Abstract:
:With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat, corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurophistological methods. The delicate fiber system can be traced to the region of the rectrochiasmatic area and especially to that of the arcuate nucleus but not farther. Nerve cells do not show any immunopositive reaction for LH-RH in the experimental conditions studied. LH-RH positive nerve fibers terminate on or in the immediate vicinity of the capillary loops penetrating the median eminence.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Sétáló G,Vigh S,Schally AV,Arimura A,Flerkó Bdoi
10.1210/endo-96-1-135subject
Has Abstractpub_date
1975-01-01 00:00:00pages
135-42issue
1eissn
0013-7227issn
1945-7170journal_volume
96pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::A new member of the connexin family was isolated from the porcine ovary. The amino acid sequence deduced from the nucleotide sequence of genomic as well as complementary DNA clones predicted the reading frame encoding the 60-kDa protein product, indicating the largest molecular mass among the connexin family genes ana...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.1.5665
更新日期:1998-01-01 00:00:00
abstract::11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0996
更新日期:2007-01-01 00:00:00
abstract::We have analyzed the factors responsible for the circadian variation in rat hepatic mRNA-S14. Regulation of this sequence, which is found in lipogenic tissues and encodes a protein (S14) believed to be associated with fatty acid synthesis, is an excellent model of the interaction of thyroid hormone and dietary factors...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-4-1563
更新日期:1987-04-01 00:00:00
abstract::Prenatal stress is associated with altered behavior and hypothalamic-pituitary-adrenal (HPA) axis function postnatally. Recent studies suggest that these outcomes are dependent on the timing of the prenatal stress. The majority of these studies have been carried out in male offspring. We hypothesized that a short peri...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0347
更新日期:2008-12-01 00:00:00
abstract::Several novel cyclic MSH analogs were synthesized, and their binding properties were tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, and MC5 receptors. We discovered a novel substance (HS024) that showed about 20-fold selectivity and very high affinity (Ki = 0.29 nM) for the MC4 recept...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.12.6352
更新日期:1998-12-01 00:00:00
abstract::Protein synthesis in bovine pituitaries was measured by incubation of tissue slices with radioactive amino acids, followed by gel electrophoresis. PRL and GH syntheses were estimated by determining the amount of radioactivity comigrating with standards of these hormones. Pituitary tissue removed from adult animals dem...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-2-576
更新日期:1981-08-01 00:00:00
abstract::Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene. Three human breast carcinoma cell lines, in which endogenous ERalpha is expressed ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.2.8620
更新日期:2002-02-01 00:00:00
abstract::In amphibians, the secretion of alpha-MSH by melanotrope cells is stimulated by TRH and inhibited by NPY. We have previously shown that NPY abrogates the stimulatory effect of TRH on alpha-MSH secretion. The aim of the present study was to characterize the receptor subtypes mediating the action of NPY and to investiga...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.5.8761
更新日期:2002-05-01 00:00:00
abstract::In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular ca...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-1-408
更新日期:1983-01-01 00:00:00
abstract::The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1375
更新日期:2007-06-01 00:00:00
abstract::Hypophysectomized female rats which received renal grafts of anterior pituitary (AP) or weight-matched intact controls were sampled under urethane anesthesia. Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-807
更新日期:1976-03-01 00:00:00
abstract::Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa209
更新日期:2021-01-01 00:00:00
abstract::Thyroid hormones increase bone turnover in vivo and stimulate bone resorption in vitro. Clinical states associated with excess circulating thyroid hormone levels are known to produce osteoporosis. To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.1.8275930
更新日期:1994-01-01 00:00:00
abstract::Insulin receptors were measured in cultured Zajdela rat hepatoma cells (ZHC cells), a stable cell line which presents differentiated hepatic functions. The number of sites was 50,000/cell at 2 C, and the dissociation constant for high affinity binding was 1.6 x 10(-10) M. Down-regulation of receptors occurred rapidly ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-3-993
更新日期:1982-09-01 00:00:00
abstract::Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.3.5845
更新日期:1998-03-01 00:00:00
abstract::Previous studies had suggested that norepinephrine (NE) and its precursors dopamine (DA) and L-DOPA acted similarly on iodine metabolism of isolated thyroid cells. Present studies indicate that this similarity extends to the inhibition by catecholamines of TSH-stimulated T4 release by mouse thyroids incubated in vitro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-2-632
更新日期:1986-02-01 00:00:00
abstract::The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1125
更新日期:2004-05-01 00:00:00
abstract::On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.12.8940390
更新日期:1996-12-01 00:00:00
abstract::The human estrogen receptor alpha (ERalpha) and the recently identified ERbeta share a high degree of amino acid homology; however, there are significant differences in regions of these receptors that would be expected to influence transcriptional activity. Consequently, we compared the mechanism(s) by which these rec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.12.7179
更新日期:1999-12-01 00:00:00
abstract::G protein-coupled receptor kinases (GRK 1-6) stimulate short-term desensitization (< 5 min) by phosphorylating G-protein coupled receptors, and also participate in receptor sequestration, which may relate to intermediate-term desensitization (30-60 min). The existence of such kinases and hence a potential role for the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.9.8756570
更新日期:1996-09-01 00:00:00
abstract::We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-subunit by muscle electroporation in female BALB/c mice. The onset of orbital pathology is characterized by muscle inflammation, adipogenesis, and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1829
更新日期:2016-04-01 00:00:00
abstract::To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-3-1498
更新日期:1989-09-01 00:00:00
abstract::The response of purified rat testicular peritubular myoid cells (PMC) to platelet-derived growth factor (PDGF) was studied. Freshly isolated PMC were devoid of measurable amounts of PDGF-binding sites. However, after 1 day in culture in serum-free conditions, specific high affinity receptors were detected. The estimat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.4.8404630
更新日期:1993-10-01 00:00:00
abstract::Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1135
更新日期:2016-01-01 00:00:00
abstract::Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies demonstrated the substantial protective role of 17β-estradiol (E2) in several types of neuron. However, most studies examined cell body protection, and the role of 17β-E2 in axonal degeneration of retinal ganglion cells (RGC) remain...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-0046
更新日期:2011-07-01 00:00:00
abstract::The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well understood. To help define the role of this isoform in bone, we developed a transgenic mouse in which targeted expression of human mCSF-1 in osteoblasts was achieved under the control of t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-221071
更新日期:2003-08-01 00:00:00
abstract::Exposure of rats to microsomal enzyme inducers perturbs thyroid hormone (TH) homeostasis through a variety of mechanisms. Glucuronidation is an important metabolic pathway for TH and is catalyzed by uridine diphosphate-dibenzo-glucuronosyltransferase (UGT) family proteins. Administration of 2,3,7,8-tetrachlorodibenzo-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0443
更新日期:2007-12-01 00:00:00
abstract::Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. In the present studi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.9.5376
更新日期:1997-09-01 00:00:00
abstract::Term pregnancy human placenta contains hCG/LH receptor mRNA transcripts and immunoreactive receptor protein. Both the receptor transcripts and receptor proteins are present only in trophoblasts. These findings led us to investigate whether hCG can regulate its own synthesis in term pregnancy human placenta. Treatment ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.6.8243330
更新日期:1993-12-01 00:00:00
abstract::Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1081
更新日期:2009-03-01 00:00:00