Abstract:
:GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs to GRF. Using a perifusion system and dispersed pituitary cells, we found that the GH response to a pulse of GRF is unaltered over a wide range of GH concentrations. We conclude that GH does not feed back at the level of the adenohypophysis to alter the responsiveness of the somatotrophs to GRF.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Kraicer J,Lussier B,Moor BC,Cowan JSdoi
10.1210/endo-122-4-1511subject
Has Abstractpub_date
1988-04-01 00:00:00pages
1511-4issue
4eissn
0013-7227issn
1945-7170journal_volume
122pub_type
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