Fibroblast growth factor stabilizes ribonucleic acid and regulates differentiated functions in a multipeptide-secreting neuroendocrine cell line.

abstract：:We have investigated the effects of hCG and estradiol on the time course of the inhibition of C17-20-lyase and the depletion of the estradiol cytosol receptor in testicular tissue of male rats. In hCG-treated animals the first significant decrease in C17-20-lyase activity was observed 16 h after injection of the hormo...

journal_title：Endocrinology

authors： Brinkmann A,Leemborg I,Rommerts F,van der Molen H

更新日期：1982-05-01 00:00:00

abstract：:We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombi...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Carlsson B,Carmignac D,Robinson IC

更新日期：1996-05-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular nucleus, and to stimulate maternal behavior. We investigated oxytocin receptor (OTR) expression and activation perinatally. Using a (35)S-labeled riboprobe complem...

journal_title：Endocrinology

authors： Meddle SL,Bishop VR,Gkoumassi E,van Leeuwen FW,Douglas AJ

更新日期：2007-10-01 00:00:00

abstract：:Catecholamines may stimulate ACTH secretion during stress. To investigate the nature and site of such an action, plasma ACTH was measured in four groups of unanesthetized adult female rats with an indwelling carotid cannula. Sequential 300-microliter blood samples were taken 60 min, 30 min, and immediately before an i...

journal_title：Endocrinology

authors： Szafarczyk A,Malaval F,Laurent A,Gibaud R,Assenmacher I

更新日期：1987-09-01 00:00:00

abstract：:Female Wistar-Furth rats were implanted sc with GH3 rat pituitary tumor cells. Tumors were palpable by 4 weeks, and animals were killed periodically from 5-9 weeks. Tumor-bearing rats (n = 10) were heavier than their respective controls, reaching a weight of 372 +/- 3 by 9 weeks vs. 195 +/- 5 g in controls (mean +/- S...

journal_title：Endocrinology

authors： Yamashita S,Slanina S,Kado H,Melmed S

更新日期：1986-03-01 00:00:00

abstract：:Specific serum binding of 25-hydroxy-cholecalciferol (25-OHD3) was measured by saturation analysis in rats of various ages, and during vitamin D deprivation. The serum binding capacity for 25-OHD3 was observed to increase until age 6-8 weeks, then decline and remain stable thereafter at 3.7 x 10(-6) M. The 25-hydroxyv...

journal_title：Endocrinology

authors： Rojanasathit S,Haddad JG

更新日期：1977-03-01 00:00:00

abstract：:The role of 11 beta,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al (F enol aldehyde) as an intermediate in the biological conversion of cortisol to a 17-deoxy-21-oic acid was studied in vitro with mouse liver as the source of enzyme. The substrate, [1,2-3H]F enol aldehyde, was synthesized and found to contain cis and tr...

journal_title：Endocrinology

authors： Singer CJ,Iohan F,Monder C

更新日期：1986-09-01 00:00:00

abstract：:Extensive remodeling of the follicular extracellular matrix occurs during the process of ovulation. This remodeling involves the breakdown of collagen, which is regulated, in part, by the action of the metalloproteinase collagenase and its associated inhibitors. In the present study, follicular metalloproteinase inhib...

journal_title：Endocrinology

authors： Curry TE Jr,Mann JS,Estes RS,Jones PB

更新日期：1990-07-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00

abstract：:With the rapid changes in lifestyle in modern society, including the high nutritional intake and reduced physical activity, the incidence of metabolic diseases has been increasing year by year. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder, usually characterized by sudden pauses of breathing during sleep...

journal_title：Endocrinology

authors： Li M,Li X,Lu Y

更新日期：2018-07-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:Neuronal remodeling in response to deafferenting lesions in the brain can be enhanced by estradiol (E2). Astrocytes are among the targets of E2 in complex interactions with neurons and may support or inhibit neuronal remodeling. In ovariectomized female rats given entorhinal cortex lesions, E2 replacement inhibited th...

