Maintenance and regulation of 17 alpha-hydroxylase expression by bovine thecal cells in primary culture.

abstract：:Osteoclast precursors have not been well characterized because there are no known markers that can detect them. We have used osteoclast-like cells formed in vitro to develop a panel of specific antibodies that react with mature osteoclasts, osteoclast precursors, and other cells in the osteoclast lineage. Monoclonal a...

journal_title：Endocrinology

authors： Kukita T,Roodman GD

更新日期：1989-08-01 00:00:00

abstract：:Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human ...

journal_title：Endocrinology

authors： Ervinna N,Mita T,Yasunari E,Azuma K,Tanaka R,Fujimura S,Sukmawati D,Nomiyama T,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2013-03-01 00:00:00

abstract：:Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...

journal_title：Endocrinology

authors： Zheng Y,Tabbaa ZM,Khan Z,Schoolmeester JK,El-Nashar S,Famuyide A,Keeney GL,Daftary GS

更新日期：2014-11-01 00:00:00

abstract：:For 3 yr, 1-yr synchronized circannual rhythms were found for the chick oviduct weights, amounts of soluble protein, concentrations of the progesterone receptor in this organ, and capacity of this steroid-receptor complex in cytosol in bind in vitro to deoxyribonucleoprotein acceptor sites. By fitting the data with 1-...

journal_title：Endocrinology

authors： Spelsberg TC,Halberg F

更新日期：1980-10-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and thermogenic differentiation of brown adipocytes during late fetal life, we have established immortalized brown adipocyte cell lines from fetuses of IGF-IR-deficient mice (IGF-IR(-/-)) as well as from wild-type mice (IGF-IR(+/+)). IGF-IR(-/-) cell...

journal_title：Endocrinology

authors： Mur C,Arribas M,Benito M,Valverde AM

更新日期：2003-02-01 00:00:00

abstract：:Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin...

journal_title：Endocrinology

authors： Archambeault DR,Tomaszewski J,Childs AJ,Anderson RA,Yao HH

更新日期：2011-11-01 00:00:00

abstract：:The population of LHRH neurons was examined in young and middle-aged female rats at two different time points associated with the LH surge on proestrus. More immunopositive LHRH neurons were detected in the brains of young but not middle-aged females killed on the evening of proestrus (1830-2030 h) compared with those...

journal_title：Endocrinology

authors： Rubin BS,King JC

更新日期：1994-01-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:After incubation with 0.5 mM isobutylmethylxanthine, 1 microM dexamethasone, and 1 microM insulin for 72 h, 3T3-L1 cells acquire the phenotypic characteristics of mature adipocytes, including a hormone-sensitive particulate cAMP phosphodiesterase activity. In addition, adipocytes contain soluble cAMP and calmodulin-se...

journal_title：Endocrinology

authors： Elks ML,Manganiello VC,Vaughan M

更新日期：1984-10-01 00:00:00

abstract：:To investigate GH's role in diabetic end organ damage, experimental diabetes was induced with streptozotocin (STZ) in bovine GH (bGH) or bGH antagonist transgenic mice and in their nontransgenic (NTG) litter mates. Body growth, blood glucose, serum insulin-like growth factor-I levels, liver GH receptor (GHR) binding, ...

journal_title：Endocrinology

authors： Chen NY,Chen WY,Bellush L,Yang CW,Striker LJ,Striker GE,Kopchick JJ

更新日期：1995-02-01 00:00:00

abstract：:Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimu...

journal_title：Endocrinology

authors： Jang H,Bhasin S,Guarneri T,Serra C,Schneider M,Lee MJ,Guo W,Fried SK,Pencina K,Jasuja R

更新日期：2015-10-01 00:00:00

abstract：:19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present stud...

journal_title：Endocrinology

authors： Funder JW,Adam WR

更新日期：1981-07-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:The role of PRL in mammalian salt and water balance remains controversial. To avoid the methodological problems of exogenous PRL administration, endogenous hyperprolactinemia was established in normal rats by implantation of extra anterior pituitary glands under the kidney capsule. To eliminate excess glucocorticoid s...

