Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line.

abstract：:SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in peripheral tissues of diabetic C57BL/KSJ-db/db mice. To clarify the impact of SHIP2 ...

journal_title：Endocrinology

authors： Kagawa S,Soeda Y,Ishihara H,Oya T,Sasahara M,Yaguchi S,Oshita R,Wada T,Tsuneki H,Sasaoka T

更新日期：2008-02-01 00:00:00

abstract：:Recent evidence suggests that inflammation may be a common underlying cause of many obesity-associated conditions. To test whether obesity changes the response to inflammation, we investigated its effects on the acute phase of the inflammatory response to an endogenous pathogen, lipopolysaccharide (LPS). Diet-induced ...

journal_title：Endocrinology

authors： Pohl J,Woodside B,Luheshi GN

更新日期：2009-11-01 00:00:00

abstract：:Nowadays, we are bombarded with information on a large number of endocrine-disrupting chemicals. We hear and read about endocrine-disrupting chemicals on blogs, the web, news stories, television specials, advertisements, and of course scientific articles. Reports claim these ubiquitous compounds are responsible for in...

journal_title：Endocrinology

authors： Rissman EF

更新日期：2016-08-01 00:00:00

abstract：:Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...

journal_title：Endocrinology

authors： Roa J,Vigo E,Castellano JM,Navarro VM,Fernández-Fernández R,Casanueva FF,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-06-01 00:00:00

abstract：:We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...

journal_title：Endocrinology

authors： Brännström M,Woessner JF Jr,Koos RD,Sear CH,LeMaire WJ

更新日期：1988-05-01 00:00:00

abstract：:The establishment of dominant ovarian follicles that are capable of ovulating fertilizable oocytes is a fundamental determinant of female fertility. This process is governed by pituitary gonadotropins as well as local ovarian factors. Within the follicle, estrogen acts in an autocrine/paracrine manner to enhance FSH a...

journal_title：Endocrinology

authors： Otsuka F,Moore RK,Wang X,Sharma S,Miyoshi T,Shimasaki S

更新日期：2005-08-01 00:00:00

abstract：:A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities and failed to increase...

journal_title：Endocrinology

authors： List EO,Berryman DE,Basu R,Buchman M,Funk K,Kulkarni P,Duran-Ortiz S,Qian Y,Jensen EA,Young JA,Yildirim G,Yakar S,Kopchick JJ

更新日期：2020-08-01 00:00:00

abstract：:Various neuropeptides have recently been isolated from the thymus, suggesting an interaction between the neuroendocrine and immune systems. We report here that the human thymus synthesizes a further peptide hormone, namely atrial natriuretic peptide (ANP). This is documented by the following findings. ANP and its proh...

journal_title：Endocrinology

authors： Vollmar AM,Schulz R

更新日期：1990-05-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:Tumoral insulin-producing cells of the RINm5F line display a poor secretory response to D-glucose. Relative to basal insulin output, which corresponds to a fractional release of stored hormone close to 25%/90 min, the glucose-induced increment in insulin release does not exceed 28 +/- 7%. The low efficiency of D-gluco...

journal_title：Endocrinology

authors： Valverde I,Barreto M,Malaisse WJ

更新日期：1988-04-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:Homogenates from male ddy mouse sublingual glands were incubated with 100 nM [125I]rT3 in the presence of 2 mM dithiothreitol (DTT). Metabolites were analyzed by HPLC or Dowex-50 minicolumn assay. 3,3'-Diiodothyronine and I- were the only appreciable products. Iodide release from rT3 was compatible with the enzymatic ...

journal_title：Endocrinology

authors： Tanaka K,Imura H

更新日期：1993-03-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a newly discovered neuropeptide that is present in high amounts in hypothalamic neuroendocrine neurons and potently stimulates the accumulation of cAMP within cells of the anterior pituitary. We have employed several specific antisera recognizing different ...

journal_title：Endocrinology

authors： Hannibal J,Mikkelsen JD,Fahrenkrug J,Larsen PJ

更新日期：1995-09-01 00:00:00

abstract：:Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...

journal_title：Endocrinology

authors： Yang CR,Lowther KM,Lalioti MD,Seli E

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a cold-induced protein expressed in brown adipose tissue (BAT), plays a role in adaptive thermogenesis by up-regulating uncoupling proteins (UCP). Here, we explore its relationship to the thermogenic actions of leptin, which also up-regulates UCPs...

journal_title：Endocrinology

authors： Kakuma T,Wang ZW,Pan W,Unger RH,Zhou YT

更新日期：2000-12-01 00:00:00

abstract：:Progesterone released by cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the cationic channel of sperm (CatSper) Ca2+ channel and controls multiple Ca2+-dependent responses essential for fertilization. We hypothesized that chemical UV filters may mimic the physiological action of pro...