journal_title：Endocrinology

authors： Rozovsky I,Wei M,Stone DJ,Zanjani H,Anderson CP,Morgan TE,Finch CE

更新日期：2002-02-01 00:00:00

abstract：:The effect of the administration of sheep anti-LHRH gamma-globulin (anti-LHRHG) on the maintenance of pregnancy was investigated in rats. Nidation was confirmed by laparotomy on day 7 or 8 of pregnancy. In one experiment, rats were then injected iv with 1 ml anti-LHRHG or normal sheep gamma-globulin (NSG) daily from d...

journal_title：Endocrinology

authors： Nishi N,Arimura A,de la Cruz KG,Schally AV

更新日期：1976-04-01 00:00:00

abstract：:Recent evidence suggests that growth hormone-releasing peptides (GHRPs) mimic an unidentified native GH-releasing hormone (GHRH)-amplifying hormone. GHRH has been shown to stimulate food intake acting on the central nervous system. The present studies were conducted to test the hypothesis that GHRPs may also potentiat...

journal_title：Endocrinology

authors： Okada K,Ishii S,Minami S,Sugihara H,Shibasaki T,Wakabayashi I

更新日期：1996-11-01 00:00:00

abstract：:Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). However, the precise a...

journal_title：Endocrinology

authors： Weems PW,Witty CF,Amstalden M,Coolen LM,Goodman RL,Lehman MN

更新日期：2016-06-01 00:00:00

abstract：:The rat anterior pituitary expresses beta(2)-adrenoceptors (ARs) on somatotrophs, lactotrophs, and corticotrophs. The present study investigates whether beta(1)-ARs exist in the anterior pituitary, in which cell type(s) they are found, and whether they are regulated by glucocorticoids. As determined by quantitative RT...

journal_title：Endocrinology

authors： Janssens K,Krylyshkina O,Hersmus N,Vankelecom H,Denef C

更新日期：2008-05-01 00:00:00

abstract：:Mitochondrial reactive oxygen species have been implicated in both diabetic complications and the progression of the underlying diabetic state. However, it is not clear whether mitochondria of diabetic origin are intrinsically altered to generate excess reactive oxygen species independent of the surrounding diabetic m...

journal_title：Endocrinology

authors： Herlein JA,Fink BD,O'Malley Y,Sivitz WI

更新日期：2009-01-01 00:00:00

abstract：:A number of cytokines have been found to be potent regulators of bone resorption and to share the properties originally attributed to osteoclast-activating factor. One such activity, differentiation-inducing factor (DIF, D-factor) from mouse spleen cells, shares a number of biological and biochemical properties with t...

journal_title：Endocrinology

authors： Reid LR,Lowe C,Cornish J,Skinner SJ,Hilton DJ,Willson TA,Gearing DP,Martin TJ

更新日期：1990-03-01 00:00:00

abstract：:Carbonyl cyanide trifluoromethoxyphenylhydrazone (FCCP), a protonophore, and methylamine, a weak base, agents that dissipate hydrogen gradients across cellular membranes, were used to probe the coupling of hydrogen gradients to the processing and secretion of the glycoprotein hormone hCG by human choriocarcinoma cells...

journal_title：Endocrinology

authors： Peters BP,Krzesicki RF,Perini F,Ruddon RW

更新日期：1986-07-01 00:00:00

abstract：:In previous studies we have shown that aromatase cytochrome P450 (P450arom) mRNA and protein increase markedly in luteal tissue between days 10-19 of gestation, whereas cholesterol side-chain cleavage cytochrome P450 (P450scc) appears to be constitutively maintained regardless of hormonal changes occurring during preg...

journal_title：Endocrinology

authors： Hickey GJ,Oonk RB,Hall PF,Richards JS

更新日期：1989-09-01 00:00:00

abstract：:Chorionic gonadotropin (CG) is an early embryo-derived signal that is known to support the corpus luteum. An in vivo baboon model was used to study the direct actions of human CG (hCG) on the endometrium, during the periimplantation period. Endometrial gene expression was analyzed using microarrays. The endometrial bi...

