Sorbin in the porcine gastrointestinal tract and pancreas: an immunocytochemical analysis.

abstract：:Antisera to porcine relaxin were produced in rabbits injected with different fractions that had been separated by polyacrylamide gel electrophoresis (PAGE). Analyses by agar double immunodiffusion demonstrated that the different fractions of relaxin separated by PAGE have similar antigenic sites and the individual fra...

journal_title：Endocrinology

authors： Larkin LH,Fields PA,Oliver RM

更新日期：1977-09-01 00:00:00

abstract：:Although tamoxifen (TAM), which is widely used in the treatment of breast cancer, also has a beneficial effect on cisplatin-refractory ovarian cancer, the biological mechanism of this effect has remained obscure. TAM, besides its action as an antiestrogen, also inhibits cell proliferation of estrogen receptor (ER)-neg...

journal_title：Endocrinology

authors： Mabuchi S,Ohmichi M,Kimura A,Ikebuchi Y,Hisamoto K,Arimoto-Ishida E,Nishio Y,Takahashi K,Tasaka K,Murata Y

更新日期：2004-03-01 00:00:00

abstract：:Estrogen receptor (ER) expression and regulation is vital to the correct functioning of the neuroendocrine brain. Islet-1 (Isl-1) is a LIM homeodomain-containing transcription factor that has been implicated in neuronal differentiation, is located in the hypothalamus, and can alter ER function in vitro. We have determ...

journal_title：Endocrinology

authors： Davis AM,Seney ML,Walker HJ,Tobet SA

更新日期：2004-01-01 00:00:00

abstract：:Animals maintained on retinol (vitamin A-alcohol)-deficient diets exhibit testicular atrophy and loss of the germinal epithelium. Retinoic acid (vitamin A-acid), when fed to retinol-deficient animals, does not prevent these lesions and had thus been thought not to play a role in the tests. Serum testosterone (T) level...

journal_title：Endocrinology

authors： Appling DR,Chytil F

更新日期：1981-06-01 00:00:00

abstract：:Previous studies had suggested that norepinephrine (NE) and its precursors dopamine (DA) and L-DOPA acted similarly on iodine metabolism of isolated thyroid cells. Present studies indicate that this similarity extends to the inhibition by catecholamines of TSH-stimulated T4 release by mouse thyroids incubated in vitro...

journal_title：Endocrinology

authors： Maayan ML,Sellitto RV,Volpert EM

更新日期：1986-02-01 00:00:00

abstract：:These studies have examined the ontogeny of specific GH- and PRL-binding proteins in rabbit liver cytosol across the fetal, early neonatal, and adult periods. The precise hormonal specificity of binding of the somatotropic/lactogenic ligand, [125I]human GH, was determined by displacement with monoclonal antibodies aga...

journal_title：Endocrinology

authors： Ymer SI,Stevenson JL,Herington AC

更新日期：1989-07-01 00:00:00

abstract：:Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity. Like neuropeptide Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice. These data suggest that...

journal_title：Endocrinology

authors： Mizuno TM,Mobbs CV

更新日期：1999-02-01 00:00:00

abstract：:Peptide-YY (PYY) is a novel enteric peptide that is structurally related to pancreatic polypeptide and neuropeptide-Y. The objectives of the present experiments were to characterize the following aspects of PYY metabolism: the distribution of PYY in the canine gastrointestinal tract, the release of PYY in response to ...

journal_title：Endocrinology

authors： Greeley GH Jr,Jeng YJ,Gomez G,Hashimoto T,Hill FL,Kern K,Kurosky T,Chuo HF,Thompson JC

更新日期：1989-03-01 00:00:00

abstract：:PTH stimulates synthesis and secretion of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in renal proximal tubule cells through activation of the protein kinase-A (PKA) or the protein kinase-C (PKC) signaling pathway. The relative contribution of the two transducing systems was explored using PTH fragments with selective act...

