Amino acid substitutions of thyroid hormone receptor-beta at codon 435 with resistance to thyroid hormone selectively alter homodimer formation.

abstract：:Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...

journal_title：Endocrinology

authors： Blackshear PJ,Nemenoff RA,Avruch J

更新日期：1984-01-01 00:00:00

abstract：:To find out whether the hippocampus is involved in central nervous system-mediated glucoregulation, we injected saline, neostigmine, dopamine, norepinephrine, bombesin, beta-endorphin, somatostatin, and prostaglandin F2 alpha into the dorsal hippocampus in anesthetized fed rats. After injection of dopamine, norepineph...

journal_title：Endocrinology

authors： Uemura K,Iguchi A,Yatomi A,Miura H,Honmura A,Yanase M,Sakamoto N

更新日期：1989-05-01 00:00:00

abstract：:Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at increased risk of adult disease. We investigated the effect of gestational age and maternal nutrition on the maternal plasma concentration of leptin and cortisol t...

journal_title：Endocrinology

authors： Bispham J,Gopalakrishnan GS,Dandrea J,Wilson V,Budge H,Keisler DH,Broughton Pipkin F,Stephenson T,Symonds ME

更新日期：2003-08-01 00:00:00

abstract：:Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing o...

journal_title：Endocrinology

authors： Inagaki T,Frankfurt M,Luine V

更新日期：2012-07-01 00:00:00

abstract：:Profound somatotroph hypoplasia in the dwarf (dw/dw) rat is accompanied by an estrogen-dependent induction of prolactin secretion by the GH secretagogue, GHRP-6. Using electron microscopy, we demonstrated that the reduction in the somatotroph population in the dw/dw pituitary is accompanied by the presence of a morpho...

journal_title：Endocrinology

authors： Huerta-Ocampo I,Christian HC,Thompson NM,El-Kasti MM,Wells T

更新日期：2005-11-01 00:00:00

abstract：:In agonadal juvenile male monkeys, continuous administration of human metastin 45-54 (hu metastin 45-54) leads to desensitization of its receptor, G protein-coupled receptor 54 (GPR54), and decreased LH. The present study extended this observation to the adult male monkey, a more preclinically relevant model in which ...

journal_title：Endocrinology

authors： Ramaswamy S,Seminara SB,Pohl CR,DiPietro MJ,Crowley WF Jr,Plant TM

更新日期：2007-07-01 00:00:00

abstract：:The effects of pineal indole compounds on the response of the neonatal rat anterior pituitary gland to LH-releasing hormone (LHRH) were studied in organ culture. After 24 h of culture under control conditions, pituitary glands from 5-day-old female rats were routinely incubated for an additional 24 h with the test com...

journal_title：Endocrinology

authors： Martin JE,Engel JN,Klein DC

更新日期：1977-03-01 00:00:00

abstract：:The mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of transcription factors, is activated by aldosterone and mediates its natriferic action in tight epithelia. MR is also expressed in nonepithelial tissues. Importantly, it mediates the deleterious effects of inappropriately high aldoster...

journal_title：Endocrinology

authors： Aguilar-Sánchez C,Hernández-Díaz I,Lorenzo-Díaz F,Navarro JF,Hughes TE,Giraldez T,Alvarez de la Rosa D

更新日期：2012-07-01 00:00:00

abstract：:A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest that a midregion PTHrP fragment may be biologically active, we hypothes...

journal_title：Endocrinology

authors： Orloff JJ,Ganz MB,Nathanson MH,Moyer MS,Kats Y,Mitnick M,Behal A,Gasalla-Herraiz J,Isales CM

更新日期：1996-12-01 00:00:00

abstract：:Excess of glucocorticoids (GCs) is a leading cause of bone fragility, and therapeutic targets are sorely needed. We report that genetic deletion or pharmacological inhibition of proline-rich tyrosine kinase 2 (Pyk2) prevents GC-induced bone loss by overriding GC effects of detachment-induced bone cell apoptosis (anoik...