journal_title：Endocrinology

authors： Adler RA,Herzberg VL,Brinck-Johnsen T,Sokol HW

更新日期：1986-04-01 00:00:00

abstract：:The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells. Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with G...

journal_title：Endocrinology

authors： Baratta M,Saleri R,Mainardi GL,Valle D,Giustina A,Tamanini C

更新日期：2002-02-01 00:00:00

abstract：:The influence of the catecholamine hormones and some of their metabolites on the enzymatic degradation of met-enkephalin by rat brain homogenates has been evaluated. The enzyme activity was determined by the release of [125I]-tyrosine from radioiodinated met-enkephalin following Porapak Q column chromatography. Each o...

journal_title：Endocrinology

authors： Caffrey JL,Hodges DH

更新日期：1982-01-01 00:00:00

abstract：:It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differen...

journal_title：Endocrinology

authors： Bodo C,Rissman EF

更新日期：2008-08-01 00:00:00

abstract：:Trophoblast hypoxia and injury, key components of placental dysfunction, are associated with fetal growth restriction and other complications of pregnancy. Accumulation of lipid droplets has been found in hypoxic nonplacental cells. Unique to pregnancy, lipid accumulation in the placenta might perturb lipid transport ...

journal_title：Endocrinology

authors： Bildirici I,Schaiff WT,Chen B,Morizane M,Oh SY,O'Brien M,Sonnenberg-Hirche C,Chu T,Barak Y,Nelson DM,Sadovsky Y

更新日期：2018-12-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period...

journal_title：Endocrinology

authors： Nava LE,Malacara JM

更新日期：1987-10-01 00:00:00

abstract：:To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

journal_title：Endocrinology

authors： Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

更新日期：1995-12-01 00:00:00

abstract：:Recent evidence suggests that growth hormone-releasing peptides (GHRPs) mimic an unidentified native GH-releasing hormone (GHRH)-amplifying hormone. GHRH has been shown to stimulate food intake acting on the central nervous system. The present studies were conducted to test the hypothesis that GHRPs may also potentiat...

journal_title：Endocrinology

authors： Okada K,Ishii S,Minami S,Sugihara H,Shibasaki T,Wakabayashi I

更新日期：1996-11-01 00:00:00

abstract：:To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...

journal_title：Endocrinology

authors： Foster DL,Jaffe RB,Niswender GD

更新日期：1975-01-01 00:00:00

abstract：:Regulation of the number of pituitary vasopressin (VP) receptors plays an important role in controlling pituitary responsiveness during alterations of the hypothalamic pituitary adrenal axis. The mechanisms regulating these VP receptors were studied by analysis of the effects of adrenalectomy and glucocorticoid admini...

journal_title：Endocrinology

authors： Rabadan-Diehl C,Makara G,Kiss A,Lolait S,Zelena D,Ochedalski T,Aguilera G

更新日期：1997-12-01 00:00:00

abstract：:Ovarian steroids act on unidentified neurons to trigger preovulatory secretion of GnRH. In the rat, important steroid target cells reside in the anterior medial preoptic nucleus (AMPN), a sexually dimorphic structure essential for stimulatory effects of ovarian steroids on LH secretion. The AMPN contains neurotensin (...

journal_title：Endocrinology

authors： Alexander MJ,Dobner PR,Miller MA,Bullock BP,Dorsa DM,Leeman SE

更新日期：1989-10-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:Animals maintained on retinol (vitamin A-alcohol)-deficient diets exhibit testicular atrophy and loss of the germinal epithelium. Retinoic acid (vitamin A-acid), when fed to retinol-deficient animals, does not prevent these lesions and had thus been thought not to play a role in the tests. Serum testosterone (T) level...

journal_title：Endocrinology

authors： Appling DR,Chytil F

更新日期：1981-06-01 00:00:00