The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action.

abstract：:In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...

journal_title：Endocrinology

authors： Wiemers DO,Shao LJ,Ain R,Dai G,Soares MJ

更新日期：2003-01-01 00:00:00

abstract：:Renin-angiotensin system blockade improves glucose intolerance and insulin resistance, which contribute to the development of metabolic syndrome. However, the contribution of impaired insulin secretion to the pathogenesis of metabolic syndrome is not well defined. To assess the contributions of angiotensin receptor ty...

journal_title：Endocrinology

authors： Rodriguez R,Viscarra JA,Minas JN,Nakano D,Nishiyama A,Ortiz RM

更新日期：2012-04-01 00:00:00

abstract：:Calcitonin is present in both the hypothalamus and pituitary of the rat, and normal rat anterior pituitary cells express calcitonin receptors. Calcitonin has been reported to inhibit or to stimulate PRL release from rat anterior pituitary cells. We have investigated the effects of salmon calcitonin on basal and stimul...

journal_title：Endocrinology

authors： Judd AM,Kubota T,Kuan SI,Jarvis WD,Spangelo BL,Macleod RM

更新日期：1990-07-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP), via its guanylyl cyclase (GC)-A receptor, plays a key role in the regulation of arterial blood pressure (ABP) and volume. Endothelial-restricted deletion of GC-A in mice [endothelial cell (EC) GC-A knockout (KO)] resulted in hypervolemic hypertension, demonstrating that the endotheliu...

journal_title：Endocrinology

authors： Sabrane K,Kruse MN,Gazinski A,Kuhn M

更新日期：2009-05-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:Follistatin (FS), which binds to the inhibin/activin beta A- or beta B-subunit is localized with and modulates the biological actions of activin in many systems. However, in contrast to the wide distribution of the activin beta-subunit proteins and messenger RNAs (mRNA) in the brain, demonstration of FS mRNA signal ha...

journal_title：Endocrinology

authors： Macconell LA,Barth S,Roberts VJ

更新日期：1996-05-01 00:00:00

abstract：:We have established a system, the CA77 rat medullary thyroid carcinoma cell line, for studying the products of somatostatin (SS) gene expression. Based on the amino acid sequence of proSS, we developed a RIA for the amino terminus of proSS (proSS-NTP) and demonstrated in acidic cell extracts two major proSS-NTP-contai...

journal_title：Endocrinology

authors： Aron DC,Roos BA

更新日期：1986-01-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However, whether berberine exerts a regulatory effect on beta-cells via AMPK or other signaling pathways and counteracts glucolipotoxicity rem...

journal_title：Endocrinology

authors： Zhou L,Wang X,Shao L,Yang Y,Shang W,Yuan G,Jiang B,Li F,Tang J,Jing H,Chen M

更新日期：2008-09-01 00:00:00

abstract：:Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of pro...

journal_title：Endocrinology

authors： Gadot M,Leibowitz G,Shafrir E,Cerasi E,Gross DJ,Kaiser N

更新日期：1994-08-01 00:00:00

abstract：:The extensive colocalization of insulin receptor (IR) and insulin-like growth factor-I receptor (IGFR) messenger RNAs during central nervous system development, together with the effects of insulin and IGF-I in neurogenesis, raises the question of how stage- and factor-specific signaling occurs. Thus, it is necessary ...

journal_title：Endocrinology

authors： García-de Lacoba M,Alarcón C,de la Rosa EJ,de Pablo F

更新日期：1999-01-01 00:00:00

abstract：:The influence of LY117018 and tamoxifen on established uterotropic influence of estradiol was examined in immature ovariectomized rats. When LY117018 was introduced on the fourth day of estradiol treatment, it regressed the uterotropic effect of estradiol. However, tamoxifen did not attenuate estradiol activity under ...

journal_title：Endocrinology

authors： Black LJ,Goode RL

更新日期：1981-09-01 00:00:00

abstract：:This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16...

journal_title：Endocrinology

authors： Tilbrook AJ,de Kretser DM,Cummins JT,Clarke IJ

更新日期：1991-12-01 00:00:00

abstract：:The present work extends our previous report that the intracerebroventricular (i.c.v.) injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the test...

journal_title：Endocrinology

authors： Ogilvie K,Rivier C

更新日期：1998-07-01 00:00:00

abstract：:This report describes properties of highly purified cathepsin-B and an additional cysteine proteinase, designated cysteine proteinase I, obtained from human thyroids. Both enzymes are localized to lysosomes. The activity profile of cysteine proteinase I combined with its sensitivity to the active site inhibitor Z-Phe-...

journal_title：Endocrinology

authors： Dunn AD,Dunn JT

更新日期：1988-08-01 00:00:00

abstract：:Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine. Forskolin mimicked the stimulatory effect on PLMT, and insulin inhibited this effe...

