Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes.

abstract：:Normal fetal preoptic area (POA), a site of GnRH production, was implanted into the third ventricle of adult female hypogonadal (hpg) mice. When the grafts were successful, the mice (genetically deficient in hypothalamic GnRH) responded with vaginal opening, cornified vaginal cells, ovarian and uterine development, an...

journal_title：Endocrinology

authors： Gibson MJ,Charlton HM,Perlow MJ,Zimmerman EA,Davies TF,Krieger DT

更新日期：1984-05-01 00:00:00

abstract：:We have compared the influence of insulin-like growth factor 1 (IGF-1) on pituitary gene expression in the rat cell lines GH4C1 and GH3. Incubation with IGF-1 increased PRL messenger RNA (mRNA) levels in GH4C1 cells by 4- to 5-fold but decreased the levels of PRL transcripts in GH3 cells. In addition, the levels of GH...

journal_title：Endocrinology

authors： Castillo AI,Aranda A

更新日期：1997-12-01 00:00:00

abstract：:Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL leve...

journal_title：Endocrinology

authors： Ruiz-Herrera X,de Los Ríos EA,Díaz JM,Lerma-Alvarado RM,Martínez de la Escalera L,López-Barrera F,Lemini M,Arnold E,Martínez de la Escalera G,Clapp C,Macotela Y

更新日期：2017-01-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:Recent evidence indicates a localized origin in the olfactory placode for the mammalian forebrain neurons that express GnRH. To identify the cellular and molecular signals that induce the GnRH phenotype, we cloned and characterized a cDNA encoding the GnRH prohormone, the precursor for both GnRH-I and GnRH-associated ...

journal_title：Endocrinology

authors： Hayes WP,Wray S,Battey JF

更新日期：1994-04-01 00:00:00

abstract：:TSH is the most important biomarker in the interpretation of thyroid function in man. Its levels are determined by circulating thyroid hormone (TH) levels that feed back centrally to regulate the expression of the subunits that comprise TSH from the pituitary. The nuclear corepressor 1 (NCoR1), is a critical coregulat...

journal_title：Endocrinology

authors： Costa-e-Sousa RH,Astapova I,Ye F,Wondisford FE,Hollenberg AN

更新日期：2012-10-01 00:00:00

abstract：:We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced ...

journal_title：Endocrinology

authors： Mori M,Yamaguchi M,Yamada M,Kobayashi I,Kobayashi S,Ishikawa K,Suzuki M

更新日期：1986-10-01 00:00:00

abstract：:The present experiments were devoted to analyzing the hypothesis that somatostatin (SS) could modulate glomerular filtration rate by interacting with mesangial cells. Studies were performed in cultured human mesangial cells, passages 3-5. Radioligand experiments demonstrated the presence in the cells of two kinds of r...

journal_title：Endocrinology

authors： Díez-Marqués ML,García-Escribano C,Medina J,Boyano-Adanez MC,Arilla E,Torrecilla G,Rodríguez-Puyol D,Rodríguez-Puyol M

更新日期：1995-08-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:The participation of growth factors in wound healing and tissue repair has been well established. Previous studies demonstrated that the expression of keratinocyte growth factor (KGF) was greatly elevated shortly after injury and that topical application of KGF accelerated healing. Steroidal antiinflammatory agents, s...

journal_title：Endocrinology

authors： Chedid M,Hoyle JR,Csaky KG,Rubin JS

更新日期：1996-06-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:The antitumor properties of antibodies to the beta-subunit of hCG (hCG beta) coupled to tetanus toxoid (tt) were studied in hamsters implanted with the BeWo strain of human choriocarcinoma. After active immunization with hCG beta-tt mixed in complete Freund's adjuvant, hamsters synthesized large quantities of antibodi...

journal_title：Endocrinology

authors： Knecht M

更新日期：1980-01-01 00:00:00

abstract：:SH2B1 is an SH2 domain-containing adaptor protein that plays a key role in the regulation of energy and glucose metabolism in both rodents and humans. Genetic deletion of SH2B1 in mice results in obesity and type 2 diabetes. Single-nucleotide polymorphisms in the SH2B1 loci and chromosomal deletions of the SH2B1 loci ...

journal_title：Endocrinology

authors： Morris DL,Cho KW,Rui L

更新日期：2010-08-01 00:00:00

abstract：:Both serotonin (5-HT) and opiates exert a stimulatory effect on PRL secretion. Some evidence suggests that the action of opiates may be elicited through serotonergic neurons. We tested this hypothesis in the present study by evaluating the effect of perturbation of the serotonergic system on PRL secretion induced by f...

journal_title：Endocrinology

authors： Pan JT,Teo KL

更新日期：1989-10-01 00:00:00

abstract：:The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...

journal_title：Endocrinology

authors： Blackmore JK,Karmakar S,Gu G,Chaubal V,Wang L,Li W,Smith CL

更新日期：2014-09-01 00:00:00

abstract：:GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor. Whereas GnRH inhibits the activity of the M-current in peripheral neurons, there is no direct evidence that the M-current is involved in the autoregulatory ...

