Abstract:
:Four 1-yr-old, i.e. immature, monkeys (M. fascicularis) were treated with testosterone. For the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. Four similarly aged monkeys served as untreated controls. The testosterone enanthate injections produced a peak level of 345 +/- 70 nmol/liter (mean +/- SD) after 24 h and the levels were 187 +/- 39 nmol/liter 7 days later. The overall mean level of circulating testosterone in the untreated monkeys was 3.5 +/- 1.1 nmol/liter. Testicular volumes of the treated monkeys became 6 times larger than those of the untreated monkeys. The testicular testosterone concentrations of the treated monkeys were about 2- to 4-fold greater than those of untreated immature monkeys but no more than 82% of the normal adult range. Spermatogenesis in varying degrees of completeness was found in the testes of all four treated monkeys. Moreover, sperm, including some motile cells were found in the ejaculates of two monkeys. These data lead to the conclusion that spermatogenesis can be initiated, although not quantitatively, in an immature nonhuman primate by testosterone treatment.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Marshall GR,Wickings EJ,Nieschlag Edoi
10.1210/endo-114-6-2228subject
Has Abstractpub_date
1984-06-01 00:00:00pages
2228-33issue
6eissn
0013-7227issn
1945-7170journal_volume
114pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-5-1796
更新日期:1985-11-01 00:00:00
abstract::19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present stud...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-1-313
更新日期:1981-07-01 00:00:00
abstract::The relationship between serum levels of rat GH (rGH), rat PRL (rPRL), corticosterone, estrogen, and testosterone and the liver-binding sites specific to [125I]iodo-human GH (hGH), -human PRL (hPRL), and -rPRL were investigated in normal rats, in rats bearing the GH- and PRL-secreting tumor (GH3), and in rats 14 days ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-103-6-2053
更新日期:1978-12-01 00:00:00
abstract::A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.1.8419140
更新日期:1993-01-01 00:00:00
abstract::High density lipoprotein (HDL) participates in reverse cholesterol transport and in the delivery of cholesterol to steroid-producing tissues. Scavenger receptor class B type I (SR-BI) was recently shown to bind HDL and mediate internalization of its cholesterol content. We have cloned the rat homolog of this receptor,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.1.5666
更新日期:1998-01-01 00:00:00
abstract::Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0898
更新日期:2007-12-01 00:00:00
abstract::Normal fetal preoptic area (POA), a site of GnRH production, was implanted into the third ventricle of adult female hypogonadal (hpg) mice. When the grafts were successful, the mice (genetically deficient in hypothalamic GnRH) responded with vaginal opening, cornified vaginal cells, ovarian and uterine development, an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-5-1938
更新日期:1984-05-01 00:00:00
abstract::The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-1-328
更新日期:1980-07-01 00:00:00
abstract::Estrogen increases the alpha 1-adrenergic contractile sensitivity of the rabbit uterus. Since estrogen treatment increases prostaglandin (PG) production by the perfused rabbit uterus, and PGs contribute to the alpha 1-adrenergic contractile response, we postulated that estrogen's effects on PG production or response m...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-3-1436
更新日期:1991-09-01 00:00:00
abstract::Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0588
更新日期:2005-01-01 00:00:00
abstract::Current in vivo and in vitro data indicate that progesterone (P) is required for epithelial proliferation in mammary glands of adult mice. P receptors (PgR) in adult mammary glands are under estrogenic regulation. By contrast in immature, pubertal 5-week-old mice, PgR are present only in low concentration and cannot b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-2-464
更新日期:1988-02-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at a high level in the fetal pituitary and decreases profoundly between embryonic day 19 and postnatal day 1 (PN1), with a further decrease from PN1 to PN4. In this series of experiments, we investigated the hypothesis that dopamine 2 receptor (Dr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2147
更新日期:2014-07-01 00:00:00
abstract::Both Snell (Pit-1(dw) or (dwj), dw/dw) and Ames (Prophet of Pit-1(df), df/df) dwarf mice fail to produce prolactin (PRL) as well as GH due to deficient transcription factor Pit-1 activity and have reduced numbers of hypothalamic PRL-inhibiting area A12 tuberoinfundibular dopaminergic (TIDA) neurons. It has been report...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0931
更新日期:2004-12-01 00:00:00
abstract::Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-1-119
更新日期:1983-07-01 00:00:00
abstract::MCRs of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined in the morning and evening in four chronically chaired adult rhesus monkeys (Macaca mulatta) by means of steady state infusion of [4-14C]testosterone and [1,2-3H]dihydrotestosterone. Morning and evening MCRs were comparable for both T and D...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-105-2-402
更新日期:1979-08-01 00:00:00
abstract::The effects of GH and PTH on cancellous histomorphometry were determined in the proximal tibial metaphysis of hypophysectomized (HYPOX) sexually mature female rats. HYPOX resulted in uterine atrophy and a loss in body weight. Longitudinal bone growth ceased and bone formation was greatly reduced. There were decreases ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.11.7588250
更新日期:1995-11-01 00:00:00
abstract::It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis. Here we analyzed premature aging, mineral homeostasis, carbohydrate metabo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1878
更新日期:2012-04-01 00:00:00
abstract::In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1120
更新日期:2013-08-01 00:00:00
abstract::Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa033
更新日期:2020-04-01 00:00:00
abstract::Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-1-251
更新日期:1983-07-01 00:00:00
abstract::Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis. Ethinyl estradiol (EE2) is a synthetic estrogen used in contraceptive pills, whereas zearalenone (ZEA) is a natural mycoestrogen fou...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1330
更新日期:2015-11-01 00:00:00
abstract::Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0530
更新日期:2008-03-01 00:00:00
abstract::Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horse...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-63
更新日期:1975-01-01 00:00:00
abstract::A chemiluminescent dot blot assay has been developed by our laboratory for rapid determinations of IGF-I in serum-free conditioned media (CM) collected from cultured cells. In contrast to IGF-I radioimmunoassays (RIAs), the IGF binding proteins (IGFBPs) did not interfere with the dot blot assay and did not require the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.5.5237
更新日期:1997-05-01 00:00:00
abstract::Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later. After ECP injection ovarian histology reveals that the follicles normally destined to ov...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-878
更新日期:1975-10-01 00:00:00
abstract::We have established immortalized human granulosa cells by triple transfection of primary cells obtained from in vitro fertilization patients with SV40 DNA, Ha-ras oncogene, and a temperature sensitive (ts) mutant of the tumor suppressor gene p53 (p53val135). Forty-one clones were isolated, and their steroidogenic resp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.11.6279
更新日期:1998-11-01 00:00:00
abstract::Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-103-2-548
更新日期:1978-08-01 00:00:00
abstract::To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1296
更新日期:2009-05-01 00:00:00
abstract::Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.7.7560
更新日期:2000-07-01 00:00:00
abstract::The present study investigates the effect of different endocrine manipulations on the gamma-aminobutyric acid (GABA)-ergic system in the rat fallopian tube. Either hypophysectomy or ovariectomy induced a significant decrease of glutamic acid decarboxylase (GAD) activity and of GABA levels in in situ tubes. This effect...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-1-334
更新日期:1986-01-01 00:00:00