Maximal testosterone production in Leydig cells from inbred mice relates to the activity of 3 beta-hydroxysteroid dehydrogenase-isomerase.

abstract：:Human myometrium contains hCG/LH receptors. There are fewer of these receptors during labor compared to no labor at preterm or term deliveries. Exogenous hCG can directly inhibit oxytocin-stimulated human myometrial contractions. These findings suggest that hCG may directly maintain myometrial quiescence during pregna...

journal_title：Endocrinology

authors： Ambrus G,Rao CV

更新日期：1994-12-01 00:00:00

abstract：:Testes of 29-35-day-old rats were separated into seminiferous tubules and interstitial tissue by collagenase treatment and examined by incubation studies with radioactive substrates. The activity of testosterone 5alpha-reductase/g protein in the interstitial tissue was 37 times greater than that in the tubules. The si...

journal_title：Endocrinology

authors： Yoshizaki K,Matsumoto K,Samuels LT

更新日期：1978-03-01 00:00:00

abstract：:The production of hydrogen peroxide (H2O2) as an essential process for iodide organification is a key reaction in TSH-induced thyroid hormone synthesis. Here we characterize the signal transduction pathway involved in TSH-induced H2O2 production in FRTL-5 thyroid cells. At higher than 1 nM TSH, N6-(L-2-phenylisopropyl...

journal_title：Endocrinology

authors： Kimura T,Okajima F,Sho K,Kobayashi I,Kondo Y

更新日期：1995-01-01 00:00:00

abstract：:Angiotensin type 1 receptor blockers are widely used for the treatment of hypertension, and one angiotensin type 1 receptor blocker, telmisartan, specifically activates the peroxisome proliferator-activated receptor (PPAR)-gamma. We studied the impact of PPARgamma mutants on transcriptional control and interaction wit...

journal_title：Endocrinology

authors： Tagami T,Yamamoto H,Moriyama K,Sawai K,Usui T,Shimatsu A,Naruse M

更新日期：2009-02-01 00:00:00

abstract：:Recently, we demonstrated that estradiol (E(2)) modulates cross-talk between protein tyrosine kinases and norepinephrine (NE) receptor signaling in the hypothalamus (HYP) and preoptic area (POA), brain areas that govern female reproductive function. We are now investigating the identity of protein tyrosine kinase(s) t...

journal_title：Endocrinology

authors： Quesada A,Etgen AM

更新日期：2001-02-01 00:00:00

abstract：:Mullerian inhibiting substance (MIS) is a 140-kilodalton homodimeric glycoprotein that causes regression of the Mullerian ducts in male embryos, and may also have a role in both males and females in the regulation of germ cell maturation. We examined the ontogeny of MIS messenger RNA (mRNA) in rat testes from midgesta...

journal_title：Endocrinology

authors： Lee MM,Cate RL,Donahoe PK,Waneck GL

更新日期：1992-02-01 00:00:00

abstract：:Cytosols of whole testicular homogenates from the Syrian golden hamster contained specific binding sites for [3H]triamcinolone acetonide that exhibited limited capacity and high affinity binding characteristic of glucocorticoid receptors in other target tissues. The receptor complex sedimented as an 8.6S binder in low...

journal_title：Endocrinology

authors： Ortlip SA,Li SA,Li JJ

更新日期：1981-11-01 00:00:00

abstract：:The availability of a mitogenic bioassay for PRL in which multiple, small samples could be analyzed led us to examine circulating and pituitary PRL bioactivity during the estrous cycle of the rat. Bio- (B) and immuno (I)-activities were compared in individual samples using rat PRL RP-1 standard. B:I ratios ranged betw...

journal_title：Endocrinology

authors： Blank MS,Ching MC,Dufau ML

更新日期：1986-05-01 00:00:00

abstract：:The expression of the lutropin receptor (LHR) in granulosa cells is a complex phenomenon under the hormonal control of FSH and estradiol. Using primary cultures of granulosa cells from immature female rats pretreated with diethylstilbestrol (a compound with estrogen-like activity), the role of FSH in LHR induction was...

journal_title：Endocrinology

authors： Chen S,Shi H,Liu X,Segaloff DL

更新日期：1999-05-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:IGF-I is an endocrine and paracrine regulator of skeletal homeostasis, principally by virtue of its anabolic effects on osteoblastic cells. In the current study, we examined the intracellular signaling pathways by which IGF-I promotes proliferation and survival in SaOS-2 human osteoblastic cells. Inhibition of each of...

journal_title：Endocrinology

authors： Grey A,Chen Q,Xu X,Callon K,Cornish J

更新日期：2003-11-01 00:00:00

abstract：:In the present study, steroidogenesis in two different Leydig tumor cell lines was compared. One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute regulatory (StAR) protein only when stimulated by trophic hormones and cAMP analogs. The other, the R2C rat tumor cell line, produces steroids...

journal_title：Endocrinology

authors： Jo Y,Stocco DM

更新日期：2004-12-01 00:00:00

abstract：:We have studied the changes in thyroid hormone economy that occur in normal pregnant rats between 17-22 days of gestation. T4 and T3 decreased in all extrathyroidal tissues studied, namely plasma, liver, kidney, lung, heart, and skeletal muscle. The exception is the concentration of T3 in cerebral cortex, which remain...

journal_title：Endocrinology

authors： Calvo R,Obregon MJ,Ruiz de Oña C,Ferreiro B,Escobar Del Rey E,Morreale de Escobar G

