Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility.

abstract：:The study of epigenetics allows for the understanding of gene × environmental interactions and provides a mechanism by which brief internal or external environmental changes can shape lasting differences in gene function and behavior. Epigenetic processes appear to impact a wide variety of physiological processes with...

journal_title：Endocrinology

authors： Auger AP,Auger CJ

更新日期：2011-02-01 00:00:00

abstract：:LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period...

journal_title：Endocrinology

authors： Nava LE,Malacara JM

更新日期：1987-10-01 00:00:00

abstract：:Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...

journal_title：Endocrinology

authors： Varayoud J,Ramos JG,Bosquiazzo VL,Muñoz-de-Toro M,Luque EH

更新日期：2008-11-01 00:00:00

abstract：:Male Sprague-Dawley rats were injected ip with 1 microgram pertussis toxin (PTX)/100 g BW. The rats were killed 24, 48, and 72 h after injection, and their pancreases were removed. At each time point, insulin secretion by isolated islets was measured under basal and glucose-stimulated conditions and in the absence and...

journal_title：Endocrinology

authors： Komatsu M,McDermott AM,Gillison SL,Sharp GW

更新日期：1995-05-01 00:00:00

abstract：:Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1986-12-01 00:00:00

abstract：:Maternal and fetal metabolism of vitamin D was examined in term pregnant rabbits fed a normal diet and in those supplemented with a large amount of vitamin D3. Term pregnant rabbits (27--30 days of gestation) fed the normal diet showed lower levels of plasma calcium, 25-hydroxyvitamin D3 (250HD3), and 24,25-dihydroxyv...

journal_title：Endocrinology

authors： Kubota M,Ohno J,Shiina Y,Suda T

更新日期：1982-06-01 00:00:00

abstract：:The concentration of biologically active LH in rhesus monkey (Macaca mulatta) serum was measured by a highly sensitive bioassay based upon testosterone production by dispersed rat interstitial cells. The sensitivity of the in vitro bioassay was equal to or higher than that of radioimmunoassay, with detection limits of...

journal_title：Endocrinology

authors： Dufau ML,Hodgen GD,Goodman AL,Catt KJ

更新日期：1977-06-01 00:00:00

abstract：:The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain express...

journal_title：Endocrinology

authors： Couse JF,Yates MM,Rodriguez KF,Johnson JA,Poirier D,Korach KS

更新日期：2006-08-01 00:00:00

abstract：:An ovarian thecal/interstitial cell preparation was obtained by enzymatic digestion of immature rat ovaries depleted of granulosa cells. A component in thecal/interstitial cell-conditioned medium inhibited specific binding of [125I]iodo-epidermal growth factor ([125I]EGF) to its cell surface receptor, as determined wi...

journal_title：Endocrinology

authors： Skinner MK,Lobb D,Dorrington JH

更新日期：1987-11-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:To assess a possible regulatory influence of opioids upon anterior pituitary function in the chimpanzee, we evaluated the effects of the specific opiate receptor antagonist naloxone and the agonistic enkephalin analog [D-Ala2, MePhe4,Met(o)-ol]enkephalin (FK 33-824; Sandoz) on serum levels of PRL, cortisol, FSH, and L...

journal_title：Endocrinology

authors： Gosselin RE,Blankstein J,Dent DW,Hobson WC,Fuller GB,Reyes FI,Winter JS,Faiman C

更新日期：1983-06-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:To elucidate the roles of the hypothalamic peptides, GH-releasing hormone (GRH) and somatostatin (SRIH), potentially responsible for altered GH dynamics in diabetes, we studied the time courses of their changes in level associated with altered GH secretion in streptozotocin (STZ)-induced diabetic mice. Diabetic mice w...

journal_title：Endocrinology

authors： Murao S,Sato M,Tamaki M,Niimi M,Ishida T,Takahara J

更新日期：1995-10-01 00:00:00

abstract：:Testicular cytosol from Sprague-Dawley rats was shown to possess an estradiol binding component which exhibited the properties of a receptor. Specific binding of estradiol by the receptor was shown, at 4C in vitro, to reach equilibrium by 6 h. That level of binding was maintained at a plateau for 18 h. Estradiol bindi...

journal_title：Endocrinology

authors： Abney TO

更新日期：1976-08-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:The purpose of this investigation was to use an approach targeted specifically on endogenous relaxin to determine the influence of relaxin on birth in the rat. To that end, a monoclonal antibody specific for rat relaxin, designated MCA1, was used to passively neutralize endogenous relaxin in intact pregnant rats. MCA1...

journal_title：Endocrinology

authors： Guico-Lamm ML,Sherwood OD

更新日期：1988-11-01 00:00:00

abstract：:The factors controlling the synthesis and degradation of the insulin-like growth factor-binding proteins (IGFBPs) during pregnancy are poorly understood. To clarify the roles of nutritional factors in the regulation of fetal and maternal IGFBP production, we examined the effects of fasting, refeeding, and glucose admi...

