Molecular cloning and characterization of anti-Müllerian hormone (AMH) from the Japanese wrinkled frog, Rana rugosa.

abstract：:Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activati...

journal_title：Endocrinology

authors： Ernst MC,Haidl ID,Zúñiga LA,Dranse HJ,Rourke JL,Zabel BA,Butcher EC,Sinal CJ

更新日期：2012-02-01 00:00:00

abstract：:Epidermal growth factor (EGF) and TGFalpha are well known for their activities in the ovary. Both factors initiate signal transduction by binding to the common EGF receptor that has been demonstrated in the ovary across vertebrates from fish to humans. Using zebrafish as the model, we demonstrated in the present study...

journal_title：Endocrinology

authors： Pang Y,Ge W

更新日期：2002-01-01 00:00:00

abstract：:We have studied calmodulin (CaM)-like activity and calcium (Ca++)-regulated phosphodiesterase (PDE) activity in cells from the rat adrenal zona glomerulosa (ZG) and zona fasciculata (ZF). Boiled cell sonicates from the ZG and ZF activated CaM-deficient PDE in a dose-dependent fashion by 2.0- to 2.3-fold. The propertie...

journal_title：Endocrinology

authors： Koletsky RJ,Brown EM,Williams GH

更新日期：1983-08-01 00:00:00

abstract：:Stimulation of mitogenesis in rat Nb2 node lymphoma cells by human (h) PRL was inhibited by inhibitors of Na+/H+ exchange (viz. amiloride and its analogs) and inhibitors of protein kinases (isoquinolinesulfonamide derivatives). The most potent were ethylisopropylamiloride (EP-Am) (IC50, 13 microM) and H-7, selective f...

journal_title：Endocrinology

authors： Too CK,Walker A,Murphy PR,Cragoe EJ Jr,Jacobs HK,Friesen HG

更新日期：1987-10-01 00:00:00

abstract：:Apoptosis is the process of cellular self-destruction, and genes such as bcl-2 and bax are known to inhibit and promote apoptosis, respectively. In this study, we show that apoptosis can be induced in pancreatic beta-cell lines, and we investigate the apoptotic pathways through the bcl-2 and bax genes and intracellula...

journal_title：Endocrinology

authors： Mizuno N,Yoshitomi H,Ishida H,Kuromi H,Kawaki J,Seino Y,Seino S

更新日期：1998-03-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:After hormonal ablation, 90% of the secretory epithelial cells of the prostate undergo apoptosis, and the remaining cells are reorganized as the tissue is remodeled. Using differential display RT-PCR of total RNA extracted from the rat ventral prostate before and 4 days after castration, we have cloned and sequenced a...

journal_title：Endocrinology

authors： Morrissey C,Bennett S,Nitsche E,Guenette RS,Wong P,Tenniswood M

更新日期：1999-07-01 00:00:00

abstract：:Thyroid hormone and retinoic acid (RA) are essential for normal neural development in vivo, yet all in vitro differentiation strategies of embryonic stem (ES) cells use only RA. We developed a novel differentiation strategy of mouse ES cells using T(3). A dominant-negative knock-in point mutation (P398H) was introduce...

journal_title：Endocrinology

authors： Liu YY,Tachiki KH,Brent GA

更新日期：2002-07-01 00:00:00

abstract：:Activins and transforming growth factor-beta (TGF beta) are crucial autocrine, paracrine, and endocrine modulators of anterior pituitary function. Activins regulate most pituitary cells and lactotropes are targets of TGF beta. Smad2 and Smad3 are two cellular mediators of activin/TGF beta signaling, whereas Smad7 is a...

journal_title：Endocrinology

authors： Bilezikjian LM,Corrigan AZ,Blount AL,Chen Y,Vale WW

更新日期：2001-03-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons act to sense and coordinate the brain's responses to metabolic cues. One neuronal network that is very sensitive to metabolic status is that controlling fertility. In this study, we investigated the impact of neuropeptides released by NPY and POM...

journal_title：Endocrinology

authors： Roa J,Herbison AE

更新日期：2012-11-01 00:00:00

abstract：:Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and ...

journal_title：Endocrinology

authors： Fujikawa T,Tamura K,Kawase T,Mori Y,Sakai RR,Sakuma K,Yamaguch A,Ogata M,Soya H,Nakashima K

更新日期：2005-08-01 00:00:00

abstract：:The role of calcium in the angiotensin II- or potassium-mediated increase in aldosterone production was analyzed in isolated glomerulosa cells prepared from bovine adrenal glands. The response to potassium was highly dependent on the extracellular calcium concentration, and a maximal response was observed at 0.5 mM ca...

journal_title：Endocrinology

authors： Foster R,Lobo MV,Rasmussen H,Marusic ET

更新日期：1981-12-01 00:00:00

abstract：:The insulin receptor, following insulin stimulation of cells, triggers formation of various signaling complexes. In rat HTC hepatoma cells overexpressing normal human insulin receptors (HTC-IR), p85 regulatory subunit of phosphatidylinositol-3-kinase (PI3K) forms signaling complexes containing the insulin receptor, in...

journal_title：Endocrinology

authors： Sung CK,Choi WS,Sanchez-Margalet V

更新日期：1998-05-01 00:00:00

abstract：:We have analyzed the factors responsible for the circadian variation in rat hepatic mRNA-S14. Regulation of this sequence, which is found in lipogenic tissues and encodes a protein (S14) believed to be associated with fatty acid synthesis, is an excellent model of the interaction of thyroid hormone and dietary factors...

journal_title：Endocrinology

authors： Kinlaw WB,Fish LH,Schwartz HL,Oppenheimer JH

更新日期：1987-04-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) stimulate the proliferation of human breast cancer cells, including the estrogen-dependent cell line MCF-7. These cells secrete regulatory IGF-binding proteins (IGFBPs) which may enhance or attenuate IGF-stimulated cell proliferation. In this study, we have used RIA to quantify t...

