Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1.

abstract：:Inside-out plasma membrane vesicles from a glucose-responsive rat insulinoma showed an ATP- and Mg2(+)-dependent uptake of Ca2+. The Km (concentration giving half-maximal activity) for Ca2+ was 60 nM. In the presence of 0.4 microM free Ca2+, the Km for ATP was 15 microM, and the Km for Mg2+ was 4 microM. Glucose (30 m...

journal_title：Endocrinology

authors： Hoenig M,Culberson LH,Ferguson DC

更新日期：1991-03-01 00:00:00

abstract：:We investigated the effects of the peripheral administration of 17 beta-estradiol (E2), estrone (E1), and the catecholestrogens, 2-hydroxyestradiol (2-OHE2) and 2-hydroxyestrone, (2-OHE1), on anterior pituitary gland PRL release in the prepuberal rat. Steroids in oil were injected sc into 25-day-old female and 35- to ...

journal_title：Endocrinology

authors： Rodriguez-Sierra JF,Blake CA

更新日期：1982-02-01 00:00:00

abstract：:Purified rat Leydig cell cytosol was found to contain a protein kinase which was dependent on the presence of both calcium and phospholipids (phosphatidylserine and diolein), i.e. calcium/phospholipid-dependent protein kinase. The peak of Ca/phospholipid-dependent protein kinase was separated from type I and type II c...

journal_title：Endocrinology

authors： Lin T

更新日期：1985-07-01 00:00:00

abstract：:Peroxisome proliferator activated receptor (PPARγ) is a nuclear receptor transcription factor that regulates adipogenesis and energy homeostasis. Recent studies suggest PPARγ may mediate some of its metabolic effects through actions in the brain. We used a Cre-recombinase-dependent (using NestinCre) conditionally acti...

journal_title：Endocrinology

authors： Stump M,Guo DF,Lu KT,Mukohda M,Cassell MD,Norris AW,Rahmouni K,Sigmund CD

更新日期：2016-11-01 00:00:00

abstract：:Mechanisms underlying lymphocyte infiltration of the thyroid gland and orbit in Graves' disease (GD) are poorly understood. The IGF-I receptor (IGF-IR) is a newly recognized self-antigen that, when activated in GD fibroblasts by IGF-I or GD-IgGs, provokes the expression of IL-16 and RANTES (regulated upon activation, ...

journal_title：Endocrinology

authors： Gianoukakis AG,Douglas RS,King CS,Cruikshank WW,Smith TJ

更新日期：2006-04-01 00:00:00

abstract：:The present study was conducted to elucidate the role of activin A in tubulogenesis of vascular endothelial cells. Activin A was produced in bovine aortic endothelial cells (BAEC). These cells also expressed the type I and type II activin receptors. When added to BAEC cultured in a collagen gel, activin A induced capi...

journal_title：Endocrinology

authors： Maeshima K,Maeshima A,Hayashi Y,Kishi S,Kojima I

更新日期：2004-08-01 00:00:00

abstract：:The fragile X syndrome is the most frequent hereditary form of mental retardation. This X-linked disorder is, in most cases, caused by an unstable and expanding trinucleotide CGG repeat located in the 5'-untranslated region of the gene involved, the fragile X mental retardation 1 (FMR1) gene. Expansion of the CGG repe...

journal_title：Endocrinology

authors： Slegtenhorst-Eegdeman KE,de Rooij DG,Verhoef-Post M,van de Kant HJ,Bakker CE,Oostra BA,Grootegoed JA,Themmen AP

更新日期：1998-01-01 00:00:00

abstract：:Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high, but similar, immunodetectable levels of each isozyme based on Western...

journal_title：Endocrinology

authors： Corbin CJ,Trant JM,Walters KW,Conley AJ

更新日期：1999-11-01 00:00:00

abstract：:Bone remodeling is a complex process of coordinated resorption and formation of bone, which is regulated by systemic hormones and by local factors. We have previously shown that the peptide hormone adrenomedullin is mitogenic to osteoblastic cells in vitro and that it promotes bone growth in vivo. The aim of the prese...

