Abstract:
:Calcitonin is present in both the hypothalamus and pituitary of the rat, and normal rat anterior pituitary cells express calcitonin receptors. Calcitonin has been reported to inhibit or to stimulate PRL release from rat anterior pituitary cells. We have investigated the effects of salmon calcitonin on basal and stimulated PRL release from rat anterior pituitary cells and have studied the effects of this peptide on the intracellular biochemical pathways involved in PRL release. Salmon calcitonin had no significant effect on basal PRL release, but inhibited (P less than 0.01) TRH-stimulated PRL release without affecting PRL release promoted by angiotensin II, neurotensin, phorbol myristate acetate (a protein kinase C activator), or maitotoxin (a calcium channel activator). Salmon calcitonin had no effect on the increase in PRL release and intracellular cAMP concentration after exposure of pituitary cells to vasoactive intestinal peptide or forskolin. Salmon calcitonin significantly decreased (P less than 0.01) the TRH-stimulated rise in inositol phosphates without affecting the angiotensin II-stimulated increase in inositol phosphates. Similarly, salmon calcitonin decreased the TRH-stimulated increase in cytosolic calcium and arachidonate liberation by pituitary cells. We conclude that salmon calcitonin selectively decreases TRH-stimulated PRL release by a mechanism that involves a decrease in inositol phosphate production, as well as a subsequent reduction in cytosolic calcium levels and in arachidonate liberation.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Judd AM,Kubota T,Kuan SI,Jarvis WD,Spangelo BL,Macleod RMdoi
10.1210/endo-127-1-191subject
Has Abstractpub_date
1990-07-01 00:00:00pages
191-9issue
1eissn
0013-7227issn
1945-7170journal_volume
127pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0829
更新日期:2006-02-01 00:00:00
abstract::GH deficiency is known to be clinically associated with a high incidence of nonalcoholic fatty liver disease, and this can be reversed by GH administration. Here we investigated the mechanistic basis for this phenomenon using engineered male mice lacking different signaling elements of the GH receptor, hepatic stat5a/...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0537
更新日期:2011-01-01 00:00:00
abstract::The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes comp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-101-5-1643
更新日期:1977-11-01 00:00:00
abstract::Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0898
更新日期:2007-12-01 00:00:00
abstract::Although it is known that LH secretion starts at 17 days of gestation in the fetal rat and that this first LH release is most likely driven by hypothalamic GnRH, an earlier role for GnRH during fetal life has been postulated with the observation that presence of GnRH is important before day 13 of gestation for the dif...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-4-1565
更新日期:1985-04-01 00:00:00
abstract::To determine if the inhibitory effects of glucocorticoids on GnRH-stimulated secretion of LH observed in male rats in vivo are exerted directly on the pituitary, dispersed pituitary cells from adult male rats were treated with 60 or 600 ng/ml cortisol (F) or corticosterone (B) during one or two 48-h incubations. Contr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-3-855
更新日期:1985-09-01 00:00:00
abstract::Dispersed Leydig cells were prepared from pig testes and purified in a discontinuous Percoll gradient. About 95% of these cells stained for 3 beta-hydroxysteroid dehydrogenase. The cells were cultured in a chemically defined medium. Testosterone production was low (2 +/- 0.4 ng/10(6) cells/day) under basal conditions,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-6-1952
更新日期:1983-06-01 00:00:00
abstract::Levels of insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins (IGFBPs) were studied in ovine follicular fluid and serum with a view to determining their respective endocrine and/or paracrine roles in ovarian folliculogenesis. Ovarian follicles of Ile-de-France ewes were dissected and measured indivi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.4.7681760
更新日期:1993-04-01 00:00:00
abstract::Using a Leydig tumor cell line (MA-10) transiently transfected with the human lutropin receptor (hLHR) and mutants thereof, we examined the identity of the G proteins activated by the agonist-engaged hLHR-wild type (wt) and by three of its naturally occurring constitutively active mutants. Two of the mutants examined,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0365
更新日期:2003-09-01 00:00:00
abstract::In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.5.7720640
更新日期:1995-05-01 00:00:00
abstract::In the testis the mesenchymally derived peritubular cells produce a paracrine factor, PModS, that mediates mesenchymal-epithelial interactions and modulates Sertoli cell functions essential for the process of spermatogenesis. PModS has a more dramatic effect on Sertoli cell differentiated functions in vitro than any r...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.1.7903930
更新日期:1994-01-01 00:00:00
abstract::MCRs of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined in the morning and evening in four chronically chaired adult rhesus monkeys (Macaca mulatta) by means of steady state infusion of [4-14C]testosterone and [1,2-3H]dihydrotestosterone. Morning and evening MCRs were comparable for both T and D...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-105-2-402
