Activation of antimetastatic Nm23-H1 gene expression by estrogen and its alpha-receptor.

abstract：:In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...

journal_title：Endocrinology

authors： Kjos T,Gotoh E,Tkacs N,Shackelford R,Ganong WF

更新日期：1991-08-01 00:00:00

abstract：:A RIA for mouse placental lactogen-I (mPL-I) was developed using recombinant mPL-I as the standard, radioligand, and antigen for antiserum production. Displacement curves for dilutions of serum and placental extracts from pregnant mice were parallel to the recombinant mPL-I standard curve. Serum from male and nonpregn...

journal_title：Endocrinology

authors： Ogren L,Southard JN,Colosi P,Linzer DI,Talamantes F

更新日期：1989-11-01 00:00:00

abstract：:Once reserved solely for the treatment of short stature, the now readily available recombinant GH has expanded the use of the hormone to include the treatment of cardiovascular, renal, muscular, skeletal, immunological, psychosocial, and metabolic abnormalities associated with GH deficiency. There are also proposals f...

journal_title：Endocrinology

authors： Thangavel C,Shapiro BH

更新日期：2007-06-01 00:00:00

abstract：:We have used in situ hybridization histochemistry to investigate interactions between the thyroid and adrenal axes in the rat. Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene ...

journal_title：Endocrinology

authors： Shi ZX,Levy A,Lightman SL

更新日期：1994-03-01 00:00:00

abstract：:Anorexia is a debilitating manifestation of many malignancies. The etiology of cancer anorexia is poorly understood, and effective treatment options are limited. To investigate the role of central melanocortin receptor signaling in the pathogenesis of cancer anorexia, we assessed the effects on food intake of the mela...

journal_title：Endocrinology

authors： Wisse BE,Frayo RS,Schwartz MW,Cummings DE

更新日期：2001-08-01 00:00:00

abstract：:The question of whether maternal melatonin could be transported in milk to suckling rats was investigated because melatonin is probably not produced in these animals during the first 10 days of life. [3H]Melatonin was found to be rapidly transferred from the maternal circulation into lactating mammary tissue, and the ...

journal_title：Endocrinology

authors： Reppert SM,Klein DC

更新日期：1978-02-01 00:00:00

abstract：:PTH increases calcium reabsorption exclusively in the distal nephron. Two mechanisms of Ca++ transport through the basolateral membrane (BLM) have been described: the ATP-dependent and the sodium gradient-dependent transport. In the present study, we investigated the effect of PTH and (Bu)2cAMP on these two mechanisms...

journal_title：Endocrinology

authors： Bouhtiauy I,Lajeunesse D,Brunette MG

更新日期：1991-01-01 00:00:00

abstract：:Atrial, brain-type, and C-type natriuretic peptides (ANP, BNP, and CNP) act via receptors with intrinsic guanylate cyclase activity. The A-type and B-type ANP receptors are selectively activated by ANP and CNP, respectively. The anterior pituitary is a site of ANP production and action, suggesting a local regulatory f...

journal_title：Endocrinology

authors： McArdle CA,Poch A,Käppler K

更新日期：1993-05-01 00:00:00

abstract：:The feedback sites of estrogen within the hypothalamus and lower brain stem involved in the suppression of pulsatile LH secretion during 48-h fasting were examined in ovariectomized rats with local estradiol (E2) implants. The animals were ovariectomized and immediately implanted stereotaxically with stainless steel c...

journal_title：Endocrinology

authors： Nagatani S,Tsukamura H,Maeda K

更新日期：1994-09-01 00:00:00

abstract：:To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

journal_title：Endocrinology

authors： Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

更新日期：2009-05-01 00:00:00

abstract：:Experiments were carried out in castrate adult male rats to further examine whether endogenous opioids are involved in CRF-induced suppression of LH secretion. Serum LH levels in rats castrated 5 days earlier were significantly reduced by intracerebroventricular administration of homologous (rat) CRF (0.02-2 nmol) wit...

journal_title：Endocrinology

authors： Almeida OF,Nikolarakis KE,Herz A

更新日期：1988-03-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00

abstract：:Previous studies have provided evidence that tumors associated with humoral hypercalcemia of malignancy produce a factor that shares certain biological properties with, but is not, native PTH. In the present study, media from Xenopus oocytes microinjected with polyadenylated RNA prepared from three human or animal tum...

journal_title：Endocrinology

authors： Broadus AE,Goltzman D,Webb AC,Kronenberg HM

更新日期：1985-10-01 00:00:00

abstract：:Estrogens are crucial for growth and function of the female genital tract. Recently, we showed that induction of uterine epithelial proliferation by estradiol is a paracrine event requiring an estrogen receptor-positive stroma. Growth factors [such as EGF (epidermal growth factor) ligands] are likely paracrine mediato...

journal_title：Endocrinology

authors： Hom YK,Young P,Wiesen JF,Miettinen PJ,Derynck R,Werb Z,Cunha GR

更新日期：1998-03-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) protects mineralocorticoid receptors from high circulating levels of glucocorticoids and cDNAs for 11 beta-HSD2 from human and sheep have been recently cloned. We have isolated the gene for mouse 11 beta-HSD2, which spans 7 kilobases and is composed of 5 exons. In ...

