Changes in the gene expression of a protein with the cdc10/SWI6 motif, V-1, during rat follicular development and corpus luteum formation.

abstract：:A variety of chronic stress paradigms have been shown to increase basal activity in the hypothalamic-pituitary-adrenocortical axis, resulting in hypercorticoidism. Despite this, chronically stressed rats typically exhibit facilitated ACTH responses to acute novel stress, suggesting that the activity of some central ne...

journal_title：Endocrinology

authors： Scribner KA,Akana SF,Walker CD,Dallman MF

更新日期：1993-12-01 00:00:00

abstract：:We have confirmed the serum calcium-raising effect of adrenalectomy in young male rats 5-6 h after parathyroidectomy that was first observed by others many years ago. (The phenomenon has also been reported in cats, dogs, and mice.) In addition, we have shown that adrenalectomy raises the serum ionized calcium as well ...

journal_title：Endocrinology

authors： Nishino K,Hirsch PF,Mahgoub A,Munson PL

更新日期：1991-05-01 00:00:00

abstract：:Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis...

journal_title：Endocrinology

authors： Goodman RL,Hileman SM,Nestor CC,Porter KL,Connors JM,Hardy SL,Millar RP,Cernea M,Coolen LM,Lehman MN

更新日期：2013-11-01 00:00:00

abstract：:We previously showed that receptor-like protein tyrosine phosphatase (RPTP)-alpha inhibited insulin-increased prolactin gene transcription. Others suggested that RPTPalpha was a key intermediary between integrins and activation of Src. We present evidence that inhibition of insulin-increased prolactin gene transcripti...

journal_title：Endocrinology

authors： Vulin AI,Jacob KK,Stanley FM

更新日期：2005-08-01 00:00:00

abstract：:Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of en...

journal_title：Endocrinology

authors： Rubin BS,Lenkowski JR,Schaeberle CM,Vandenberg LN,Ronsheim PM,Soto AM

更新日期：2006-08-01 00:00:00

abstract：:Administration of the preferential mu-opioid receptor agonist, morphine, and selective K-opioid receptor agonists elicits activation of the hypothalamus-pituitary-adrenocortical axis, although the site or the molecular mechanisms for these effects have not been determined. The expression ofFos, the protein product of ...

journal_title：Endocrinology

authors： Laorden ML,Castells MT,Martínez MD,Martínez PJ,Milanés MV

更新日期：2000-04-01 00:00:00

abstract：:The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell sorting. Purified A cells lack secretory activity in 1-h incubation at 1.4 mM glucose. Their release mechanism can be activated by arginine, alanine, and glutamine,...

journal_title：Endocrinology

authors： Pipeleers DG,Schuit FC,Van Schravendijk CF,Van de Winkel M

更新日期：1985-09-01 00:00:00

abstract：:Mature 31- and 34-kDa inhibin A and B negatively regulate the release of FSH from the anterior pituitary; however, a direct comparison of these hormones in vivo has not been undertaken. The bioactivities of highly purified preparations of recombinant human 31-kDa inhibin A and B were determined in rat pituitary cells ...

journal_title：Endocrinology

authors： Makanji Y,Temple-Smith PD,Walton KL,Harrison CA,Robertson DM

更新日期：2009-10-01 00:00:00

abstract：:The mechanisms whereby tissue sensitivity to PRL is controlled are not well understood. Here we report that expression of mRNA and protein for members of the SOCS/CIS/JAB family of cytokine signaling inhibitors is increased by PRL administration in ovary and adrenal gland of the lactating rat deprived of circulating P...

journal_title：Endocrinology

authors： Tam SP,Lau P,Djiane J,Hilton DJ,Waters MJ

更新日期：2001-11-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the role of MIF in the development of immunoinflammatory diabetes induced in susceptible strains of mice by multiple low doses of strepto...

journal_title：Endocrinology

authors： Cvetkovic I,Al-Abed Y,Miljkovic D,Maksimovic-Ivanic D,Roth J,Bacher M,Lan HY,Nicoletti F,Stosic-Grujicic S

更新日期：2005-07-01 00:00:00

abstract：:In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...

journal_title：Endocrinology

authors： Mendez P,Garcia-Segura LM

更新日期：2006-06-01 00:00:00

abstract：:The effects of cilostazol, a dual inhibitor of type 3 phosphodiesterase and adenosine uptake, on ion currents were investigated in pituitary GH(3) cells and pheochromocytoma PC12 cells. In whole-cell configuration, cilostazol (10 microm) reversibly increased the amplitude of Ca(2+)-activated K(+) current [I(K(Ca))]. C...

journal_title：Endocrinology

authors： Wu SN,Liu SI,Huang MH

更新日期：2004-03-01 00:00:00

abstract：:Groups of female ferrets born in the laboratory received sc Silastic capsules containing testosterone (T), 5 alpha-dihydrotestosterone (DHT), 17 beta-estradiol (E), or no steroid for 15 days beginning on the day of birth; an additional group of male ferrets received empty sc capsules neonatally. All ferrets were gonad...

