Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform.

abstract：:Two experiments tested whether serotonergic neurons participate in the acute feedback effects of estradiol on LH and PRL secretion. In the first study, ovariectomized female rats received oil vehicle or estradiol benzoate and were killed 3 h later. The turnover of serotonin [5-hydroxytryptamine (5-HT)] in microdissect...

journal_title：Endocrinology

authors： Johnson MD,Crowley WR

更新日期：1983-12-01 00:00:00

abstract：:MCRs of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined in the morning and evening in four chronically chaired adult rhesus monkeys (Macaca mulatta) by means of steady state infusion of [4-14C]testosterone and [1,2-3H]dihydrotestosterone. Morning and evening MCRs were comparable for both T and D...

journal_title：Endocrinology

authors： Sholl SA,Toivola PT,Robinson JA

更新日期：1979-08-01 00:00:00

abstract：:To investigate the possibility that a common phenomenon might exist by which glucocorticoids influence responses to thyroid hormones, the cytosol levels of four proteins were measured after 2 days of treatment with L-T3 (T3; 50 micrograms/100 g. day 2) and/or cortisone (2 mg/100 g./day) in adult male hypothyroid rats....

journal_title：Endocrinology

authors： Shapiro LE,Sachchidananda J

更新日期：1982-08-01 00:00:00

abstract：:Melanocortin receptor 4 (MCR4) and CB(1) cannabinoid receptors independently modulate food intake. Although an interaction between the cannabinoid and melanocortin systems has been found in recovery from hemorrhagic shock, the interaction between these systems in modulating food intake has not yet been examined. The p...

journal_title：Endocrinology

authors： Verty AN,McFarlane JR,McGregor IS,Mallet PE

更新日期：2004-07-01 00:00:00

abstract：:The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a high-glucose milieu. Rat IRPTCs were cultured in monolayer. ANG and ANG mRNA expre...

journal_title：Endocrinology

authors： Zhang SL,Chen X,Wei CC,Filep JG,Tang SS,Ingelfinger JR,Chan JS

更新日期：2002-12-01 00:00:00

abstract：:The mechanism by which xylazine raises plasma glucose but lowers insulin concentrations was examined in Holstein cows. Intravenous injection of xylazine (15-150 micrograms/kg) induced a dose-dependent hyperglycemia and hypoinsulinemia for 3-4 h. An alpha 2-adrenergic blocking agent, yohimbine, and an alpha 1- and alph...

journal_title：Endocrinology

authors： Hsu WH,Hummel SK

更新日期：1981-09-01 00:00:00

abstract：:The rate-limiting event for combination of hCG alpha- and beta-subunits in JAR choriocarcinoma cells is the rate of disulfide bond formation in the beta-subunit. This is accompanied by a conformational change that produces a combination-competent form of the beta-subunit. The combination reaction, however, is incomple...

journal_title：Endocrinology

authors： Beebe JS,Huth JR,Ruddon RW

更新日期：1990-01-01 00:00:00

abstract：:Chronically elevated fatty acids contribute to insulin resistance through poorly defined mechanisms. Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) have been implicated in lipid-induced insulin resistance. However, the UPR is also a fundamental mechanism required for cell adaptati...

journal_title：Endocrinology

authors： Achard CS,Laybutt DR

更新日期：2012-05-01 00:00:00

abstract：:The effects of estradiol valerate and constant light exposure on the histological appearance of the arcuate nucleus were assessed in female rats. Both of these treatments caused significant increases in the numbers of reactive microglial cells and astrocytic granules in the nucleus. Ovariectomy before either treatment...

journal_title：Endocrinology

authors： Brawer JR,Schipper H,Naftolin F

更新日期：1980-07-01 00:00:00

abstract：:The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...

journal_title：Endocrinology

authors： Lippert RN,Ellacott KL,Cone RD

更新日期：2014-05-01 00:00:00

abstract：:Osteoclast-like multinucleated giant cells are induced in bone marrow cultures by 1,25-dihydroxyvitamin D3 and other agents. These cells resemble osteoclasts in their morphology, their ability to resorb bone, and the possession of calcitonin receptors. We report here a biphasic effect of transforming growth factor-bet...