journal_title：Endocrinology

authors： Rehfeld A,Dissing S,Skakkebæk NE

更新日期：2016-11-01 00:00:00

abstract：:The level of fructose 2,6-bisphosphate (F2,6P2), a potent stimulator of 6-phosphofructo-1-kinase and inhibitor of fructose 1,6-bisphosphatase, was measured in three different muscle types (tensor fascia latae, biceps femoris, and soleus) and in the liver of normal and diabetic rats. The mean (+/- SEM) content of F2,6P...

journal_title：Endocrinology

authors： Dall'Aglio E,Reaven GM,Azhar S

更新日期：1986-01-01 00:00:00

abstract：:We have previously demonstrated that the gonadotropin-mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death-related genes, including members of the bcl-2 gene family (bcl-2, bax, and bcl-x). Recently, the product of the p53 tumor suppressor gene, a pro...

journal_title：Endocrinology

authors： Tilly KI,Banerjee S,Banerjee PP,Tilly JL

更新日期：1995-04-01 00:00:00

abstract：:With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat, corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurophistological methods. The delica...

journal_title：Endocrinology

authors： Sétáló G,Vigh S,Schally AV,Arimura A,Flerkó B

更新日期：1975-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) inhibits the embryonic migration of GnRH neurons and regulates hypothalamic GnRH release. A subset of GnRH neurons expresses GABA along their migratory route in the nasal compartment before entering the brain, suggesting that GABA produced by GnRH neurons may help regulate the migratory ...

journal_title：Endocrinology

authors： Heger S,Seney M,Bless E,Schwarting GA,Bilger M,Mungenast A,Ojeda SR,Tobet SA

更新日期：2003-06-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:Thyroid hormone action is mediated through its nuclear receptors (TRs), which bind to target DNA sequences [thyroid hormone response element (TRE)] as a homodimer or a heterodimer with 9-cis-retinoic acid receptors. Mutations of TR beta identified in patients with resistance to thyroid hormone (RTH) cluster primarily ...

journal_title：Endocrinology

authors： Nomura Y,Nagaya T,Tsukaguchi H,Takamatsu J,Seo H

更新日期：1996-10-01 00:00:00

abstract：:Somatostatin has been demonstrated to negatively regulate pancreatic growth in vivo. In this study we used the AR4-2J rat pancreatic acinar tumor cell line to investigate the effect of a stable somatostatin analog, SMS 201-995 (SMS) on cell proliferation. SMS induced an antiproliferative effect on both serum or epider...

journal_title：Endocrinology

authors： Viguerie N,Tahiri-Jouti N,Ayral AM,Cambillau C,Scemama JL,Bastié MJ,Knuhtsen S,Estève JP,Pradayrol L,Susini C

更新日期：1989-02-01 00:00:00

abstract：:Seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. Plasma samples were analyzed for monkey chorionic gonadotropin (mCG), monkey chorionic somatomammotropin (mCS), and prolactin by radioimmunoassay. Levels o...

journal_title：Endocrinology

authors： Walsh SW,Wolf RC,Meyer RK,Aubert ML,Friesen HG

更新日期：1977-03-01 00:00:00

abstract：:Exposure of adipocytes to glucocorticoid hormones in vitro causes inhibition of glucose transport and metabolsim. Maximal inhibition of glucose oxidations is reduced from 42-50 to 22-25 to 5-8% in young, mature, and senescent rat adipocytes, respectively. Percent values also reflect absolute reductions since basal lev...

journal_title：Endocrinology

authors： Roth GS,Livingston JN

更新日期：1976-09-01 00:00:00

abstract：:Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary somatotrophs, generate deleterious effects. We recently described a targeted secretion inhibitor (SXN101742) comprising a GHRH domain and the endopeptidase domain of botulinum toxin serotype D (GHRH-light chain endopeptidase type D d...

journal_title：Endocrinology

authors： Somm E,Bonnet N,Zizzari P,Tolle V,Toulotte A,Jones R,Epelbaum J,Martinez A,Hüppi PS,Aubert ML

更新日期：2013-11-01 00:00:00

abstract：:Steady state levels of plasma membrane receptors (measured in radioligand assays) result from processes that contribute to the production of receptors (synthesis, recycling, and unmasking) as well as those that contribute to the loss of receptors (degradation, internalization, and inactivation). Accordingly, we have p...

journal_title：Endocrinology

authors： Braden TD,Conn PM

更新日期：1990-05-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

journal_title：Endocrinology

authors： Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

更新日期：1995-12-01 00:00:00