Abstract:
:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecular mechanisms playing a role in the control of energy balance by the central nervous system, especially during the past 3 decades. Despite the wealth of newfound knowledge, effective therapies for prevention of and/or intervention in obesity have not been forthcoming. That said, recent technological advances and the revisiting of previously discarded concepts have identified novel neural mechanisms involved in the control of energy homeostasis, thereby providing potential new targets and experimental approaches that may bring us closer to effective therapies to improve metabolic control. This review summarizes some of the most recent findings, with special emphasis on the role of neural circuits of the hypothalamus.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Perez-Tilve Ddoi
10.1210/en.2016-1944subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1085-1094issue
5eissn
0013-7227issn
1945-7170pii
2991888journal_volume
158pub_type
杂志文章,评审相关文献
ENDOCRINOLOGY文献大全abstract::Estrogen unresponsiveness among primate species can result from overexpression of a heterogeneous nuclear ribonucleoprotein (hnRNP) that competes with estrogen receptor (ER) for binding to the estrogen-response element (ERE). This hnRNP has been coined the "ERE-binding protein" (ERE-BP). The ERE-BP is a member of the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0160
更新日期:2005-10-01 00:00:00
abstract::Although leptin is a hormone mainly produced by the adipose tissue, it is also produced by the gastric mucosa and the mammary epithelium and is present in maternal milk. The effects of milk leptin on the neonate are not known. The purpose of the investigation was to evaluate the short-term effects of the administratio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0112
更新日期:2005-06-01 00:00:00
abstract::Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2004
更新日期:2013-10-01 00:00:00
abstract::The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-3151
更新日期:1990-12-01 00:00:00
abstract::In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. Th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.1.4865
更新日期:1997-01-01 00:00:00
abstract::Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-2673
更新日期:1990-12-01 00:00:00
abstract::Centrally administered histamine (HA) stimulates the secretion of adenohypophysial POMC-derived peptides, which subsequently cause release of corticosterone. The effect of HA on POMC-derived peptide release is indirect, and it is possible that hypothalamic neurons containing corticotropin-releasing hormone (CRH), argi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.3.8070360
更新日期:1994-09-01 00:00:00
abstract::Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1003
更新日期:2012-09-01 00:00:00
abstract::Human livers, obtained from donors at the time of transplant, were homogenized in 0.25 M sucrose and fractionated by differential centrifugation. The specific binding of [125I] human (h) GH to total particulate fractions from 18 livers varied from 0.4-5.1% of the total radioactivity/100 micrograms protein. Binding aff...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-4-2167
更新日期:1989-10-01 00:00:00
abstract::Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1096
更新日期:2013-07-01 00:00:00
abstract::The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-1-55
更新日期:1987-01-01 00:00:00
abstract::Serum triiodothyronine (T3) in rats did not change if food intake was restricted without altering the composition of the diet. Feeding a hypocaloric low-protein high-carbohydrate diet caused increases in serum T3, while feeding a hypocaloric high-protein low-carbohydrate diet caused decreases in serum T3. These change...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-102-6-1925
更新日期:1978-06-01 00:00:00
abstract::Leptin has been postulated to comprise part of an adipostat, whereby during states of excessive energy storage, elevated levels of the hormone prevent further weight gain by inhibiting appetite. A physiological role for leptin in this regard remains unclear because the presence of excessive food, and therefore the nee...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1558
更新日期:2004-07-01 00:00:00
abstract::Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0421
更新日期:2004-09-01 00:00:00
abstract::We have previously documented that raloxifene enhances the mechanical properties of dog vertebrae independent of changes in bone mass, suggesting a positive effect of raloxifene on material-level mechanical properties. The goal of this study was to determine the separate effects of raloxifene on the material-level mec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0275
更新日期:2007-08-01 00:00:00
abstract::A recent report suggests that estrogen induction of hypothalamic progestin receptors is not a prerequisite for the facilitation by progesterone of female sexual behavior in rats. Progesterone was found to facilitate sexual behavior despite no apparent induction of progestin receptors by 1-(o-chlorophenyl) 1-(p-chlorop...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-6-2052
更新日期:1984-12-01 00:00:00
abstract::The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAM...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-5-2249
更新日期:1985-11-01 00:00:00
abstract::Although GH plays a key role in postnatal growth and differentiation, its role in fetal differentiation is not clear at the present. The aim of the present study was to investigate whether GH plays a role in fetal sexual differentiation, and we used in vitro organ culture assay of sexual differentiation to determine t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.9.8756530
更新日期:1996-09-01 00:00:00
abstract::Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR). EMD 21388 also inhibits the binding of T4 to human, dog, and rat serum TTR in vitro and w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-6-2890
更新日期:1990-06-01 00:00:00
abstract::Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1813
更新日期:2013-02-01 00:00:00
abstract::Permanent effects of postnatal gonads on dopamine (DA)-mediated regulation of PRL secretion were examined in adult male rats of the Wistar-Imamichi strain. Rats were bilaterally orchidectomized at varying postnatal days, i.e. 8 h after birth [neonatal castration (NC)] or at 1, 2, 3, 4, or 6 weeks of age, and subjected...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-6-2205
更新日期:1987-06-01 00:00:00
abstract::A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest that a midregion PTHrP fragment may be biologically active, we hypothes...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.12.8940360
更新日期:1996-12-01 00:00:00
abstract::To identify genes that are differentially expressed in the developing testis we used representational difference analysis of complementary DNA from gonads of mouse embryos at 13.5 days postcoitum (dpc). Three genes were identified. One of them was a novel gene termed tescalcin that encoded a putative EF-hand Ca(2+)-bi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.1.7882
更新日期:2001-01-01 00:00:00
abstract::The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragments in the regulatio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.9.6979
更新日期:1999-09-01 00:00:00
abstract::The effects of human pancreatic GH-releasing factor-40 (hpGRF-40; 0.01-100 nM) and (Bu)2cAMP (0.015-1.5 mM) on GH release from primary monolayer cultures of pituitary cells were evaluated in rats of three age groups: postnatal days 2 and 12, and young adult males (3-4 months). Both hpGRF-40 and (Bu)2cAMP elicited a do...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-1-69
更新日期:1986-01-01 00:00:00
abstract::Sex differences in liver gene expression are determined by pituitary growth hormone secretion patterns, which regulate sex-dependent liver transcription factors and establish sex-specific chromatin states. Hypophysectomy (hypox) identifies two major classes of liver sex-biased genes, defined by their sex-dependent pos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00949
更新日期:2019-05-01 00:00:00
abstract::In this study, the potential interactions between dihydrotestosterone (DHT), a survival factor, and transforming growth factor-beta (TGF-beta), an apoptotic inducer, were examined in a derivative of the hormone-sensitive prostate cancer cell line LNCAP: The LNCaP TGF-beta receptor II cells, engineered to express TGF-b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.6.8218
更新日期:2001-06-01 00:00:00
abstract::We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.11.7123
更新日期:1999-11-01 00:00:00
abstract::The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-2-1177
更新日期:1991-02-01 00:00:00
abstract::The purpose of this experiment was to determine whether surgical stress on the morning of proestrus would elicit an early release of gonadotropin from the pituitary. Animals exhibiting 5-day estrous cycles underwent bilateral sham-ovariectomy under ether anesthesia at 0800 h of proestrus. These animals had high levels...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-718
更新日期:1975-09-01 00:00:00