Triiodothyronine binding to liver nuclear solubilized proteins in vitro.

abstract：:From the MtTF4 tumor of rat pituitary origin we established the F4Z2 cell line whose growth is stimulated by 17 beta-estradiol (E2). Taking E2 actions as references we investigated actions of other effectors on the proliferation, protein, and insulin growth factor-I (IGF-I) secretions of F4F2 cells. Dexamethasone (Dex...

journal_title：Endocrinology

authors： Zhou-Li F,Joly-Pharaboz MO,Bouillard B,Albaladejo V,Nicolas B,Andre J

更新日期：1991-06-01 00:00:00

abstract：:An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...

journal_title：Endocrinology

authors： Henrikson KP,Jazin EE,Greenwood JA,Dickerman HW

更新日期：1990-01-01 00:00:00

abstract：:For 3 yr, 1-yr synchronized circannual rhythms were found for the chick oviduct weights, amounts of soluble protein, concentrations of the progesterone receptor in this organ, and capacity of this steroid-receptor complex in cytosol in bind in vitro to deoxyribonucleoprotein acceptor sites. By fitting the data with 1-...

journal_title：Endocrinology

authors： Spelsberg TC,Halberg F

更新日期：1980-10-01 00:00:00

abstract：:The effects of dopamine on PRL secretion and lysosomal enzyme activity in anterior pituitary tissue from rats selected during various stages of the estrous cycle were examined under in vitro conditions. During the estrous cycle, there was a marked variation in the capacity of dopamine to stimulate the activity of the ...

journal_title：Endocrinology

authors： Nansel DD,Gudelsky GA,Reymond MJ,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

journal_title：Endocrinology

authors： Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

更新日期：2009-05-01 00:00:00

abstract：:A serially transplantable, chemically induced pancreatic islet cell tumor was developed in Lewis rats. The original tumor was induced by the administration of streptozotocin and nicotinamide. It was subsequently maintained by ip or sc transplantation of tissue fragments into recipient animals. Tumors generally grew to...

journal_title：Endocrinology

authors： Chick WL,Appel MC,Weir GC,Like AA,Lauris V,Porter JG,Chute RN

更新日期：1980-10-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...

journal_title：Endocrinology

authors： Bai JX,Yan B,Zhao ZN,Xiao X,Qin WW,Zhang R,Jia LT,Meng YL,Jin BQ,Fan DM,Wang T,Yang AG

更新日期：2013-02-01 00:00:00

abstract：:Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such as rosiglitazone, produce insulin sensitization in rodent models of insulin resistance and type 2 diabetes. In sharp contrast to the TZDs that produce significant increases in body weight gai...

journal_title：Endocrinology

authors： Leibowitz MD,Ardecky RJ,Boehm MF,Broderick CL,Carfagna MA,Crombie DL,D'Arrigo J,Etgen GJ,Faul MM,Grese TA,Havel H,Hein NI,Heyman RA,Jolley D,Klausing K,Liu S,Mais DE,Mapes CM,Marschke KB,Michellys PY,Montrose-Rafi

更新日期：2006-02-01 00:00:00

abstract：:In vertebrates, activation of the GnRH receptor is necessary to initiate the reproductive cascade. However, little is known about the characteristics of GnRH receptors before the vertebrates evolved. Recently genome sequencing was completed for amphioxus, Branchiostoma floridae. To understand the GnRH receptors (GnRHR...

journal_title：Endocrinology

authors： Tello JA,Sherwood NM

更新日期：2009-06-01 00:00:00

abstract：:Prolactin has been associated with many effects and has been implicated in the pathogenesis of pregnancy-related hypertensive disorders, although little is known about its vascular effects. The present study was designed to determine the primary effect of prolactin on regional vascular beds and the mechanisms involved...

journal_title：Endocrinology

authors： Molinari C,Grossini E,Mary DA,Uberti F,Ghigo E,Ribichini F,Surico N,Vacca G

更新日期：2007-08-01 00:00:00

abstract：:A new perfusion system of isolated rat femora was established, and the effect of PTH or calcitonin (CT) on cAMP release from the adult bone was examined. Stimulation of cAMP release from the isolated perfused bone peaked rapidly between 5 and 10 min after human PTH (hPTH)-(1-34) or eel CT injection, respectively, and ...

journal_title：Endocrinology

authors： Sugimoto T,Fukase M,Tsutsumi M,Imai Y,Hishikawa R,Yoshimoto Y,Fujita T

更新日期：1985-11-01 00:00:00

abstract：:Calcium (Ca2+) ionophore A23187 increased the intracellular cAMP content and PRL release in normal rat anterior pituitary cells. Cotreatment with dopamine reduced both control and A23187-stimulated cAMP accumulation and PRL release. The dopamine antagonist spiperone restored the response of cAMP to ionophoric stimulat...

journal_title：Endocrinology

authors： Schettini G,Cronin MJ,MacLeod RM

更新日期：1983-05-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:Disruption of the pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mice has demonstrated a role for this highly conserved neuropeptide in the regulation of metabolism and temperature control. Localization of PACAP neurons within hypothalamic nuclei that regulate appetite suggest PACAP may affect feed...

journal_title：Endocrinology

authors： Adams BA,Gray SL,Isaac ER,Bianco AC,Vidal-Puig AJ,Sherwood NM

更新日期：2008-04-01 00:00:00

abstract：:During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...

journal_title：Endocrinology

authors： Jennings JC,Mohan S,Baylink DJ

更新日期：1989-07-01 00:00:00

abstract：:Using a sensitive method for the simultaneous measurement of TSH subunit mRNAs, we have investigated their hormonal regulation in the pituitary glands of normal and hypothyroid rats. Oligodeoxyribonucleotides (probes) complementary to coding regions of rat alpha- and TSH beta-subunit mRNAs were synthesized. These prob...