journal_title：Endocrinology

authors： Naot D,Callon KE,Grey A,Cooper GJ,Reid IR,Cornish J

更新日期：2001-05-01 00:00:00

abstract：:Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 thera...

journal_title：Endocrinology

authors： O'Sullivan U,Gluckman PD,Breier BH,Woodall S,Siddiqui RA,McCutcheon SN

更新日期：1989-11-01 00:00:00

abstract：:Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)]c) and insulin secretion in mouse islets. Alone PKA activator ...

journal_title：Endocrinology

authors： Henquin JC,Nenquin M

更新日期：2014-09-01 00:00:00

abstract：:Proteolytic degradation of extracellular matrix components has been suggested to play an essential role in the occurrence of ovulation. Recent studies in our laboratory have indicated that the plasminogen activator and matrix metalloproteinase systems, which were previously believed to be crucial for ovulation, are no...

journal_title：Endocrinology

authors： Wahlberg P,Nylander A,Ahlskog N,Liu K,Ny T

更新日期：2008-10-01 00:00:00

abstract：:Recent evidence indicates a localized origin in the olfactory placode for the mammalian forebrain neurons that express GnRH. To identify the cellular and molecular signals that induce the GnRH phenotype, we cloned and characterized a cDNA encoding the GnRH prohormone, the precursor for both GnRH-I and GnRH-associated ...

journal_title：Endocrinology

authors： Hayes WP,Wray S,Battey JF

更新日期：1994-04-01 00:00:00

abstract：:Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was local...

journal_title：Endocrinology

authors： Chaudhary J,Mosher R,Kim G,Skinner MK

更新日期：2000-08-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...

journal_title：Endocrinology

authors： Ionut V,Castro AV,Woolcott OO,Stefanovski D,Iyer MS,Broussard JL,Mkrtchyan H,Burch M,Elazary R,Kirkman E,Bergman RN

更新日期：2014-04-01 00:00:00

abstract：:The neuronal growth-associated protein (GAP)-43 has been localized in both long fibers and punctate clusters by immunocytochemistry within the rat anterior pituitary (AP). After adrenalectomy (ADX), GAP-43 immunoreactivity (GAP-43-ir) is greatly increased and is associated with corticotrophs at the light microscopic l...

journal_title：Endocrinology

authors： Paden CM,Watt JA,Selong TH,Paterson CL,Cranston HJ

更新日期：2006-02-01 00:00:00

abstract：:Chorionic gonadotropin (CG) is an early embryo-derived signal that is known to support the corpus luteum. An in vivo baboon model was used to study the direct actions of human CG (hCG) on the endometrium, during the periimplantation period. Endometrial gene expression was analyzed using microarrays. The endometrial bi...

journal_title：Endocrinology

authors： Sherwin JR,Sharkey AM,Cameo P,Mavrogianis PM,Catalano RD,Edassery S,Fazleabas AT

更新日期：2007-02-01 00:00:00

abstract：:We compared the somatomedin (SM) activity of perfusates of livers from normal and hypophysectomized (hypox) rats with and without the addition of growth hormone (GH) to the perfusions. Livers were perfused for a total of 3 hours, with a change of Waymouth's medium MB 752/l every 30 min, in a continously recirculating ...

journal_title：Endocrinology

authors： Phillips LS,Herington AC,Karl IE,Daughaday WH

更新日期：1976-03-01 00:00:00

abstract：:Activating ras point mutations are frequently found in skeletal muscle tumors such as rhabdomyosarcomas. In this study we investigated the impact of two different H-ras mutants in skeletal muscle differentiation: RasV12, a constitutively active form, and RasV12C40, a mutant deficient in Raf1 activation. Stably transfe...

