The Endocrine Society Centennial: No Longer a Surprise: Estrogenic Chemicals in a Multitude of Places.

abstract：:In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with ...

journal_title：Endocrinology

authors： Varghese S,Rydziel S,Jeffrey JJ,Canalis E

更新日期：1994-06-01 00:00:00

abstract：:Uterine contractions at parturition depend upon a variety of factors, including gamma-aminobutyric acid (GABA)-ergic stimulation. A new subunit of the GABA(A) receptor, pi, has recently been identified as being particularly abundant in the rat uterus. Reduced derivatives of progesterone, such as the 3alpha,5alpha-redu...

journal_title：Endocrinology

authors： Fujii E,Mellon SH

更新日期：2001-05-01 00:00:00

abstract：:Lipoprotein lipase (LPL) is a key regulator of triglyceride clearance. Its coordinated regulation during feeding and fasting is critical for maintaining lipid homeostasis and energy supply. Angiopoietin-like (Angptl)3 and Angptl4 are secreted proteins that have been demonstrated to regulate triglyceride metabolism by ...

journal_title：Endocrinology

authors： Köster A,Chao YB,Mosior M,Ford A,Gonzalez-DeWhitt PA,Hale JE,Li D,Qiu Y,Fraser CC,Yang DD,Heuer JG,Jaskunas SR,Eacho P

更新日期：2005-11-01 00:00:00

abstract：:We characterized four antipeptide polyclonal antibodies (abs) able to specifically recognize each thyroid hormone receptor (TR) isoform. The abs immunoprecipitated both the in vitro synthesized receptor and the receptor expressed in E. coli and their specificity was confirmed by competition studies and immunohistochem...

journal_title：Endocrinology

authors： Falcone M,Miyamoto T,Fierro-Renoy F,Macchia E,DeGroot LJ

更新日期：1992-11-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...

journal_title：Endocrinology

authors： Haines CD,Harvey PA,Luczak ED,Barthel KK,Konhilas JP,Watson PA,Stauffer BL,Leinwand LA

更新日期：2012-09-01 00:00:00

abstract：:Ewes were treated systemically during the periovulatory period with the antihistamines diphenhydramine (H1-receptor antagonist) and(or) cimetidine (H2-receptor antagonist). None of the treatments prevented ovulation. However, the combination of drugs inhibited subsequent function of the corpus luteum (CL) as assessed ...

journal_title：Endocrinology

authors： Halterman SD,Murdoch WJ

更新日期：1986-12-01 00:00:00

abstract：:To determine if CRH and glucocorticoids are respectively required for hypophagia and catabolism in malnutrition, we have subjected wild-type (WT) and CRH knockout (KO) mice to dietary protein deprivation. Compared with WT mice, CRH KO mice exhibited greater decreases in food intake and negligible change in plasma cort...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-08-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:Immunoreactive LHRH was detected in hypothalamic and extrahypothalamic brain extracts of the rat, bird (pigeon and chicken), reptile (tortoise and lizard), amphibian (frog and toad), teleost (cichid), and elasmobranch (dogfish) and in the whole brain of the cyclostome (bagfish). The concentration of hypothalamic immun...

journal_title：Endocrinology

authors： King JA,Millar RP

更新日期：1980-03-01 00:00:00

abstract：:Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the consumption of caffeine during pregnancy may increase the risk of pregnancy loss; however, little is known about the direct effect of caffeine on normal trophoblast ...

journal_title：Endocrinology

authors： Grant I,Cartwright JE,Lumicisi B,Wallace AE,Whitley GS

更新日期：2012-09-01 00:00:00

abstract：:Treatment of inflammation is often accomplished through the use of glucocorticoids. However, their use is limited by side effects. We have examined the activity of a novel glucocorticoid receptor ligand that binds the receptor efficiently and strongly represses inflammatory gene expression. This compound has potent an...

journal_title：Endocrinology

authors： López FJ,Ardecky RJ,Bebo B,Benbatoul K,De Grandpre L,Liu S,Leibowitz MD,Marschke K,Rosen J,Rungta D,Viveros HO,Yen WC,Zhi L,Negro-Vilar A,Miner JN

更新日期：2008-05-01 00:00:00

abstract：:The LHX3 transcription factor is required for pituitary and nervous system development in mammals. Mutations in the human gene are associated with hormone-deficiency diseases. The gene generates two mRNAs, hLHX3a and hLHX3b, which encode three proteins with different properties. Here, the cis elements and trans-acting...

journal_title：Endocrinology

authors： Yaden BC,Garcia M 3rd,Smith TP,Rhodes SJ

更新日期：2006-01-01 00:00:00

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:Recently, we have reported that retinoic acid (RA), similarly to retinol acetate, is able to reinitiate spermatogenesis in vitamin A-deficient rats. Here, we investigated the expression of RA receptors RAR alpha, RAR beta, RAR gamma, and retinoid X receptor RXR alpha by Northern blot analysis of poly(A)+ RNA of testes...

