Increased water excretion in hyperprolactinemic rats.

abstract：:In the gonads and adrenal glands, the transient increase in steroidogenesis after hormonal stimulation requires modulation of steroidogenic acute regulatory protein (Star) expression and activity in a tightly regulated process involving cAMP and Ca(2+). In Leydig cells, the cAMP and Ca(2+) pathways account for most if...

journal_title：Endocrinology

authors： Abdou HS,Villeneuve G,Tremblay JJ

更新日期：2013-01-01 00:00:00

abstract：:A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities and failed to increase...

journal_title：Endocrinology

authors： List EO,Berryman DE,Basu R,Buchman M,Funk K,Kulkarni P,Duran-Ortiz S,Qian Y,Jensen EA,Young JA,Yildirim G,Yakar S,Kopchick JJ

更新日期：2020-08-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00

abstract：:The feedback sites of estrogen within the hypothalamus and lower brain stem involved in the suppression of pulsatile LH secretion during 48-h fasting were examined in ovariectomized rats with local estradiol (E2) implants. The animals were ovariectomized and immediately implanted stereotaxically with stainless steel c...

journal_title：Endocrinology

authors： Nagatani S,Tsukamura H,Maeda K

更新日期：1994-09-01 00:00:00

abstract：:At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...

journal_title：Endocrinology

authors： Yin W,Maguire SM,Pham B,Garcia AN,Dang NV,Liang J,Wolfe A,Hofmann HA,Gore AC

更新日期：2015-08-01 00:00:00

abstract：:Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell ...

journal_title：Endocrinology

authors： Tagliati F,Zatelli MC,Bottoni A,Piccin D,Luchin A,Culler MD,Degli Uberti EC

更新日期：2006-07-01 00:00:00

abstract：:In vivo studies have suggested that serotonin (5HT) influences anterior pituitary function at the hypothalamic level. The present in vitro study investigated the possibility that 5HT may act directly on the anterior pituitary. The high affinity uptake of [3H]5HT into adult rat anterior pituitary tissue was examined in...

journal_title：Endocrinology

authors： Johns MA,Azmitia EC,Krieger DT

更新日期：1982-03-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the spontaneous and TRH-induced TSH release were investigated in vitro on perifused rat pituitaries. The dynamic pattern of TSH release was measured in response to a 6-min pulse of TRH (10 nM) with or without GABA addition. GABA had no effect on spontaneous TSH release ...

journal_title：Endocrinology

authors： Tapia-Arancibia L,Roussel JP,Astier H

更新日期：1987-09-01 00:00:00

abstract：:The antigenic epitopes of human GH (hGH) have been investigated using monoclonal antibodies (Mabs) to hGH. A panel of 12 Mabs was incorporated into two-site binding assays in order to investigate the antigenic surface of hGH. Nine reaction patterns were observed. The Mabs were further characterized in terms of their c...

journal_title：Endocrinology

authors： Strasburger CJ,Kostyo J,Vogel T,Barnard GJ,Kohen F

更新日期：1989-03-01 00:00:00

abstract：:The molecular links between membrane excitability and neurohormone synthesis were investigated using a simple model system: the bag cell neurons of Aplysia. We tested the hypothesis that the electrical afterdischarge, which leads to depletion of egg-laying hormone (ELH) by triggering secretion, rapidly stimulates ELH ...

journal_title：Endocrinology

authors： Lee W,Wayne NL

更新日期：1998-12-01 00:00:00

abstract：:In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total NADPH/NADP and inhibition of glucose oxidation via the pentose phosphate shunt (PPS). NADH an...

journal_title：Endocrinology

authors： Ammon HP,Verspohl E

更新日期：1976-12-01 00:00:00

abstract：:Type 1 transforming growth factor-beta (TGF beta 1) was found to be a potent inducer of the secretion of a 49,000 mol wt protein by normal rat kidney (NRK) cells. This protein was related to type 1 plasminogen activator inhibitor (PAI-1) on the basis of molecular mass, activity in the presence of sodium dodecyl sulfat...

journal_title：Endocrinology

authors： Newman MJ,Lane EA,Iannotti AM,Nugent MA,Pepinsky RB,Keski-Oja J

更新日期：1990-06-01 00:00:00

abstract：:Sorbin is a 153-amino acid peptide that was initially discovered in the porcine duodenum. We have reported previously that this peptide regulates intestinal electrolyte transport and have described accumulation sites in the rat digestive tract. In the present study, we investigated the anatomical distribution and the ...

journal_title：Endocrinology

authors： El Fadil FA,Nicol P,Leduque P,Berger F,Descroix-Vagne M,Pansu D

更新日期：1997-11-01 00:00:00

abstract：:Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...

journal_title：Endocrinology

authors： de Greef WJ,Zeilmaker GH

更新日期：1979-07-01 00:00:00

abstract：:The role of the paraventricular nucleus-dorsal anterior hypothalamus (PVN-DAHA) in the control of anterior pituitary gland secretion of FSH and LH in castrated male and female rats was examined. Bilateral radiofrequency lesions of the PVN-DAHA in chronically ovariectomized (OVX) rats lowered plasma FSH levels by 33% (...

journal_title：Endocrinology

authors： Lumpkin MD,McCann SM

更新日期：1984-12-01 00:00:00

abstract：:Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL leve...

journal_title：Endocrinology

authors： Ruiz-Herrera X,de Los Ríos EA,Díaz JM,Lerma-Alvarado RM,Martínez de la Escalera L,López-Barrera F,Lemini M,Arnold E,Martínez de la Escalera G,Clapp C,Macotela Y