journal_title：Endocrinology

authors： De Alvaro C,Nieto-Vazquez I,Rojas JM,Lorenzo M

更新日期：2008-02-01 00:00:00

abstract：:The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in this model are scanty and contradictory. In the present study, we inves...

journal_title：Endocrinology

authors： Nguyen-Yamamoto L,Deal CL,Finkelstein JA,Van Vliet G

更新日期：1994-03-01 00:00:00

abstract：:Nuclear proteins extracted from purified nuclei with 0.4M KCl at pH 7.4 OR 8.5 are able to bind L-triiodothyronine (T3) giving rise to nuclear thyroid hormone binding protein-T3 (NTBP-T3) complexes. Binding is maximum in 3 h at 20 C. It is thermolabile even at 36 C, inhibited by p-hydroxymercuribenzoate and markedly e...

journal_title：Endocrinology

authors： Torresani J,DeGroot LJ

更新日期：1975-05-01 00:00:00

abstract：:It is known that the circadian rhythm in hepatic phosphoenolpyruvate carboxykinase expression (a limiting catalytic step of gluconeogenesis) and hepatic glucose production is maintained by both daily oscillation in autonomic inputs to the liver and night feeding behavior. However, increased glycemia and reduced melato...

journal_title：Endocrinology

authors： Nogueira TC,Lellis-Santos C,Jesus DS,Taneda M,Rodrigues SC,Amaral FG,Lopes AM,Cipolla-Neto J,Bordin S,Anhê GF

更新日期：2011-04-01 00:00:00

abstract：:Male rats, kept under a lighting condition of 14-h light, 10-h dark, were subjected to scheduled feeding regimens. Food was available either in the early light phase or the early dark phase. The 24-h rhythms of serum corticosterone and of N-acetylserotonin (NAS) and melatonin (MT) in the pineal and serum were determin...

journal_title：Endocrinology

authors： Ho AK,Burns TG,Grota LJ,Brown GM

更新日期：1985-05-01 00:00:00

abstract：:Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and perit...

journal_title：Endocrinology

authors： Pini M,Gove ME,Sennello JA,van Baal JW,Chan L,Fantuzzi G

更新日期：2008-08-01 00:00:00

abstract：:There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...

journal_title：Endocrinology

authors： Heindel JJ,Balbus J,Birnbaum L,Brune-Drisse MN,Grandjean P,Gray K,Landrigan PJ,Sly PD,Suk W,Cory Slechta D,Thompson C,Hanson M

更新日期：2015-10-01 00:00:00

abstract：:Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...

journal_title：Endocrinology

authors： Martinez-Arguelles DB,Papadopoulos V

更新日期：2015-01-01 00:00:00

abstract：:We have established a system, the CA77 rat medullary thyroid carcinoma cell line, for studying the products of somatostatin (SS) gene expression. Based on the amino acid sequence of proSS, we developed a RIA for the amino terminus of proSS (proSS-NTP) and demonstrated in acidic cell extracts two major proSS-NTP-contai...

journal_title：Endocrinology

authors： Aron DC,Roos BA

更新日期：1986-01-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) that interfere with the steroid axis can affect amelogenesis, leading to enamel hypomineralization similar to that of molar incisor hypomineralization, a recently described enamel disease. We investigated the sex steroid receptors that may mediate the effects of EDCs during rat am...

journal_title：Endocrinology

authors： Jedeon K,Loiodice S,Salhi K,Le Normand M,Houari S,Chaloyard J,Berdal A,Babajko S

更新日期：2016-11-01 00:00:00

abstract：:The concentrations and contents of vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) in the brain and of these peptides along with secretin and glucagon-like immunoreactivity (GLI) in the gut were compared in a group of 16 5-day fasted adult Sprague-Dawley rats with the corresponding peptides in a group of...

journal_title：Endocrinology

authors： Zheng B,Eng J,Yalow RS

更新日期：1987-02-01 00:00:00