更新日期：1990-07-01 00:00:00

abstract：:Regulation of the number of pituitary vasopressin (VP) receptors plays an important role in controlling pituitary responsiveness during alterations of the hypothalamic pituitary adrenal axis. The mechanisms regulating these VP receptors were studied by analysis of the effects of adrenalectomy and glucocorticoid admini...

journal_title：Endocrinology

authors： Rabadan-Diehl C,Makara G,Kiss A,Lolait S,Zelena D,Ochedalski T,Aguilera G

更新日期：1997-12-01 00:00:00

abstract：:Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...

journal_title：Endocrinology

authors： Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V

更新日期：2010-06-01 00:00:00

abstract：:We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pu...

journal_title：Endocrinology

authors： Mukhina S,Liu D,Guo K,Raccurt M,Borges-Bendris S,Mertani HC,Lobie PE

更新日期：2006-04-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:Both fructose consumption and increased intracellular glucocorticoid activation have been implicated in the pathogenesis of the metabolic syndrome. Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11β-HSD...

journal_title：Endocrinology

authors： Senesi S,Legeza B,Balázs Z,Csala M,Marcolongo P,Kereszturi E,Szelényi P,Egger C,Fulceri R,Mandl J,Giunti R,Odermatt A,Bánhegyi G,Benedetti A

更新日期：2010-10-01 00:00:00

abstract：:Estradiol-17beta (E2) is suspected to exert a role in the regulation of testicular activity. Using a nonmammalian vertebrate model (the frog, Rana esculenta), we have investigated whether c-fos activity is detectable in the testis during the annual sexual cycle and whether E2 exerts a regulatory role on spermatogenesi...

journal_title：Endocrinology

authors： Cobellis G,Pierantoni R,Minucci S,Pernas-Alonso R,Meccariello R,Fasano S

更新日期：1999-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta) is a multifunctional growth factor in bone that is secreted as a latent complex and must be activated in order to influence cellular activity. We have investigated the influence of dexamethasone (Dex; a potent glucocorticoid) on the secretion and activation of latent TGF beta...

journal_title：Endocrinology

authors： Oursler MJ,Riggs BL,Spelsberg TC

更新日期：1993-11-01 00:00:00

abstract：:Estrogen has wide-ranging and complex effects on the reproductive axis, which are often difficult to interpret from in vivo studies. Estrogen negatively regulates tonic GnRH synthesis and also plays a pivotal role in the positive regulation of GnRH necessary for the preovulatory surge. To dissect the mechanisms by whi...

journal_title：Endocrinology

authors： Roy D,Angelini NL,Belsham DD

更新日期：1999-11-01 00:00:00

abstract：:The possibility of direct pituitary effects of sex steroids on gonadotropin gene expression and synthesis was studied in male rats. The animals were treated with a potent GnRH antagonist, Ac-D-pClPhe-D-pClPhe-D-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-D-Ala-+ ++NH2CH3COOH (Org 30276; 0.5 mg/kg BW, sc, twice daily) for 10 days. G...

journal_title：Endocrinology

authors： Perheentupa A,Huhtaniemi I

更新日期：1990-06-01 00:00:00

abstract：:In order to delineate the ages of onset and decline in sensitivity to growth hormone (GH) in rats, the ability of ovine GH in vitro to stimulate amino acid uptake and protein synthesis was studied in diaphragm muscle. GH (25 mug/ml) produced a significant, but small (12-17%), stimulation of alpha-aminoisobutyric acid ...

journal_title：Endocrinology

authors： Nutting DF

更新日期：1976-05-01 00:00:00

abstract：:A series of rat and mouse monoclonal antibodies to the human progesterone receptor (PR) has recently been produced. These antibodies were used for the immunocytochemical identification of PR in several mammalian species including humans. The specificity of the monoclonal antibodies for PR was confirmed by using compet...

journal_title：Endocrinology

authors： Press MF,Greene GL

更新日期：1988-03-01 00:00:00

abstract：:There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans. However, the roles of two other tachykinins, substance P (SP) and neurokinin A, which act primarily via NK1R and NK2R, respecti...

journal_title：Endocrinology

authors： Fergani C,Mazzella L,Coolen LM,McCosh RB,Hardy SL,Newcomb N,Grachev P,Lehman MN,Goodman RL

更新日期：2016-12-01 00:00:00

abstract：:A monoclonal antibody directed against bovine TSH was obtained by hybridoma technology. This antibody was specific for TSH and did not react with bovine LH and FSH. Affinity chromatography of crude TSH was performed on anti-TSH Sepharose. Bovine TSH was purified in a single step to near homogeneity by this technique, ...

journal_title：Endocrinology

authors： Lock AJ,van Denderen J,Aarden LA

更新日期：1988-01-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone-producing adrenal cortex and the catecholamine-producing ...

journal_title：Endocrinology

authors： Sun N,Wu Y,Nanba K,Sbiera S,Kircher S,Kunzke T,Aichler M,Berezowska S,Reibetanz J,Rainey WE,Fassnacht M,Walch A,Kroiss M

更新日期：2018-03-01 00:00:00

abstract：:Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...

journal_title：Endocrinology

authors： Potau N,Bailey AC,Roach E,Williams JA,Goldfine ID

更新日期：1984-07-01 00:00:00

abstract：:Intraluteal infusion of the prostaglandin (PG) synthesis inhibitor, sodium meclofenamate (Mec) causes premature luteolysis in rhesus monkeys. To evaluate further the actions of PG synthesis inhibitors in primate luteal function, we examined the in vitro effects of Mec and another inhibitor, flurbiprofen (Flur), on PG,...

journal_title：Endocrinology

authors： Zelinski-Wooten MB,Sargent EL,Molskness TA,Stouffer RL

更新日期：1990-03-01 00:00:00