Voltage-dependent calcium current in human decidual cells and its relation to prolactin secretion.

abstract：:Renin-angiotensin system blockade improves glucose intolerance and insulin resistance, which contribute to the development of metabolic syndrome. However, the contribution of impaired insulin secretion to the pathogenesis of metabolic syndrome is not well defined. To assess the contributions of angiotensin receptor ty...

journal_title：Endocrinology

authors： Rodriguez R,Viscarra JA,Minas JN,Nakano D,Nishiyama A,Ortiz RM

更新日期：2012-04-01 00:00:00

abstract：:A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial...

journal_title：Endocrinology

authors： Whitby S,Salamonsen LA,Evans J

更新日期：2018-01-01 00:00:00

abstract：:Liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor that belongs to the NR5A subgroup of nuclear receptors. LRH-1 induces key genes to regulate metabolic process, ovarian function, cancer cell proliferation, and steroidogenesis. In the breast, LRH-1 modulates and synergizes with endogenous estrogen signalin...

journal_title：Endocrinology

authors： Lazarus KA,Brown KA,Young MJ,Zhao Z,Coulson RS,Chand AL,Clyne CD

更新日期：2014-05-01 00:00:00

abstract：:We studied the role of calcium in dopaminergic control of the neuroendocrine effects of neurotensin. In primary cultures of dispersed normal female rat anterior pituitary cells the interactions of dopamine and neurotensin were examined with reference to the rate of PRL release, the magnitude of 45Ca2+ uptake, the rate...

journal_title：Endocrinology

authors： Login IS,Kuan SI,Judd AM,MacLeod RM

更新日期：1990-10-01 00:00:00

abstract：:The effects of short term (1-month) and life-long 60% ad libitum food restriction on the adrenocortical response to restraint stress were compared in young and aged Fischer 344 rats. In rats restricted for 1 month (study 1), the adrenocortical response differed as a function of age. In 8-month-old animals, the initial...

journal_title：Endocrinology

authors： Stewart J,Meaney MJ,Aitken D,Jensen L,Kalant N

更新日期：1988-10-01 00:00:00

abstract：:PTH increased PG synthase-2 transcription in osteoblastic MC3T3-E1 cells at 30 min, as assessed by nuclear run-on assays. To determine the signaling pathways used by PTH, the activity of a construct containing the PG synthase-2 gene between nucleotides -963 and +70 linked to a luciferase reporter was analyzed in stabl...

journal_title：Endocrinology

authors： Tetradis S,Pilbeam CC,Liu Y,Herschman HR,Kream BE

更新日期：1997-09-01 00:00:00

abstract：:The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian pathologies, such as premature ovarian failure and infertility. Identification and functional investigation of the factors i...

journal_title：Endocrinology

authors： Wang N,Zhang P,Guo X,Zhou Z,Sha J

更新日期：2011-03-01 00:00:00

abstract：:Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic hormone leptin and contribute to energy homeostasis by integrating peripheral and central information. The melanocortin and beta-endorphin neuropeptides are processed from POMC and putatively coreleased at axon terminals. Mela...

journal_title：Endocrinology

authors： Appleyard SM,Hayward M,Young JI,Butler AA,Cone RD,Rubinstein M,Low MJ

更新日期：2003-05-01 00:00:00

abstract：:Recent data suggest that proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. However, characterization of the cell types involved in inflammation and how these cells promote insulin resistance in human adipocytes are unclear. We simulated acute inflammation using...

journal_title：Endocrinology

authors： Chung S,Lapoint K,Martinez K,Kennedy A,Boysen Sandberg M,McIntosh MK

更新日期：2006-11-01 00:00:00

abstract：:Species-specific differences in genes encoding type II GnRH receptor indicate that a functional hepta-helical receptor is produced in monkeys but not in rodents, cows, chimpanzees, or humans. To further investigate the extent of evolutionary differences, we sequenced the type II GnRH receptor gene from wild-type Soay ...

journal_title：Endocrinology

authors： Gault PM,Morgan K,Pawson AJ,Millar RP,Lincoln GA

更新日期：2004-05-01 00:00:00

abstract：:In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...