journal_title：Endocrinology

authors： Cole TJ

更新日期：1995-10-01 00:00:00

abstract：:The steroid hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] can elicit biological responses via a nongenomic pathway that involves rapid opening of the plasma membrane Ca2+ channels. There is also evidence that 1,25-(OH)2D3 influences insulin secretion in the pancreatic beta-cell, which is primarily mediated by ...

journal_title：Endocrinology

authors： Sergeev IN,Rhoten WB

更新日期：1995-07-01 00:00:00

abstract：:The adrenal zona glomerulosa (ZG) secretes aldosterone to regulate sodium balance. Chronic sodium restriction increases aldosterone accompanied by ZG expansion. The ZG is innervated by sympathetic, vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY), and sensory, calcitonin gene-related peptide, ne...

journal_title：Endocrinology

authors： Tran PV,Georgieff MK,Engeland WC

更新日期：2010-10-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00

abstract：:Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...

journal_title：Endocrinology

authors： Hofland J,van Weerden WM,Steenbergen J,Dits NF,Jenster G,de Jong FH

更新日期：2012-12-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) plays an important role in development of the central nervous system and is neurotropic for a variety of neurons. In this study, we investigated whether bFGF is neurotropic for GT1 GnRH neuronal cell lines and if these cells express functional FGF receptors (FGFRs). The GT1 cell l...

journal_title：Endocrinology

authors： Tsai PS,Werner S,Weiner RI

更新日期：1995-09-01 00:00:00

abstract：:The actions and the mechanisms of action of epidermal growth factor (EGF) in testicular steroidogenesis were investigated using a model of primary culture of purified porcine Leydig cells from immature intact animals. EGF decreased (1.7-fold) human CG (hCG)-induced dehydroepiandrosterone (DHEA) accumulation in the med...

journal_title：Endocrinology

authors： Sordoillet C,Chauvin MA,de Peretti E,Morera AM,Benahmed M

更新日期：1991-04-01 00:00:00

abstract：:Melanocortin receptor 4 (MCR4) and CB(1) cannabinoid receptors independently modulate food intake. Although an interaction between the cannabinoid and melanocortin systems has been found in recovery from hemorrhagic shock, the interaction between these systems in modulating food intake has not yet been examined. The p...

journal_title：Endocrinology

authors： Verty AN,McFarlane JR,McGregor IS,Mallet PE

更新日期：2004-07-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:The enzyme glutamate decarboxylase-65 (GAD65) is a major autoantigen in autoimmune diabetes. The mechanism whereby autoreactivity to GAD65, an intracellular protein, is triggered is unknown, and it is possible that immunoreactive GAD65 is released by injured pancreatic islet beta-cells. There is a great need for metho...

journal_title：Endocrinology

authors： Waldrop MA,Suckow AT,Marcovina SM,Chessler SD

更新日期：2007-10-01 00:00:00

abstract：:CRF dose-dependently enhanced corticosterone (B) secretion by rat adrenal slices including both cortex and medulla. Conversely, CRF did not exert any B response by fragments of adrenocortical autotransplants, which are completely deprived of chromaffin tissue. However, autotransplant quarters exhibited a dose-dependen...

journal_title：Endocrinology

authors： Andreis PG,Neri G,Mazzocchi G,Musajo F,Nussdorfer GG

更新日期：1992-07-01 00:00:00

abstract：:The molecular forms of GnRH in amphibia have not been characterized structurally. An antiserum to mammalian GnRH that shows appreciable cross-reactivity with chicken GnRH-I ([Gln8]GnRH), chicken GnRH-II ([His5,Trp7,Tyr8]GnRH), and salmon GnRH ([Trp7, Leu8]GnRH) was used in a RIA to detect GnRH-related peptides in an e...

journal_title：Endocrinology

authors： Conlon JM,Collin F,Chiang YC,Sower SA,Vaudry H

更新日期：1993-05-01 00:00:00

abstract：:Thyroid hormones are essential for normal development and metabolism. Thyroid hormone biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen, where it is organified on selected tyrosyls of thyroglobulin. Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane gly...

journal_title：Endocrinology

authors： Bizhanova A,Kopp P

更新日期：2009-03-01 00:00:00

abstract：:We examined the effects of bombesin on rat pancreatic digestive enzyme gene expression using cloned complementary DNA probes for amylase, trypsinogen I, chymotrypsinogen B, and lysophospholipase. Rats were injected sc three times daily with 5 nmol/kg body wt bombesin. Pancreata were investigated after 6, 12, 24, 48, a...

journal_title：Endocrinology

authors： Rosewicz S,Liehr RM,Solomon TE,Riecken EO,Logsdon CD

更新日期：1992-03-01 00:00:00

abstract：:Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...

journal_title：Endocrinology

authors： Resnick CE,Fielder PJ,Rosenfeld RG,Adashi EY

更新日期：1998-03-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00