journal_title：Endocrinology

authors： van Pelt AM,van den Brink CE,de Rooij DG,van der Saag PT

更新日期：1992-07-01 00:00:00

abstract：:The actions and the mechanisms of action of epidermal growth factor (EGF) in testicular steroidogenesis were investigated using a model of primary culture of purified porcine Leydig cells from immature intact animals. EGF decreased (1.7-fold) human CG (hCG)-induced dehydroepiandrosterone (DHEA) accumulation in the med...

journal_title：Endocrinology

authors： Sordoillet C,Chauvin MA,de Peretti E,Morera AM,Benahmed M

更新日期：1991-04-01 00:00:00

abstract：:Most studies of lipoprotein requirements for steroid secretion by the adrenal have examined the mixed cell population of the whole gland; none have examined lipoprotein requirements of guinea pig adrenocortical cells. In this study the effect of exogenous lipoprotein on the ability of cells from each of the different ...

journal_title：Endocrinology

authors： Black VH

更新日期：1987-02-01 00:00:00

abstract：:Amphibian skin has functional characteristics of epithelium in the mammalian distal nephron and plays an important role in sodium and water metabolism in these animals. A peptide extracted from the skin of the Australian frog Crinia georgiana has been purified, has been determined to have the amino acid sequence of [A...

journal_title：Endocrinology

authors： Siragy H,Howell N,Rose CE Jr,Khosla MC,Peach MJ,Carey RM

更新日期：1988-01-01 00:00:00

abstract：:The effects of alloxan-induced diabetes on uterine decidualization and the associated changes in uterine blood flow (UBF) and corpus luteum activity were evaluated in rats between days 4-9 of pseudopregnancy (day 0 = ovulation). Rats were made diabetic (D) with a 40 mg/kg injection (iv) of alloxan on day 1 of pseudopr...

journal_title：Endocrinology

authors： Garris DR

更新日期：1988-02-01 00:00:00

abstract：:In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Rusvai E,Fejes-Tóth G

更新日期：1994-04-01 00:00:00

abstract：:Vitellogenin (Vg) is a major yolk protein precursor in numerous oviparous animals. Numerous studies in bilateral oviparous animals have shown that Vg sequences are conserved across taxa and that Vgs are synthesized by somatic-cell lineages, transported to and accumulated in oocytes, and eventually used for supporting ...

journal_title：Endocrinology

authors： Shikina S,Chen CJ,Chung YJ,Shao ZF,Liou JY,Tseng HP,Lee YH,Chang CF

更新日期：2013-09-01 00:00:00

abstract：:Our previous studies implicated the involvement of protein kinase-A in the inhibitory effects of isoproterenol and relaxin on oxytocin-stimulated phosphoinositide turnover in rat myometrium. To understand the possible mechanisms involved, the properties and regulation of phospholipase-C (PLC) in purified myometrial pl...

journal_title：Endocrinology

authors： Wen Y,Anwer K,Singh SP,Sanborn BM

更新日期：1992-09-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:Fibroblast growth factor 9 (FGF9) signal has a role in organogenesis of the mammalian testis by controlling migration of mesonephric cells to the XY gonad, but neither it nor the FGF receptors is expressed sex-specifically. Of the Sprouty genes encoding antagonists of receptor tyrosine kinases including FGFr, mSprouty...

journal_title：Endocrinology

authors： Chi L,Itäranta P,Zhang S,Vainio S

更新日期：2006-08-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

journal_title：Endocrinology

authors： Traish AM,Müller RE,Wotiz HH

更新日期：1986-04-01 00:00:00

abstract：:Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological processes, including sleep. Beginning at puberty, girls report more sleep complaints than boys, which is maintained throughout the reproductive life stage. Sleep problems are exacerbated during the menopausal transition, evidenced by g...

journal_title：Endocrinology

authors： Brown AMC,Gervais NJ

更新日期：2020-09-01 00:00:00

abstract：:We previously examined the segregation patterns of two polymorphic restriction enzyme sites for EcoRI and HindIII in the 3'-flanking region of human CG-alpha gene in placenta and choriocarcinoma. We observed that a unique combination of restriction sites predominates in choriocarcinoma while this pattern was rare in p...

journal_title：Endocrinology

authors： Otani T,Boime I

更新日期：1986-11-01 00:00:00

abstract：:Thyroid hormones increase bone turnover in vivo and stimulate bone resorption in vitro. Clinical states associated with excess circulating thyroid hormone levels are known to produce osteoporosis. To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence ...

journal_title：Endocrinology

authors： Britto JM,Fenton AJ,Holloway WR,Nicholson GC

更新日期：1994-01-01 00:00:00

abstract：:Evidence is presented that in vitamin D deficiency there are aberrations of estrogen metabolism in the laying hen. Five White Leghorn hens, 35 weeks of age, all laying soft shelled eggs as a result of complete withdrawal of supplemental vitamin D3 (D3) from the diet, were found to have a 3-fold higher molar ratio of p...

journal_title：Endocrinology

authors： Tsang CP,Grunder AA

更新日期：1984-12-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00