Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A.

abstract：:We constructed seven chimeric molecules in which sequential segments in the cDNA for thyroid peroxidase (TPO) were replaced with the homologous regions of myeloperoxidase (MPO) cDNA. The sizes of the translated cDNA segments A through G ranged from 23-175 amino acid residues in length. The TPO-MPO cDNA chimeras, inser...

journal_title：Endocrinology

authors： Nishikawa T,Nagayama Y,Seto P,Rapoport B

更新日期：1993-12-01 00:00:00

abstract：:We have previously shown that placental protein 12 (PP12) is synthesized and secreted by human term pregnancy decidua in vitro. In the present study, fragments of proliferative and secretory phase endometrium were cultured in media in the presence and absence of progesterone (P) and 17 beta-estradiol (E2) for 96 h. Th...

journal_title：Endocrinology

authors： Rutanen EM,Koistinen R,Sjöberg J,Julkunen M,Wahlström T,Bohn H,Seppälä M

更新日期：1986-03-01 00:00:00

abstract：:Parathyroid tissue from patients with hyperparathyroidism (HPT) exhibited reduced immunohistochemical reactivity with monoclonal antiparathyroid antibodies, previously shown to stain intensely the surface of normal human parathyroid cells and to interfere with a receptor mechanism of these cells which is involved in t...

journal_title：Endocrinology

authors： Juhlin C,Klareskog L,Nygren P,Ljunghall S,Gylfe E,Rastad J,Akerström G

更新日期：1988-06-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:Although the increased expression of Igf-I in liver in response to GH is well characterized, the intracellular signaling pathways that mediate this effect have not been identified. Intracellular signaling molecules belonging to the Janus kinase-signal transducer and activator of transcription 5b (JAK2-STAT5b) pathway ...

journal_title：Endocrinology

authors： Davey HW,Xie T,McLachlan MJ,Wilkins RJ,Waxman DJ,Grattan DR

更新日期：2001-09-01 00:00:00

abstract：:Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of ...

journal_title：Endocrinology

authors： Gershon E,Hadas R,Elbaz M,Booker E,Muchnik M,Kleinjan-Elazary A,Karasenti S,Genin O,Cinnamon Y,Gray PC

更新日期：2018-04-01 00:00:00

abstract：:This study provides the first demonstration that human hepatocarcinoma-derived cell line HepG2 contains GnRH receptors and responds to various molecular forms of GnRH in terms of inhibition of proliferation in a time- and dose-related manner. In addition, GnRH peptides also significantly inhibited the uptake of [3H]th...

journal_title：Endocrinology

authors： Pati D,Habibi HR

更新日期：1995-01-01 00:00:00

abstract：:Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4 measurements, but qWestern is technically complex and labor intensiv...

journal_title：Endocrinology

authors： Yang Q,Eskurza I,Kiernan UA,Phillips DA,Blüher M,Graham TE,Kahn BB

更新日期：2012-03-01 00:00:00

abstract：:Hypophysectomized female rats which received renal grafts of anterior pituitary (AP) or weight-matched intact controls were sampled under urethane anesthesia. Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormo...

journal_title：Endocrinology

authors： Udeschini G,Cocchi D,Panerai AE,Gil-Ad I,Rossi GL,Chiodin PG,Liuzzi A,Müller EE

更新日期：1976-03-01 00:00:00

abstract：:Magnocellular hypothalamic neurons in the rat supraoptic nucleus (SON) normally produce either vasopressin (VP) or oxytocin (OT). Here we demonstrate that many magnocellular neurons in the SON of lactating rats synthesize both hormones at the same time. We show the colocalization of the messenger (m) RNA that encodes ...

journal_title：Endocrinology

authors： Mezey E,Kiss JZ

更新日期：1991-10-01 00:00:00

abstract：:To define further the mechanism by which metoclopramide, a dopamine antagonist, stimulates aldosterone secretion, seven lambs were injected iv with metoclopramide during a constant infusion of 5% dextrose in water and again during a constant infusion of trimethapan, a ganglionic blocker. In addition, suspensions of ad...

journal_title：Endocrinology

authors： Wilson TA,Kaiser DL,Peach MJ,Wright EM,Carey RM

更新日期：1983-09-01 00:00:00

abstract：:The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the thyroid glands of rats. Eighteen hours after injection of a relatively small dose, iodination in the thyroid remained inhibited by more than 90%. We previously s...

journal_title：Endocrinology

authors： Taurog A,Dorris ML

更新日期：1989-06-01 00:00:00

abstract：:Dispersed Leydig cells were prepared from pig testes and purified in a discontinuous Percoll gradient. About 95% of these cells stained for 3 beta-hydroxysteroid dehydrogenase. The cells were cultured in a chemically defined medium. Testosterone production was low (2 +/- 0.4 ng/10(6) cells/day) under basal conditions,...

journal_title：Endocrinology

authors： Benahmed M,Reventos J,Saez JM

更新日期：1983-06-01 00:00:00

abstract：:The role of anti-Müllerian hormone (AMH) during gonad development has been studied extensively in many species of mammal, bird, reptile, and fish but remains unresolved in amphibians. In male mammalian embryos, Sox9 activates AMH expression, which initiates regression of the Müllerian ducts. However, Sox9 (Sry-related...