journal_title：Endocrinology

authors： Sherwin JR,Sharkey AM,Cameo P,Mavrogianis PM,Catalano RD,Edassery S,Fazleabas AT

更新日期：2007-02-01 00:00:00

abstract：:Insulin is a potent regulator of Sp1 transcription factor. To examine if glucagon, which usually antagonizes insulin, regulates Sp1, we assessed the levels of Sp1 by Western blotting from H-411E cells exposed to glucagon with or without insulin. Glucagon alone (1.5 x 10(-9) to 1.5 x 10(-5) M) stimulated Sp1 accumulati...

journal_title：Endocrinology

authors： Keembiyehetty CN,Candelaria RP,Majumdar G,Raghow R,Martinez-Hernandez A,Solomon SS

更新日期：2002-04-01 00:00:00

abstract：:Actions of protein products resulting from alternative splicing of the Igf1 gene have received increasing attention in recent years. However, the significance and functional relevance of these observations remain poorly defined. To address functions of IGF-I splice variants, we examined the impact of loss of IGF-IEa a...

journal_title：Endocrinology

authors： Matheny RW Jr,Nindl BC

更新日期：2011-05-01 00:00:00

abstract：:The study of the biochemical mechanisms regulating the differentiation of the ovarian androgen-producing cells has been difficult because of the lack of a method for isolating the theca-interstitial cells (TIC) from the granulosa and other cell types. We report here a simple, rapid and reproducible method for obtainin...

journal_title：Endocrinology

authors： Magoffin DA,Erickson GF

更新日期：1988-05-01 00:00:00

abstract：:Insulin radioreceptor assays were developed using splenic leukocytes and peripheral erythrocytes from individual mice. Splenic leukocytes were prepared using an NH4Cl buffer which did not alter insulin binding, but gave much higher yields than density gradient methods. Mouse erythrocytes were isolated from heparinized...

journal_title：Endocrinology

authors： Shimizu F,Kahn CR

更新日期：1982-02-01 00:00:00

abstract：:A monoclonal antibody which recognizes the [125I]human GH ([125I]hGH)-binding proteins of rabbit liver has been produced using hybridoma technology. A CB6F1/J mouse was immunized over a period of 82 days with a partially purified GH receptor (GHr) preparation. On the 83rd day, spleen cells from the mouse were fused wi...

journal_title：Endocrinology

authors： Simpson JS,Hughes JP,Friesen HG

更新日期：1983-06-01 00:00:00

abstract：:Compelling evidence indicates a crucial role of prostaglandin F2α (PGF2α) in parturition. Both the maternal and fetal sides of the fetal membranes synthesize PGF2α, which exerts effects via the prostaglandin F2α receptor (FP) that is coupled to the activation of protein kinase C (PKC). Cyclooxygenase-2 (COX-2) catalyz...

journal_title：Endocrinology

authors： Guo CM,Kasaraneni N,Sun K,Myatt L

更新日期：2012-10-01 00:00:00

abstract：:RNA blot hybridization analysis with cloned rat CRF precursor (prepro-CRF) cDNA as a probe showed that prepro-CRF mRNA existed in rat hypothalamic and extrahypothalamic brain tissue, whereas it was undetectable in the pituitary and adrenal. To study the effect of glucocorticoid on the level of prepro-CRF mRNA in the h...

journal_title：Endocrinology

authors： Jingami H,Matsukura S,Numa S,Imura H

更新日期：1985-10-01 00:00:00

abstract：:This study was aimed at testing the hypothesis that different forms of fibronectin (FN), produced as a consequence of the alternative splicing of the precursor messenger RNA, play specific roles during development of the ovarian follicle. In particular, we were interested in determining the effect of the ED-I (also te...

journal_title：Endocrinology

authors： Colman-Lerner A,Fischman ML,Lanuza GM,Bissell DM,Kornblihtt AR,Barañao JL

更新日期：1999-06-01 00:00:00