Circadian regulation of cortisol release in behaviorally split golden hamsters.

abstract：:Basic fibroblast growth factor (bFGF) plays an important role in development of the central nervous system and is neurotropic for a variety of neurons. In this study, we investigated whether bFGF is neurotropic for GT1 GnRH neuronal cell lines and if these cells express functional FGF receptors (FGFRs). The GT1 cell l...

journal_title：Endocrinology

authors： Tsai PS,Werner S,Weiner RI

更新日期：1995-09-01 00:00:00

abstract：:The insulin receptor, following insulin stimulation of cells, triggers formation of various signaling complexes. In rat HTC hepatoma cells overexpressing normal human insulin receptors (HTC-IR), p85 regulatory subunit of phosphatidylinositol-3-kinase (PI3K) forms signaling complexes containing the insulin receptor, in...

journal_title：Endocrinology

authors： Sung CK,Choi WS,Sanchez-Margalet V

更新日期：1998-05-01 00:00:00

abstract：:Follistatin (FS), which binds to the inhibin/activin beta A- or beta B-subunit is localized with and modulates the biological actions of activin in many systems. However, in contrast to the wide distribution of the activin beta-subunit proteins and messenger RNAs (mRNA) in the brain, demonstration of FS mRNA signal ha...

journal_title：Endocrinology

authors： Macconell LA,Barth S,Roberts VJ

更新日期：1996-05-01 00:00:00

abstract：:It is generally accepted that cholesterol affects dynamic membrane properties and the function of membrane bound proteins involved in secretion processes. In the present study we employed GH4C1 cells treated with human lipoprotein-deficient serum (h-LPDS), exogenous cholesterol and high density lipoprotein (HDL3) to i...

journal_title：Endocrinology

authors： Lasa M,Perez-Caballero FJ,Usera F,Chiloeches A,Montes A,Toro MJ

更新日期：1993-04-01 00:00:00

abstract：:To identify genes that are differentially expressed in the developing testis we used representational difference analysis of complementary DNA from gonads of mouse embryos at 13.5 days postcoitum (dpc). Three genes were identified. One of them was a novel gene termed tescalcin that encoded a putative EF-hand Ca(2+)-bi...

journal_title：Endocrinology

authors： Perera EM,Martin H,Seeherunvong T,Kos L,Hughes IA,Hawkins JR,Berkovitz GD

更新日期：2001-01-01 00:00:00

abstract：:Exposure of FRTL-5 cells to iodide (I-) in excess of 3 microM suppresses the concentrative uptake of I-. The depression of I- uptake measured at the steady state is due to decrease in the rate of I- influx and not to an effect on I- efflux. Exposure to NaI is associated with decreased T4 secretion and also depressed N...

journal_title：Endocrinology

authors： Grollman EF,Smolar A,Ommaya A,Tombaccini D,Santisteban P

更新日期：1986-06-01 00:00:00

abstract：:Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4 measurements, but qWestern is technically complex and labor intensiv...

journal_title：Endocrinology

authors： Yang Q,Eskurza I,Kiernan UA,Phillips DA,Blüher M,Graham TE,Kahn BB

更新日期：2012-03-01 00:00:00

abstract：:It has been postulated that the rate of hepatic very low density lipoprotein (VLDL) apolipoprotein (apo) B secretion is dependent upon the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. To test this hypothesis in vivo, apoB kinetic studies were carried out in miniature pigs before and after 21 ...

journal_title：Endocrinology

authors： Burnett JR,Wilcox LJ,Telford DE,Kleinstiver SJ,Barrett PH,Newton RS,Huff MW

更新日期：1999-11-01 00:00:00

abstract：:Granulosa cells isolated from the ovaries of pregnant mare serum gonadotropin (PMSG)-treated immature rats were cultured with relaxin or FSH. Both hormones increased the secretion of plasminogen activator into the culture medium. Relaxin caused a dose-related rise in plasminogen activator but did not increase cAMP or ...

journal_title：Endocrinology

authors： Too CK,Weiss TJ,Bryant-Greenwood GD

更新日期：1982-10-01 00:00:00

abstract：:Although polychlorinated biphenyls (PCBs) have been shown to accumulate in the adrenal, little is known about the effects of these endocrine disruptors on adrenal steroidogenesis. Our previous studies showed that high concentrations of PCB126 stimulated CYP11B1 and CYP11B2 mRNA expression and consequently raised corti...

journal_title：Endocrinology

authors： Lin TC,Chien SC,Hsu PC,Li LA

更新日期：2006-03-01 00:00:00

abstract：:To elucidate the metabolic fate and possible role of androgens and their derivatives during primate fetal development, aromatase (AROM), 5 alpha-reductase (5 alpha R), and androgen receptor (AR; cytosolic) levels were assessed in the brain, heart (HRT), lung (LNG), and skeletal muscle (MUS) of fetal rhesus monkeys. An...

journal_title：Endocrinology

authors： Sholl SA,Goy RW,Kim KL

更新日期：1989-02-01 00:00:00

abstract：:Previous descriptions of pulsatile LH release in immature female rats have been mostly inaccurate because of infrequent blood sampling, discontinuous and unbalanced blood replacement procedures, and possibly because of the use of a heterologous RIA. The present study was undertaken to circumvent these problems and to ...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1985-08-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:The signals that regulate cardiac myocyte maturation in the neonatal heart are not completely understood. In our study we examined the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on primary cultures of ventricular myocytes isolated from neonatal rat hearts. Our data show that 1,25-(OH)2D3 inhibited an increase ...