journal_title：Endocrinology

authors： Kodama M,Suda M,Sakamoto D,Iwasaki T,Matsuo Y,Uno Y,Matsuda Y,Nakamura Y,Maekawa S,Katsu Y,Nakamura M

更新日期：2015-05-01 00:00:00

abstract：:At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...

journal_title：Endocrinology

authors： Yin W,Maguire SM,Pham B,Garcia AN,Dang NV,Liang J,Wolfe A,Hofmann HA,Gore AC

更新日期：2015-08-01 00:00:00

abstract：:The active form of vitamin D, 1,25-dihydroxyvitamin D3, [1,25(OH)2D3] has potent actions on innate and adaptive immunity. Although endocrine synthesis of 1,25(OH)2D3 takes place in the kidney, the enzyme that catalyzes this, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27b1 in humans, Cyp27b1 in mice), is expressed at m...

journal_title：Endocrinology

authors： Liu N,Nguyen L,Chun RF,Lagishetty V,Ren S,Wu S,Hollis B,DeLuca HF,Adams JS,Hewison M

更新日期：2008-10-01 00:00:00

abstract：:We have recently disclosed sustained episodes of LH release (minisurges) during the afternoons of the juvenile-peripubertal transition period in the female rat. To determine if these LH minisurges are gonad independent, i.e. develop in the absence of the ovaries, animals were ovariectomized when neonates, and the mode...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1986-03-01 00:00:00

abstract：:Brain-derived neurotropic factor (BDNF) is a member of the nerve growth factor family that is important for neuronal survival and plasticity. We recently demonstrated that stress decreases BDNF messenger RNA (mRNA) levels in the hippocampus, which raises the possibility that BDNF may play a role in regulation of the h...

journal_title：Endocrinology

authors： Smith MA,Makino S,Kim SY,Kvetnansky R

更新日期：1995-09-01 00:00:00

abstract：:Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...

journal_title：Endocrinology

authors： Tsuchida K,Vaughan JM,Wiater E,Gaddy-Kurten D,Vale WW

更新日期：1995-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a newly discovered neuropeptide that is present in high amounts in hypothalamic neuroendocrine neurons and potently stimulates the accumulation of cAMP within cells of the anterior pituitary. We have employed several specific antisera recognizing different ...

journal_title：Endocrinology

authors： Hannibal J,Mikkelsen JD,Fahrenkrug J,Larsen PJ

更新日期：1995-09-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAM...

journal_title：Endocrinology

authors： Dere WH,Hirayu H,Rapoport B

更新日期：1985-11-01 00:00:00

abstract：:Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...

journal_title：Endocrinology

authors： Abboud M,Puglisi DA,Davies BN,Rybchyn M,Whitehead NP,Brock KE,Cole L,Gordon-Thomson C,Fraser DR,Mason RS

更新日期：2013-09-01 00:00:00

abstract：:The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...

journal_title：Endocrinology

authors： Anan M,Uchihashi K,Aoki S,Matsunobu A,Ootani A,Node K,Toda S

更新日期：2011-04-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United States and is strongly associated with hepatic insulin resistance. We examined whether the thyroid hormone receptor-α (Thra) would be a potential therapeutic target to prevent diet-induced NAFLD and insulin resistance. Fo...

journal_title：Endocrinology

authors： Jornayvaz FR,Lee HY,Jurczak MJ,Alves TC,Guebre-Egziabher F,Guigni BA,Zhang D,Samuel VT,Silva JE,Shulman GI

更新日期：2012-02-01 00:00:00

abstract：:The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity. Several antagonists have been developed to decrease the orexigenic signaling, but none of these have been approved for the treatment of obesit...

journal_title：Endocrinology

authors： Hedegaard MA,Holst B

更新日期：2020-04-01 00:00:00

abstract：:Chloroquine is widely used as a lysosomal enzyme inhibitor, and while effects on DNA repair and membrane recycling have also been reported, there has been no investigation of effects on the processing of secretory products. To determine whether chloroquine had any effect on secretion and secretory organelles, we monit...

journal_title：Endocrinology

authors： Conconi MV,Walker AM

更新日期：1984-03-01 00:00:00

abstract：:The effect of synthetic atrial natriuretic factor (ANF) on adrenal steroidogenesis has been studied in primary culture of bovine adrenal cells. ANF-(8-33) produced a potent 40-70% inhibition of angiotensin II-, ACTH-, PGE1-, and forskolin-stimulated secretion of aldosterone production from zona glomerulosa cells with ...

journal_title：Endocrinology

authors： De Léan A,Racz K,Gutkowska J,Nguyen TT,Cantin M,Genest J

更新日期：1984-10-01 00:00:00

abstract：:Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...

journal_title：Endocrinology

authors： Potau N,Bailey AC,Roach E,Williams JA,Goldfine ID

更新日期：1984-07-01 00:00:00

abstract：:The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...

journal_title：Endocrinology

authors： Hauner H

更新日期：1990-08-01 00:00:00