Inhibition of the enzymatic degradation of Met-enkephalin by catecholamines.

abstract：:The ability of cultured midpregnancy mouse ovarian cells to synthesize progesterone de novo and from oxogenous pregnenolone has been assessed. The conversion of pregnenolone to progesterone is almost completely blocked by cyanoketone, a known inhibitor of delta5,3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity,...

journal_title：Endocrinology

authors： Salomon DS,Sherman MI

更新日期：1976-09-01 00:00:00

abstract：:31P nuclear magnetic resonance (NMR) was used to study the effects of 17 beta-estradiol on the content of phosphates and on the flux catalyzed by creatine kinase in immature rat uteri. Perifusion with oxygenated medium at 36 C maintained the uteri in a viable state for at least 10 h in vitro during 31P NMR measurement...

journal_title：Endocrinology

authors： Degani H,Victor TA,Kaye AM

更新日期：1988-04-01 00:00:00

abstract：:Decidual/trophoblast PRL-related protein (d/tPRP) is a member of the PRL gene family and is dually expressed in uterine and placental tissues in a highly coordinated pattern during pregnancy. In the present study, we describe the isolation and characterization of the d/tPRP gene. A lambda DASH II Wistar-Kyoto rat geno...

journal_title：Endocrinology

authors： Orwig KE,Dai G,Rasmussen CA,Soares MJ

更新日期：1997-06-01 00:00:00

abstract：:Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies demonstrated the substantial protective role of 17β-estradiol (E2) in several types of neuron. However, most studies examined cell body protection, and the role of 17β-E2 in axonal degeneration of retinal ganglion cells (RGC) remain...

journal_title：Endocrinology

authors： Kitaoka Y,Munemasa Y,Hayashi Y,Kuribayashi J,Koseki N,Kojima K,Kumai T,Ueno S

更新日期：2011-07-01 00:00:00

abstract：:To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...

journal_title：Endocrinology

authors： Foster DL,Jaffe RB,Niswender GD

更新日期：1975-01-01 00:00:00

abstract：:Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...

journal_title：Endocrinology

authors： Martinez-Arguelles DB,Papadopoulos V

更新日期：2015-01-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase activity and reductase mRNA level were determined in adrenals from hamsters treated with ACTH, with or without cycloheximide or aminoglutethimide. Both reductase activity and reductase mRNA level were similarly enhanced by ACTH administration compared to levels...

journal_title：Endocrinology

authors： Lehoux JG,Lefebvre A,De Médicis E,Bélisle S,Bellabarba D

更新日期：1989-07-01 00:00:00

abstract：:To identify genes involved in regulated insulin secretion, we have established and characterized two sublines derived from the mouse pancreatic beta-cell line MIN6, designated B1 and C3. They have a similar insulin content, but differ in their secretory properties. B1 responded to glucose in a concentration- and cell ...

journal_title：Endocrinology

authors： Lilla V,Webb G,Rickenbach K,Maturana A,Steiner DF,Halban PA,Irminger JC

更新日期：2003-04-01 00:00:00

abstract：:Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we...

journal_title：Endocrinology

authors： Iwasaki H,Hirata Y,Iwashina M,Sato K,Marumo F

更新日期：1996-07-01 00:00:00

abstract：:Steroid receptor activation in developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. We report that estrogen receptors can be activated in a ligand-independent manner within developing brain by membrane dopamine receptors. Neonatal treatment with...

journal_title：Endocrinology

authors： Olesen KM,Jessen HM,Auger CJ,Auger AP

更新日期：2005-09-01 00:00:00

abstract：:The effects of K+ depletion and ouabain (0.1, 0.5, and 1 mM) on glucagon and insulin release from the in vitro perfused rat pancreas were studied in the absence or presence of arginine (10 mM). In the absence of arginine, K+ depletion resulted in an inhibition of glucagon release, both at a low (2.8 mM) and a higher (...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Malaisse WJ

更新日期：1983-07-01 00:00:00

abstract：:A study was conducted to determine the influence of conditions known to alter ACTH secretion on prolactin release by the pituitary. Dexamethasone or 0.9% NaCl was injected subcutaneously into intact male rats 4 hr before a 2-min ether stress. Other rats were submitted to the ether stress 2 weeks following adrenalectom...

journal_title：Endocrinology

authors： Harms PG,Langlier P,McCann SM

更新日期：1975-02-01 00:00:00

abstract：:To determine the relationship between the concentrations of serum T3 and hepatic nuclear T3 receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results...

journal_title：Endocrinology

authors： Las MS,Surks MI

更新日期：1981-10-01 00:00:00

abstract：:Recent evidence has suggested that a circadian rhythm exists for plasma beta-endorphin-like immunoreactivity. The purpose of the present study was to examine the long term effects of surgical trauma on plasma beta-endorphin dynamics. Blood samples for RIA were obtained from female baboons every 4 h for three 48-h peri...

