Abstract:
:The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAMP and forskolin each enhanced c-myc expression 2.7-fold. These data indicate that TSH, via cAMP as a second messenger, can regulate expression of a cellular oncogene in a non-neoplastic, specific target cell.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Dere WH,Hirayu H,Rapoport Bdoi
10.1210/endo-117-5-2249subject
Has Abstractpub_date
1985-11-01 00:00:00pages
2249-51issue
5eissn
0013-7227issn
1945-7170journal_volume
117pub_type
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