journal_title：Endocrinology

authors： Shinar DM,Rodan GA

更新日期：1990-06-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors with established roles in cholesterol, lipid, and carbohydrate metabolism, although their function in adipocytes is not well characterized. Increased adipose tissue mass in obesity is associated with increased adipocyte lipolysis. Fatty acids (FA) generated by lipolysis c...

journal_title：Endocrinology

authors： Stenson BM,Rydén M,Steffensen KR,Wåhlén K,Pettersson AT,Jocken JW,Arner P,Laurencikiene J

更新日期：2009-09-01 00:00:00

abstract：:Four 1-yr-old, i.e. immature, monkeys (M. fascicularis) were treated with testosterone. For the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. Four similarly aged monkeys served as untreated controls. The t...

journal_title：Endocrinology

authors： Marshall GR,Wickings EJ,Nieschlag E

更新日期：1984-06-01 00:00:00

abstract：:Neonatal exposure to high doses of estrogen results in permanent suppression of prostate growth and reduced sensitivity to androgens in adulthood. It is unclear whether alterations in prostate growth are due to a direct effect of estrogens on the gland or are the result of hypothalamic-pituitary-gonadal axis suppressi...

journal_title：Endocrinology

authors： Jarred RA,Cancilla B,Prins GS,Thayer KA,Cunha GR,Risbridger GP

更新日期：2000-09-01 00:00:00

abstract：:The nuclear receptor peroxisome proliferator-activated receptor (PPAR)gamma modulates the expression of numerous genes involved in glucose and lipid homeostasis and plays a critical role in adipocyte differentiation. Expression of uncoupling protein (UCP)1, which is necessary for thermogenesis, is strongly stimulated ...

journal_title：Endocrinology

authors： Sell H,Berger JP,Samson P,Castriota G,Lalonde J,Deshaies Y,Richard D

更新日期：2004-08-01 00:00:00

abstract：:More than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone (LHRH) and follicle stimulating hormone-releasing hormone (FSHRH) activities in search for LHRH and FSHRH which differ from the decapeptide (pyro)Glu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 (I). Among the porcine fractions te...

journal_title：Endocrinology

authors： Schally AV,Arimura A,Redding TW,Debeljuk L,Carter W,Dupont A,Vilchez-Martinez JA

更新日期：1976-02-01 00:00:00

abstract：:Genetically obese Zucker rats, like obese humans, have normal or elevated circulating insulin-like growth factor-I (IGF-I) levels in the presence of low GH secretion. Hyperinsulinemia, increased energy status, or other nutritional factors associated with obesity could be responsible for these findings directly by incr...

journal_title：Endocrinology

authors： Melián E,Velasco B,Barrios R,Sanchez-Franco F

更新日期：1997-03-01 00:00:00

abstract：:In cultured rat pituitary cells, increases in the cytosolic calcium concentration ([Ca2+]i) and LH release are induced by activation of GnRH receptors as well as by nonreceptor-mediated stimuli. Treatment of pituitary cells with the myosin light chain kinase (MLCK) inhibitor, wortmannin, attenuated GnRH-induced LH rel...

journal_title：Endocrinology

authors： Rao K,Paik WY,Zheng L,Jobin RM,Tomić M,Jiang H,Nakanishi S,Stojilkovic SS

更新日期：1997-04-01 00:00:00

abstract：:For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells tha...

journal_title：Endocrinology

authors： Ducy P

更新日期：2020-10-01 00:00:00

abstract：:The rate of internalization and degradation of radioiodinated hCG and ovine LH (oLH) as well as homologous and heterologous recombinants of their subunits was studied in suspensions of ovine luteal cells. Hormone bound to the plasma membrane was quantified by treating the cells with acidic buffer (pH 3.0) and quantifi...

journal_title：Endocrinology

authors： Mock EJ,Papkoff H,Niswender GD

更新日期：1983-07-01 00:00:00

abstract：:In the present study, steroidogenesis in two different Leydig tumor cell lines was compared. One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute regulatory (StAR) protein only when stimulated by trophic hormones and cAMP analogs. The other, the R2C rat tumor cell line, produces steroids...