journal_title：Endocrinology

authors： Carr FE,Ridgway EC,Chin WW

更新日期：1985-09-01 00:00:00

abstract：:The pigeon crop has long been known as a target tissue for PRL action. This study investigates the molecular events associated with PRL stimulation of the pigeon crop sac. Several experiments were performed comparing isolates from PRL-injected pigeons (200 micrograms/day, im, for 3 days) to saline-treated pigeons. Ele...

journal_title：Endocrinology

authors： Pukac LA,Horseman ND

更新日期：1984-05-01 00:00:00

abstract：:We previously reported that cAMP inhibits autocrine IGF-I gene expression in rat C6 glioma cells. In this study we examined the influence of cAMP on IGF-binding protein gene expression in C6 cells. cAMP potently inhibited IGF-binding protein-3 mRNA and, to a lesser extent, IGF-binding protein-4 mRNA and transiently st...

journal_title：Endocrinology

authors： Wang L,Ma X,Yeh LC,Adamo ML

更新日期：2001-09-01 00:00:00

abstract：:To elucidate the roles of the hypothalamic peptides, GH-releasing hormone (GRH) and somatostatin (SRIH), potentially responsible for altered GH dynamics in diabetes, we studied the time courses of their changes in level associated with altered GH secretion in streptozotocin (STZ)-induced diabetic mice. Diabetic mice w...

journal_title：Endocrinology

authors： Murao S,Sato M,Tamaki M,Niimi M,Ishida T,Takahara J

更新日期：1995-10-01 00:00:00

abstract：:P19 EPI-7, a differentiated murine embryonal carcinoma cell line with an epithelioid morphology, does not require external growth factors for proliferation under clonal and subconfluent conditions. At saturation density, however, cells become quiescent in the G1/G0 phase of the cell cycle from which they can be restim...

journal_title：Endocrinology

authors： van Zoelen EJ,Koornneef I,Holthuis JC,Ward-van Oostwaard TM,Feijen A,de Poorter TL,Mummery CL,van Buul-Offers SC

更新日期：1989-04-01 00:00:00

abstract：:Diabetes is associated with increased generation of cytokines and tissue inflammation, but it is unclear how increased cytokine synthesis is causally related to the development of diabetic complications. Here, we report that exposure to high (25 mm) glucose, but not iso-osmotic concentrations of mannitol or 3-methyl g...

journal_title：Endocrinology

authors： Ramana KV,Tammali R,Reddy AB,Bhatnagar A,Srivastava SK

更新日期：2007-09-01 00:00:00

abstract：:The roles of steroids in zebrafish sex differentiation, gonadal development, and function of the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant zebrafish to explore such processes. Fdx1b is an essential electron-providing cofactor to mitochondrial steroidogenic enzymes, which are cruci...

journal_title：Endocrinology

authors： Oakes JA,Li N,Wistow BRC,Griffin A,Barnard L,Storbeck KH,Cunliffe VT,Krone NP

更新日期：2019-10-01 00:00:00

abstract：:The hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), can efficiently increase cAMP levels in pituitary cells and release a number of pituitary hormones, suggesting an important physiological role for this peptide in pituitary function. Exposure of GH3 rat pituitary cells to PACAP resul...

journal_title：Endocrinology

authors： Coleman DT,Chen X,Sassaroli M,Bancroft C

更新日期：1996-04-01 00:00:00

abstract：:The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons h...

journal_title：Endocrinology

authors： Brown J,Sagante A,Mayer T,Wright A,Bugescu R,Fuller PM,Leinninger G

更新日期：2018-09-01 00:00:00

abstract：:Cultured astroglial cells were found to contain a type II 5'-deiodinase (5'D) activity which was increased by 10(-3) M (Bu)2cAMP but not by 2 X 10(-3) M n-butyrate. 8-Bromo-cAMP (8-Br-cAMP) (10(-3) M) also increased this enzyme activity. Cycloheximide (2 micrograms/ml) inhibited the 8-Br-cAMP effect on 5'D activity. F...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Pierre M,Francon J

更新日期：1988-09-01 00:00:00

abstract：:The effects of L-leucine, D-leucine, and L-isoleucine upon the secretion of glucagon and insulin were investigated using the isolated, perfused rat pancreas. All experiments were conducted in the presence of 5.6 mM D-glucose. Ten-minute perfusions of 2, 5, and 10 mM L-leucine induced the release of glucagon and insuli...

journal_title：Endocrinology

authors： Pek S,Santiago JC,Tai TY

更新日期：1978-10-01 00:00:00

abstract：:To determine if CRH and glucocorticoids are respectively required for hypophagia and catabolism in malnutrition, we have subjected wild-type (WT) and CRH knockout (KO) mice to dietary protein deprivation. Compared with WT mice, CRH KO mice exhibited greater decreases in food intake and negligible change in plasma cort...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-08-01 00:00:00

abstract：:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...

journal_title：Endocrinology

authors： Larson KR,Russo KA,Fang Y,Mohajerani N,Goodson ML,Ryan KK

更新日期：2017-10-01 00:00:00

abstract：:Seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. Plasma samples were analyzed for monkey chorionic gonadotropin (mCG), monkey chorionic somatomammotropin (mCS), and prolactin by radioimmunoassay. Levels o...

journal_title：Endocrinology

authors： Walsh SW,Wolf RC,Meyer RK,Aubert ML,Friesen HG

更新日期：1977-03-01 00:00:00