Abstract:
:We report here 1) that GnRH and a potent GnRH agonist inhibit basal and LH stimulated ovarian androgen biosynthesis in vitro, 2) that the inhibitory effects of GnRH are dose-dependent and completely inhibited by concomitant treatment with a GnRH antagonist and 3) that the GnRH action is very rapid (t1/2 = 10 min) and persists after thorough washing of the cells. These data suggest that GnRH acts at a stereospecific binding site on ovarian theca and/or interstitial cells (probably the theca cells) to rapidly and perhaps irreversibly inhibit androgen biosynthesis.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Magoffin DA,Reynolds DS,Erickson GFdoi
10.1210/endo-109-2-661subject
Has Abstractpub_date
1981-08-01 00:00:00pages
661-3issue
2eissn
0013-7227issn
1945-7170journal_volume
109pub_type
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