journal_title：Endocrinology

authors： McIntosh TK

更新日期：1987-05-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00

abstract：:Removal of the 18-hydroxy group of the hemiacetal form of aldosterone transforms its activity from that of pure agonist to predominant antagonist. The 18-deoxy derivative possesses one third of the binding affinity of aldosterone for the cytoplasmic mineralocorticoid receptor of rat kidney and exhibits an approximate ...

journal_title：Endocrinology

authors： Ulick S,Marver D,Adam WR,Funder JW

更新日期：1979-05-01 00:00:00

abstract：:Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of en...

journal_title：Endocrinology

authors： Rubin BS,Lenkowski JR,Schaeberle CM,Vandenberg LN,Ronsheim PM,Soto AM

更新日期：2006-08-01 00:00:00

abstract：:Cloning of GnRH receptors from several animal species has made it possible to investigate receptor function using site-directed mutagenesis. However, many mutant GnRH receptors exhibit decreased ligand binding, which makes analysis of their ligand binding characteristics technically difficult. To increase the affinity...

journal_title：Endocrinology

authors： Flanagan CA,Fromme BJ,Davidson JS,Millar RP

更新日期：1998-10-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is produced in multiple tissues and is believed to exert its action in a paracrine or autocrine fashion. We have investigated the GH dependency of tissue IGF-I gene expression in rats harboring implanted somatomammotropic tumors. Circulating GH and radioimmunoassayable IGF-I levels...

journal_title：Endocrinology

authors： Fagin JA,Brown A,Melmed S

更新日期：1988-05-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:Androgen regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) activities and accumulation of the mRNAs encoding these two enzymes in rodent kidney and accessory sex organs were studied. The ODC mRNA concentration and enzyme activity were increased by androgens in kidney, prosta...

journal_title：Endocrinology

authors： Crozat A,Palvimo JJ,Julkunen M,Jänne OA

更新日期：1992-03-01 00:00:00

abstract：:Male Sprague-Dawley rats were infused continuously for 13 days with vehicle or 75 pmol (31.2 ng)/day 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by means of Alzet osmotic minipumps implanted s.c. Animals infused with 1,25-(OH)2D3 exhibited mild hypercalcemia (11.2 vs. 10.2 mg/dl in controls), a 136% increase in the serum ...

journal_title：Endocrinology

authors： Wronski TJ,Halloran BP,Bikle DD,Globus RK,Morey-Holton ER

更新日期：1986-12-01 00:00:00

abstract：:RIAs specific for the alpha-subunit of glycoprotein hormones were used to monitor the subunit conformation in ovine FSH and TSH and in recombinants of ovine LH alpha with (ovine and porcine) LH beta and hCG beta. Differences in log-logit slopes of the RIA dilution curves were interpreted to indicate changes, presumabl...

journal_title：Endocrinology

authors： Strickland TW,Puett D

更新日期：1982-07-01 00:00:00

abstract：:Levels of plasma prolactin were estimated in ovariectomized, estrogen-treated rats following the systemic administration of several neural blocking and stimulating drugs. Phenoxybenzamine, an alpha-adrenergic blocker, at high doses, increased plasma prolactin. Phenotlamine, another alpha-adrenergic blocker, and propra...

journal_title：Endocrinology

authors： Lawson DM,Gala RR

更新日期：1975-02-01 00:00:00

abstract：:The influence of development and estrogen, thyroid hormone, corticosteroid, and fibrate administration on apolipoprotein (apo) A-IV mRNA levels in the liver and intestine and on serum or plasma concentrations of apo A-IV was studied in the rat. Treatment of ovariectomized rats with ethinyl estradiol provoked a dose-de...

journal_title：Endocrinology

authors： Staels B,van Tol A,Verhoeven G,Auwerx J

更新日期：1990-04-01 00:00:00

abstract：:Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit...

journal_title：Endocrinology

authors： Dijk W,Mattijssen F,de la Rosa Rodriguez M,Loza Valdes A,Loft A,Mandrup S,Kalkhoven E,Qi L,Borst JW,Kersten S

更新日期：2017-05-01 00:00:00

abstract：:In the corpus luteum, prostaglandin F2 alpha (PGF2 alpha) appears to be a physiological agent with both antisteroidogenic and luteolytic actions. It is hypothesized that the antisteroidogenic action of PGF2 alpha acts through altered transport of cholesterol to the mitochondrial cytochrome P450 side-chain cleavage enz...

journal_title：Endocrinology

authors： McLean MP,Billheimer JT,Warden KJ,Irby RB

更新日期：1995-11-01 00:00:00

abstract：:Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

journal_title：Endocrinology

authors： Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

更新日期：2019-12-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00