abstract：:Androgens are the primary regulators of epididymal structure and functions. Principal cells are the major cell type of the tissue and are particularly sensitive to androgen removal. To distinguish the direct effects of androgens on this cell type, DNA microarrays were used to identify androgen-regulated genes in the m...

journal_title：Endocrinology

authors： Seenundun S,Robaire B

更新日期：2007-01-01 00:00:00

abstract：:The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in ch...

journal_title：Endocrinology

authors： Cheng S,Xing W,Pourteymoor S,Schulte J,Mohan S

更新日期：2016-01-01 00:00:00

abstract：:Poor growth before birth is associated with impaired insulin sensitivity later in life, increasing the risk of type 2 diabetes. The tissue sites at which insulin resistance first develops after intrauterine growth restriction (IUGR), and its molecular basis, are unclear. We have therefore characterized the effects of ...

journal_title：Endocrinology

authors： De Blasio MJ,Gatford KL,Harland ML,Robinson JS,Owens JA

更新日期：2012-05-01 00:00:00

abstract：:Early obesity and late onset of insulin resistance associated with hormonal imbalances occur in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and explores some molecular links of horm...

journal_title：Endocrinology

authors： Zhang H,Chen X,Aravindakshan J,Sairam MR

更新日期：2007-12-01 00:00:00

abstract：:Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...

journal_title：Endocrinology

authors： Bai JX,Yan B,Zhao ZN,Xiao X,Qin WW,Zhang R,Jia LT,Meng YL,Jin BQ,Fan DM,Wang T,Yang AG

更新日期：2013-02-01 00:00:00

abstract：:Marked development of the mammary parenchyma (ducts, lobules, and alveoli) occurs during the last third of the 115-day gestation period in the gilt. These changes in the mammary gland are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin play...

journal_title：Endocrinology

authors： Winn RJ,Baker MD,Merle CA,Sherwood OD

更新日期：1994-09-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00

abstract：:The Jar choriocarcinoma cell line was used as an in vitro placental cell model to determine the effects of polypeptide growth factors on hCG beta secretion. Epidermal and fibroblast growth factor (FGF) treatment of serum-free cultures stimulated hCG beta secretion 2.5- and 4.0-fold over basal serum-free control levels...

journal_title：Endocrinology

authors： Oberbauer AM,Linkhart TA,Mohan S,Longo LD

更新日期：1988-12-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1a...

journal_title：Endocrinology

authors： Miwa M,Kozawa O,Tokuda H,Uematsu T

更新日期：1999-11-01 00:00:00

abstract：:Postnatal development of the ovine uterus between birth and postnatal day (PND) 56 involves budding differentiation of the endometrial glandular epithelium from the luminal epithelium (LE) followed by extensive coiling and branching morphogenesis of the tubular glands. To determine the short- and long-term effects of ...

journal_title：Endocrinology

authors： Hayashi K,Carpenter KD,Spencer TE

更新日期：2004-07-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:IGFs (IGF-I and IGF-II) are essential for development, and their bioactivities are tightly regulated by six related IGF-binding proteins (IGFBPs). IGFBP-5 is the most highly conserved binding protein and is expressed in several key developmental lineages as well as in multiple adult tissues including the mammary gland...

journal_title：Endocrinology

authors： Ning Y,Hoang B,Schuller AG,Cominski TP,Hsu MS,Wood TL,Pintar JE

更新日期：2007-05-01 00:00:00

abstract：:G protein-coupled receptor kinases (GRK 1-6) stimulate short-term desensitization (< 5 min) by phosphorylating G-protein coupled receptors, and also participate in receptor sequestration, which may relate to intermediate-term desensitization (30-60 min). The existence of such kinases and hence a potential role for the...

journal_title：Endocrinology

authors： Neill JD,Musgrove LC,Sellers JC,Duck LW

更新日期：1996-09-01 00:00:00