journal_title：Endocrinology

authors： Kelly KL,Wong EH

更新日期：1987-06-01 00:00:00

abstract：:The purpose of this study was to determine whether normal morphological development occurs in pituitary corticotrophs deprived of products of the hypothalamic paraventricular nucleus (PVN), e.g. corticotropin releasing hormone and arginine vasopressin (AVP), after PVN lesions. In addition, we have attempted to ascerta...

journal_title：Endocrinology

authors： McDonald TJ,Hoffman GE,Nathanielsz PW

更新日期：1992-09-01 00:00:00

abstract：:Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...

journal_title：Endocrinology

authors： Murray I,Havel PJ,Sniderman AD,Cianflone K

更新日期：2000-03-01 00:00:00

abstract：:The rat S14 gene is synergistically regulated by thyroid hormone and carbohydrates. The 5'-flanking region of this gene contains both carbohydrate and thyroid hormone response elements (TREs). We recently located the carbohydrate response element (CHORE) between -1583 and -1069 bases from the start site of transcripti...

journal_title：Endocrinology

authors： Sudo Y,Mariash CN

更新日期：1993-07-01 00:00:00

abstract：:Insulin radioreceptor assays were developed using splenic leukocytes and peripheral erythrocytes from individual mice. Splenic leukocytes were prepared using an NH4Cl buffer which did not alter insulin binding, but gave much higher yields than density gradient methods. Mouse erythrocytes were isolated from heparinized...

journal_title：Endocrinology

authors： Shimizu F,Kahn CR

更新日期：1982-02-01 00:00:00

abstract：:Cultures of Sertoli cells were treated with freshly isolated, intact germ cells to determine if germ cells were capable of influencing Sertoli cell function. By using two-dimensional polyacrylamide gel electrophoresis and autoradiography, germ cells were found to increase several-fold the incorporation of [32P]orthoph...

journal_title：Endocrinology

authors： Ireland ME,Welsh MJ

更新日期：1987-04-01 00:00:00

abstract：:The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...

journal_title：Endocrinology

authors： Anan M,Uchihashi K,Aoki S,Matsunobu A,Ootani A,Node K,Toda S

更新日期：2011-04-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:Localized expression of cytochromes P450 17 alpha-hydroxylase (P450c17) and aromatase (P450arom) was investigated in embryonic cell layers of elongating porcine blastocysts by immunocytochemistry. Blastocysts were flushed from the uterus on day 12 of pregnancy, fixed in paraformaldehyde, embedded in paraffin, sectione...

journal_title：Endocrinology

authors： Conley AJ,Christenson LK,Ford SP,Christenson RK

更新日期：1994-12-01 00:00:00

abstract：:Early postnatal hyperalimentation has long-term implications for obesity and developing renal disease. Suppressor of cytokine signaling (SOCS) 3 inhibits phosphorylation of signal transducer and activator of transcription (STAT) 3 and ERK1/2 and thereby plays a pivotal role in mediating leptin resistance. In addition,...

journal_title：Endocrinology

authors： Alcazar MA,Boehler E,Rother E,Amann K,Vohlen C,von Hörsten S,Plank C,Dötsch J

更新日期：2012-03-01 00:00:00

abstract：:Identification of RF-amide-related peptides (RFRP), as putative mammalian orthologs of the avian gonadotropin-inhibitory hormone, has drawn considerable interest on its potential effects and mechanisms of action in the control of gonadotropin secretion in higher vertebrates. Yet, these analyses have so far relied most...

journal_title：Endocrinology

authors： Pineda R,Garcia-Galiano D,Sanchez-Garrido MA,Romero M,Ruiz-Pino F,Aguilar E,Dijcks FA,Blomenröhr M,Pinilla L,van Noort PI,Tena-Sempere M

更新日期：2010-04-01 00:00:00

abstract：:The development of acquired resistance to antihormonal agents in breast cancer is a major therapeutic problem. We have developed a tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line to investigate the mechanisms behind this condition. Both epidermal growth factor receptor (EGFR) and c-erbB2 mRNA and protein exp...

journal_title：Endocrinology

authors： Knowlden JM,Hutcheson IR,Jones HE,Madden T,Gee JM,Harper ME,Barrow D,Wakeling AE,Nicholson RI

更新日期：2003-03-01 00:00:00

abstract：:Chronically elevated fatty acids contribute to insulin resistance through poorly defined mechanisms. Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) have been implicated in lipid-induced insulin resistance. However, the UPR is also a fundamental mechanism required for cell adaptati...

journal_title：Endocrinology

authors： Achard CS,Laybutt DR

更新日期：2012-05-01 00:00:00