Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma.

abstract：:These studies have examined the ontogeny of specific GH- and PRL-binding proteins in rabbit liver cytosol across the fetal, early neonatal, and adult periods. The precise hormonal specificity of binding of the somatotropic/lactogenic ligand, [125I]human GH, was determined by displacement with monoclonal antibodies aga...

journal_title：Endocrinology

authors： Ymer SI,Stevenson JL,Herington AC

更新日期：1989-07-01 00:00:00

abstract：:Previous experiments showed that LSH/SsLak female hamsters cease ovarian cyclicity after 2-4 weeks of short photoperiod (SP) treatment. This study was designed to reveal early hormonal and histological changes on day 1 of the estrous cycle (estrus) in SP-treated animals and changes brought about by the SP-induced acyc...

journal_title：Endocrinology

authors： Hauser UE,Benson B

更新日期：1987-01-01 00:00:00

abstract：:In a previous paper, we demonstrated that an inhibitory action of excess iodide on thyrotropin-induced thyroid hormone secretion occurs at a site subsequent to the generation of cyclic AMP. In the present study, however, we have found that thyroidal cyclic AMP formation induced by thyrotropin in vitro was markedly inh...

journal_title：Endocrinology

authors： Hashizume K,Akasu F,Takazawa K,Endo W,Onaya T

更新日期：1976-12-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:In adult rats hysterectomized on day 8 of pseudopregnancy, the mean serum progesterone (P) level fell from 88 ng/ml on day 8 to 44 ng/ml on day 15 (n = 61). In response to a single sc injection of 0.5 ml of a specific antiserum to LH (LHAS) on day 10, the P level fell to less than 10 by day 15 in 29 of 33 rats; howeve...

journal_title：Endocrinology

authors： Sanchez-Criado J,Rothchild I

更新日期：1986-10-01 00:00:00

abstract：:A competitive protein-binding (CPB) assay, suitable for measuring corticosterone levels in 20 mul of mouse plasma or 100 mg of brain, is described. The postnatal development of adrenocortical function was determined in C57BL/10 and DBA/1 mice by CPB assay of basal and stressinduced levels of plasma corticosterone and ...

journal_title：Endocrinology

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1976-06-01 00:00:00

abstract：:To ascertain if reductions in fetal plasma cortisol cause increases in fetal plasma ACTH, we treated pregnant ewes or their fetuses with aminoglutethimide (10 mg/kg BW) and metyrapone (20 mg/kg BW) and measured the hormonal responses with RIAs. When given to fetuses (n = 9) at 0.90 +/- 0.01 gestation (term-145 days), ...

journal_title：Endocrinology

authors： Rose JC,Turner CS,Ray D,Rawashdeh N

更新日期：1988-09-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a C cell neoplasm-secreting calcitonin. Surgery remains the only treatment as the primary tumor and metastases resist radio- and chemotherapies. MTC produces high amounts of prostaglandins (PGs). Nonsteroidal antiinflammatory drugs have an antitumoral effect, generally related to the ...

journal_title：Endocrinology

authors： Quidville V,Segond N,Pidoux E,Cohen R,Jullienne A,Lausson S

更新日期：2004-05-01 00:00:00

abstract：:Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary somatotrophs, generate deleterious effects. We recently described a targeted secretion inhibitor (SXN101742) comprising a GHRH domain and the endopeptidase domain of botulinum toxin serotype D (GHRH-light chain endopeptidase type D d...

journal_title：Endocrinology

authors： Somm E,Bonnet N,Zizzari P,Tolle V,Toulotte A,Jones R,Epelbaum J,Martinez A,Hüppi PS,Aubert ML

更新日期：2013-11-01 00:00:00

abstract：:The effect of diabetes mellitus on the synthesis and secretion of thyroid hormone ws investigated in mice with streptozotocin-induced diabetes. Thyroid glands were labeled in vivo with 131I for 2 h. In control animals, TSH stimulated the synthesis of PB127I and 131I-labeled iodothyronines and simultaneously decreased ...

journal_title：Endocrinology

authors： Bagchi N,Brown TR,Shivers B,Lucas S,Mack RE

更新日期：1981-11-01 00:00:00

abstract：:Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...

journal_title：Endocrinology

authors： Ramaswamy S,Dwarki K,Ali B,Gibbs RB,Plant TM

更新日期：2013-05-01 00:00:00

abstract：:Na(+)/I(-) symporter (NIS)-mediated iodide uptake into thyroid follicular cells serves as the basis of radioiodine therapy for thyroid cancer. NIS protein is also expressed in the majority of breast tumors, raising potential for radionuclide therapy of breast cancer. KT5823, a staurosporine-related protein kinase inhi...

journal_title：Endocrinology

authors： Beyer S,Lakshmanan A,Liu YY,Zhang X,Wapnir I,Smolenski A,Jhiang S

更新日期：2011-03-01 00:00:00

abstract：:The insulin-like growth factors (IGF)-I and -II are bound to specific carrier proteins in the circulation. For investigation of their physiological role, the acid-stable subunit of the major binding protein (SmBP) was isolated from human plasma Cohn fraction IV. Its effect on the mitogenic activity of IGF-I was studie...