journal_title：Endocrinology

authors： Xu C,Roepke TA,Zhang C,Rønnekleiv OK,Kelly MJ

更新日期：2008-05-01 00:00:00

abstract：:cAMP is involved in the regulation of secretory activity in lactotrope, thyrotrope, and gonadotrope cells. The present study examined whether pulsatile or intermittent changes in cAMP are more effective than a continuous stimulation in increasing pituitary hormone gene expression. Pituitaries from adult female rats we...

journal_title：Endocrinology

authors： Haisenleder DJ,Yasin M,Marshall JC

更新日期：1992-12-01 00:00:00

abstract：:Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...

journal_title：Endocrinology

authors： Blackshear PJ,Nemenoff RA,Avruch J

更新日期：1984-01-01 00:00:00

abstract：:Pulsatile administration of glucagon to perifused rat hepatocytes stimulates hepatocyte glucose production (HGP) more effectively than continuous administration. Having established that this effect was due to delayed relaxation of glucagon-stimulated HGP (t1/2 for decay = 3.54 +/- 0.60 min) we wished to examine the me...

journal_title：Endocrinology

authors： Weigle DS,Sweet IR,Goodner CJ

更新日期：1987-08-01 00:00:00

abstract：:The purpose of this study is to establish a primary LHRH cell culture system using embryonic olfactory placode and to examine whether LHRH cells derived from olfactory placode and the migratory pathway of LHRH neurons mature in vitro. Six monkey fetuses at the ages of E34-E36 were delivered surgically and the area inc...

journal_title：Endocrinology

authors： Terasawa E,Quanbeck CD,Schulz CA,Burich AJ,Luchansky LL,Claude P

更新日期：1993-11-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:Various hormones and growth factors act at least in part by raising the cytosolic pH of the target cell. In the present studies we examined the influence of the muscarinic cholinergic agonist carbachol on intracellular pH (pHi) in chicken granulosa cells. The pHi in granulosa cells from the two largest preovulatory fo...

journal_title：Endocrinology

authors： Li M,Morley P,Schwartz JL,Whitfield JF,Tsang BK

更新日期：1992-07-01 00:00:00

abstract：:We examined the effects of bombesin on rat pancreatic digestive enzyme gene expression using cloned complementary DNA probes for amylase, trypsinogen I, chymotrypsinogen B, and lysophospholipase. Rats were injected sc three times daily with 5 nmol/kg body wt bombesin. Pancreata were investigated after 6, 12, 24, 48, a...

journal_title：Endocrinology

authors： Rosewicz S,Liehr RM,Solomon TE,Riecken EO,Logsdon CD

更新日期：1992-03-01 00:00:00

abstract：:The beta-subunit of hCG (hCG beta) displays immunological cross-reactivity with human LH (hLH). A detailed study was undertaken to investigate the effect of chemical and enzymatic modifications on the immunological behavior of hCG beta, particularly on its cross-reactivity with hLH, with a view to obtaining a highly h...

journal_title：Endocrinology

authors： Ghai RD,Mise T,Pandian MR,Bahl OP

更新日期：1980-11-01 00:00:00

abstract：:Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it in white adipose tissue (WAT), but knowledge of the mechanisms underlying the inhibitory effect of central leptin on the insulin-dependent glucose uptake in WAT is limited. After 7 d intracerebroventricular leptin tre...

journal_title：Endocrinology

authors： Bonzón-Kulichenko E,Fernández-Agulló T,Moltó E,Serrano R,Fernández A,Ros M,Carrascosa JM,Arribas C,Martínez C,Andrés A,Gallardo N

更新日期：2011-04-01 00:00:00

abstract：:Experiments were carried out to characterize the prolactin stimulation of labeled uridine uptake into mammary gland explants which were initially preincubated for 2 days in medium containing insulin plus hydrocortisone. Prolactin was found to enhance labeled uridine uptake after 4 h but not after 2 h when uridine conc...

journal_title：Endocrinology

authors： Rillema JA

更新日期：1975-05-01 00:00:00

abstract：:17 beta-Estradiol (E2; 100 micrograms/kg X day) was infused iv for 6 days into three chronically catheterized ovine fetuses beginning at 105-106 days of gestation (term, 147 days) and into four younger fetuses for 3 days commencing at 87-92 days. Control studies were performed on three fetuses at each age. At 90 days,...

journal_title：Endocrinology

authors： Gluckman PD,Marti-Henneberg C,Kaplan SL,Grumbach MM

更新日期：1983-05-01 00:00:00

abstract：:Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes. Hepatocytes were freshly isolated from Sprague-Dawley rats treated with dexamethasone (1 mg/kg) for 4 days and from untreated littermates. Dexamet...

journal_title：Endocrinology

authors： Karasik A,Kahn CR

更新日期：1988-11-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:PGs are important mediators of the ovulatory process and prostaglandin G/H synthase-2 (PGHS-2) is a key rate-limiting enzyme in the PG biosynthetic pathway. To determine whether PGHS-2 is regulated in equine follicles before ovulation and, if so, to characterize its time course of induction, preovulatory follicles wer...

journal_title：Endocrinology

authors： Sirois J,Doré M

更新日期：1997-10-01 00:00:00