journal_title：Endocrinology

authors： Sato AY,Cregor M,McAndrews K,Li T,Condon KW,Plotkin LI,Bellido T

更新日期：2019-07-01 00:00:00

abstract：:Synthesis of GH, PRL, and proopiomelanocortin (POMC) by the adult ovine pituitary was examined by culturing intact tissue explants in vitro and analyzing newly synthesized proteins by two-dimensional gel electrophoresis. Spots on autoradiographs of two-dimensional gels were identified by comigration with known standar...

journal_title：Endocrinology

authors： Miller WL,Leisti S,Johnson LK

更新日期：1982-10-01 00:00:00

abstract：:Human decidual cells synthesize and release decidual PRL (dPRL) immunologically and biochemically identical to human pituitary PRL. However, stimulators and inhibitors of PRL secretion such as TRH, bromocriptine or dopamine have no effect on dPRL release. The evidence for the involvement of Ca2+ in dPRL release is bas...

journal_title：Endocrinology

authors： Sartor P,Couderc B,Corcuff JB,Odessa MF,Mayer G,Dufy B

更新日期：1992-06-01 00:00:00

abstract：:A clonal cell line (44-2C) which synthesizes and secretes somatostatin, neurotensin, calcitonin (CT), and CT gene-related peptide and transiently expresses c-fos was used to characterize the mechanism of action of basic fibroblast growth factor (bFGF). bFGF had two modes of action: 1) short term incubation of 44-2C ce...

journal_title：Endocrinology

authors： Zeytin FN,Rusk SF,Raymond V,Mandell AJ

更新日期：1988-03-01 00:00:00

abstract：:Recent evidence indicates that endogenous GnRH is required for maintenance of its own pituitary receptors (GnRH-R). We have measured GnRH-R in pituitaries of hypogonadotrophic hypogonadal (hpg) mice, in whom hypothalamic GnRH is deficient or absent. The GnRH-R concentration in hpg male mouse pituitaries was 10.6 +/- 1...

journal_title：Endocrinology

authors： Young LS,Speight A,Charlton HM,Clayton RN

更新日期：1983-07-01 00:00:00

abstract：:The PRL-stimulating effect of metoclopramide (2-methoxy-5-chloroprocainamide) was examined in normal and adrenalectomized male rats pretreated with DL-p-chlorophenylalanine methyl ester (PCPA), an inhibitor of serotonin biosynthesis. PCPA significantly reduced the hypothalamic content of serotonin, increased basal PRL...

journal_title：Endocrinology

authors： Fang VS,Shian LR

更新日期：1981-05-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:The population of LHRH neurons was examined in young and middle-aged female rats at two different time points associated with the LH surge on proestrus. More immunopositive LHRH neurons were detected in the brains of young but not middle-aged females killed on the evening of proestrus (1830-2030 h) compared with those...

journal_title：Endocrinology

authors： Rubin BS,King JC

更新日期：1994-01-01 00:00:00

abstract：:The binding of oxytocin (OT) to receptors in rabbit amnion cells stimulates PGE2 release. We previously studied the binding characteristics, changes in receptor concentration during pregnancy, and agonist specificity of OT action on amnion cells. In this study the molecular size of OT receptors in rabbit amnion was es...

journal_title：Endocrinology

authors： Hinko A,Soloff MS,Potier M

更新日期：1992-06-01 00:00:00

abstract：:Permanent effects of postnatal gonads on dopamine (DA)-mediated regulation of PRL secretion were examined in adult male rats of the Wistar-Imamichi strain. Rats were bilaterally orchidectomized at varying postnatal days, i.e. 8 h after birth [neonatal castration (NC)] or at 1, 2, 3, 4, or 6 weeks of age, and subjected...

journal_title：Endocrinology

authors： Watanobe H,Takebe K

更新日期：1987-06-01 00:00:00

abstract：:Previously, we demonstrated that excision of the GnRH first intron (intron A) was largely attenuated in non-GnRH-producing tissues but accelerated in GnRH neurons. In the present study, we examined the splicing rate of GnRH pre-mRNA in developing normal mice and adult hypogonadal mice. The preoptic area and cerebral c...