journal_title：Endocrinology

authors： Blum WF,Jenne EW,Reppin F,Kietzmann K,Ranke MB,Bierich JR

更新日期：1989-08-01 00:00:00

abstract：:Although prolactinomas can be effectively treated with dopamine agonists, about 20% of patients develop dopamine resistance or tumor recurrence after surgery, indicating a need for better understanding of underlying disease mechanisms. Although estrogen-induced rat prolactinomas have been widely used to investigate th...

journal_title：Endocrinology

authors： Tong Y,Zheng Y,Zhou J,Oyesiku NM,Koeffler HP,Melmed S

更新日期：2012-08-01 00:00:00

abstract：:Carboxyl-terminal fragments of PTH (C-PTH) appear to have biological properties different from those mediated by the amino-terminal portions of PTH and PTH-related peptide (PTHrP). To characterize a C-PTH receptor that may be involved in mediating these functions, we performed RRAs and affinity cross-linking studies w...

journal_title：Endocrinology

authors： Inomata N,Akiyama M,Kubota N,Jüppner H

更新日期：1995-11-01 00:00:00

abstract：:The mechanisms by which oxytocin (OT) stimulates extracellular signal-regulated kinase 1/2 (ERK1/2) are only partially understood. OT receptor (OTR) signals predominantly through Galpha(q), but ERK1/2 phosphorylation (ERK1/2-P) in PHM1 myometrial cells was not eliminated by inhibition of downstream effectors such as p...

journal_title：Endocrinology

authors： Zhong M,Yang M,Sanborn BM

更新日期：2003-07-01 00:00:00

abstract：:Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks....

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-11-01 00:00:00

abstract：:In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...

journal_title：Endocrinology

authors： Mendez P,Garcia-Segura LM

更新日期：2006-06-01 00:00:00

abstract：:To address the role of the GH-binding protein (GHBP) in GH physiology, two forms of recombinant human GHBP (rhGHBP) were given alone or in combination with rhGH to hypophysectomized rats or GH-deficient dwarf rats. Hypophysectomized rats were given daily sc injections of excipient, hGH, rhGHBP, or rhGH plus rhGHBP (pr...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Spencer SA,McKay P,Mulkerrin M,Moore J,Cunningham BC

更新日期：1996-10-01 00:00:00

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00

abstract：:The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...

journal_title：Endocrinology

authors： Jamaluddin MFB,Ko YA,Kumar M,Brown Y,Bajwa P,Nagendra PB,Skerrett-Byrne DA,Hondermarck H,Baker MA,Dun MD,Scott RJ,Nahar P,Tanwar PS

更新日期：2018-02-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be determined. Using two...

journal_title：Endocrinology

authors： Date Y,Kojima M,Hosoda H,Sawaguchi A,Mondal MS,Suganuma T,Matsukura S,Kangawa K,Nakazato M

更新日期：2000-11-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms whereby ovarian hormones, and particularly estrogens, modulate fat cell metabolism, we investigated the effects of estradiol administration on c-fos and c-jun expressions in fat cells from ovariectomized (OVX) rats. Estradiol treatment resulted in a rapid increase in c-fo...

journal_title：Endocrinology

authors： Garcia E,Lacasa D,Giudicelli Y

更新日期：2000-08-01 00:00:00

abstract：:The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable therapeutic potential in the treatment of cancer. We previously reported that the 16-kilodalton N-terminal fragment of ra...

journal_title：Endocrinology

authors： Clapp C,Martial JA,Guzman RC,Rentier-Delure F,Weiner RI

更新日期：1993-09-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:In the murine Ob 17 preadipocyte cell line, the thyroid hormone T3 is an adipogenic factor necessary at an early stage for differentiation into adipocyte. We demonstrate here that this T3 dependence may involve a transient expression (at both the messenger RNA and the protein levels) of c-ErbA beta-type receptors (T3R...

journal_title：Endocrinology

authors： Dace A,Sarkissian G,Schneider L,Martin-El Yazidi C,Bonne J,Margotat A,Planells R,Torresani J

更新日期：1999-07-01 00:00:00

abstract：:Neuronal remodeling in response to deafferenting lesions in the brain can be enhanced by estradiol (E2). Astrocytes are among the targets of E2 in complex interactions with neurons and may support or inhibit neuronal remodeling. In ovariectomized female rats given entorhinal cortex lesions, E2 replacement inhibited th...

journal_title：Endocrinology

authors： Rozovsky I,Wei M,Stone DJ,Zanjani H,Anderson CP,Morgan TE,Finch CE

更新日期：2002-02-01 00:00:00

abstract：:The ABCB1-type multidrug resistance efflux transporter P-glycoprotein (P-gp) has been hypothesized to regulate hypothalamic-pituitary-adrenal axis activity by limiting the access of glucocorticoids to the brain. In vivo systemic administration studies using P-gp-deficient mice have shown increased glucocorticoid entry...

journal_title：Endocrinology

authors： Mason BL,Pariante CM,Thomas SA

更新日期：2008-10-01 00:00:00