Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/beta-lipotropin precursor mRNA in the pituitary in rats.

abstract：:Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later. After ECP injection ovarian histology reveals that the follicles normally destined to ov...

journal_title：Endocrinology

authors： Greenwald GS

更新日期：1975-10-01 00:00:00

abstract：:The factors controlling the synthesis and degradation of the insulin-like growth factor-binding proteins (IGFBPs) during pregnancy are poorly understood. To clarify the roles of nutritional factors in the regulation of fetal and maternal IGFBP production, we examined the effects of fasting, refeeding, and glucose admi...

journal_title：Endocrinology

authors： Osborn BH,Fowlkes J,Han VK,Freemark M

更新日期：1992-10-01 00:00:00

abstract：:There is evidence that the IGF system plays an important role in the growth and function of the thyroid gland. Proteolysis is an important posttranslational process that modulates the affinity of IGF binding proteins (IGFBPs) to IGFs, thus regulating their activity. IGFBP-3 has been shown to be cleaved by members of t...

journal_title：Endocrinology

authors： Wang J,Grünler J,Lewitt MS

更新日期：2004-03-01 00:00:00

abstract：:Organ weight was compared in adult mice with deletion of one (IRS-1-/+) or both (IRS-1-/-) copies of the insulin receptor substrate-1 (IRS-1) gene and IRS-1+/+ littermates. IRS-1-/+ mice showed modest reductions in weight of most organs in proportion to a decrease in body weight. IRS-1-/- mice showed major reductions ...

journal_title：Endocrinology

authors： Pete G,Fuller CR,Oldham JM,Smith DR,D'Ercole AJ,Kahn CR,Lund PK

更新日期：1999-12-01 00:00:00

abstract：:LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase. This study examined the role of microRNA miR-122 in LRBP-mediated LHR mRNA expression. Real-time PCR analysis of ovaries from pregnant mare serum g...

journal_title：Endocrinology

authors： Menon B,Sinden J,Franzo-Romain M,Botta RB,Menon KM

更新日期：2013-12-01 00:00:00

abstract：:It is widely accepted that expression of protooncogenes is coupled with cellular proliferation and differentiation. Since ACTH stimulates not only steroidogenesis but also cellular proliferation, we investigated whether ACTH affects the expression of c-fos, c-myc, and beta-actin genes. The effect of ACTH on adrenal gl...

journal_title：Endocrinology

authors： Imai T,Seo H,Murata Y,Ohno M,Satoh Y,Funahashi H,Takagi H,Matsui N

更新日期：1990-10-01 00:00:00

abstract：:This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16...

journal_title：Endocrinology

authors： Tilbrook AJ,de Kretser DM,Cummins JT,Clarke IJ

更新日期：1991-12-01 00:00:00

abstract：:The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

journal_title：Endocrinology

authors： Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

更新日期：2021-03-01 00:00:00

abstract：:PGs are important mediators of the ovulatory process and prostaglandin G/H synthase-2 (PGHS-2) is a key rate-limiting enzyme in the PG biosynthetic pathway. To determine whether PGHS-2 is regulated in equine follicles before ovulation and, if so, to characterize its time course of induction, preovulatory follicles wer...

journal_title：Endocrinology

authors： Sirois J,Doré M

更新日期：1997-10-01 00:00:00

abstract：:To mimick a state of hyperinsulinemia, normal rats were infused with insulin for 4 days via minipumps, and compared to saline infused rats. At the end of the experimental period, the abundance of mRNA was increased in white adipose tissue (WAT) and decreased in muscles of "insulinized" rats compared to controls. These...

journal_title：Endocrinology

authors： Cusin I,Terrettaz J,Rohner-Jeanrenaud F,Zarjevski N,Assimacopoulos-Jeannet F,Jeanrenaud B

更新日期：1990-12-01 00:00:00

abstract：:In the present study, steroidogenesis in two different Leydig tumor cell lines was compared. One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute regulatory (StAR) protein only when stimulated by trophic hormones and cAMP analogs. The other, the R2C rat tumor cell line, produces steroids...

journal_title：Endocrinology

authors： Jo Y,Stocco DM

更新日期：2004-12-01 00:00:00

abstract：:The largest subtype of breast cancer is characterized by the expression and activity of the estrogen receptor alpha (ERalpha/ER). Although several effective therapies have significantly improved survival, the adaptability of cancer cells means that patients frequently stop responding or develop resistance to endocrine...

journal_title：Endocrinology

authors： Farcas AM,Nagarajan S,Cosulich S,Carroll JS

更新日期：2021-02-01 00:00:00

abstract：:We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...

journal_title：Endocrinology

authors： Rabbani SA,Khalili P,Arakelian A,Pizzi H,Chen G,Goltzman D

更新日期：2005-07-01 00:00:00

abstract：:A central feature of glucocorticoid (GC)-induced osteoporosis is decreased bone formation, secondary to decreased numbers of functional osteoblasts. We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished bo...

journal_title：Endocrinology

authors： Engelbrecht Y,de Wet H,Horsch K,Langeveldt CR,Hough FS,Hulley PA

更新日期：2003-02-01 00:00:00

abstract：:The distribution of androgen receptor expression within the developing rat gubernaculum was examined at different times during fetal and neonatal development using polyclonal antibodies directed at the amino-terminus (amino acids 1-21) and the carboxy-terminus (amino acids 898-917) of the androgen receptor. These stud...