journal_title：Endocrinology

authors： O'Connell TD,Giacherio DA,Jarvis AK,Simpson RU

更新日期：1995-02-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:The rat anterior pituitary expresses beta(2)-adrenoceptors (ARs) on somatotrophs, lactotrophs, and corticotrophs. The present study investigates whether beta(1)-ARs exist in the anterior pituitary, in which cell type(s) they are found, and whether they are regulated by glucocorticoids. As determined by quantitative RT...

journal_title：Endocrinology

authors： Janssens K,Krylyshkina O,Hersmus N,Vankelecom H,Denef C

更新日期：2008-05-01 00:00:00

abstract：:Uterine contractions at parturition depend upon a variety of factors, including gamma-aminobutyric acid (GABA)-ergic stimulation. A new subunit of the GABA(A) receptor, pi, has recently been identified as being particularly abundant in the rat uterus. Reduced derivatives of progesterone, such as the 3alpha,5alpha-redu...

journal_title：Endocrinology

authors： Fujii E,Mellon SH

更新日期：2001-05-01 00:00:00

abstract：:Recent studies from our laboratory demonstrated clearly that only a portion of all Sertoli cells secrete transferrin (TF). These findings raised the possibility that differences in the functional type of Sertoli cells from one location to another may account in part for the stage-related variation in TF release along ...

journal_title：Endocrinology

authors： Garza MM,Schwarz LK,Bonner JM,Boockfor FR

更新日期：1991-04-01 00:00:00

abstract：:Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...

journal_title：Endocrinology

authors： Barreiro ML,Gaytan F,Castellano JM,Suominen JS,Roa J,Gaytan M,Aguilar E,Dieguez C,Toppari J,Tena-Sempere M

更新日期：2004-11-01 00:00:00

abstract：:The availability of a mitogenic bioassay for PRL in which multiple, small samples could be analyzed led us to examine circulating and pituitary PRL bioactivity during the estrous cycle of the rat. Bio- (B) and immuno (I)-activities were compared in individual samples using rat PRL RP-1 standard. B:I ratios ranged betw...

journal_title：Endocrinology

authors： Blank MS,Ching MC,Dufau ML

更新日期：1986-05-01 00:00:00

abstract：:Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with ...

journal_title：Endocrinology

authors： Turgeon MO,Silander TL,Doycheva D,Liao XH,Rigden M,Ongaro L,Zhou X,Joustra SD,Wit JM,Wade MG,Heuer H,Refetoff S,Bernard DJ

更新日期：2017-04-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by peripheral immune cells and also by endocrine cells in the anterior pituitary gland. MIF exerts its proinflammatory actions in the host-defense system by blocking the inhibitory effects of glucocorticoids on the release of other pro...

journal_title：Endocrinology

authors： Tierney T,Patel R,Stead CA,Leng L,Bucala R,Buckingham JC

更新日期：2005-01-01 00:00:00

abstract：:Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...

journal_title：Endocrinology

authors： Adamson AD,Friedrichsen S,Semprini S,Harper CV,Mullins JJ,White MR,Davis JR

更新日期：2008-02-01 00:00:00

abstract：:The production of hydrogen peroxide (H2O2) as an essential process for iodide organification is a key reaction in TSH-induced thyroid hormone synthesis. Here we characterize the signal transduction pathway involved in TSH-induced H2O2 production in FRTL-5 thyroid cells. At higher than 1 nM TSH, N6-(L-2-phenylisopropyl...

journal_title：Endocrinology

authors： Kimura T,Okajima F,Sho K,Kobayashi I,Kondo Y

更新日期：1995-01-01 00:00:00

abstract：:In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...

journal_title：Endocrinology

authors： Mendez P,Garcia-Segura LM

更新日期：2006-06-01 00:00:00

abstract：:IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an...

journal_title：Endocrinology

authors： Rotwein P

更新日期：2018-06-01 00:00:00

abstract：:Anterior pituitary cells from adult male rats were cultured on a natural extracellular matrix (ECM). From the 5th day, spindle-shaped cells, fusing to form elongated fibers, were observed among the epithelial cells. These fibers later increased in size and number and were identified as striated muscle fibers, based on...

journal_title：Endocrinology

authors： Spira O,Atzmon R,Rahamim E,Bar-Shavit R,Gross J,Gordon A,Vlodavsky I

更新日期：1988-06-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...

journal_title：Endocrinology

authors： Dover AR,Hadoke PW,Macdonald LJ,Miller E,Newby DE,Walker BR

更新日期：2007-01-01 00:00:00

abstract：:NADPH-cytochrome P-450 reductase (EC 1.6.2.4), the enzyme involved in progesterone 17-hydroxylation, was purified to apparent homogeneity by detergent solubilization of the microsomal fractions of liver and testis from untreated rats. The enzymes from these two tissues were then compared with regard to several paramet...

journal_title：Endocrinology

authors： Hales DB,Betz G

更新日期：1986-08-01 00:00:00

abstract：:We studied the direct effects of glucocorticoids on plasminogen activator (PA) production by rat granulosa cells. PA production was assayed by culturing rat granulosa cells on [125I]fibrin plates and determining the extent of fibrinolysis after addition of the specific substrate plasminogen. In granulosa cells from pr...

journal_title：Endocrinology

authors： Wang C,Leung A

更新日期：1989-04-01 00:00:00