journal_title：Endocrinology

authors： Jo Y,Stocco DM

更新日期：2004-12-01 00:00:00

abstract：:GH promptly increases cytosolic free calcium ([Ca2+]i) in freshly isolated rat adipocytes. Adipocytes deprived of GH for 3 h or longer are incapable of increasing [Ca2+]i in response to GH, but instead respond in an insulin-like manner. Insulin blocks the GH-induced increase in [Ca2+]i in GH-replete cells and stimulat...

journal_title：Endocrinology

authors： Gaur S,Yamaguchi H,Goodman HM

更新日期：2000-02-01 00:00:00

abstract：:Fundamental complications of insulin resistance and type 2 diabetes include the development of nonalcoholic fatty liver disease and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very-low-density lipoprotein (VLDL) production. Recently, central glucagon-like peptide-2 receptor (GLP2...

journal_title：Endocrinology

authors： Taher J,Baker C,Alvares D,Ijaz L,Hussain M,Adeli K

更新日期：2018-09-01 00:00:00

abstract：:IGF binding protein-2 (IGFBP-2) has been implicated in the development and spread of a number of tumor types, and its abrogation in experimental models of cancer is associated with decreased tumor growth. This suggests that targeted inhibition of IGFBP-2 expression in some cancers may have therapeutic benefit. In this...

journal_title：Endocrinology

authors： Martin JL,Baxter RC

更新日期：2007-05-01 00:00:00

abstract：:Exercise has a potent insulin-sensitivity enhancing effect on skeletal muscle, but the intracellular mechanisms that mediate this effect are not well understood. In muscle, Ras-related C3 botulinum toxin substrate 1 (Rac1) regulates both insulin- and contraction-stimulated glucose transport and is dysregulated in insu...

journal_title：Endocrinology

authors： Sylow L,Møller LL,D'Hulst G,Schjerling P,Jensen TE,Richter EA

更新日期：2016-08-01 00:00:00

abstract：:Artificial copulomimetic cervical stimulation (CS) induces an immediate release of oxytocin (OT) and prolactin (PRL) followed by a daily PRL rhythm characterized by nocturnal and diurnal surges. Although we have shown that the initial release of PRL is induced by the immediate release of OT, we tested whether the PRL ...

journal_title：Endocrinology

authors： Helena CV,McKee DT,Bertram R,Walker AM,Freeman ME

更新日期：2009-07-01 00:00:00

abstract：:The trace element vanadium (V) exerts insulin-like effects in vitro. The present study examined its effects on glucose homeostasis in rats made diabetic by streptozotocin. Na3VO4 (0.2 or 0.5 mg/ml) was administered ad libitum in drinking water. Fed plasma glucose levels (approximately 26 mmol/liter) fell by 30% and 56...

journal_title：Endocrinology

authors： Brichard SM,Okitolonda W,Henquin JC

更新日期：1988-10-01 00:00:00

abstract：:Insulin-like growth factor (IGF) action in the brain is modulated by IGF-binding proteins (IGFBPs) whose abundance can be altered by other locally expressed growth factors. However, the mechanisms involved are unclear. We here employed the neuroblastoma cell line SK-N-MC as a model to define the mechanisms involved in...

journal_title：Endocrinology

authors： Russo VC,Rekaris G,Baker NL,Bach LA,Werther GA

更新日期：1999-07-01 00:00:00

abstract：:Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...

journal_title：Endocrinology

authors： Schreiber NB,Spicer LJ

更新日期：2012-09-01 00:00:00

abstract：:We describe an in vitro system for evaluating the direct effects of catecholamines on the activity of the type II iodothyronine 5'-deiodinase in dispersed rat brown adipocytes. Incubation with norepinephrine or phenylephrine for 3-4 h causes up to a 5-fold increase in deiodinase activity in these cells. As found in vi...

journal_title：Endocrinology

authors： Obregon MJ,Mills I,Silva JE,Larsen PR

更新日期：1987-03-01 00:00:00