journal_title：Endocrinology

authors： Janovick JA,Haviv F,Fitzpatrick TD,Conn PM

更新日期：1993-08-01 00:00:00

abstract：:Telomerase activity is essential for protection of cells against the telomere erosion that occurs with each round of cell replication, and thus appears to play a role in the indefinite replication potential of some, but not all, eukaryotic cells. In this regard, some tissues contain stem cells that have a long prolife...

journal_title：Endocrinology

authors： Banerjee PP,Banerjee S,Zirkin BR,Brown TR

更新日期：1998-03-01 00:00:00

abstract：:Mice with the recessively inherited obese-hyperglycemic syndrome (ob/ob) and their nonobese litter mates were studied over a 26-week period. The body weights and serum glucose levels of ob/ob mice began to rise markedly at 5-6 weeks of age and remained elevated throughout the period of study. Obese mice were significa...

journal_title：Endocrinology

authors： Larson BA,Sinha YN,Vanderlaan WP

更新日期：1976-01-01 00:00:00

abstract：:We have developed and characterized a primary cell culture system to study the regulation of 17 alpha-hydroxylase cytochrome P450 (P45017 alpha) gene expression in bovine thecal cells. Conditions have been established for the dispersal and growth of thecal cells isolated from bovine follicles, which maintain the expre...

journal_title：Endocrinology

authors： Demeter-Arlotto M,Rainey WE,Simpson ER

更新日期：1993-03-01 00:00:00

abstract：:Nuclear binding of cytoplasmic estrogen receptors was measured in an in vitro cell-free system, using various mixtures of cytosols and nuclei from uteri of mature (6-9 month old) and senescent (24-25 month old) Wistar rats. Both nuclei and cytoplasmic receptors from senescent uteri were 25-35% less efficient in suppor...

journal_title：Endocrinology

authors： Chuknyiska RS,Haji M,Foote RH,Roth GS

更新日期：1985-02-01 00:00:00

abstract：:It is believed that a combination of environmental factors with mutagens induces carcinomas derived from thyroid follicular cells. In this study we tried to ascertain whether a single short-term exposure to external radiation is sufficient to induce thyroid carcinomas in rats under long-term high or low dietary iodine...

journal_title：Endocrinology

authors： Boltze C,Brabant G,Dralle H,Gerlach R,Roessner A,Hoang-Vu C

更新日期：2002-07-01 00:00:00

abstract：:In adult male rhesus monkeys, 1 day of fasting leads to a profound suppression of LH secretion that is rapidly reversed with refeeding. To test the hypothesis that changes in insulin secretion during fasting and refeeding mediate the changes in LH secretion, blood samples for LH measurement were obtained between 0900-...

journal_title：Endocrinology

authors： Williams NI,Lancas MJ,Cameron JL

更新日期：1996-06-01 00:00:00

abstract：:Previous studies from our laboratory demonstrated that daily afternoon melatonin injections from 20-40 days of age inhibited sexual development of young male rats, whereas in adult animals, similar injections had no effect. The present study was designed to determine more precisely the critical age period during which...

journal_title：Endocrinology

authors： Lang U,Aubert ML,Rivest RW,Vinas-Bradtke JC,Sizonenko PC

更新日期：1984-12-01 00:00:00

abstract：:The maximum amounts of angiotensins II and III that were confined to the kidney during intrarenal arterial administration in conscious dogs were determined to be 2 and 12 pmol/kg X min, respectively. These doses were infused chronically intrarenally to uninephrectomized dogs. A significant reduction in urinary volume ...

journal_title：Endocrinology

authors： Dickstein GM,Woodson JF,Lamb NE,Rose CE Jr,Peach MJ,Carey RM

更新日期：1985-11-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

journal_title：Endocrinology

authors： Naulé L,Maione L,Kaiser UB

更新日期：2021-01-01 00:00:00

abstract：:We previously reported the existence of a descending multisynaptic, pituitary-independent, neural pathway between the hypothalamus and the testes in the male rat. Stimulation of this pathway by the intracerebroventricular (icv) injection of IL-1beta or corticotropin-releasing factor blunts the testosterone (T) respons...