更新日期:1979-08-01 00:00:00
abstract::Des-acyl ghrelin (DAG), the most abundant form of ghrelin in humans, has been found to reduce arterial blood pressure and prevent cardiac and endothelial cell apoptosis. Despite this, data regarding its direct effect on cardiac function and coronary blood flow, as well as the related involvement of autonomic nervous s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1922
更新日期:2016-06-01 00:00:00
abstract::Catecholamines may stimulate ACTH secretion during stress. To investigate the nature and site of such an action, plasma ACTH was measured in four groups of unanesthetized adult female rats with an indwelling carotid cannula. Sequential 300-microliter blood samples were taken 60 min, 30 min, and immediately before an i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-3-883
更新日期:1987-09-01 00:00:00
abstract::Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.6.8854
更新日期:2002-06-01 00:00:00
abstract::Recent studies from our laboratory (Endocrinology 136:4762-4768, 1995) demonstrating that the expression of cAMP-dependent nuclear transcription factor CREB (cAMP response element binding protein) is lost following ovulation in macaques has revealed a novel mechanism by which the cytoplasmic and nuclear actions the cA...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.8.5346
更新日期:1997-08-01 00:00:00
abstract::The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1070
更新日期:2011-11-01 00:00:00
abstract::Binding of PTH to purified canine renal cortical membranes was investigated using biologically active radioiodinated bovine PTH-(1-84) [bPTH-(1-84)] as radioligand. PTH-(1-84) is thought to be the major circulating form of bioactive PTH, but oxidative inactivation upon iodination has prevented its use as a radioligand...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-4-1303
更新日期:1983-04-01 00:00:00
abstract::The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1125
更新日期:2004-05-01 00:00:00
abstract::In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1941
更新日期:2015-05-01 00:00:00
abstract::Glucocorticoid (Gc) excess, from endogenous overproduction in disorders of the hypothalamic-pituitary-adrenal axis or exogenous medical therapy, is recognized to cause adverse metabolic side effects. The Gc receptor (GR) is widely expressed throughout the body, including brain regions such as the hypothalamus. However...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1571
更新日期:2016-11-01 00:00:00
abstract::The estrogenic and antiestrogenic actions of the geometric isomers of tamoxifen and 4-hydroxytamoxifen were determined in a PRL synthesis assay using primary cultures of dispersed immature rat pituitary gland cells. 4-Hydroxytamoxifen was 100 times more potent as an antiestrogen than tamoxifen. The cis isomer of tamox...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-4-1449
更新日期:1988-04-01 00:00:00
abstract::Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1beta to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, release T lymphocyte chemotactic activity. The effect of IL-1beta ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0199
更新日期:2003-07-01 00:00:00
abstract::In the murine Ob 17 preadipocyte cell line, the thyroid hormone T3 is an adipogenic factor necessary at an early stage for differentiation into adipocyte. We demonstrate here that this T3 dependence may involve a transient expression (at both the messenger RNA and the protein levels) of c-ErbA beta-type receptors (T3R...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.7.6860
更新日期:1999-07-01 00:00:00
abstract::The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0607
更新日期:2011-01-01 00:00:00
abstract::Growth hormone (GH) is the key hormone involved in the regulation of growth and metabolism, two functions that are highly modulated during infancy. GH secretion, controlled mainly by GH releasing hormone (GHRH), has a characteristic pattern during postnatal development that results in peaks of blood concentration at b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0298
更新日期:2010-12-01 00:00:00
abstract::The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0220
更新日期:2003-10-01 00:00:00
abstract::Orally delivered salt stimulates renal salt excretion more effectively than does iv delivered salt. Although the mechanisms that underlie this "postprandial natriuresis" are poorly understood, the peptide uroguanylin (UGn) is thought to be a key mediator. However, the lack of selective assays for UGn gene products has...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1725
更新日期:2008-09-01 00:00:00
abstract::The pancreatic polypeptide cell, the only mature endocrine cell in the fetal pig pancreas, produces equimolar amounts of two peptides, pancreatic polypeptide and pancreatic icosapeptide, from the same precursor. The amino acid sequence of pancreatic polypeptide is more homogeneous among species, whereas pancreatic ico...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.10.8409
更新日期:2001-10-01 00:00:00
abstract::The regulation of TRH gene expression in the paraventricular nucleus of the hypothalamus (PVH) by leptin is critical for normal function of the thyroid axis in rodents and humans. The TRH neuron in the PVH expresses both leptin and melanocortin-4 receptors, suggesting that both signaling systems may regulate TRH gene ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1312
更新日期:2004-05-01 00:00:00