journal_title：Endocrinology

authors： Janulis M,Wong MS,Favus MJ

更新日期：1993-08-01 00:00:00

abstract：:A heterologous RIA for rat GH-releasing factor (rGRF) was established using synthetic rGRF-(1-43)OH for both standard reference and radioiodination with the antiserum produced against human GRF-(1-44) NH2. The regional distribution of rGRF-like immunoreactivity (LI) in rat hypothalamus was examined according to the Pa...

journal_title：Endocrinology

authors： Kita T,Chihara K,Abe H,Minamitani N,Kaji H,Kodama H,Kashio Y,Okimura Y,Fujita T,Ling N

更新日期：1985-01-01 00:00:00

abstract：:The possibility that the responsiveness of plasma aldosterone concentration to angiotensin II alters with changes in sodium balance was investigated in male beagle dogs under conditions of controlled sodium and potassium intake. Angiotensin II was infused at four different rates (usually 3, 6, 12, and 24 ng/kg/min), e...

journal_title：Endocrinology

authors： Nicholls MG,Tree M,Brown JJ,Douglas BH,Fraser R,Hay GD,Lever AF,Morton JJ,Robertson JI

更新日期：1978-02-01 00:00:00

abstract：:In order to elucidate the putative role of inhibin in regulation of spermatogenesis, expression of inhibin subunits was examined at defined stages of the cycle of the rat seminiferous epithelium. Twenty 2-mm segments of seminiferous tubules at stages XIII-I, II-VI, VII-VIII, and IX-XII were dissected using the transil...

journal_title：Endocrinology

authors： Bhasin S,Krummen LA,Swerdloff RS,Morelos BS,Kim WH,diZerega GS,Ling N,Esch F,Shimasaki S,Toppari J

更新日期：1989-02-01 00:00:00

abstract：:The existence of renin in a number of extrarenal tissues has been well documented, but the physiological role of extrarenal renin remains unknown. To study the physiological role of adrenal renin, we developed a serum-free culture system for adrenal capsular/zona glomrulosa explants. Explants showed good viability in ...

journal_title：Endocrinology

authors： Shier DN,Kusano E,Stoner GD,Franco-Saenz R,Mulrow PJ

更新日期：1989-07-01 00:00:00

abstract：:In higher primates, FSH secretion appears to be regulated by a control system consistent with that described by the classical inhibin hypothesis. The purpose of the present experiment was to examine the time course of inhibin's action to suppress FSH secretion in the intact adult male rhesus monkey. To this end, five ...

journal_title：Endocrinology

authors： Ramaswamy S,Pohl CR,McNeilly AS,Winters SJ,Plant TM

更新日期：1998-08-01 00:00:00

abstract：:Cultures of Sertoli cells were treated with freshly isolated, intact germ cells to determine if germ cells were capable of influencing Sertoli cell function. By using two-dimensional polyacrylamide gel electrophoresis and autoradiography, germ cells were found to increase several-fold the incorporation of [32P]orthoph...

journal_title：Endocrinology

authors： Ireland ME,Welsh MJ

更新日期：1987-04-01 00:00:00

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:Recently, we reported that ovariectomy (OVX)-induced FSH hypersecretion can be elicited in hypophysectomized rats bearing renal pituitary allografts isolated from direct hypothalamic intervention. The possible role of the FSH-stimulating protein, activin-B, in eliciting this response was investigated using passive imm...

journal_title：Endocrinology

authors： DePaolo LV,Bald LN,Fendly BM

更新日期：1992-03-01 00:00:00

abstract：:It is assumed that after complete bilateral adrenalectomy (ADX), no adrenal tissue will redevelop and adrenal hormone levels will remain low and unaffected by stress. However, anecdotal observations in animals and in patients suggest that under some unknown circumstances the opposite can occur. Herein, we studied whet...

journal_title：Endocrinology

authors： Gotlieb N,Albaz E,Shaashua L,Sorski L,Matzner P,Rosenne E,Amram B,Benbenishty A,Golomb E,Ben-Eliyahu S