journal_title：Endocrinology

authors： Selvage DJ,Lee SY,Parsons LH,Seo DO,Rivier CL

更新日期：2004-04-01 00:00:00

abstract：:The effect of conditioned vs. fresh culture medium on the dopaminergic inhibition of TSH and PRL secretion by primary cultures of male rat anterior pituitary cells has been studied. In the presence of conditioned medium (that had been in contact with the cells over the 3-day culture period) 10(-6) M dopamine (DA) inhi...

journal_title：Endocrinology

authors： Foord SM,Peters JR,Dieguez C,Shewring G,Hall R,Scanlon MF

更新日期：1986-04-01 00:00:00

abstract：:In animal models of inflammation, the pregnancy hormone relaxin was shown to reduce the recruitment of leukocytes, especially neutrophils, in inflamed tissues. The current study was designed to clarify whether relaxin could inhibit activation of isolated human neutrophils and, if so, whether the nitric oxide (NO) bios...

journal_title：Endocrinology

authors： Masini E,Nistri S,Vannacci A,Bani Sacchi T,Novelli A,Bani D

更新日期：2004-03-01 00:00:00

abstract：:Induction of cyclin proteins is required for progression of cells through the G(1)-S and G(2)-M cell cycle checkpoints and is a primary mechanism by which mitogens regulate cell cycle progression. IGF-I and the epidermal growth factor (EGF)-related ligands are mitogens for mammary epithelial cells in vitro and are ess...

journal_title：Endocrinology

authors： Stull MA,Richert MM,Loladze AV,Wood TL

更新日期：2002-05-01 00:00:00

abstract：:To determine whether altered noradrenergic activation of the hypothalamo-pituitary-adrenal (HPA) axis contributes to the attenuated neuroendocrine response to stress observed during lactation, the effect of intracerebroventricular injection of the alpha1-agonist methoxamine (100 microg) was compared between virgin and...

journal_title：Endocrinology

authors： Windle RJ,Brady MM,Kunanandam T,Da Costa AP,Wilson BC,Harbuz M,Lightman SL,Ingram CD

更新日期：1997-09-01 00:00:00

abstract：:Cannabinoids (CBs) exert untoward effects on reproduction by reducing LH secretion and suppressing gonadal function. Recent evidence suggests these effects are due primarily to hypothalamic dysfunction; however, the mechanism is obscure. Using immortalized hypothalamic GnRH neurons, we find these cells produce and sec...

journal_title：Endocrinology

authors： Gammon CM,Freeman GM Jr,Xie W,Petersen SL,Wetsel WC

更新日期：2005-10-01 00:00:00

abstract：:Glucocorticoid feedback inhibition at the level of the brain is extremely complex, involving feedback at both hypothalamic and suprahypothalamic levels. The hippocampus has been implicated as a suprahypothalamic mediator of such feedback, based on numerous lesion, stimulation, and steroid implantation studies. These r...

journal_title：Endocrinology

authors： Sapolsky RM,Armanini MP,Sutton SW,Plotsky PM

更新日期：1989-12-01 00:00:00

abstract：:Most of the constitutive hepatic P450 isoforms expressed in the rat exhibit dramatic gender differences. Whereas only male hepatocytes contain CYP2A2, 2C11, and 3A2, only female hepatocytes express CYP2C12 and 3- to 4-fold greater levels of CYP2C7. This sexually dimorphic expression of hepatic P450 isoforms is regulat...

journal_title：Endocrinology

authors： Pampori NA,Shapiro BH

更新日期：1999-03-01 00:00:00

abstract：:Sulfation is an important metabolic pathway facilitating the degradation of thyroid hormone by the type I iodothyronine deiodinase. Different human and rat tissues contain cytoplasmic sulfotransferases that show a substrate preference for 3,3'-diiodothyronine (3,3'-T2) > T3 > rT3 > T4. During investigation of the expr...

journal_title：Endocrinology

authors： Friesema EC,Docter R,Krenning EP,Everts ME,Hennemann G,Visser TJ

更新日期：1998-02-01 00:00:00