更新日期：2017-01-01 00:00:00

abstract：:This study investigated the relationship between plasma gonadotropin concentrations and the initiation and maintenance of preovulatory follicular growth in macaques. Eight adult cynomolgus monkeys were treated with a GnRH antagonist [AcD2Nal1-4ClDPhe2, DTrp3, DArg6, DAla10]GnRH X HOAc to block endogenous gonadotropin ...

journal_title：Endocrinology

authors： Zeleznik AJ,Kubik CJ

更新日期：1986-11-01 00:00:00

abstract：:Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. In the present studi...

journal_title：Endocrinology

authors： Li M,Li J,Hoodless PA,Tzukazaki T,Wrana JL,Attisano L,Tsang BK

更新日期：1997-09-01 00:00:00

abstract：:Posttranslational modifications of prolactin (PRL), including phosphorylation, vary with physiologic state and alter biologic activity. In light of the growing evidence for a role for PRL in proliferation in mammary cancer, we examined the ability of a mimic of phosphorylated human PRL, S179D-PRL, to initiate signals ...

journal_title：Endocrinology

authors： Schroeder MD,Brockman JL,Walker AM,Schuler LA

更新日期：2003-12-01 00:00:00

abstract：:We report here 1) that GnRH and a potent GnRH agonist inhibit basal and LH stimulated ovarian androgen biosynthesis in vitro, 2) that the inhibitory effects of GnRH are dose-dependent and completely inhibited by concomitant treatment with a GnRH antagonist and 3) that the GnRH action is very rapid (t1/2 = 10 min) and ...

journal_title：Endocrinology

authors： Magoffin DA,Reynolds DS,Erickson GF

更新日期：1981-08-01 00:00:00

abstract：:The classical model for the mechanism of action of steroids holds that unbound receptors for steroids reside exclusively in the cytoplasmic compartment and that they undergo translocation to the nucleus when bound to steroids in a process which is temperature sensitive. We have in the past proposed that unbound recept...

journal_title：Endocrinology

authors： Sheridan PJ,Buchanan JM,Anselmo VC,Martin PM

更新日期：1981-04-01 00:00:00

abstract：:Calcitonin is present in both the hypothalamus and pituitary of the rat, and normal rat anterior pituitary cells express calcitonin receptors. Calcitonin has been reported to inhibit or to stimulate PRL release from rat anterior pituitary cells. We have investigated the effects of salmon calcitonin on basal and stimul...

journal_title：Endocrinology

authors： Judd AM,Kubota T,Kuan SI,Jarvis WD,Spangelo BL,Macleod RM

更新日期：1990-07-01 00:00:00

abstract：:The effects of LH on glucose metabolism within cumulus cell-enclosed bovine oocytes were determined. Cumulus cell-enclosed bovine oocytes were matured in vitro (IVM) in control medium alone or supplemented with LH, FSH, or TSH, then individually assayed for the metabolism of D-[5-3H]glucose, D-[1-14C]glucose, D-[6-14C...

journal_title：Endocrinology

authors： Zuelke KA,Brackett BG

更新日期：1992-12-01 00:00:00

abstract：:To study the interaction of TSH receptor (TSHR) autoantibodies with receptor protein; it is necessary first to express the receptor in the proper conformation including the formation of correct disulfide bridges. However, the reducing environment of the Escherichia coli (E. coli) cytoplasm prevents the generation of p...

journal_title：Endocrinology

authors： Bobovnikova Y,Graves PN,Vlase H,Davies TF

更新日期：1997-02-01 00:00:00

abstract：:The possible role of atrial natriuretic factor (ANF) in the regulation of adrenal sensitivity to angiotensin II (AII) was investigated in vivo and in vitro by analyzing the characteristics of the inhibitory effect of ANF on aldosterone production stimulated by AII and other stimuli. In isolated adrenal glomerulosa cel...

journal_title：Endocrinology

authors： Aguilera G

更新日期：1987-01-01 00:00:00

abstract：:Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...

journal_title：Endocrinology

authors： Qin J,Zhao N,Wang S,Liu S,Liu Y,Cui X,Wang S,Xiang Y,Fan C,Li Y,Shan Z,Teng W

更新日期：2020-04-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5-year survival rate <35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified maternal embryonic leucine zipper kinase (MELK) as 4.1-fold overexpressed in ACC compared with normal adrenal samples. High MELK...

journal_title：Endocrinology

authors： Kiseljak-Vassiliades K,Zhang Y,Kar A,Razzaghi R,Xu M,Gowan K,Raeburn CD,Albuja-Cruz M,Jones KL,Somerset H,Fishbein L,Leong S,Wierman ME

更新日期：2018-07-01 00:00:00

abstract：:Pituitary growth hormone (GH) content and plasma GH response to pentobarbital (PB) of severely hypothyroid rats are markedly decreased compared with euthyroid rats. Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (...

journal_title：Endocrinology

authors： Hervás F,Morreale de Escobar G,Escobar del Rey F

更新日期：1976-01-01 00:00:00

abstract：:In various forms of shock, TRH is equivalent to naloxone in reversing the hypotension and improving the survival rate. The present findings indicate that in spontaneously hypertensive rats (SHR), TRH has another naloxone-like effect in antagonizing the antihypertensive response to clonidine and alpha-methyldopa. When ...

journal_title：Endocrinology

authors： Kunos G,Newman F,Farsang C,Ungar W

更新日期：1984-12-01 00:00:00