更新日期：2018-01-01 00:00:00

abstract：:Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon. Recent evidence suggests that serum- and glucocorticoid-regulated kinase (SGK) is induced by aldosterone and acts as a key mediator of aldosterone action in epithelial tissues. Induction of SGK messen...

journal_title：Endocrinology

authors： Bhargava A,Fullerton MJ,Myles K,Purdy TM,Funder JW,Pearce D,Cole TJ

更新日期：2001-04-01 00:00:00

abstract：:Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis t...

journal_title：Endocrinology

authors： Molnár CS,Vida B,Sipos MT,Ciofi P,Borsay BÁ,Rácz K,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z,Hrabovszky E

更新日期：2012-11-01 00:00:00

abstract：:Fetuin-A is a biomarker reported to be important in many metabolic disorders, including obesity, diabetes, and hepatic steatosis. Although it is well known that fetuin-A is increased in diabetes and nonalcoholic fatty liver disease (NAFLD), the levels of fetuin-A in diabetic patients with NAFLD are unknown. Furthermor...

journal_title：Endocrinology

authors： Ou HY,Wu HT,Hung HC,Yang YC,Wu JS,Chang CJ

更新日期：2012-07-01 00:00:00

abstract：:In the present study the effects of stimulus deprivation on vasoactive intestinal peptide (VIP)- and alpha 1-adrenergically mediated amplification of VIP-stimulated cAMP and cGMP accumulation were examined. Dispersed pinealocytes were prepared from either Sprague-Dawley rats maintained for 2 weeks in a normal lighting...

journal_title：Endocrinology

authors： Chik CL,Ho AK

更新日期：1991-02-01 00:00:00

abstract：:The median eminence (ME) region of the hypothalamus was electrically stimulated through permanently implanted electrodes in 1 unanesthetized sheep. Plasma concentrations of GH and prolactin (PRL) were measured at 10-min intervals before, during and after 30-min periods of electrical stimulation or sham procedures. The...

journal_title：Endocrinology

authors： Malven PV

更新日期：1975-10-01 00:00:00

abstract：:In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...

journal_title：Endocrinology

authors： Khan A,Hong-Lie C,Landau BR

更新日期：1995-05-01 00:00:00

abstract：:Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membr...

journal_title：Endocrinology

authors： Ku CY,Qian A,Wen Y,Anwer K,Sanborn BM

更新日期：1995-04-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:Immunohistochemical (immunoperoxidase) studies were performed on 478 sections from 97 rat pituitary glands with rabbit antisera to unconjugated human synthetic calcitonin beta-endorphin, and/or ACTH-(17--39). Calcitonin-positive cells were present in a majority of the anterior lobes studied, whereas they were present ...

journal_title：Endocrinology

authors： Watkins WB,Moore RY,Burton D,Bone HG 3rd,Catherwood BD,Deftos LJ

更新日期：1980-06-01 00:00:00

abstract：:Enlargement of the chimeric ventral prostate gland (VP) was induced by directly implanting either fetal urogenital sinus mesenchyme (UGM) or intact fetal urogenital sinus (UGS) into the VP of intact adult rats. The macromolecular content in the chimeric prostate increased from 40-100% (UGM implants) to 200-300% (UGS i...

journal_title：Endocrinology

authors： Thompson TC,Chung LW

更新日期：1986-06-01 00:00:00

abstract：:Attempts to assess human placental GH variant (hGH-V) and chorionic somatomammotropin (hCS) RNA in choriocarcinoma cell lines have been hampered by low levels of expression and limited sensitivity of RNA blotting analysis. We examined human choriocarcinoma BeWo, JAR, and JEG-3 cell lines as well as samples of complete...

journal_title：Endocrinology

authors： Lytras A,Bock ME,Dodd JG,Cattini PA

更新日期：1994-06-01 00:00:00