journal_title：Endocrinology

authors： Osborn BH,Fowlkes J,Han VK,Freemark M

更新日期：1992-10-01 00:00:00

abstract：:The production of hydrogen peroxide (H2O2) as an essential process for iodide organification is a key reaction in TSH-induced thyroid hormone synthesis. Here we characterize the signal transduction pathway involved in TSH-induced H2O2 production in FRTL-5 thyroid cells. At higher than 1 nM TSH, N6-(L-2-phenylisopropyl...

journal_title：Endocrinology

authors： Kimura T,Okajima F,Sho K,Kobayashi I,Kondo Y

更新日期：1995-01-01 00:00:00

abstract：:The metabolism of 25-hydroxycholesterol (25-OH-cholesterol) to progestins by mitochondria and dispersed cells prepared from ovaries of PMSG-hCG-primed rats was studied. Mitochondria converted [3H]25-OH-cholesterol into [3H]pregnenolone and [3H]progesterone. Unlabeled 25-OH-cholesterol also stimulated mitochondrial ste...

journal_title：Endocrinology

authors： Toaff ME,Schleyer H,Strauss JF 3rd

更新日期：1982-12-01 00:00:00

abstract：:Renin-angiotensin system blockade improves glucose intolerance and insulin resistance, which contribute to the development of metabolic syndrome. However, the contribution of impaired insulin secretion to the pathogenesis of metabolic syndrome is not well defined. To assess the contributions of angiotensin receptor ty...

journal_title：Endocrinology

authors： Rodriguez R,Viscarra JA,Minas JN,Nakano D,Nishiyama A,Ortiz RM

更新日期：2012-04-01 00:00:00

abstract：:In female mammals, reproduction is sensitive to the availability of metabolic fuels, and food deprivation has been shown to suppress pulsatile LH secretion, attenuate the preovulatory LH surge, and prevent ovulation. It has been suggested that food deprivation impairs fertility by reducing the secretion of GnRH by GnR...

journal_title：Endocrinology

authors： Berriman SJ,Wade GN,Blaustein JD

更新日期：1992-11-01 00:00:00

abstract：:At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...

journal_title：Endocrinology

authors： Yin W,Maguire SM,Pham B,Garcia AN,Dang NV,Liang J,Wolfe A,Hofmann HA,Gore AC

更新日期：2015-08-01 00:00:00

abstract：:PRL has been reported to exist as a number of mol wt and charge variants. We have attempted to determine the relationships among the charge and lower mol wt variants by two-dimensional gel analysis of pituitary and pituitary cell extracts. Silver-stained gels of the extracts showed three major charge isoforms of 24,00...

journal_title：Endocrinology

authors： Oetting WS,Walker AM

更新日期：1985-10-01 00:00:00

abstract：:The effects of dopamine (DA) on voltage-dependent Ca2+ currents were investigated in cultured rat lactotroph cells using the patch clamp recording technique. Each recorded cell was identified by the reverse hemolytic plaque assay. In the whole-cell configuration, two types of Ca2+ currents, L and T, were characterized...

journal_title：Endocrinology

authors： Lledo PM,Legendre P,Israel JM,Vincent JD

更新日期：1990-09-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:The effects of insulin treatment and dietary glucose on the responsiveness of adipose tissue to insulin and GH after hypophysectomy were studied. Male rats, 130-150 g, were hypophysectomized. Glucose metabolism was measured by determining the production of CO2 from [14C]glucose and the incorporation of glucose into li...

journal_title：Endocrinology

authors： Gause I,Isaksson O,Lindahl A,Edén S

更新日期：1985-03-01 00:00:00

abstract：:The response of purified rat testicular peritubular myoid cells (PMC) to platelet-derived growth factor (PDGF) was studied. Freshly isolated PMC were devoid of measurable amounts of PDGF-binding sites. However, after 1 day in culture in serum-free conditions, specific high affinity receptors were detected. The estimat...

journal_title：Endocrinology

authors： Gnessi L,Emidi A,Scarpa S,Palleschi S,Ragano-Caracciolo M,Silvestroni L,Modesti A,Spera G

更新日期：1993-10-01 00:00:00

abstract：:Renal prostaglandin E2 (PGE2) synthesis is enhanced by exogenous vasopressin (AVP). To determine whether the pressor or the antidiuretic activities of AVP are related to its effect on PGE2 synthesis, AVP and the nonpressor analog, 1-deamino-8-D-arginine vasopressin (dD'AVP), were administered to the isolated perfused ...

journal_title：Endocrinology

authors： Zipser RD,Myers SI,Needleman P

更新日期：1981-02-01 00:00:00