journal_title：Endocrinology

authors： Seong JY,Kim BW,Park S,Son GH,Kim K

更新日期：2001-10-01 00:00:00

abstract：:The estrogen-induced and -dependent Syrian hamster renal tumor is the most intensively studied model in estrogen carcinogenesis. Yet, it remains confounding that the kidney of this species behaves as an estrogen target tissue. As both reproductive and urinary systems arise from the same germinal ridge, we propose that...

journal_title：Endocrinology

authors： Li JJ,Weroha SJ,Davis MF,Tawfik O,Hou X,Li SA

更新日期：2001-09-01 00:00:00

abstract：:The potential effects of insulin and insulin-like growth factor I (IGF-I) on mesangial cell (MC) metabolism and growth were examined. Radiolabeled insulin or IGF-I were incubated with cell membranes from rapidly proliferating (subconfluent) or nonproliferating (confluent) MC in the presence of increasing concentration...

journal_title：Endocrinology

authors： Abrass CK,Raugi GJ,Gabourel LS,Lovett DH

更新日期：1988-11-01 00:00:00

abstract：:IGF-binding protein-3 (IGFBP-3) is the major circulating carrier protein for IGF, and also acts as a potent antiproliferative agent in various cell types. Recently, IGFBP-3 was reported to mediate high glucose-induced apoptosis in mesangial cells and podocytes. In this study, we investigated the role of IGFBP-3 in hig...

journal_title：Endocrinology

authors： Yoo EG,Lee WJ,Kim JH,Chae HW,Hyun SE,Kim DH,Kim HS,Oh Y

更新日期：2011-08-01 00:00:00

abstract：:The membrane fraction from the ovaries of pseudopregnant rats exhibits specific, high affinity binding of high density lipoproteins (HDL). Previous studies have indicated that HDL binding in this tissue is up-regulated by hCG and may be involved in supplying cholesterol as substrate for steroid hormone production. To ...

journal_title：Endocrinology

authors： Ferreri K,Menon KM

更新日期：1990-04-01 00:00:00

abstract：:The effects of dopamine (DA) on voltage-dependent Ca2+ currents were investigated in cultured rat lactotroph cells using the patch clamp recording technique. Each recorded cell was identified by the reverse hemolytic plaque assay. In the whole-cell configuration, two types of Ca2+ currents, L and T, were characterized...

journal_title：Endocrinology

authors： Lledo PM,Legendre P,Israel JM,Vincent JD

更新日期：1990-09-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:For 3 yr, 1-yr synchronized circannual rhythms were found for the chick oviduct weights, amounts of soluble protein, concentrations of the progesterone receptor in this organ, and capacity of this steroid-receptor complex in cytosol in bind in vitro to deoxyribonucleoprotein acceptor sites. By fitting the data with 1-...

journal_title：Endocrinology

authors： Spelsberg TC,Halberg F

更新日期：1980-10-01 00:00:00

abstract：:In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...

journal_title：Endocrinology

authors： Chatzopoulou A,Roy U,Meijer AH,Alia A,Spaink HP,Schaaf MJ

更新日期：2015-05-01 00:00:00

abstract：:We have developed and characterized a primary cell culture system to study the regulation of 17 alpha-hydroxylase cytochrome P450 (P45017 alpha) gene expression in bovine thecal cells. Conditions have been established for the dispersal and growth of thecal cells isolated from bovine follicles, which maintain the expre...

journal_title：Endocrinology

authors： Demeter-Arlotto M,Rainey WE,Simpson ER

更新日期：1993-03-01 00:00:00

abstract：:The nuclear receptor steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential regulator of endocrine development and function, and the expression of the corresponding gene (sf-1/ad4bp) is precisely regulated in a time- and tissue-dependent manner. We previously demonstrated that the basal promoter...

journal_title：Endocrinology

authors： Hoivik EA,Bjanesoy TE,Mai O,Okamoto S,Minokoshi Y,Shima Y,Morohashi K,Boehm U,Bakke M

更新日期：2011-05-01 00:00:00