journal_title：Endocrinology

authors： Baum MJ,Gallagher CA,Martin JT,Damassa DA

更新日期：1982-09-01 00:00:00

abstract：:There is growing international interest in how environmental conditions experienced during development can shape adult phenotypes and the extent to which such induced changes are adaptive. One physiological system that links an individual to changes in environmental circumstances during development is the hypothalamic...

journal_title：Endocrinology

authors： Spencer KA,Evans NP,Monaghan P

更新日期：2009-04-01 00:00:00

abstract：:Experiments were done to examine whether rat relaxin is dipsogenic and whether such dipsogenic effects of rat relaxin are related to time of injection during the light-dark cycle. Female rats were fitted with a chronic intra-cerebro-ventricular (i.c.v.) cannula. Rat relaxin (2.5, 5, 10, 25, 50, or 100 ng/2 microl in 0...

journal_title：Endocrinology

authors： Summerlee AJ,Hornsby DJ,Ramsey DG

更新日期：1998-05-01 00:00:00

abstract：:Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). We studied a young Saudi Arabian girl who exhibited the typical clinical features of HVDRR, but without alopecia. Analysis of her VDR gene revealed a homozygous T to C mutation in exon ...

journal_title：Endocrinology

authors： Malloy PJ,Xu R,Peng L,Peleg S,Al-Ashwal A,Feldman D

更新日期：2004-11-01 00:00:00

abstract：:In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then extracted, separated by...

journal_title：Endocrinology

authors： Rommerts FF,King SR,Span PN

更新日期：2001-12-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:The neuroendocrine basis for short-day induced testicular regression was studied in Syrian hamsters of the LSH/Ss Lak strain. Adult animals were maintained either under long or short days (14:10D or 6L:18D, respectively) and given single, daily ip injections of N-methyl-D-aspartate (NMDA) (25 mg/kg BW); control animal...

journal_title：Endocrinology

authors： Urbanski HF

更新日期：1990-11-01 00:00:00

abstract：:To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

journal_title：Endocrinology

authors： Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

更新日期：1995-12-01 00:00:00

abstract：:Cultured pineal ependymal cells from rat fetuses aged 17 to 19 days post-coitum release into their media a substance that has hydroosmotic, antidiuretic and rat uterine activities. Paper chromatography of concentrates from culture media demonstrates that the substance possessing all the above activities was eluted fro...

journal_title：Endocrinology

authors： Pavel S,Goldstein R,Ghinea E,Calb M

更新日期：1977-01-01 00:00:00

abstract：:An immunomodulatory role for LHRH was suggested when we reported the presence of immunoactive and bioactive LHRH and its mRNA in rat splenic and thymic lymphocytes. In this paper we report that human peripheral T-cells as well as its subsets CD4+ and CD8+ contained immunoactive and bioactive LHRH. Furthermore, analysi...

journal_title：Endocrinology

authors： Azad N,La Paglia N,Jurgens KA,Kirsteins L,Emanuele NV,Kelley MR,Lawrence AM,Mohagheghpour N

更新日期：1993-07-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...

journal_title：Endocrinology

authors： Felton RG,Steiner CC,Durrant BS,Keisler DH,Milnes MR,Tubbs CW

更新日期：2015-12-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:Caveolae and their principal component caveolin have been implicated in playing a major role in G protein-mediated transmembrane signaling. We examined whether caveolin interacts with adenylyl cyclase, an effector of G protein signaling, using a 20-mer peptide derived from the N-terminus scaffolding domain of caveolin...

journal_title：Endocrinology

authors： Toya Y,Schwencke C,Couet J,Lisanti MP,Ishikawa Y

更新日期：1998-04-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:Studies in mice have identified the ob gene product, leptin, as a signaling factor regulating body weight homeostasis and energy balance. Defective production of the encoded protein may be one of the causes for the development of obesity. Using a high affinity antibody, that in immunohistochemical studies specifically...

journal_title：Endocrinology

authors： McGregor GP,Desaga JF,Ehlenz K,Fischer A,Heese F,Hegele A,Lammer C,Peiser C,Lang RE

更新日期：1996-04-01 00:00:00

abstract：:It is well established that LH has an obligatory role in the acute production of progesterone by the primate corpus luteum in vivo because interruption of LH support to the corpus luteum at any time during the luteal phase is accompanied by an immediate and sustained fall in serum progesterone concentrations. However,...

journal_title：Endocrinology

authors： Ravindranath N,Little-Ihrig L,Benyo DF,Zeleznik AJ

更新日期：1992-11-01 00:00:00

abstract：:An estrogen (E2)-dependent 90,000-92,000 M(r) protein is synthesized and released by the sheep oviduct in a temporally and regionally specific manner during the first few days of pregnancy, where it associates with the embryo. The present study was undertaken to further define the nature of this protein and its regula...

journal_title：Endocrinology

authors： DeSouza MM,Murray MK

更新日期：1995-06-01 00:00:00