journal_title：Endocrinology

authors： Husmann DA,McPhaul MJ

更新日期：1991-01-01 00:00:00

abstract：:As a model of the changes in peripheral iodothyronine metabolism that occur during ontogeny, we have studied the metabolism of 125I-labeled T4 and several of its partially deiodinated derivatives by the liver of the chick embryo. Homogenates of livers obtained from chicks varying in embryonic age from 8 days to the ti...

journal_title：Endocrinology

authors： Borges M,LaBourene J,Ingbar SH

更新日期：1980-12-01 00:00:00

abstract：:The LHX3 transcription factor is required for pituitary and nervous system development in mammals. Mutations in the human gene are associated with hormone-deficiency diseases. The gene generates two mRNAs, hLHX3a and hLHX3b, which encode three proteins with different properties. Here, the cis elements and trans-acting...

journal_title：Endocrinology

authors： Yaden BC,Garcia M 3rd,Smith TP,Rhodes SJ

更新日期：2006-01-01 00:00:00

abstract：:As ovariectomy induces obesity in rats, we have investigated the influence of ovariectomy and hormone replacement on the proliferation and differentiation capacities of rat cultured preadipocytes removed from different fat depots (femoral sc, parametrial, and perirenal). Ovariectomy induced increased proliferation and...

journal_title：Endocrinology

authors： Lacasa D,Garcia E,Agli B,Giudicelli Y

更新日期：1997-07-01 00:00:00

abstract：:A model for the study of testicular function in experimental uremia induced by subtotal nephrectomy in mature male rats is described. Glomerular filtration rate was reduced by 87%, resulting in stable uremia for up to 13 weeks with characteristic biochemical changes and reduction in weight of testes, prostate, seminal...

journal_title：Endocrinology

authors： Handelsman DJ,Spaliviero JA,Turtle JR

更新日期：1985-11-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:The mechanisms by which oxytocin (OT) stimulates extracellular signal-regulated kinase 1/2 (ERK1/2) are only partially understood. OT receptor (OTR) signals predominantly through Galpha(q), but ERK1/2 phosphorylation (ERK1/2-P) in PHM1 myometrial cells was not eliminated by inhibition of downstream effectors such as p...

journal_title：Endocrinology

authors： Zhong M,Yang M,Sanborn BM

更新日期：2003-07-01 00:00:00

abstract：:The dose-dependent displacement characteristics of a biologically active 20,000 molecular weight human pituitary growth hormone variant (20K) and of human growth hormone (hGH) were compared using hGH liver plasma membrane receptors both from 20-30 day pregnant rabbits and from normal female rats and also using mammary...

journal_title：Endocrinology

authors： Sigel MB,Thorpe NA,Kobrin MS,Lewis UJ,Vanderlaan WP

更新日期：1981-04-01 00:00:00

abstract：:We have studied the relationship between the levels of the alpha and beta subunit of TSH and alpha and TSH-beta mRNA content in pituitaries from euthyroid, short-term, and long-term hypothyroid mice and in various mouse TSH-secreting tumors. TSH, alpha, and TSH-beta were determined by specific radioimmunoassay. alpha ...

journal_title：Endocrinology

authors： Gurr JA,Kourides IA

更新日期：1984-08-01 00:00:00

abstract：:Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...

journal_title：Endocrinology

authors： Hong MH,Sun H,Jin CH,Chapman M,Hu J,Chang W,Burnett K,Rosen J,Negro-Vilar A,Miner JN

更新日期：2008-03-01 00:00:00

abstract：:The role of anti-Müllerian hormone (AMH) during gonad development has been studied extensively in many species of mammal, bird, reptile, and fish but remains unresolved in amphibians. In male mammalian embryos, Sox9 activates AMH expression, which initiates regression of the Müllerian ducts. However, Sox9 (Sry-related...

journal_title：Endocrinology

authors： Kodama M,Suda M,Sakamoto D,Iwasaki T,Matsuo Y,Uno Y,Matsuda Y,Nakamura Y,Maekawa S,Katsu Y,Nakamura M

更新日期：2015-05-01 00:00:00

abstract：:The master circadian clock located within the hypothalamic suprachiasmatic nucleus (SCN) is necessary for the circadian rhythm of glucocorticoid (GC) release. The pathways by which the SCN sustains rhythmic GC release remain unclear. We studied the circadian regulation of cortisol release in the behaviorally split gol...

journal_title：Endocrinology

authors： Lilley TR,Wotus C,Taylor D,Lee JM,de la Iglesia HO

更新日期：2012-02-01 00:00:00

abstract：:A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled t...

journal_title：Endocrinology

authors： Rékási Z,Szöke B,Nagy A,Groot K,Rékási ES,Schally AV

更新日期：1993-05-01 00:00:00

abstract：:Maternal and fetal metabolism of vitamin D was examined in term pregnant rabbits fed a normal diet and in those supplemented with a large amount of vitamin D3. Term pregnant rabbits (27--30 days of gestation) fed the normal diet showed lower levels of plasma calcium, 25-hydroxyvitamin D3 (250HD3), and 24,25-dihydroxyv...

journal_title：Endocrinology

authors： Kubota M,Ohno J,Shiina Y,Suda T

更新日期：1982-06-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...

journal_title：Endocrinology

authors： Ogle TF,Kitay JI

更新日期：1976-01-01 00:00:00