journal_title：Endocrinology

authors： Martin JL,Coverley JA,Pattison ST,Baxter RC

更新日期：1995-03-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:We constructed seven chimeric molecules in which sequential segments in the cDNA for thyroid peroxidase (TPO) were replaced with the homologous regions of myeloperoxidase (MPO) cDNA. The sizes of the translated cDNA segments A through G ranged from 23-175 amino acid residues in length. The TPO-MPO cDNA chimeras, inser...

journal_title：Endocrinology

authors： Nishikawa T,Nagayama Y,Seto P,Rapoport B

更新日期：1993-12-01 00:00:00

abstract：:The Src homology 2-containing tyrosine phosphatase, Shp-2, is a crucial enzyme that mediates intracellular signaling and is implicated in cell proliferation and differentiation. Here we investigated the involvement of the Shp-2 tyrosine phosphatase in determining the downstream signaling pathways initiated by the Ret ...

journal_title：Endocrinology

authors： D'Alessio A,Califano D,Incoronato M,Santelli G,Florio T,Schettini G,Carlomagno MS,Cerchia L,de Franciscis V

更新日期：2003-10-01 00:00:00

abstract：:Both serotonin (5-HT) and opiates exert a stimulatory effect on PRL secretion. Some evidence suggests that the action of opiates may be elicited through serotonergic neurons. We tested this hypothesis in the present study by evaluating the effect of perturbation of the serotonergic system on PRL secretion induced by f...

journal_title：Endocrinology

authors： Pan JT,Teo KL

更新日期：1989-10-01 00:00:00

abstract：:Intestinal calcium and phosphate transport was studied in normal and hypophosphatemic mice fed a variety of dietary regimens with and without vitamin D. Regardless of dietary phosphorus levels, the genetic hypophosphatemic mice had drastically reduced levels of serum inorganic phosphate and intestinal phosphate transp...

journal_title：Endocrinology

authors： O'Doherty PJ,DeLuca HF,Eicher EM

更新日期：1977-10-01 00:00:00

abstract：:Dynamic bone histomorphometry, [3H]thymidine radioautography, and Northern analysis for bone matrix proteins and insulin-like growth factor-I (IGF-I) were performed in calvariae of ovariectomized (OVX) and estrogen-treated OVX rats. Treatment of OVX rats with diethylstilbestrol (DES) for 2 weeks reduced the periosteal...

journal_title：Endocrinology

authors： Turner RT,Backup P,Sherman PJ,Hill E,Evans GL,Spelsberg TC

更新日期：1992-08-01 00:00:00

abstract：:A relationship between the actions of TSH and IGF-1 was first recognized several decades ago. The close physical and functional associations between their respective receptors (TSHR and IGF-1R) has been described more recently in thyroid epithelium and human orbital fibroblasts as has the noncanonical behavior of IGF-...

journal_title：Endocrinology

authors： Atkins SJ,Lentz SI,Fernando R,Smith TJ

更新日期：2015-12-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...

journal_title：Endocrinology

authors： Vendrell J,El Bekay R,Peral B,García-Fuentes E,Megia A,Macias-Gonzalez M,Fernández Real J,Jimenez-Gomez Y,Escoté X,Pachón G,Simó R,Selva DM,Malagón MM,Tinahones FJ

更新日期：2011-11-01 00:00:00

abstract：:Tissue levels of bioactive and immunoactive ACTH were measured in both the anterior and neuro-intermediate lobes of the rat pituitary. Similar concentrations of bioactive (65 ng/mg) and immunoactive (83 ng/mg) ACTH were found in the anterior lobes control rats. A 2-min ether stress had no effect on either bioactive or...

journal_title：Endocrinology

authors： Moriarty CM,Moriarty GC

更新日期：1975-06-01 00:00:00

abstract：:In teleosts, the pituitary contains a single glycoprotein gonadotropic hormone (GTH) composed of two dissimilar alpha- and beta-subunits. The European eel, Anguilla anguilla L, is sexually immature at the silver stage due to a deficiency in GTH synthesis and secretion. In previous studies we (S.D., YA.F.) have demonst...

journal_title：Endocrinology

authors： Counis R,Dufour S,Ribot G,Quérat B,Fontaine YA,Jutisz M

更新日期：1987-09-01 00:00:00

abstract：:Inside-out plasma membrane vesicles from a glucose-responsive rat insulinoma showed an ATP- and Mg2(+)-dependent uptake of Ca2+. The Km (concentration giving half-maximal activity) for Ca2+ was 60 nM. In the presence of 0.4 microM free Ca2+, the Km for ATP was 15 microM, and the Km for Mg2+ was 4 microM. Glucose (30 m...

journal_title：Endocrinology

authors： Hoenig M,Culberson LH,Ferguson DC

更新日期：1991-03-01 00:00:00

abstract：:Retinoic acid (RA), a naturally occurring metabolite of vitamin A, plays an essential role in regulating cellular growth, differentiation, and death in a variety of tissues, particularly during fetal development. However, essentially nothing is known of the effects of RA on fetal gametogenesis. Using a recently valida...

journal_title：Endocrinology

authors： Morita Y,Tilly JL

更新日期：1999-06-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central aspect in the development of pathological conditions. Testosterone can act through the classic androgen receptor (AR) in the cytoplasm, eliciting genomic signaling,...

journal_title：Endocrinology

authors： Peinetti N,Scalerandi MV,Cuello Rubio MM,Leimgruber C,Nicola JP,Torres AI,Quintar AA,Maldonado CA

更新日期：2018-02-01 00:00:00